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Compile Data Set for Download or QSAR

Found 80 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1232   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164943
PNG
(US10166239, Ex. 3-40-3 | US9067914, Ex. 3-40-3)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(C)C
Show InChI InChI=1S/C27H29N7O2/c1-17(2)22-7-5-19(11-29-22)16-36-24-8-6-18(9-25(24)35-4)14-34-26-23(32-27(34)28)10-20(12-30-26)21-13-31-33(3)15-21/h5-13,15,17H,14,16H2,1-4H3,(H2,28,32)
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US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164941
PNG
(US10166239, Ex. 3-40-1 | US9067914, Ex. 3-40-1)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H23F3N6O3/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)38-26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
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Article
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164929
PNG
(US10166239, Ex. 3-35-3 | US9067914, Ex. 3-35-3)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N6O2/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
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Article
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164945
PNG
(US10166239, Ex. 3-40-5 | US9067914, Ex. 3-40-5)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(n1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N7O2S/c1-32-10-15(8-29-32)14-6-17-20(28-7-14)33(22(27)31-17)9-13-3-4-18(19(5-13)34-2)35-11-16-12-36-21(30-16)23(24,25)26/h3-8,10,12H,9,11H2,1-2H3,(H2,27,31)
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Article
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164930
PNG
(US10166239, Ex. 3-35-4 | US9067914, Ex. 3-35-4)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C1CC1
Show InChI InChI=1S/C27H27N7O2/c1-33-15-21(13-31-33)20-10-23-26(30-12-20)34(27(28)32-23)14-17-4-8-24(25(9-17)35-2)36-16-18-3-7-22(29-11-18)19-5-6-19/h3-4,7-13,15,19H,5-6,14,16H2,1-2H3,(H2,28,32)
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Article
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164928
PNG
(US10166239, Ex. 3-35-2 | US9067914, Ex. 3-35-2)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N7O2/c1-34-13-18(11-32-34)17-8-19-23(31-10-17)35(24(29)33-19)12-15-3-5-20(21(7-15)36-2)37-14-16-4-6-22(30-9-16)25(26,27)28/h3-11,13H,12,14H2,1-2H3,(H2,29,33)
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Article
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164944
PNG
(US10166239, Ex. 3-40-4 | US9067914, Ex. 3-40-4)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(CC(F)(F)F)cc1
Show InChI InChI=1S/C27H25F3N6O2/c1-35-15-21(13-33-35)20-10-22-25(32-12-20)36(26(31)34-22)14-19-7-8-23(24(9-19)37-2)38-16-18-5-3-17(4-6-18)11-27(28,29)30/h3-10,12-13,15H,11,14,16H2,1-2H3,(H2,31,34)
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US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164942
PNG
(US10166239, Ex. 3-40-2 | US9067914, Ex. 3-40-2)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C26H23F3N6O2S/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)38-26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
PDB
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Article
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164940
PNG
(US10166239, Ex. 3-39 | US9067914, Ex. 3-39)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(cc1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C27H23F5N6O2/c1-37-14-19(12-35-37)18-10-21-24(34-11-18)38(25(33)36-21)13-17-5-8-22(23(9-17)39-2)40-15-16-3-6-20(7-4-16)26(28,29)27(30,31)32/h3-12,14H,13,15H2,1-2H3,(H2,33,36)
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Article
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164901
PNG
(US10166239, Ex. 3-15 | US9067914, Ex. 3-15)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
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Article
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164956
PNG
(US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/s2
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US Patent
n/an/a 0.300n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164962
PNG
(US10166239, Ex. 3-53 | US9067914, Ex. 3-53)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1/C26H24F3N7O2/c1-15(36-24-20(34-25(36)30)8-18(11-32-24)19-12-33-35(2)13-19)17-5-6-21(22(9-17)37-3)38-14-16-4-7-23(31-10-16)26(27,28)29/h4-13,15H,14H2,1-3H3,(H2,30,34)
PDB
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Article
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164902
PNG
(US10166239, Ex. 3-16 | US9067914, Ex. 3-16)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccc(nc3)P(C)(C)=O)cc2OC)cc1
Show InChI InChI=1S/C29H30N5O4P/c1-36-23-9-5-19(6-10-23)18-38-25-11-7-20(13-26(25)37-2)17-34-28-24(33-29(34)30)14-22(16-32-28)21-8-12-27(31-15-21)39(3,4)35/h5-16H,17-18H2,1-4H3,(H2,30,33)
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US Patent
n/an/a 0.5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164931
PNG
(US10166239, Ex. 3-35-5 | US9067914, Ex. 3-35-5)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(C)n1
Show InChI InChI=1S/C23H23N7O2S/c1-14-27-18(13-33-14)12-32-20-5-4-15(6-21(20)31-3)10-30-22-19(28-23(30)24)7-16(8-25-22)17-9-26-29(2)11-17/h4-9,11,13H,10,12H2,1-3H3,(H2,24,28)
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US Patent
n/an/a 0.5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164927
PNG
(US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1
Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164912
PNG
(US10166239, Ex. 3-20 | US9067914, Ex. 3-20)
Show SMILES COc1cc(Cn2cnc3cc(cnc23)-c2cnn(c2)C2CCNCC2)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C29H31N7O2/c1-20-3-4-22(13-31-20)18-38-27-6-5-21(11-28(27)37-2)16-35-19-33-26-12-23(14-32-29(26)35)24-15-34-36(17-24)25-7-9-30-10-8-25/h3-6,11-15,17,19,25,30H,7-10,16,18H2,1-2H3
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US Patent
n/an/a 0.900n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164911
PNG
(US10166239, Ex. 3-19 | US9067914, Ex. 3-19)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-c3cnn(c3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C29H31N7O3/c1-37-27-11-20(3-5-26(27)39-18-21-4-6-28(38-2)31-13-21)16-35-19-33-25-12-22(14-32-29(25)35)23-15-34-36(17-23)24-7-9-30-10-8-24/h3-6,11-15,17,19,24,30H,7-10,16,18H2,1-2H3
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US Patent
n/an/a 1n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164964
PNG
(US10166239, Ex. 3-55 | US9067914, Ex. 3-55)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1c(N)nc2cc(cnc12)C#CCCO
Show InChI InChI=1/C26H24F3N5O3/c1-16(34-24-20(33-25(34)30)11-17(13-32-24)5-3-4-10-35)19-7-8-21(22(12-19)36-2)37-15-18-6-9-23(31-14-18)26(27,28)29/h6-9,11-14,16,35H,4,10,15H2,1-2H3,(H2,30,33)
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n/an/a 1n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164885
PNG
(US10166239, Ex. 3-1 | US9067914, Ex. 3-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C27H27N5O3/c1-31-16-21(14-29-31)20-7-10-24-23(13-20)30-27(28)32(24)15-19-6-11-25(26(12-19)34-3)35-17-18-4-8-22(33-2)9-5-18/h4-14,16H,15,17H2,1-3H3,(H2,28,30)
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n/an/a 1n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164937
PNG
(US10166239, Ex. 3-37-5 | US9067914, Ex. 3-37-5)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccncc3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-11-17(3-5-22(23)35-16-18-4-6-24(34-2)29-13-18)15-32-25-21(31-26(32)27)12-20(14-30-25)19-7-9-28-10-8-19/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 2n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164950
PNG
(US10166239, Ex. 3-45 | US9067914, Ex. 3-45)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2cnn(C)c2)cn1
Show InChI InChI=1/C27H28N6O3/c1-17(33-23-8-6-20(11-22(23)31-27(33)28)21-14-30-32(2)15-21)19-7-9-24(25(12-19)34-3)36-16-18-5-10-26(35-4)29-13-18/h5-15,17H,16H2,1-4H3,(H2,28,31)
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n/an/a 3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164934
PNG
(US10166239, Ex. 3-37-2 | US9067914, Ex. 3-37-2)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccn(C)n3)cc2OC)cn1
Show InChI InChI=1S/C25H25N7O3/c1-31-9-8-19(30-31)18-11-20-24(28-13-18)32(25(26)29-20)14-16-4-6-21(22(10-16)33-2)35-15-17-5-7-23(34-3)27-12-17/h4-13H,14-15H2,1-3H3,(H2,26,29)
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n/an/a 3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164888
PNG
(US10166239, Ex. 3-2-3 | US9067914, Ex. 3-2-3)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cnn(CCN4CCOCC4)c3)cc2OC)cc1
Show InChI InChI=1S/C32H36N6O4/c1-39-27-7-3-23(4-8-27)22-42-30-10-5-24(17-31(30)40-2)20-38-29-9-6-25(18-28(29)35-32(38)33)26-19-34-37(21-26)12-11-36-13-15-41-16-14-36/h3-10,17-19,21H,11-16,20,22H2,1-2H3,(H2,33,35)
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n/an/a 3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164939
PNG
(US10166239, Ex. 3-38 | US9067914, Ex. 3-38)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccccn3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-11-17(6-8-22(23)35-16-18-7-9-24(34-2)29-13-18)15-32-25-21(31-26(32)27)12-19(14-30-25)20-5-3-4-10-28-20/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 4n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164938
PNG
(US10166239, Ex. 3-37-6 | US9067914, Ex. 3-37-6)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cccnc3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-10-17(5-7-22(23)35-16-18-6-8-24(34-2)29-12-18)15-32-25-21(31-26(32)27)11-20(14-30-25)19-4-3-9-28-13-19/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164957
PNG
(US10166239, Ex. 3-49-6b | US9067914, Ex. 3-49-6b)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/s2
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n/an/a 5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164932
PNG
(US10166239, Ex. 3-36 | US9067914, Ex. 3-36)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccccc3)cc2OC)cn1
Show InChI InChI=1S/C27H25N5O3/c1-33-24-12-18(8-10-23(24)35-17-19-9-11-25(34-2)29-14-19)16-32-26-22(31-27(32)28)13-21(15-30-26)20-6-4-3-5-7-20/h3-15H,16-17H2,1-2H3,(H2,28,31)
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n/an/a 6n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164891
PNG
(US10166239, Ex. 3-5 | US9067914, Ex. 3-5)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)-c3cnn(c3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C30H32N6O3/c1-37-29-13-21(3-7-28(29)39-19-22-4-8-30(38-2)32-15-22)17-35-20-33-26-14-23(5-6-27(26)35)24-16-34-36(18-24)25-9-11-31-12-10-25/h3-8,13-16,18,20,25,31H,9-12,17,19H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164961
PNG
(US10166239, Ex. 3-52 | US9067914, Ex. 3-52)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1cnc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1/C26H23F3N6O2/c1-16(35-15-32-21-8-19(11-31-25(21)35)20-12-33-34(2)13-20)18-5-6-22(23(9-18)36-3)37-14-17-4-7-24(30-10-17)26(27,28)29/h4-13,15-16H,14H2,1-3H3
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n/an/a 7n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164889
PNG
(US10166239, Ex. 3-3 | US9067914, Ex. 3-3)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3ccc(nc3)P(C)(C)=O)cc2OC)cc1
Show InChI InChI=1S/C30H31N4O4P/c1-36-24-10-5-20(6-11-24)19-38-27-13-7-21(15-28(27)37-2)18-34-26-12-8-22(16-25(26)33-30(34)31)23-9-14-29(32-17-23)39(3,4)35/h5-17H,18-19H2,1-4H3,(H2,31,33)
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n/an/a 7n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164947
PNG
(US10166239, Ex. 3-42 | US9067914, Ex. 3-42)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)C#CCCO)cc2OC)cn1
Show InChI InChI=1S/C25H25N5O4/c1-32-22-12-18(6-8-21(22)34-16-19-7-9-23(33-2)27-14-19)15-30-24-20(29-25(30)26)11-17(13-28-24)5-3-4-10-31/h6-9,11-14,31H,4,10,15-16H2,1-2H3,(H2,26,29)
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n/an/a 7n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164910
PNG
(US10166239, Ex. 3-18-7 | US9067914, Ex. 3-18-7)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC[C@H]3C(O)=O)cc2OC)cn1
Show InChI InChI=1/C26H27N5O5/c1-34-23-10-17(5-7-22(23)36-15-18-6-8-24(35-2)27-12-18)14-30-16-29-20-11-19(13-28-25(20)30)31-9-3-4-21(31)26(32)33/h5-8,10-13,16,21H,3-4,9,14-15H2,1-2H3,(H,32,33)/t21-/s2
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n/an/a 8n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164887
PNG
(US10166239, Ex. 3-2-2 | US9067914, Ex. 3-2-2)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3ccncc3)cc2OC)cc1
Show InChI InChI=1S/C28H26N4O3/c1-33-23-7-3-19(4-8-23)18-35-26-10-5-20(15-27(26)34-2)17-32-25-9-6-22(16-24(25)31-28(32)29)21-11-13-30-14-12-21/h3-16H,17-18H2,1-2H3,(H2,29,31)
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n/an/a 8n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164933
PNG
(US10166239, Ex. 3-37-1 | US9067914, Ex. 3-37-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccc(F)cc3)cc2OC)cn1
Show InChI InChI=1S/C27H24FN5O3/c1-34-24-11-17(3-9-23(24)36-16-18-4-10-25(35-2)30-13-18)15-33-26-22(32-27(33)29)12-20(14-31-26)19-5-7-21(28)8-6-19/h3-14H,15-16H2,1-2H3,(H2,29,32)
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n/an/a 9n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164936
PNG
(US10166239, Ex. 3-37-4 | US9067914, Ex. 3-37-4)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3c(C)nn(C)c3C)cc2OC)cn1
Show InChI InChI=1S/C27H29N7O3/c1-16-25(17(2)33(3)32-16)20-11-21-26(30-13-20)34(27(28)31-21)14-18-6-8-22(23(10-18)35-4)37-15-19-7-9-24(36-5)29-12-19/h6-13H,14-15H2,1-5H3,(H2,28,31)
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n/an/a 14n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164965
PNG
(US10166239, Ex. 3-56 | US9067914, Ex. 3-56)
Show SMILES COc1cc(Cn2cnc3cc(cnc23)C#CCCO)ccc1OCc1ccc(nc1)C(F)F
Show InChI InChI=1S/C25H22F2N4O3/c1-33-23-11-18(6-8-22(23)34-15-19-5-7-20(24(26)27)28-13-19)14-31-16-30-21-10-17(4-2-3-9-32)12-29-25(21)31/h5-8,10-13,16,24,32H,3,9,14-15H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164908
PNG
(US10166239, Ex. 3-18-5 | US9067914, Ex. 3-18-5)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CC4(C3)CCNCC4)cc2OC)cn1
Show InChI InChI=1S/C28H32N6O3/c1-35-25-11-20(3-5-24(25)37-16-21-4-6-26(36-2)30-13-21)15-33-19-32-23-12-22(14-31-27(23)33)34-17-28(18-34)7-9-29-10-8-28/h3-6,11-14,19,29H,7-10,15-18H2,1-2H3
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n/an/a 25n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164913
PNG
(US10166239, Ex. 3-21 | US9067914, Ex. 3-21)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-c3noc(n3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C28H29N7O4/c1-36-24-11-18(3-5-23(24)38-16-19-4-6-25(37-2)30-13-19)15-35-17-32-22-12-21(14-31-27(22)35)26-33-28(39-34-26)20-7-9-29-10-8-20/h3-6,11-14,17,20,29H,7-10,15-16H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164917
PNG
(US10166239, Ex. 3-25 | US9067914, Ex. 3-25)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C3CCCNC3)cc2OC)cn1
Show InChI InChI=1/C28H30N8O3/c1-37-26-10-19(5-7-25(26)39-17-20-6-8-27(38-2)30-12-20)15-35-18-32-23-11-22(14-31-28(23)35)36-16-24(33-34-36)21-4-3-9-29-13-21/h5-8,10-12,14,16,18,21,29H,3-4,9,13,15,17H2,1-2H3
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n/an/a 32n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164926
PNG
(US10166239, Ex. 3-34 | US9067914, Ex.3-34)
Show SMILES CCC(Oc1ccc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)cc1OC)c1ccc(OC)nc1
Show InChI InChI=1/C27H29N7O3/c1-5-22(18-7-9-25(36-4)29-12-18)37-23-8-6-17(10-24(23)35-3)15-34-26-21(32-27(34)28)11-19(13-30-26)20-14-31-33(2)16-20/h6-14,16,22H,5,15H2,1-4H3,(H2,28,32)
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n/an/a 32n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164966
PNG
(US10166239, Ex. 3-57 | US9067914, Ex. 3-57)
Show SMILES COc1ccc(cn1)C(C)Oc1ccc(Cn2cnc3cc(cnc23)-c2cnn(C)c2)cc1OC
Show InChI InChI=1/C26H26N6O3/c1-17(19-6-8-25(34-4)27-11-19)35-23-7-5-18(9-24(23)33-3)14-32-16-29-22-10-20(12-28-26(22)32)21-13-30-31(2)15-21/h5-13,15-17H,14H2,1-4H3
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n/an/a 35n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164949
PNG
(US10166239, Ex. 3-44 | US9067914, Ex. 344)
Show SMILES COc1cc2CCCC(Oc3ccc(Cn4c(N)nc5cc(cnc45)-c4cnn(C)c4)cc3OC)c2cn1
Show InChI InChI=1/C28H29N7O3/c1-34-16-20(13-32-34)19-10-22-27(31-12-19)35(28(29)33-22)15-17-7-8-24(25(9-17)36-2)38-23-6-4-5-18-11-26(37-3)30-14-21(18)23/h7-14,16,23H,4-6,15H2,1-3H3,(H2,29,33)
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n/an/a 39n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164935
PNG
(US10166239, Ex. 3-37-3 | US9067914, Ex. 3-37-3)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cncnc3)cc2OC)cn1
Show InChI InChI=1S/C25H23N7O3/c1-33-22-7-16(3-5-21(22)35-14-17-4-6-23(34-2)29-9-17)13-32-24-20(31-25(32)26)8-18(12-30-24)19-10-27-15-28-11-19/h3-12,15H,13-14H2,1-2H3,(H2,26,31)
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n/an/a 51n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164915
PNG
(US10166239, Ex. 3-23 | US9067914, Ex. 3-23)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-c3nnc(o3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C28H29N7O4/c1-36-24-11-18(3-5-23(24)38-16-19-4-6-25(37-2)30-13-19)15-35-17-32-22-12-21(14-31-26(22)35)28-34-33-27(39-28)20-7-9-29-10-8-20/h3-6,11-14,17,20,29H,7-10,15-16H2,1-2H3
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n/an/a 51n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164904
PNG
(US10166239, Ex. 3-18-1 | US9067914, Ex. 3-18-1)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC(CC3)C(C)(C)N)cc2OC)cn1
Show InChI InChI=1S/C29H36N6O3/c1-29(2,30)22-9-11-34(12-10-22)23-14-24-28(32-16-23)35(19-33-24)17-20-5-7-25(26(13-20)36-3)38-18-21-6-8-27(37-4)31-15-21/h5-8,13-16,19,22H,9-12,17-18,30H2,1-4H3
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n/an/a 54n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164948
PNG
(US10166239, Ex. 3-43 | US9067914, Ex. 3-43)
Show SMILES COc1ccc(cn1)C(Oc1ccc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)cc1OC)C1CC1
Show InChI InChI=1/C28H29N7O3/c1-34-16-21(14-32-34)20-11-22-27(31-13-20)35(28(29)33-22)15-17-4-8-23(24(10-17)36-2)38-26(18-5-6-18)19-7-9-25(37-3)30-12-19/h4,7-14,16,18,26H,5-6,15H2,1-3H3,(H2,29,33)
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n/an/a 58n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164946
PNG
(US10166239, Ex. 3-41 | US9067914, Ex. 3-41)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)C#CC3CCCCC3)cc2OC)cn1
Show InChI InChI=1S/C29H31N5O3/c1-35-26-15-22(10-12-25(26)37-19-23-11-13-27(36-2)31-17-23)18-34-28-24(33-29(34)30)14-21(16-32-28)9-8-20-6-4-3-5-7-20/h10-17,20H,3-7,18-19H2,1-2H3,(H2,30,33)
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n/an/a 65n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164951
PNG
(US10166239, Ex. 3-46 | US9067914, Ex. 3-46)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2ccc(F)cc2)cn1
Show InChI InChI=1/C29H27FN4O3/c1-18(21-8-12-26(27(15-21)35-2)37-17-19-4-13-28(36-3)32-16-19)34-25-11-7-22(14-24(25)33-29(34)31)20-5-9-23(30)10-6-20/h4-16,18H,17H2,1-3H3,(H2,31,33)
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n/an/a 85n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164886
PNG
(US10166239, Ex. 3-2-1 | US9067914, Ex. 3-2-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cncnc3)cc2OC)cc1
Show InChI InChI=1S/C27H25N5O3/c1-33-22-7-3-18(4-8-22)16-35-25-10-5-19(11-26(25)34-2)15-32-24-9-6-20(12-23(24)31-27(32)28)21-13-29-17-30-14-21/h3-14,17H,15-16H2,1-2H3,(H2,28,31)
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n/an/a 86n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM164916
PNG
(US10166239, Ex. 3-24 | US9067914, Ex. 3-24)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C(C)(C)N)cc2OC)cn1
Show InChI InChI=1S/C26H28N8O3/c1-26(2,27)23-14-34(32-31-23)19-10-20-25(29-12-19)33(16-30-20)13-17-5-7-21(22(9-17)35-3)37-15-18-6-8-24(36-4)28-11-18/h5-12,14,16H,13,15,27H2,1-4H3
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n/an/a 88n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...


US Patent US10166239 (2019)


Article DOI: 10.1016/j.bmcl.2008.02.026
BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
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