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Compile Data Set for Download or QSAR

Found 251 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 2623   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356049
PNG
(US10604535, Example 1A | US9815850, Compound 1A | ...)
Show SMILES CN1c2cc(Cl)sc2CC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C20H18ClN3O3S/c1-24-16-11-18(21)28-17(16)8-7-14(20(24)26)22-19(25)15-10-13(27-23-15)9-12-5-3-2-4-6-12/h2-6,10-11,14H,7-9H2,1H3,(H,22,25)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356229
PNG
(US10604535, Example 1B | US9815850, Compound 1B | ...)
Show SMILES CN1c2cc(Cl)sc2CC[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C20H18ClN3O3S/c1-24-16-11-18(21)28-17(16)8-7-14(20(24)26)22-19(25)15-10-13(27-23-15)9-12-5-3-2-4-6-12/h2-6,10-11,14H,7-9H2,1H3,(H,22,25)/t14-/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356230
PNG
(US10604535, Example 2B | US9815850, Compound 2 | U...)
Show SMILES CN1c2ccccc2C(F)CC(NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C22H20FN3O3/c1-26-20-10-6-5-9-16(20)17(23)13-19(22(26)28)24-21(27)18-12-15(29-25-18)11-14-7-3-2-4-8-14/h2-10,12,17,19H,11,13H2,1H3,(H,24,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356233
PNG
(US10604535, Example 3 | US9815850, Compound 3 | US...)
Show SMILES CN1c2ccccc2C(=C)C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-15-12-20(23(28)26(2)21-11-7-6-10-18(15)21)24-22(27)19-14-17(29-25-19)13-16-8-4-3-5-9-16/h3-11,14,20H,1,12-13H2,2H3,(H,24,27)/t20-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356234
PNG
(US10604535, Example 4 | US9815850, Compound 4 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)c(C)c2Cl)C1=O
Show InChI InChI=1S/C22H21ClN4O3/c1-14-19(23)20(25-27(14)12-15-8-4-3-5-9-15)21(28)24-16-13-30-18-11-7-6-10-17(18)26(2)22(16)29/h3-11,16H,12-13H2,1-2H3,(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50233233
PNG
(CHEMBL4088627 | US10604535, Example 5 | US9815850,...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2ncc(Cc3ccccc3)s2)C1=O
Show InChI InChI=1S/C21H19N3O3S/c1-24-17-9-5-6-10-18(17)27-13-16(21(24)26)23-19(25)20-22-12-15(28-20)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,25)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356236
PNG
(US10604535, Example 6 | US9815850, Compound 6 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)c(C)c2F)C1=O
Show InChI InChI=1S/C22H21FN4O3/c1-14-19(23)20(25-27(14)12-15-8-4-3-5-9-15)21(28)24-16-13-30-18-11-7-6-10-17(18)26(2)22(16)29/h3-11,16H,12-13H2,1-2H3,(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356237
PNG
(US10604535, Example 7 | US9815850, Compound 7 | US...)
Show SMILES CN1c2ccccc2C2CC2[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-26-20-10-6-5-9-16(20)17-13-18(17)21(23(26)28)24-22(27)19-12-15(29-25-19)11-14-7-3-2-4-8-14/h2-10,12,17-18,21H,11,13H2,1H3,(H,24,27)/t17?,18?,21-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356238
PNG
(US10604535, Example 7A | US9815850, Compound 7A | ...)
Show SMILES CN1c2ccccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C23H21N3O3/c1-26-20-10-6-5-9-16(20)17-13-18(17)21(23(26)28)24-22(27)19-12-15(29-25-19)11-14-7-3-2-4-8-14/h2-10,12,17-18,21H,11,13H2,1H3,(H,24,27)/t17-,18-,21-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356240
PNG
(US10604535, Example 8 | US9815850, Compound 8 | US...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(on2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C23H21N3O4/c1-26-18-9-5-6-10-19(18)29-14-17(22(26)28)24-21(27)16-13-20(30-25-16)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,17H,11-12,14H2,1H3,(H,24,27)/t17-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356241
PNG
(US10604535, Example 9 | US9815850, Compound 9 | US...)
Show SMILES CN1c2ccccc2C2(CC2)C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O
Show InChI InChI=1S/C24H23N3O3/c1-27-21-10-6-5-9-18(21)24(11-12-24)15-20(23(27)29)25-22(28)19-14-17(30-26-19)13-16-7-3-2-4-8-16/h2-10,14,20H,11-13,15H2,1H3,(H,25,28)/t20-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356242
PNG
(US10604535, Example 10 | US9815850, Compound 10 | ...)
Show SMILES CN1c2ccccc2C(F)(F)CC(NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373521
PNG
(US9896458, No. 11)
Show SMILES CN1c2ccccc2[C@H](F)CC(NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356243
PNG
(US10604535, Example 11A | US9815850, Compound 11 |...)
Show SMILES CN1c2ccccc2[C@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373524
PNG
(US9896458, No. 12)
Show SMILES CN1c2ccccc2[C@@H](F)CC(NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356246
PNG
(US10604535, Example 12A | US9815850, Compound 12 |...)
Show SMILES CN1c2ccccc2[C@@H](F)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356248
PNG
(US10604535, Example 12B | US9815850, Compound 12B ...)
Show SMILES CN1c2ccccc2[C@H](F)C[C@@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356249
PNG
(US10604535, Example 13 | US9815850, Compound 13 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc3[C@H](CCn3n2)c2ccccc2)C1=O
Show InChI InChI=1S/C23H22N4O3/c1-26-19-9-5-6-10-21(19)30-14-18(23(26)29)24-22(28)17-13-20-16(11-12-27(20)25-17)15-7-3-2-4-8-15/h2-10,13,16,18H,11-12,14H2,1H3,(H,24,28)/t16-,18+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356250
PNG
(US10604535, Example 14 | US9815850, Compound 14 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2cc(CC(F)(F)F)on2)C1=O
Show InChI InChI=1S/C16H14F3N3O4/c1-22-12-4-2-3-5-13(12)25-8-11(15(22)24)20-14(23)10-6-9(26-21-10)7-16(17,18)19/h2-6,11H,7-8H2,1H3,(H,20,23)/t11-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356264
PNG
(US10604535, Example 30 | US9815850, Compound 30 | ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2ccnc12)c1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C23H20N4O2/c28-23(20-15-18(29-26-20)14-16-6-2-1-3-7-16)25-19-11-10-17-8-4-5-9-21(17)27-13-12-24-22(19)27/h1-9,12-13,15,19H,10-11,14H2,(H,25,28)/t19-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356265
PNG
(US10604535, Example 32 | US9815850, Compound 32 | ...)
Show SMILES CN1c2cccc(Cl)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356267
PNG
(US10604535, Example 35 | US9815850, Compound 35 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc([nH]2)C2(CC2)c2ccccc2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356268
PNG
(US10604535, Example 38A | US9815850, Compound 38A ...)
Show SMILES CN1c2nc(C)sc2CC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356270
PNG
(US10604535, Example 41 | US9815850, Compound 41 | ...)
Show SMILES CN1c2ccncc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356271
PNG
(US10604535, Example 169 | US9815850, Compound 169 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356273
PNG
(US10604535, Example 44 | US9815850, Compound 44 | ...)
Show SMILES CN1c2ccccc2C2(CC2)C[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356274
PNG
(US10604535, Example 45 | US9815850, Compound 45 | ...)
Show SMILES Cc1c(F)c(nn1Cc1ccccc1)C(=O)N[C@H]1COc2ccccc2NC1=O
Show InChI InChI=1S/C21H19FN4O3/c1-13-18(22)19(25-26(13)11-14-7-3-2-4-8-14)21(28)24-16-12-29-17-10-6-5-9-15(17)23-20(16)27/h2-10,16H,11-12H2,1H3,(H,23,27)(H,24,28)/t16-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356275
PNG
(US10604535, Example 46A | US9815850, Compound 46A ...)
Show SMILES CN1c2ccccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356278
PNG
(US10604535, Example 50A | US9815850, Compound 50A ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)C2C[C@H]2Cc2ccccc2)C1=O
Show InChI InChI=1S/C21H22N2O3/c1-23-18-9-5-6-10-19(18)26-13-17(21(23)25)22-20(24)16-12-15(16)11-14-7-3-2-4-8-14/h2-10,15-17H,11-13H2,1H3,(H,22,24)/t15-,16?,17+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356280
PNG
(US9815850, Compound 51 | US9896458, No. 51)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356281
PNG
(US10604535, Example 52 | US9815850, Compound 52 | ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2ccnc12)c1nnc(Cc2ccccc2)[nH]1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356282
PNG
(US10604535, Example 54B | US9815850, Compound 54A ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356282
PNG
(US10604535, Example 54B | US9815850, Compound 54A ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc([nH]2)C2CCc3ccccc23)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356284
PNG
(US10604535, Example 55 | US9815850, Compound 55 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccn3)cc2F)C1=O
Show InChI InChI=1S/C20H18FN5O3/c1-25-16-7-2-3-8-17(16)29-12-15(20(25)28)23-19(27)18-14(21)11-26(24-18)10-13-6-4-5-9-22-13/h2-9,11,15H,10,12H2,1H3,(H,23,27)/t15-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356285
PNG
(US10604535, Example 56 | US9815850, Compound 56 | ...)
Show SMILES CN1c2cccc(C#N)c2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356286
PNG
(US10604535, Example 57 | US9815850, Compound 57 | ...)
Show SMILES Fc1cn(Cc2ccccc2)nc1C(=O)N[C@H]1COc2cccnc2NC1=O
Show InChI InChI=1S/C19H16FN5O3/c20-13-10-25(9-12-5-2-1-3-6-12)24-16(13)19(27)22-14-11-28-15-7-4-8-21-17(15)23-18(14)26/h1-8,10,14H,9,11H2,(H,22,27)(H,21,23,26)/t14-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356287
PNG
(US10604535, Example 58 | US9815850, Compound 58 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc(s2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C22H20N4O3S/c1-26-16-9-5-6-10-17(16)29-13-15(20(26)28)23-18(27)19-24-25-21(30-19)22(11-12-22)14-7-3-2-4-8-14/h2-10,15H,11-13H2,1H3,(H,23,27)/t15-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356288
PNG
(US10604535, Example 59 | US9815850, Compound 59 | ...)
Show SMILES CN1c2ccccc2C2(CC2)C[C@H](NC(=O)c2cc(Cc3ccccc3)[nH]n2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356289
PNG
(US10604535, Example 60A | US9815850, Compound 60A ...)
Show SMILES CN1c2ccccc2[C@@H]2C[C@@H]2[C@H](NC(=O)c2cc(Cc3ccccc3)[nH]n2)C1=O
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356291
PNG
(US10604535, Example 61 | US9815850, Compound 61 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2coc(n2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C23H21N3O4/c1-26-18-9-5-6-10-19(18)29-14-17(21(26)28)24-20(27)16-13-30-22(25-16)23(11-12-23)15-7-3-2-4-8-15/h2-10,13,17H,11-12,14H2,1H3,(H,24,27)/t17-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356292
PNG
(US10604535, Example 62 | US9815850, Compound 62 | ...)
Show SMILES O=C(N[C@H]1COc2cccnc2NC1=O)c1cc(on1)C1(CC1)c1ccccc1
Show InChI InChI=1S/C21H18N4O4/c26-19(23-15-12-28-16-7-4-10-22-18(16)24-20(15)27)14-11-17(29-25-14)21(8-9-21)13-5-2-1-3-6-13/h1-7,10-11,15H,8-9,12H2,(H,23,26)(H,22,24,27)/t15-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356293
PNG
(US10604535, Example 63 | US9815850, Compound 63 | ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2ncc(s2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C22H20N4O3S/c1-26-18-16(8-5-11-23-18)29-13-15(21(26)28)25-19(27)20-24-12-17(30-20)22(9-10-22)14-6-3-2-4-7-14/h2-8,11-12,15H,9-10,13H2,1H3,(H,25,27)/t15-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356294
PNG
(US10604535, Example 64 | US9815850, Compound 64 | ...)
Show SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(Cc3ccccc3)cc2F)C1=O
Show InChI InChI=1S/C21H19FN4O3/c1-25-17-9-5-6-10-18(17)29-13-16(21(25)28)23-20(27)19-15(22)12-26(24-19)11-14-7-3-2-4-8-14/h2-10,12,16H,11,13H2,1H3,(H,23,27)/t16-/m0/s1
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356296
PNG
(US10604535, Example 173 | US9815850, Compound 173 ...)
Show SMILES CN1c2ncccc2OC[C@H](NC(=O)c2nnc(o2)C2(CC2)c2ccccc2)C1=O
Show InChI InChI=1S/C21H19N5O4/c1-26-16-15(8-5-11-22-16)29-12-14(19(26)28)23-17(27)18-24-25-20(30-18)21(9-10-21)13-6-3-2-4-7-13/h2-8,11,14H,9-10,12H2,1H3,(H,23,27)/t14-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356297
PNG
(US10604535, Example 67A | US9815850, Compound 67A ...)
Show SMILES CN1c2ccccc2[C@H]2C[C@H]2[C@H](NC(=O)c2nnc(Cc3ccccc3)[nH]2)C1=O
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356299
PNG
(US10604535, Example 68A | US9815850, Compound 68A ...)
Show SMILES O=C(N[C@H]1COc2ccccc2-n2ccnc12)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM356301
PNG
(US10604535, Example 69A | US9815850, Compound 69A ...)
Show SMILES O=C(N[C@H]1CCc2ccccc2-n2cnnc12)c1nnc(Cc2ccccc2)[nH]1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM373567
PNG
(US10604535, Example 70A | US9896458, No. 70A)
Show SMILES O=C(N[C@H]1COc2ccccc2-n2ccnc12)c1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C22H18N4O3/c27-22(17-13-16(29-25-17)12-15-6-2-1-3-7-15)24-18-14-28-20-9-5-4-8-19(20)26-11-10-23-21(18)26/h1-11,13,18H,12,14H2,(H,24,27)/t18-/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Test compounds were diluted in DMSO and 0.1 μL of solution was dispensed to each well of a 384-well white solid microplate. The assay buffer was...


US Patent US9896458 (2018)


BindingDB Entry DOI: 10.7270/Q2XW4N44
More data for this
Ligand-Target Pair
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