BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 44 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 50033185   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341104
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(4-(trifluor...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O2/c1-31-20-5-3-2-4-19(20)28-10-12-29(13-11-28)21(30)18-14-17(26-27-18)15-6-8-16(9-7-15)22(23,24)25/h2-9,14H,10-13H2,1H3,(H,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341098
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-(3-fluor...)
Show SMILES Fc1cccc(COc2ccccc2N2CCN(CC2)C(=O)c2cc(n[nH]2)-c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C27H24ClFN4O2/c28-21-10-8-20(9-11-21)23-17-24(31-30-23)27(34)33-14-12-32(13-15-33)25-6-1-2-7-26(25)35-18-19-4-3-5-22(29)16-19/h1-11,16-17H,12-15,18H2,(H,30,31)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341099
PNG
(2-(2-(4-(3-(4-chlorophenyl)-1H-pyrazole-5-carbonyl...)
Show SMILES NC(=O)COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN5O3/c23-16-7-5-15(6-8-16)17-13-18(26-25-17)22(30)28-11-9-27(10-12-28)19-3-1-2-4-20(19)31-14-21(24)29/h1-8,13H,9-12,14H2,(H2,24,29)(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341079
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Show SMILES COc1ccccc1N1CCN(CC1(C)C)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN4O2/c1-23(2)15-27(12-13-28(23)20-6-4-5-7-21(20)30-3)22(29)19-14-18(25-26-19)16-8-10-17(24)11-9-16/h4-11,14H,12-13,15H2,1-3H3,(H,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341105
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(4-(trifluor...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H21F3N4O3/c1-31-20-5-3-2-4-19(20)28-10-12-29(13-11-28)21(30)18-14-17(26-27-18)15-6-8-16(9-7-15)32-22(23,24)25/h2-9,14H,10-13H2,1H3,(H,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341075
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2/c1-28-20-5-3-2-4-19(20)25-10-12-26(13-11-25)21(27)18-14-17(23-24-18)15-6-8-16(22)9-7-15/h2-9,14H,10-13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341076
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyb...)
Show SMILES COc1ccccc1CN1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN4O2/c1-29-21-5-3-2-4-17(21)15-26-10-12-27(13-11-26)22(28)20-14-19(24-25-20)16-6-8-18(23)9-7-16/h2-9,14H,10-13,15H2,1H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341080
PNG
((3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(4-(2...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(nn1C)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN4O2/c1-25-20(15-18(24-25)16-7-9-17(23)10-8-16)22(28)27-13-11-26(12-14-27)19-5-3-4-6-21(19)29-2/h3-10,15H,11-14H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341093
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-ethylphe...)
Show SMILES CCc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN4O/c1-2-16-5-3-4-6-21(16)26-11-13-27(14-12-26)22(28)20-15-19(24-25-20)17-7-9-18(23)10-8-17/h3-10,15H,2,11-14H2,1H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341081
PNG
((5-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-yl)(4-(2...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(-c2ccc(Cl)cc2)n(C)n1
Show InChI InChI=1S/C22H23ClN4O2/c1-25-20(16-7-9-17(23)10-8-16)15-18(24-25)22(28)27-13-11-26(12-14-27)19-5-3-4-6-21(19)29-2/h3-10,15H,11-14H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341078
PNG
((S)-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-meth...)
Show SMILES COc1ccccc1N1CCN([C@@H](C)C1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN4O2/c1-15-14-26(20-5-3-4-6-21(20)29-2)11-12-27(15)22(28)19-13-18(24-25-19)16-7-9-17(23)10-8-16/h3-10,13,15H,11-12,14H2,1-2H3,(H,24,25)/t15-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341109
PNG
((3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl)(4-(2-meth...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H20Cl2N4O2/c1-29-20-5-3-2-4-19(20)26-8-10-27(11-9-26)21(28)18-13-17(24-25-18)15-7-6-14(22)12-16(15)23/h2-7,12-13H,8-11H2,1H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 205n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341108
PNG
(4-(5-(4-(2-methoxyphenyl)piperazine-1-carbonyl)-1H...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H21N5O2/c1-29-21-5-3-2-4-20(21)26-10-12-27(13-11-26)22(28)19-14-18(24-25-19)17-8-6-16(15-23)7-9-17/h2-9,14H,10-13H2,1H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 208n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341103
PNG
((3-(4-fluorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN4O2/c1-28-20-5-3-2-4-19(20)25-10-12-26(13-11-25)21(27)18-14-17(23-24-18)15-6-8-16(22)9-7-15/h2-9,14H,10-13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341082
PNG
((5-(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)(4-(2-...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc([nH]c1C)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H24ClN3O2/c1-16-19(15-20(25-16)17-7-9-18(24)10-8-17)23(28)27-13-11-26(12-14-27)21-5-3-4-6-22(21)29-2/h3-10,15,25H,11-14H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 280n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341097
PNG
((4-(5-chloro-2-methoxyphenyl)piperazin-1-yl)(3-(4-...)
Show SMILES COc1ccc(Cl)cc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20Cl2N4O2/c1-29-20-7-6-16(23)12-19(20)26-8-10-27(11-9-26)21(28)18-13-17(24-25-18)14-2-4-15(22)5-3-14/h2-7,12-13H,8-11H2,1H3,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341106
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-p-tolyl-1H-p...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(C)cc1
Show InChI InChI=1S/C22H24N4O2/c1-16-7-9-17(10-8-16)18-15-19(24-23-18)22(27)26-13-11-25(12-14-26)20-5-3-4-6-21(20)28-2/h3-10,15H,11-14H2,1-2H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341094
PNG
(2-(4-(3-(4-chlorophenyl)-1H-pyrazole-5-carbonyl)pi...)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)N1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C21H18ClN5O/c22-17-7-5-15(6-8-17)18-13-19(25-24-18)21(28)27-11-9-26(10-12-27)20-4-2-1-3-16(20)14-23/h1-8,13H,9-12H2,(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341074
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-phenyl-1H-py...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C21H22N4O2/c1-27-20-10-6-5-9-19(20)24-11-13-25(14-12-24)21(26)18-15-17(22-23-18)16-7-3-2-4-8-16/h2-10,15H,11-14H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341102
PNG
((3-(3-fluorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1cccc(F)c1
Show InChI InChI=1S/C21H21FN4O2/c1-28-20-8-3-2-7-19(20)25-9-11-26(12-10-25)21(27)18-14-17(23-24-18)15-5-4-6-16(22)13-15/h2-8,13-14H,9-12H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 580n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341083
PNG
((5-(4-chlorophenyl)isoxazol-3-yl)(4-(2-methoxyphen...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(on1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN3O3/c1-27-19-5-3-2-4-18(19)24-10-12-25(13-11-24)21(26)17-14-20(28-23-17)15-6-8-16(22)9-7-15/h2-9,14H,10-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341101
PNG
((3-(2-fluorophenyl)-1H-pyrazol-5-yl)(4-(2-methoxyp...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccccc1F
Show InChI InChI=1S/C21H21FN4O2/c1-28-20-9-5-4-8-19(20)25-10-12-26(13-11-25)21(27)18-14-17(23-24-18)15-6-2-3-7-16(15)22/h2-9,14H,10-13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341095
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-hydroxyp...)
Show SMILES Oc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19ClN4O2/c21-15-7-5-14(6-8-15)16-13-17(23-22-16)20(27)25-11-9-24(10-12-25)18-3-1-2-4-19(18)26/h1-8,13,26H,9-12H2,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341086
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(pyridin-4-...)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)N1CCN(Cc2ccncc2)CC1
Show InChI InChI=1S/C20H20ClN5O/c21-17-3-1-16(2-4-17)18-13-19(24-23-18)20(27)26-11-9-25(10-12-26)14-15-5-7-22-8-6-15/h1-8,13H,9-12,14H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341077
PNG
((3-cyclohexyl-1H-pyrazol-5-yl)(4-(2-methoxyphenyl)...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)C1CCCCC1
Show InChI InChI=1S/C21H28N4O2/c1-27-20-10-6-5-9-19(20)24-11-13-25(14-12-24)21(26)18-15-17(22-23-18)16-7-3-2-4-8-16/h5-6,9-10,15-16H,2-4,7-8,11-14H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341073
PNG
((3-phenyl-1H-pyrazol-5-yl)(4-phenylpiperazin-1-yl)...)
Show SMILES O=C(N1CCN(CC1)c1ccccc1)c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H20N4O/c25-20(19-15-18(21-22-19)16-7-3-1-4-8-16)24-13-11-23(12-14-24)17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341107
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(4-(methylsu...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H24N4O4S/c1-30-21-6-4-3-5-20(21)25-11-13-26(14-12-25)22(27)19-15-18(23-24-19)16-7-9-17(10-8-16)31(2,28)29/h3-10,15H,11-14H2,1-2H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341115
PNG
((R)-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-meth...)
Show SMILES COc1ccccc1N1CCN([C@H](C)C1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN4O2/c1-15-14-26(20-5-3-4-6-21(20)29-2)11-12-27(15)22(28)19-13-18(24-25-19)16-7-9-17(23)10-8-16/h3-10,13,15H,11-12,14H2,1-2H3,(H,24,25)/t15-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341113
PNG
(4-(3-(4-chlorophenyl)-1H-pyrazole-5-carbonyl)-1-(2...)
Show SMILES COc1ccccc1N1CCN(CC1=O)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN4O3/c1-29-19-5-3-2-4-18(19)26-11-10-25(13-20(26)27)21(28)17-12-16(23-24-17)14-6-8-15(22)9-7-14/h2-9,12H,10-11,13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341110
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(pyridin-2-y...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccccn1
Show InChI InChI=1S/C20H21N5O2/c1-27-19-8-3-2-7-18(19)24-10-12-25(13-11-24)20(26)17-14-16(22-23-17)15-6-4-5-9-21-15/h2-9,14H,10-13H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341100
PNG
((3-benzyl-1H-pyrazol-5-yl)(4-(2-methoxyphenyl)pipe...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(Cc2ccccc2)[nH]n1
Show InChI InChI=1S/C22H24N4O2/c1-28-21-10-6-5-9-20(21)25-11-13-26(14-12-25)22(27)19-16-18(23-24-19)15-17-7-3-2-4-8-17/h2-10,16H,11-15H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341085
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(pyridin-3-...)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)N1CCN(Cc2cccnc2)CC1
Show InChI InChI=1S/C20H20ClN5O/c21-17-5-3-16(4-6-17)18-12-19(24-23-18)20(27)26-10-8-25(9-11-26)14-15-2-1-7-22-13-15/h1-7,12-13H,8-11,14H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.81E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341116
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-phenylisoxaz...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C21H21N3O3/c1-26-19-10-6-5-9-18(19)23-11-13-24(14-12-23)21(25)20-15-17(22-27-20)16-7-3-2-4-8-16/h2-10,15H,11-14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341084
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(pyridin-2-...)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)N1CCN(Cc2ccccn2)CC1
Show InChI InChI=1S/C20H20ClN5O/c21-16-6-4-15(5-7-16)18-13-19(24-23-18)20(27)26-11-9-25(10-12-26)14-17-3-1-2-8-22-17/h1-8,13H,9-12,14H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.09E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341111
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(pyridin-3-y...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1cccnc1
Show InChI InChI=1S/C20H21N5O2/c1-27-19-7-3-2-6-18(19)24-9-11-25(12-10-24)20(26)17-13-16(22-23-17)15-5-4-8-21-14-15/h2-8,13-14H,9-12H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.10E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341112
PNG
((4-(2-methoxyphenyl)piperazin-1-yl)(3-(pyridin-4-y...)
Show SMILES COc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccncc1
Show InChI InChI=1S/C20H21N5O2/c1-27-19-5-3-2-4-18(19)24-10-12-25(13-11-24)20(26)17-14-16(22-23-17)15-6-8-21-9-7-15/h2-9,14H,10-13H2,1H3,(H,22,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341114
PNG
(1-(2-methoxyphenyl)-4-(3-phenyl-1H-pyrazol-5-ylsul...)
Show SMILES COc1ccccc1N1CCN(CC1)S(=O)(=O)c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O3S/c1-27-19-10-6-5-9-18(19)23-11-13-24(14-12-23)28(25,26)20-15-17(21-22-20)16-7-3-2-4-8-16/h2-10,15H,11-14H2,1H3,(H,21,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.40E+3n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341092
PNG
((4-(biphenyl-2-yl)piperazin-1-yl)(3-phenyl-1H-pyra...)
Show SMILES O=C(N1CCN(CC1)c1ccccc1-c1ccccc1)c1cc(n[nH]1)-c1ccccc1
Show InChI InChI=1S/C26H24N4O/c31-26(24-19-23(27-28-24)21-11-5-2-6-12-21)30-17-15-29(16-18-30)25-14-8-7-13-22(25)20-9-3-1-4-10-20/h1-14,19H,15-18H2,(H,27,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341096
PNG
(2-(4-(3-(4-chlorophenyl)-1H-pyrazole-5-carbonyl)pi...)
Show SMILES NC(=O)c1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN5O2/c22-15-7-5-14(6-8-15)17-13-18(25-24-17)21(29)27-11-9-26(10-12-27)19-4-2-1-3-16(19)20(23)28/h1-8,13H,9-12H2,(H2,23,28)(H,24,25)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341091
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-o-tolylpipe...)
Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O/c1-15-4-2-3-5-20(15)25-10-12-26(13-11-25)21(27)19-14-18(23-24-19)16-6-8-17(22)9-7-16/h2-9,14H,10-13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341089
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(4-methoxyp...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2/c1-28-18-8-6-17(7-9-18)25-10-12-26(13-11-25)21(27)20-14-19(23-24-20)15-2-4-16(22)5-3-15/h2-9,14H,10-13H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341087
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(cyclohexyl...)
Show SMILES Clc1ccc(cc1)-c1cc([nH]n1)C(=O)N1CCN(CC2CCCCC2)CC1
Show InChI InChI=1S/C21H27ClN4O/c22-18-8-6-17(7-9-18)19-14-20(24-23-19)21(27)26-12-10-25(11-13-26)15-16-4-2-1-3-5-16/h6-9,14,16H,1-5,10-13,15H2,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341088
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(3-methoxyp...)
Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2/c1-28-18-4-2-3-17(13-18)25-9-11-26(12-10-25)21(27)20-14-19(23-24-20)15-5-7-16(22)8-6-15/h2-8,13-14H,9-12H2,1H3,(H,23,24)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(Homo sapiens (Human))
BDBM50341090
PNG
((3-(4-chlorophenyl)-1H-pyrazol-5-yl)(4-(2-(trifluo...)
Show SMILES FC(F)(F)c1ccccc1N1CCN(CC1)C(=O)c1cc(n[nH]1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClF3N4O/c22-15-7-5-14(6-8-15)17-13-18(27-26-17)20(30)29-11-9-28(10-12-29)19-4-2-1-3-16(19)21(23,24)25/h1-8,13H,9-12H2,(H,26,27)
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Euroscreen SA

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant NK3 receptor expressed in CHO cells assessed as inhibition of NKB-induced increase of intracellular calcium ...


Bioorg Med Chem Lett 21: 1991-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.033
BindingDB Entry DOI: 10.7270/Q2B56K16
More data for this
Ligand-Target Pair