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Compile Data Set for Download or QSAR

Found 17 hits Enz. Inhib. hit(s) with all data for assayid = 2 entry = 50040014   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387889
PNG
(CHEMBL2058666)
Show SMILES CCc1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C22H28N4O2/c1-2-16-13-24-22(25-14-16)26-10-7-17(8-11-26)4-3-9-23-18-5-6-19-20(27)15-28-21(19)12-18/h5-6,12-15,17,23,27H,2-4,7-11H2,1H3
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n/an/an/an/a 159n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387913
PNG
(CHEMBL2058674)
Show SMILES CC(C)c1noc(n1)N1CCC(CCCNc2ccc3CCC(=O)c3c2)CC1
Show InChI InChI=1S/C22H30N4O2/c1-15(2)21-24-22(28-25-21)26-12-9-16(10-13-26)4-3-11-23-18-7-5-17-6-8-20(27)19(17)14-18/h5,7,14-16,23H,3-4,6,8-13H2,1-2H3
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n/an/an/an/a 158n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387895
PNG
(CHEMBL2058395)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(OCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C20H30N2O5S/c1-20(2,3)27-19(23)22-11-8-15(9-12-22)5-4-10-21-16-6-7-18-17(13-16)26-14-28(18,24)25/h6-7,13,15,21H,4-5,8-12,14H2,1-3H3
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n/an/an/an/a 266n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387897
PNG
(CHEMBL2058397)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(NNS3(=O)=O)c2)CC1
Show InChI InChI=1S/C19H30N4O4S/c1-19(2,3)27-18(24)23-11-8-14(9-12-23)5-4-10-20-15-6-7-17-16(13-15)21-22-28(17,25)26/h6-7,13-14,20-22H,4-5,8-12H2,1-3H3
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n/an/an/an/a 331n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387888
PNG
(CHEMBL2058398)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3C(=O)CCc3c2)CC1
Show InChI InChI=1S/C22H32N2O3/c1-22(2,3)27-21(26)24-13-10-16(11-14-24)5-4-12-23-18-7-8-19-17(15-18)6-9-20(19)25/h7-8,15-16,23H,4-6,9-14H2,1-3H3
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n/an/an/an/a 87n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387899
PNG
(CHEMBL2058400)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H30N2O4/c1-21(2,3)27-20(25)23-11-8-15(9-12-23)5-4-10-22-16-6-7-17-18(24)14-26-19(17)13-16/h6-7,13-15,22,24H,4-5,8-12H2,1-3H3
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n/an/an/an/a 66n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387900
PNG
(CHEMBL2058401)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3C(=O)NCc3c2)CC1
Show InChI InChI=1S/C21H31N3O3/c1-21(2,3)27-20(26)24-11-8-15(9-12-24)5-4-10-22-17-6-7-18-16(13-17)14-23-19(18)25/h6-7,13,15,22H,4-5,8-12,14H2,1-3H3,(H,23,25)
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n/an/an/an/a 515n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387902
PNG
(CHEMBL2058403)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3CCC(=O)c3c2)CC1
Show InChI InChI=1S/C22H32N2O3/c1-22(2,3)27-21(26)24-13-10-16(11-14-24)5-4-12-23-18-8-6-17-7-9-20(25)19(17)15-18/h6,8,15-16,23H,4-5,7,9-14H2,1-3H3
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n/an/an/an/a 123n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387903
PNG
(CHEMBL2058404)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3occ(O)c3c2)CC1
Show InChI InChI=1S/C21H30N2O4/c1-21(2,3)27-20(25)23-11-8-15(9-12-23)5-4-10-22-16-6-7-19-17(13-16)18(24)14-26-19/h6-7,13-15,22,24H,4-5,8-12H2,1-3H3
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n/an/an/an/a 262n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387904
PNG
(CHEMBL2058405)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3OCCC(=O)c3c2)CC1
Show InChI InChI=1S/C22H32N2O4/c1-22(2,3)28-21(26)24-12-8-16(9-13-24)5-4-11-23-17-6-7-20-18(15-17)19(25)10-14-27-20/h6-7,15-16,23H,4-5,8-14H2,1-3H3
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n/an/an/an/a 351n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387905
PNG
(CHEMBL2058406)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3CNC(=O)c3c2)CC1
Show InChI InChI=1S/C21H31N3O3/c1-21(2,3)27-20(26)24-11-8-15(9-12-24)5-4-10-22-17-7-6-16-14-23-19(25)18(16)13-17/h6-7,13,15,22H,4-5,8-12,14H2,1-3H3,(H,23,25)
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n/an/an/an/a 892n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387906
PNG
(CHEMBL2058667)
Show SMILES COc1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H26N4O3/c1-27-17-12-23-21(24-13-17)25-9-6-15(7-10-25)3-2-8-22-16-4-5-18-19(26)14-28-20(18)11-16/h4-5,11-15,22,26H,2-3,6-10H2,1H3
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n/an/an/an/a 60n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387907
PNG
(CHEMBL2058668)
Show SMILES COC(=O)c1cnc(nc1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C22H26N4O4/c1-29-21(28)16-12-24-22(25-13-16)26-9-6-15(7-10-26)3-2-8-23-17-4-5-18-19(27)14-30-20(18)11-17/h4-5,11-15,23,27H,2-3,6-10H2,1H3
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n/an/an/an/a 139n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387910
PNG
(CHEMBL2058671)
Show SMILES CC(C)c1nnc(o1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H28N4O3/c1-14(2)20-23-24-21(28-20)25-10-7-15(8-11-25)4-3-9-22-16-5-6-17-18(26)13-27-19(17)12-16/h5-6,12-15,22,26H,3-4,7-11H2,1-2H3
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n/an/an/an/a 1.02E+3n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387911
PNG
(CHEMBL2058672)
Show SMILES CC(C)c1nsc(n1)N1CCC(CCCNc2ccc3c(O)coc3c2)CC1
Show InChI InChI=1S/C21H28N4O2S/c1-14(2)20-23-21(28-24-20)25-10-7-15(8-11-25)4-3-9-22-16-5-6-17-18(26)13-27-19(17)12-16/h5-6,12-15,22,26H,3-4,7-11H2,1-2H3
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n/an/an/an/a 812n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387912
PNG
(CHEMBL2058673)
Show SMILES CCc1cnc(nc1)N1CCC(CCCNc2ccc3CCC(=O)c3c2)CC1
Show InChI InChI=1S/C23H30N4O/c1-2-17-15-25-23(26-16-17)27-12-9-18(10-13-27)4-3-11-24-20-7-5-19-6-8-22(28)21(19)14-20/h5,7,14-16,18,24H,2-4,6,8-13H2,1H3
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n/an/an/an/a 167n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50387893
PNG
(CHEMBL2058391)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCCNc2ccc3c(CCS3(=O)=O)c2)CC1
Show InChI InChI=1S/C21H32N2O4S/c1-21(2,3)27-20(24)23-12-8-16(9-13-23)5-4-11-22-18-6-7-19-17(15-18)10-14-28(19,25)26/h6-7,15-16,22H,4-5,8-14H2,1-3H3
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n/an/an/an/a 224n/an/an/an/a



Sanwa Kagaku Kenkyusho Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 receptor expressed in CHO-K1 cells assessed as cAMP accumulation after 30 mins by HTRF assay


Bioorg Med Chem Lett 22: 5123-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.117
BindingDB Entry DOI: 10.7270/Q2TD9ZC4
More data for this
Ligand-Target Pair