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Compile Data Set for Download or QSAR

Found 209 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 488   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272699
PNG
(US10065963, Example 102)
Show SMILES COC(=O)C1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272700
PNG
(US10065963, Example 103A)
Show SMILES CNC(=O)C1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)[C@@H](C)NC(=O)c1c(N)nn2cccnc12
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272701
PNG
(US10065963, Example 103B)
Show SMILES CNC(=O)C1CCN(C1)c1c(cc(Cl)c2cn[nH]c12)[C@H](C)NC(=O)c1c(N)nn2cccnc12
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272702
PNG
(US10065963, Example 104)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCC[C@@H](C1)NC(C)=O
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272703
PNG
(US10065963, Example 105)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCC[C@@H](C1)NS(C)(=O)=O
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272704
PNG
(US10065963, Example 106)
Show SMILES CCOC(=O)C1CCN(CC1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272705
PNG
(US10065963, Example 107)
Show SMILES CNC(=O)C1CCN(CC1)c1c(cc(Cl)c2cn[nH]c12)C(C)NC(=O)c1c(N)nn2cccnc12
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272706
PNG
(US10065963, Example 108)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCC(CC1)C(=O)N(C)C
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272707
PNG
(2-Amino-N-{1-[4-chloro-7-(1,1-dioxido-1,4- thiazep...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCCS(=O)(=O)CC1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272708
PNG
(2-Amino-N-{1-[4-chloro-7-(1,1-dioxido-1,2,5- thiad...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCNS(=O)(=O)CC1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272709
PNG
(2-Amino-N-{1-[4-chloro-7-(2,2-dimethyl-1,1- dioxid...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCS(=O)(=O)C(C)(C)C1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272710
PNG
(US10065963, Example 112A)
Show SMILES C[C@@H](NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCS(=O)(=O)C(C)C1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272711
PNG
(US10065963, Example 112B)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCS(=O)(=O)C(C)C1
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272712
PNG
(2-Amino-N-{1-[3,4-dichloro-7-(1,1- dioxidothiomorp...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCS(=O)(=O)CC1
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272713
PNG
(2-Amino-N-{1-[3,4-dichloro-7-(1,1-dioxido-1,4- thi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCCS(=O)(=O)CC1
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272708
PNG
(2-Amino-N-{1-[4-chloro-7-(1,1-dioxido-1,2,5- thiad...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cn[nH]c2c1N1CCNS(=O)(=O)CC1
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272715
PNG
(2-Amino-N-{1-[3,4-dichloro-7-(2,2-dimethyl-1,1- di...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)n[nH]c2c1N1CCS(=O)(=O)C(C)(C)C1
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272717
PNG
(US10065963, Example 118)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1cn[nH]c1
PDB
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272718
PNG
(2-Amino-N-{1-[8-chloro-3-methyl-5-(1-methyl- 1H-py...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1cnn(C)c1
Show InChI InChI=1S/C21H20ClN9O/c1-11(27-21(32)17-19(23)28-30-6-4-5-24-20(17)30)14-7-15(22)16-9-25-12(2)31(16)18(14)13-8-26-29(3)10-13/h4-11H,1-3H3,(H2,23,28)(H,27,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272719
PNG
(2-Amino-N-[1-(8-chloro-3-methyl-5-pyridin-3- ylimi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1cccnc1
Show InChI InChI=1S/C22H19ClN8O/c1-12(28-22(32)18-20(24)29-30-8-4-7-26-21(18)30)15-9-16(23)17-11-27-13(2)31(17)19(15)14-5-3-6-25-10-14/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272720
PNG
(2-Amino-N-[1-(8-chloro-3-methyl-5- phenylimidazo[1...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cnc(C)n2c1-c1ccccc1
Show InChI InChI=1S/C23H20ClN7O/c1-13(28-23(32)19-21(25)29-30-10-6-9-26-22(19)30)16-11-17(24)18-12-27-14(2)31(18)20(16)15-7-4-3-5-8-15/h3-13H,1-2H3,(H2,25,29)(H,28,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272721
PNG
(US10065963, Example 122)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(Cl)nc(C)n2c1-c1cn[nH]c1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272722
PNG
(US10065963, Example 123)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(F)nc(C)n2c1-c1cn[nH]c1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272724
PNG
(US10065963, Example 125)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(nc(C)n2c1-c1ccccc1)[N+]#[C-]
Show InChI InChI=1S/C24H19ClN8O/c1-13(29-24(34)18-21(26)31-32-11-7-10-28-23(18)32)16-12-17(25)20-22(27-3)30-14(2)33(20)19(16)15-8-5-4-6-9-15/h4-13H,1-2H3,(H2,26,31)(H,29,34)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272725
PNG
(US10065963, Example 126)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(nc(C)n2c1-c1ccccc1)C#C
Show InChI InChI=1S/C25H20ClN7O/c1-4-19-22-18(26)13-17(21(33(22)15(3)30-19)16-9-6-5-7-10-16)14(2)29-25(34)20-23(27)31-32-12-8-11-28-24(20)32/h1,5-14H,2-3H3,(H2,27,31)(H,29,34)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272726
PNG
(US10065963, Example 127)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cccnc1
Show InChI InChI=1S/C21H17ClN8O/c1-12(27-21(31)17-19(23)28-30-7-3-6-26-20(17)30)14-8-15(22)16-10-25-11-29(16)18(14)13-4-2-5-24-9-13/h2-12H,1H3,(H2,23,28)(H,27,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272727
PNG
(US10065963, Example 128)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(ncn2c1-c1cccnc1)[N+]#[C-]
Show InChI InChI=1S/C22H16ClN9O/c1-12(29-22(33)16-19(24)30-32-8-4-7-27-21(16)32)14-9-15(23)18-20(25-2)28-11-31(18)17(14)13-5-3-6-26-10-13/h3-12H,1H3,(H2,24,30)(H,29,33)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272728
PNG
(US10065963, Example 129)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2c(C)ncn2c1-c1cccnc1
Show InChI InChI=1S/C22H19ClN8O/c1-12(28-22(32)17-20(24)29-31-8-4-7-26-21(17)31)15-9-16(23)18-13(2)27-11-30(18)19(15)14-5-3-6-25-10-14/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272729
PNG
(US10065963, Example 130)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cc[nH]n1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272730
PNG
(2-Amino-N-(1-{8-chloro-5-[5- (methylsulfonyl)pyrid...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cncc(c1)S(C)(=O)=O
Show InChI InChI=1S/C22H19ClN8O3S/c1-12(28-22(32)18-20(24)29-31-5-3-4-27-21(18)31)15-7-16(23)17-10-26-11-30(17)19(15)13-6-14(9-25-8-13)35(2,33)34/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272732
PNG
(2-Amino-N-[1-(8-chloro-5-pyridin-2- ylimidazo[1,5-...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1ccccn1
Show InChI InChI=1S/C21H17ClN8O/c1-12(27-21(31)17-19(23)28-30-8-4-7-26-20(17)30)13-9-14(22)16-10-24-11-29(16)18(13)15-5-2-3-6-25-15/h2-12H,1H3,(H2,23,28)(H,27,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272733
PNG
(2-Amino-N-{1-[8-chloro-5-(5-methoxypyridin- 3-yl)i...)
Show SMILES COc1cncc(c1)-c1c(cc(Cl)c2cncn12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H19ClN8O2/c1-12(28-22(32)18-20(24)29-31-5-3-4-27-21(18)31)15-7-16(23)17-10-26-11-30(17)19(15)13-6-14(33-2)9-25-8-13/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272734
PNG
(2-Amino-N-[1-(8-chloro-5-{4- [(methylamino)sulfony...)
Show SMILES CNS(=O)(=O)c1ccc(cc1)-c1c(cc(Cl)c2cncn12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C23H21ClN8O3S/c1-13(29-23(33)19-21(25)30-32-9-3-8-28-22(19)32)16-10-17(24)18-11-27-12-31(18)20(16)14-4-6-15(7-5-14)36(34,35)26-2/h3-13,26H,1-2H3,(H2,25,30)(H,29,33)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272735
PNG
(2-Amino-N-(1-{8-chloro-5-[4- (methylsulfonyl)pheny...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C22H19ClN8O3S/c1-12(28-22(32)18-20(24)29-31-7-3-6-26-21(18)31)14-8-15(23)16-10-25-11-30(16)19(14)13-4-5-17(27-9-13)35(2,33)34/h3-12H,1-2H3,(H2,24,29)(H,28,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272736
PNG
(2-Amino-N-{1-[8-chloro-5-(5-cyanopyridin-3- yl)imi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cncc(c1)C#N
Show InChI InChI=1S/C22H16ClN9O/c1-12(29-22(33)18-20(25)30-32-4-2-3-28-21(18)32)15-6-16(23)17-10-27-11-31(17)19(15)14-5-13(7-24)8-26-9-14/h2-6,8-12H,1H3,(H2,25,30)(H,29,33)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272737
PNG
(2-Amino-N-[1-(8-chloro-5-pyrazin-2- ylimidazo[1,5-...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cnccn1
Show InChI InChI=1S/C20H16ClN9O/c1-11(27-20(31)16-18(22)28-30-6-2-3-26-19(16)30)12-7-13(21)15-9-24-10-29(15)17(12)14-8-23-4-5-25-14/h2-11H,1H3,(H2,22,28)(H,27,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272738
PNG
(US10065963, Example 139)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cn[nH]c1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272739
PNG
(US10065963, Example 140)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1-c1cnn(C)c1
Show InChI InChI=1S/C20H18ClN9O/c1-11(26-20(31)16-18(22)27-30-5-3-4-24-19(16)30)13-6-14(21)15-8-23-10-29(15)17(13)12-7-25-28(2)9-12/h3-11H,1-2H3,(H2,22,27)(H,26,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272740
PNG
(US10065963, Example 141)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C21H24ClN9O3S/c1-13(26-20(32)17-18(23)27-31-5-3-4-25-19(17)31)14-10-15(22)16-11-24-12-30(16)21(14)28-6-8-29(9-7-28)35(2,33)34/h3-5,10-13H,6-9H2,1-2H3,(H2,23,27)(H,26,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272741
PNG
(US10065963, Example 142)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCCC1
Show InChI InChI=1S/C20H21ClN8O/c1-12(25-19(30)16-17(22)26-29-8-4-5-24-18(16)29)13-9-14(21)15-10-23-11-28(15)20(13)27-6-2-3-7-27/h4-5,8-12H,2-3,6-7H2,1H3,(H2,22,26)(H,25,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272742
PNG
(US10065963, Example 143)
Show SMILES COC1CCN(CC1)c1c(cc(Cl)c2cncn12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-13(27-21(32)18-19(24)28-31-7-3-6-26-20(18)31)15-10-16(23)17-11-25-12-30(17)22(15)29-8-4-14(33-2)5-9-29/h3,6-7,10-14H,4-5,8-9H2,1-2H3,(H2,24,28)(H,27,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272743
PNG
(2-Amino-N-{1-[8-chloro-5-(3- methoxypyrrolidin-1-y...)
Show SMILES COC1CCN(C1)c1c(cc(Cl)c2cncn12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H23ClN8O2/c1-12(26-20(31)17-18(23)27-30-6-3-5-25-19(17)30)14-8-15(22)16-9-24-11-29(16)21(14)28-7-4-13(10-28)32-2/h3,5-6,8-9,11-13H,4,7,10H2,1-2H3,(H2,23,27)(H,26,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272744
PNG
(2-Amino-N-[1-(8-chloro-5-morpholin-4- ylimidazo[1,...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCOCC1
Show InChI InChI=1S/C20H21ClN8O2/c1-12(25-19(30)16-17(22)26-29-4-2-3-24-18(16)29)13-9-14(21)15-10-23-11-28(15)20(13)27-5-7-31-8-6-27/h2-4,9-12H,5-8H2,1H3,(H2,22,26)(H,25,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272745
PNG
(US10065963, Example 146)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCC(O)CC1
Show InChI InChI=1S/C21H23ClN8O2/c1-12(26-20(32)17-18(23)27-30-6-2-5-25-19(17)30)14-9-15(22)16-10-24-11-29(16)21(14)28-7-3-13(31)4-8-28/h2,5-6,9-13,31H,3-4,7-8H2,1H3,(H2,23,27)(H,26,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272746
PNG
(US10065963, Example 147)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCC(Br)CC1
Show InChI InChI=1S/C21H22BrClN8O/c1-12(27-20(32)17-18(24)28-31-6-2-5-26-19(17)31)14-9-15(23)16-10-25-11-30(16)21(14)29-7-3-13(22)4-8-29/h2,5-6,9-13H,3-4,7-8H2,1H3,(H2,24,28)(H,27,32)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272748
PNG
(US10065963, Example 149)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCNS(=O)(=O)CC1
Show InChI InChI=1S/C20H22ClN9O3S/c1-12(26-19(31)16-17(22)27-30-5-2-3-24-18(16)30)13-9-14(21)15-10-23-11-29(15)20(13)28-6-4-25-34(32,33)8-7-28/h2-3,5,9-12,25H,4,6-8H2,1H3,(H2,22,27)(H,26,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272749
PNG
(2-Amino-N-(1-{8-chloro-5-[(3S,5S)-3,5- dihydroxypi...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1C[C@@H](O)C[C@H](O)C1
Show InChI InChI=1S/C21H23ClN8O3/c1-11(26-20(33)17-18(23)27-30-4-2-3-25-19(17)30)14-6-15(22)16-7-24-10-29(16)21(14)28-8-12(31)5-13(32)9-28/h2-4,6-7,10-13,31-32H,5,8-9H2,1H3,(H2,23,27)(H,26,33)/t11?,12-,13-/m0/s1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272750
PNG
(2-Amino-N-{1-[8-chloro-5-(1,1-dioxido-1,4- thiazep...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCCS(=O)(=O)CC1
Show InChI InChI=1S/C21H23ClN8O3S/c1-13(26-20(31)17-18(23)27-30-6-2-4-25-19(17)30)14-10-15(22)16-11-24-12-29(16)21(14)28-5-3-8-34(32,33)9-7-28/h2,4,6,10-13H,3,5,7-9H2,1H3,(H2,23,27)(H,26,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272750
PNG
(2-Amino-N-{1-[8-chloro-5-(1,1-dioxido-1,4- thiazep...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCCS(=O)(=O)CC1
Show InChI InChI=1S/C21H23ClN8O3S/c1-13(26-20(31)17-18(23)27-30-6-2-4-25-19(17)30)14-10-15(22)16-11-24-12-29(16)21(14)28-5-3-8-34(32,33)9-7-28/h2,4,6,10-13H,3,5,7-9H2,1H3,(H2,23,27)(H,26,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM272752
PNG
(2-Amino-N-{1-[8-chloro-5-(4-cyanopiperidin-1- yl)i...)
Show SMILES CC(NC(=O)c1c(N)nn2cccnc12)c1cc(Cl)c2cncn2c1N1CCC(CC1)C#N
Show InChI InChI=1S/C22H22ClN9O/c1-13(28-21(33)18-19(25)29-32-6-2-5-27-20(18)32)15-9-16(23)17-11-26-12-31(17)22(15)30-7-3-14(10-24)4-8-30/h2,5-6,9,11-14H,3-4,7-8H2,1H3,(H2,25,29)(H,28,33)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q2H41TFS
More data for this
Ligand-Target Pair
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