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Compile Data Set for Download or QSAR

Found 62 hits of ec50 data for polymerid = 10170,9837   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229576
PNG
(US9334279, 1052)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cscn1
PDB

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US Patent
n/an/an/an/a 0.300n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229547
PNG
(US9334279, 1023)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1nccs1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.460n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229564
PNG
(US9334279, 1040)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(cc1)C(F)(F)F)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229583
PNG
(US9334279, 1059)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1ccc(C)cc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229567
PNG
(US9334279, 1043)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1ccnc(c1)-c1ncc(C)s1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229584
PNG
(US9334279, 1060)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1ccccc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229565
PNG
(US9334279, 1041)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1nccs1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229559
PNG
(US9334279, 1035)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229560
PNG
(US9334279, 1036)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1cscn1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 0.75n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229541
PNG
(US9334279, 1017)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cncs1
PDB

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n/an/an/an/a 0.950n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229529
PNG
(US9334279, 1005)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cccnc1
PDB

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n/an/an/an/a 1.48n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229578
PNG
(US9334279, 1054)
Show SMILES CC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(cc1)C(F)(F)F)-c1nccs1)C(=O)NS(=O)(=O)C1CC1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229577
PNG
(US9334279, 1053)
Show SMILES CC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC(C)(C)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(cc1)C(F)(F)F)-c1nccs1)C(=O)NS(=O)(=O)C1CC1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229543
PNG
(US9334279, 1019)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ncccn1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229575
PNG
(US9334279, 1051)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccccn1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229545
PNG
(US9334279, 1021)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccccn1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229574
PNG
(US9334279, 1050)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1cccnc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229548
PNG
(US9334279, 1024)
Show SMILES C[C@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1nccs1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229549
PNG
(US9334279, 1025)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1ccnc(c1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229572
PNG
(US9334279, 1048)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ncccn1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229551
PNG
(US9334279, 1027)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(Cl)cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)n1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229571
PNG
(US9334279, 1047)
Show SMILES CC(C)Oc1ccc(cn1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1nccs1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229553
PNG
(US9334279, 1029)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(Cl)cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)n1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229570
PNG
(US9334279, 1046)
Show SMILES CC(C)Oc1ccc(cn1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1nccs1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229555
PNG
(US9334279, 1031 | US9334279, 1062)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(ccn1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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n/an/an/an/a 3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229569
PNG
(US9334279, 1045)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1ccnc(c1)-c1nc(C)cs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229557
PNG
(US9334279, 1033)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC(C)(C)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1cncs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229558
PNG
(US9334279, 1034)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1cncs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229561
PNG
(US9334279, 1037)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccccn1)-c1ccc(OC(C)C)cc1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229562
PNG
(US9334279, 1038)
Show SMILES CC[C@@H]1OCCC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1cncs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229563
PNG
(US9334279, 1039)
Show SMILES CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC(C)(C)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(cc1)C(F)(F)F)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229579
PNG
(US9334279, 1055)
Show SMILES CC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC(C)(C)C(F)(F)F)Oc1ccnc(c1)-c1nc(C)cs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229537
PNG
(US9334279, 1013)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-n1cccn1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229580
PNG
(US9334279, 1056)
Show SMILES CC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC(C)(C)C(F)(F)F)Oc1cc(OC)nc(c1)-c1nccs1)C(=O)NS(=O)(=O)C1CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229535
PNG
(US9334279, 1011)
Show SMILES COc1cccc(n1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccc(OC(C)C)cc1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229581
PNG
(US9334279, 1057)
Show SMILES CC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)O[C@@H]1C[C@@H]2C[C@@H]2C1)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1nccs1)C(=O)NS(=O)(=O)C1CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229533
PNG
(US9334279, 1009)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccncc1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229531
PNG
(US9334279, 1007)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1nccs1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229555
PNG
(US9334279, 1031 | US9334279, 1062)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(ccn1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229527
PNG
(US9334279, 1003)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cncs1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229568
PNG
(US9334279, 1044)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C1)Oc1ccnc(c1)-c1ncc(C)s1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229525
PNG
(US9334279, 1001)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cnccn1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229588
PNG
(US9334279, 1064)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1ccc(cn1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229587
PNG
(US9334279, 1063)
Show SMILES CC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC(C)(C)C(F)(F)F)Oc1ccc(cn1)-c1nccs1)C(=O)NS(=O)(=O)C1CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229556
PNG
(US9334279, 1032 | US9334279, 1061)
Show SMILES C[C@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(ccn1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229528
PNG
(US9334279, 1004)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1cncs1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229550
PNG
(US9334279, 1026)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(Cl)ccn1)C(=O)NS(=O)(=O)C1CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229573
PNG
(US9334279, 1049)
Show SMILES C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC2(CCCOC2)C(F)(F)F)[C@H](C)C1)Oc1cc(nc(c1)-c1cccnc1)-c1nccs1)C(=O)NS(=O)(=O)C1(C)CC1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229546
PNG
(US9334279, 1022)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ccccn1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
NS3/4A protease


(Hepatitis C virus genotype 1a (strain H77) (HCV))
BDBM229544
PNG
(US9334279, 1020)
Show SMILES CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ncccn1
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
HCV replicon luciferase assays were developed to monitor the inhibitory effects of compounds described in the disclosure on HCV genotypes 1a and 1b v...


US Patent US9334279 (2016)

More data for this
Ligand-Target Pair
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