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Compile Data Set for Download or QSAR

Found 159 hits of ec50 data for polymerid = 2094,5889   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.10n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


J Med Chem 52: 1785-94 (2009)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50346264
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-methylphe...)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O6/c1-3-27-17-8-5-14(6-9-17)10-16-11-15(7-4-13(16)2)22-21(26)20(25)19(24)18(12-23)28-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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n/an/an/an/a 1.10n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.10n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...


J Med Chem 51: 1145-9 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50346265
PNG
((2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4-fluo...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(F)cccc12
Show InChI InChI=1S/C24H26FNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 1.90n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50257797
PNG
((2S,3R,4R,5S,6R)-2-(2-(4-ethylbenzyl)phenyl)-6-(hy...)
Show SMILES CCc1ccc(Cc2ccccc2[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H26O5/c1-2-13-7-9-14(10-8-13)11-15-5-3-4-6-16(15)21-20(25)19(24)18(23)17(12-22)26-21/h3-10,17-25H,2,11-12H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a>2n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


J Med Chem 52: 1785-94 (2009)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50346266
PNG
((2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-cyclopropylbenzy...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1S/C24H26ClNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 2.30n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 2.40n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay


Eur J Med Chem 55: 32-8 (2012)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50346267
PNG
((2R,3R,4S,5S,6R)-2-(3-(4-cyclopropylbenzyl)-4,6-di...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(F)cc(F)cc12
Show InChI InChI=1S/C24H25F2NO5/c25-16-8-17(26)20-15(7-12-1-3-13(4-2-12)14-5-6-14)10-27(18(20)9-16)24-23(31)22(30)21(29)19(11-28)32-24/h1-4,8-10,14,19,21-24,28-31H,5-7,11H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 2.80n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 3n/an/an/an/a


TBA

Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 6.60n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


J Med Chem 52: 1785-94 (2009)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 6.60n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...


J Med Chem 51: 1145-9 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50244463
PNG
((2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-[2-(4-methyl-be...)
Show SMILES Cc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O6/c1-12-6-8-13(9-7-12)10-14-4-2-3-5-15(14)25-20-19(24)18(23)17(22)16(11-21)26-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a 8n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50244463
PNG
((2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-[2-(4-methyl-be...)
Show SMILES Cc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O6/c1-12-6-8-13(9-7-12)10-14-4-2-3-5-15(14)25-20-19(24)18(23)17(22)16(11-21)26-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a 8n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a 9.20n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...


J Med Chem 51: 1145-9 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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n/an/an/an/a 12n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50346266
PNG
((2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-cyclopropylbenzy...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1S/C24H26ClNO5/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-26(18)24-23(30)22(29)21(28)19(12-27)31-24/h1-7,11,15,19,21-24,27-30H,8-10,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 14n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50245105
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-methylb...)
Show SMILES Cc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O5/c1-12-5-7-13(8-6-12)9-14-3-2-4-15(10-14)20-19(24)18(23)17(22)16(11-21)25-20/h2-8,10,16-24H,9,11H2,1H3/t16-,17-,18+,19-,20+/m1/s1
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n/an/an/an/a 22n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


J Med Chem 52: 1785-94 (2009)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50245105
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-methylb...)
Show SMILES Cc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O5/c1-12-5-7-13(8-6-12)9-14-3-2-4-15(10-14)20-19(24)18(23)17(22)16(11-21)25-20/h2-8,10,16-24H,9,11H2,1H3/t16-,17-,18+,19-,20+/m1/s1
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n/an/an/an/a 22n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50174677
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C24H27NO7/c26-12-19-21(27)22(28)23(29)24(32-19)31-18-3-1-2-16-20(18)15(11-25-16)6-4-13-5-7-17-14(10-13)8-9-30-17/h1-3,5,7,10-11,19,21-29H,4,6,8-9,12H2/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 24n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



Bristol-Myers Squibb Co

Curated by ChEMBL


Assay Description
Inhibition of human kidney SGLT2 assessed as renal glucose reabsorption


J Med Chem 52: 1785-94 (2009)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 35.6n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...


J Med Chem 51: 1145-9 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161721
PNG
(CHEMBL3787068)
Show SMILES COC(=O)CC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C28H31ClN2O7/c1-37-23(33)12-22(32)30-13-21-25(34)26(35)27(36)28(38-21)31-14-18(24-19(29)3-2-4-20(24)31)11-15-5-7-16(8-6-15)17-9-10-17/h2-8,14,17,21,25-28,34-36H,9-13H2,1H3,(H,30,32)/t21-,25-,26+,27-,28-/s2
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n/an/an/an/a 39n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161654
PNG
(CHEMBL3787515)
Show SMILES CC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1S/C12H23NO7/c14-4-2-1-3-9(16)13-5-7-10(17)12(19)11(18)8(6-15)20-7/h7-8,10-12,14-15,17-19H,1-6H2,(H,13,16)
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n/an/an/an/a 42n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50389350
PNG
(CHEMBL2064100)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)c1cn(Cc2ccc(cc2)C2CC2)c2c(F)cccc12
Show InChI InChI=1S/C23H24FNO4/c24-18-3-1-2-16-17(23-22(28)21(27)19(26)12-29-23)11-25(20(16)18)10-13-4-6-14(7-5-13)15-8-9-15/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23+/m1/s1
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n/an/an/an/a 47n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay


Eur J Med Chem 55: 32-8 (2012)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 50n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in Xenopus oocyte assessed as [14C]-alpha-methyl glucopyranoside uptake


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50389351
PNG
(CHEMBL2064101)
Show SMILES Cc1cccc2c(cn(Cc3ccc(cc3)C3CC3)c12)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C24H27NO4/c1-14-3-2-4-18-19(24-23(28)22(27)20(26)13-29-24)12-25(21(14)18)11-15-5-7-16(8-6-15)17-9-10-17/h2-8,12,17,20,22-24,26-28H,9-11,13H2,1H3/t20-,22+,23-,24+/m1/s1
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n/an/an/an/a 50n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay


Eur J Med Chem 55: 32-8 (2012)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50174679
PNG
((2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-...)
Show SMILES Cn1cc(CCc2ccc3OCCc3c2)c2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cccc12
Show InChI InChI=1S/C25H29NO7/c1-26-12-16(7-5-14-6-8-18-15(11-14)9-10-31-18)21-17(26)3-2-4-19(21)32-25-24(30)23(29)22(28)20(13-27)33-25/h2-4,6,8,11-12,20,22-25,27-30H,5,7,9-10,13H2,1H3/t20-,22-,23+,24-,25-/m1/s1
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n/an/an/an/a 67n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50244462
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(p-tolylth...)
Show SMILES Cc1ccc(Sc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C19H22O5S/c1-11-5-7-13(8-6-11)25-14-4-2-3-12(9-14)19-18(23)17(22)16(21)15(10-20)24-19/h2-9,15-23H,10H2,1H3/t15-,16-,17+,18-,19+/m1/s1
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n/an/an/an/a 69n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 77n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50389349
PNG
(CHEMBL2064099)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)c1cn(Cc2ccc(cc2)C2CC2)c2ccccc12
Show InChI InChI=1S/C23H25NO4/c25-20-13-28-23(22(27)21(20)26)18-12-24(19-4-2-1-3-17(18)19)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,12,16,20-23,25-27H,9-11,13H2/t20-,21+,22-,23+/m1/s1
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n/an/an/an/a 87n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay


Eur J Med Chem 55: 32-8 (2012)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 108n/an/an/an/a


TBA

Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161652
PNG
(CHEMBL3785293)
Show SMILES O[C@@H]1[C@@H](CNC(=O)CCl)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C26H28Cl2N2O5/c27-11-21(31)29-12-20-23(32)24(33)25(34)26(35-20)30-13-17(22-18(28)2-1-3-19(22)30)10-14-4-6-15(7-5-14)16-8-9-16/h1-7,13,16,20,23-26,32-34H,8-12H2,(H,29,31)/t20-,23-,24+,25-,26-/s2
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n/an/an/an/a 113n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161720
PNG
(CHEMBL3787651)
Show SMILES CCOC(=O)CC(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C29H33ClN2O7/c1-2-38-24(34)13-23(33)31-14-22-26(35)27(36)28(37)29(39-22)32-15-19(25-20(30)4-3-5-21(25)32)12-16-6-8-17(9-7-16)18-10-11-18/h3-9,15,18,22,26-29,35-37H,2,10-14H2,1H3,(H,31,33)/t22-,26-,27+,28-,29-/s2
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n/an/an/an/a 118n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161656
PNG
(CHEMBL3786435)
Show SMILES COC(=O)c1cn(C[C@H]2O[C@H]([C@H](O)[C@@H](O)[C@@H]2O)n2cc(Cc3ccc(cc3)C3CC3)c3c(Cl)cccc23)nn1
Show InChI InChI=1/C28H29ClN4O6/c1-38-28(37)20-13-32(31-30-20)14-22-24(34)25(35)26(36)27(39-22)33-12-18(23-19(29)3-2-4-21(23)33)11-15-5-7-16(8-6-15)17-9-10-17/h2-8,12-13,17,22,24-27,34-36H,9-11,14H2,1H3/t22-,24-,25+,26-,27-/s2
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n/an/an/an/a 119n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 123n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161716
PNG
(CHEMBL3785254)
Show SMILES O[C@@H]1[C@@H](CNC(=O)NCCCCl)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C28H33Cl2N3O5/c29-11-2-12-31-28(37)32-14-22-24(34)25(35)26(36)27(38-22)33-15-19(23-20(30)3-1-4-21(23)33)13-16-5-7-17(8-6-16)18-9-10-18/h1,3-8,15,18,22,24-27,34-36H,2,9-14H2,(H2,31,32,37)/t22-,24-,25+,26-,27-/s2
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n/an/an/an/a 151n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161730
PNG
(CHEMBL3785936)
Show SMILES O[C@H]1[C@H](O)[C@@H](CNC(=O)CCBr)O[C@H]([C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C27H30BrClN2O5/c28-11-10-22(32)30-13-21-24(33)25(34)26(35)27(36-21)31-14-18(23-19(29)2-1-3-20(23)31)12-15-4-6-16(7-5-15)17-8-9-17/h1-7,14,17,21,24-27,33-35H,8-13H2,(H,30,32)/t21-,24-,25+,26-,27-/s2
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n/an/an/an/a 151n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50389353
PNG
(CHEMBL2064098)
Show SMILES COc1ccc(Cn2cc([C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c3cccc(F)c23)cc1
Show InChI InChI=1S/C21H22FNO5/c1-27-13-7-5-12(6-8-13)9-23-10-15(14-3-2-4-16(22)18(14)23)21-20(26)19(25)17(24)11-28-21/h2-8,10,17,19-21,24-26H,9,11H2,1H3/t17-,19+,20-,21+/m1/s1
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n/an/an/an/a 151n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay


Eur J Med Chem 55: 32-8 (2012)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161731
PNG
(CHEMBL3786935)
Show SMILES O[C@@H]1[C@@H](CNC(=O)CCCl)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C27H30Cl2N2O5/c28-11-10-22(32)30-13-21-24(33)25(34)26(35)27(36-21)31-14-18(23-19(29)2-1-3-20(23)31)12-15-4-6-16(7-5-15)17-8-9-17/h1-7,14,17,21,24-27,33-35H,8-13H2,(H,30,32)/t21-,24-,25+,26-,27-/s2
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n/an/an/an/a 160n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 160n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in Xenopus oocyte assessed as [14C]-alpha-methyl glucopyranoside uptake


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1S/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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TBA

Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161732
PNG
(CHEMBL3786954)
Show SMILES O[C@@H]1[C@@H](CNC(=O)C(Cl)Cl)O[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C26H27Cl3N2O5/c27-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)12-31(18)26-23(34)22(33)21(32)19(36-26)11-30-25(35)24(28)29/h1-7,12,15,19,21-24,26,32-34H,8-11H2,(H,30,35)/t19-,21-,22+,23-,26-/s2
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n/an/an/an/a 184n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50245134
PNG
((2S,3R,4R,5S,6R)-2-(3-benzylphenyl)-6-(hydroxymeth...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1cccc(Cc2ccccc2)c1
Show InChI InChI=1S/C19H22O5/c20-11-15-16(21)17(22)18(23)19(24-15)14-8-4-7-13(10-14)9-12-5-2-1-3-6-12/h1-8,10,15-23H,9,11H2/t15-,16-,17+,18-,19+/m1/s1
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n/an/an/an/a 190n/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as intracellular accumulation of [14C]-alpha-methyl glucopyranoside


Bioorg Med Chem Lett 18: 4770-3 (2008)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1S/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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n/an/an/an/a 203n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50335145
PNG
(4-Chloro-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyr...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1S/C23H24ClNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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n/an/an/an/a 205n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells incubated for 120 mins at 37 degC by [14C]-AMG uptake assay


Eur J Med Chem 55: 32-8 (2012)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50335139
PNG
(4-Chloro-3-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc3OCCOc3c2)c2c(Cl)cccc12
Show InChI InChI=1S/C22H22ClNO6/c23-14-2-1-3-15-19(14)13(8-12-4-5-17-18(9-12)29-7-6-28-17)10-24(15)22-21(27)20(26)16(25)11-30-22/h1-5,9-10,16,20-22,25-27H,6-8,11H2/t16-,20+,21-,22-/m1/s1
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n/an/an/an/a 233n/an/an/an/a


TBA

Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161655
PNG
(CHEMBL3785403)
Show SMILES NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C24H27ClN2O4/c25-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)12-27(18)24-23(30)22(29)21(28)19(11-26)31-24/h1-7,12,15,19,21-24,28-30H,8-11,26H2/t19-,21-,22+,23-,24-/s2
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n/an/an/an/a 237n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50335150
PNG
(4-Bromo-3-(4-cyclopropylbenzyl)-1-(beta-D-xylopyra...)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Br)cccc12
Show InChI InChI=1S/C23H24BrNO4/c24-17-2-1-3-18-20(17)16(10-13-4-6-14(7-5-13)15-8-9-15)11-25(18)23-22(28)21(27)19(26)12-29-23/h1-7,11,15,19,21-23,26-28H,8-10,12H2/t19-,21+,22-,23-/m1/s1
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n/an/an/an/a 241n/an/an/an/a


TBA

Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as sodium-dependent [14C]-alpha-methyl-D-glucopyranoside uptake after 2 hrs by liquid scint...


Citation and Details
More data for this
Ligand-Target Pair
Sodium-Dependent Glucose Cotransporter 2 (SGLT2)


(Homo sapiens (human))
BDBM50161722
PNG
(CHEMBL3785234)
Show SMILES CCOC(=O)C(=O)NC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(Cc2ccc(cc2)C2CC2)c2c(Cl)cccc12
Show InChI InChI=1/C28H31ClN2O7/c1-2-37-28(36)26(35)30-13-21-23(32)24(33)25(34)27(38-21)31-14-18(22-19(29)4-3-5-20(22)31)12-15-6-8-16(9-7-15)17-10-11-17/h3-9,14,17,21,23-25,27,32-34H,2,10-13H2,1H3,(H,30,35)/t21-,23-,24+,25-,27-/s2
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National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG uptake after 120 mins by scintillation counting method


Bioorg Med Chem 24: 2242-50 (2016)

More data for this
Ligand-Target Pair
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