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Compile Data Set for Download or QSAR

Found 139 hits of ec50 data for polymerid = 2200   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295513
PNG
((S)-6-amino-2-((S)-2-amino-3-(1H-indol-3-yl)propan...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O
Show InChI InChI=1S/C41H61N9O7S2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37(53)29(43)22-26-23-45-30-10-6-5-9-28(26)30/h5-6,9-10,12-15,23-24,29,31-35,45,51H,7-8,11,16-22,42-43H2,1-4H3,(H2,44,52)(H,46,57)(H,47,53)(H,48,56)(H,49,54)(H,50,55)/t29-,31+,32-,33-,34-,35-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098174
PNG
(CHEMBL3588929)
Show SMILES Brc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)NN2CCCCNC2=O)cc1
Show InChI InChI=1S/C18H29NO2/c1-13(2)16-11-15(12-17(14(3)4)18(16)20)5-6-19-7-9-21-10-8-19/h11-14,20H,5-10H2,1-4H3
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Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295514
PNG
(CHEMBL556625 | N-(4-Chlorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295526
PNG
(CHEMBL564392 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-14-11-17(12-16-5-4-6-20(13-16)29-3)22(28)26(25-14)15(2)21(27)24-19-9-7-18(23)8-10-19/h4-11,13,15H,12H2,1-3H3,(H,24,27)
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n/an/an/an/a 6n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295527
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098173
PNG
(CHEMBL3590206)
Show SMILES CCOC(=O)C1CCCN(C1)C(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C17H28N2O/c1-12(2)15-9-14(10-16(13(3)4)17(15)18)11-19-5-7-20-8-6-19/h9-10,12-13H,5-8,11,18H2,1-4H3
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Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295517
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C22H23N3O3/c1-15-7-9-19(10-8-15)23-21(26)14-25-22(27)18(11-16(2)24-25)12-17-5-4-6-20(13-17)28-3/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295517
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C22H23N3O3/c1-15-7-9-19(10-8-15)23-21(26)14-25-22(27)18(11-16(2)24-25)12-17-5-4-6-20(13-17)28-3/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295518
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295518
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295519
PNG
(CHEMBL554291 | N-(3,4-Dimethoxyphenyl)-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
Show InChI InChI=1S/C23H25N3O5/c1-15-10-17(11-16-6-5-7-19(12-16)29-2)23(28)26(25-15)14-22(27)24-18-8-9-20(30-3)21(13-18)31-4/h5-10,12-13H,11,14H2,1-4H3,(H,24,27)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295514
PNG
(CHEMBL556625 | N-(4-Chlorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 16n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295515
PNG
(CHEMBL560780 | N-(4-Iodophenyl)-2-[5-(3-methoxyben...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
Show InChI InChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 18n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295515
PNG
(CHEMBL560780 | N-(4-Iodophenyl)-2-[5-(3-methoxyben...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
Show InChI InChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 18n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295521
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(cc3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-14-10-16(11-15-4-3-5-19(12-15)31-2)21(30)28(27-14)13-20(29)26-18-8-6-17(7-9-18)22(23,24)25/h3-10,12H,11,13H2,1-2H3,(H,26,29)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295524
PNG
(CHEMBL551589 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 21n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186957
PNG
(1-(3-tert-butyl-2-methyl-5-oxo-1-phenyl-2,5-dihydr...)
Show SMILES Cn1c(c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1)C(C)(C)C
Show InChI InChI=1S/C21H23ClN4O2/c1-21(2,3)18-17(24-20(28)23-15-12-10-14(22)11-13-15)19(27)26(25(18)4)16-8-6-5-7-9-16/h5-13H,1-4H3,(H2,23,24,28)
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n/an/an/an/a 23n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186961
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,...)
Show SMILES CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cnc4ccccc4c3)c2=O)cc1
Show InChI InChI=1S/C24H25N5O2S/c1-15(2)22-21(27-24(31)26-17-9-11-19(32-4)12-10-17)23(30)29(28(22)3)18-13-16-7-5-6-8-20(16)25-14-18/h5-15H,1-4H3,(H2,26,27,31)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186952
PNG
(1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyra...)
Show SMILES Cc1c(NC(=O)Nc2ccc(I)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C18H17IN4O2/c1-12-16(21-18(25)20-14-10-8-13(19)9-11-14)17(24)23(22(12)2)15-6-4-3-5-7-15/h3-11H,1-2H3,(H2,20,21,25)
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Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21702
PNG
(2-ethyl-1-[(3R)-1-[(5-methoxy-1H-indol-2-yl)carbon...)
Show SMILES CCc1nc2ccccc2n1[C@@H]1CCN(C1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C23H24N4O2/c1-3-22-25-19-6-4-5-7-21(19)27(22)16-10-11-26(14-16)23(28)20-13-15-12-17(29-2)8-9-18(15)24-20/h4-9,12-13,16,24H,3,10-11,14H2,1-2H3/t16-/m1/s1
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n/an/an/an/a 34n/an/a7.237



Amgen



Assay Description
hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...


Bioorg Med Chem Lett 17: 6633-7 (2007)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295524
PNG
(CHEMBL551589 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 38n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098177
PNG
(CHEMBL3588926)
Show SMILES Brc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C19H30N2O2/c1-13(2)17-10-16(11-18(14(3)4)19(17)23)12-20-6-8-21(9-7-20)15(5)22/h10-11,13-14,23H,6-9,12H2,1-5H3
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n/an/an/an/a 40n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186968
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2...)
Show SMILES CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1
Show InChI InChI=1S/C19H22N6O2S/c1-12(2)17-16(18(26)25(24(17)3)14-9-20-11-21-10-14)23-19(27)22-13-5-7-15(28-4)8-6-13/h5-12H,1-4H3,(H2,22,23,27)
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n/an/an/an/a 43n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21692
PNG
(1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(p...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
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n/an/an/an/a 44n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186953
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2cnc3ccccc3c2)n1C
Show InChI InChI=1S/C24H22F3N5O2/c1-14(2)21-20(30-23(34)29-17-10-8-16(9-11-17)24(25,26)27)22(33)32(31(21)3)18-12-15-6-4-5-7-19(15)28-13-18/h4-14H,1-3H3,(H2,29,30,34)
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n/an/an/an/a 44n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21692
PNG
(1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(p...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
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n/an/an/an/a 44n/an/a7.237



Amgen



Assay Description
hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...


Bioorg Med Chem Lett 17: 6633-7 (2007)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295520
PNG
(CHEMBL556485 | N-Benzo[1,3]dioxol-5-yl-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4OCOc4c3)c2=O)c1
Show InChI InChI=1S/C22H21N3O5/c1-14-8-16(9-15-4-3-5-18(10-15)28-2)22(27)25(24-14)12-21(26)23-17-6-7-19-20(11-17)30-13-29-19/h3-8,10-11H,9,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 45n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098176
PNG
(CHEMBL3588927)
Show SMILES Clc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C17H27NO/c1-13(2)16-9-15(10-17(11-16)14(3)4)12-18-5-7-19-8-6-18/h9-11,13-14H,5-8,12H2,1-4H3
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n/an/an/an/a 50n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/an/an/a 60n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probene...


Bioorg Med Chem 23: 3913-24 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/an/an/a 64n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenec...


Bioorg Med Chem 23: 3913-24 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186963
PNG
(1-(4-chlorophenyl)-3-(3-isopropyl-2-methyl-5-oxo-1...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C
Show InChI InChI=1S/C23H22ClN5O2/c1-14(2)21-20(27-23(31)26-17-10-8-16(24)9-11-17)22(30)29(28(21)3)18-12-15-6-4-5-7-19(15)25-13-18/h4-14H,1-3H3,(H2,26,27,31)
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n/an/an/an/a 80n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186942
PNG
(1-(3-fluoro-4-methylphenyl)-3-(3-isopropyl-2-methy...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C21H23FN4O2/c1-13(2)19-18(20(27)26(25(19)4)16-8-6-5-7-9-16)24-21(28)23-15-11-10-14(3)17(22)12-15/h5-13H,1-4H3,(H2,23,24,28)
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n/an/an/an/a 81n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295516
PNG
(CHEMBL552396 | N-(4-Fluorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
Show InChI InChI=1S/C21H20FN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 82n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186938
PNG
(1-(3-tert-butyl-2-methyl-5-oxo-1-phenyl-2,5-dihydr...)
Show SMILES Cc1ccc(NC(=O)Nc2c(n(C)n(-c3ccccc3)c2=O)C(C)(C)C)cc1F
Show InChI InChI=1S/C22H25FN4O2/c1-14-11-12-15(13-17(14)23)24-21(29)25-18-19(22(2,3)4)26(5)27(20(18)28)16-9-7-6-8-10-16/h6-13H,1-5H3,(H2,24,25,29)
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n/an/an/an/a 83n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295521
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(cc3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-14-10-16(11-15-4-3-5-19(12-15)31-2)21(30)28(27-14)13-20(29)26-18-8-6-17(7-9-18)22(23,24)25/h3-10,12H,11,13H2,1-2H3,(H,26,29)
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n/an/an/an/a 88n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186943
PNG
(1-(4-bromophenyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2...)
Show SMILES Cc1c(NC(=O)Nc2ccc(Br)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C18H17BrN4O2/c1-12-16(21-18(25)20-14-10-8-13(19)9-11-14)17(24)23(22(12)2)15-6-4-3-5-7-15/h3-11H,1-2H3,(H2,20,21,25)
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n/an/an/an/a 90n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/an/an/a 96n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR ass...


Bioorg Med Chem 23: 3913-24 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186970
PNG
(1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyra...)
Show SMILES Cc1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C19H17F3N4O2/c1-12-16(17(27)26(25(12)2)15-6-4-3-5-7-15)24-18(28)23-14-10-8-13(9-11-14)19(20,21)22/h3-11H,1-2H3,(H2,23,24,28)
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n/an/an/an/a 100n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098181
PNG
(CHEMBL1289381)
Show SMILES COc1ccc(CCNC(=O)Nc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C21H33NO3/c1-6-25-21(24)17-7-9-22(10-8-17)13-16-11-18(14(2)3)20(23)19(12-16)15(4)5/h11-12,14-15,17,23H,6-10,13H2,1-5H3
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n/an/an/an/a 100n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186958
PNG
(1-(2-ethyl-3-isopropyl-5-oxo-1-phenyl-2,5-dihydro-...)
Show SMILES CCn1c(C(C)C)c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C22H25FN4O2/c1-5-26-20(14(2)3)19(21(28)27(26)17-9-7-6-8-10-17)25-22(29)24-16-12-11-15(4)18(23)13-16/h6-14H,5H2,1-4H3,(H2,24,25,29)
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n/an/an/an/a 100n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295525
PNG
(CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)
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n/an/an/an/a 118n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295525
PNG
(CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)
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n/an/an/an/a 118n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21701
PNG
(2-ethyl-1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]py...)
Show SMILES CCc1nc2ccccc2n1C1CCN(C1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C23H24N4O2/c1-3-22-25-19-6-4-5-7-21(19)27(22)16-10-11-26(14-16)23(28)20-13-15-12-17(29-2)8-9-18(15)24-20/h4-9,12-13,16,24H,3,10-11,14H2,1-2H3
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n/an/an/an/a 130n/an/a7.237



Amgen



Assay Description
hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...


Bioorg Med Chem Lett 17: 6633-7 (2007)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098180
PNG
(CHEMBL3588923)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C17H27NO2/c1-12(2)15-9-14(10-16(13(3)4)17(15)19)11-18-5-7-20-8-6-18/h9-10,12-13,19H,5-8,11H2,1-4H3
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n/an/an/an/a 130n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295523
PNG
(CHEMBL562380 | N-(4-Bromophenyl)-2-[5-(4-methoxybe...)
Show SMILES COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-11-16(12-15-3-9-19(28-2)10-4-15)21(27)25(24-14)13-20(26)23-18-7-5-17(22)6-8-18/h3-11H,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 131n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295523
PNG
(CHEMBL562380 | N-(4-Bromophenyl)-2-[5-(4-methoxybe...)
Show SMILES COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-11-16(12-15-3-9-19(28-2)10-4-15)21(27)25(24-14)13-20(26)23-18-7-5-17(22)6-8-18/h3-11H,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 131n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


J Med Chem 52: 5044-57 (2010)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098000
PNG
(CHEMBL3588922)
Show SMILES CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](Cc1ccc2ccccc2c1)N1C[C@@H](Cc2ccc(O)cc2)N(CC2CCCCC2)C(=O)C1=O
Show InChI InChI=1/C43H55N5O5/c1-2-9-35-25-44-40(50)41(51)47(35)28-36-14-8-21-45(36)27-37(24-32-15-18-33-12-6-7-13-34(33)22-32)48-29-38(23-30-16-19-39(49)20-17-30)46(42(52)43(48)53)26-31-10-4-3-5-11-31/h6-7,12-13,15-20,22,31,35-38,49H,2-5,8-11,14,21,23-29H2,1H3,(H,44,50)/t35-,36-,37+,38+/s2
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n/an/an/an/a 140n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098178
PNG
(CHEMBL3588925)
Show SMILES Brc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C21H29NO/c1-15(2)19-11-18(12-20(16(3)4)21(19)23)14-22(5)13-17-9-7-6-8-10-17/h6-12,15-16,23H,13-14H2,1-5H3
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n/an/an/an/a 140n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Bioorg Med Chem 23: 4072-81 (2015)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186954
PNG
(1-(4-chlorophenyl)-3-(3-ethyl-2-methyl-5-oxo-1-phe...)
Show SMILES CCc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C19H19ClN4O2/c1-3-16-17(22-19(26)21-14-11-9-13(20)10-12-14)18(25)24(23(16)2)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H2,21,22,26)
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n/an/an/an/a 140n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186956
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2cncnc2)n1C
Show InChI InChI=1S/C19H19F3N6O2/c1-11(2)16-15(17(29)28(27(16)3)14-8-23-10-24-9-14)26-18(30)25-13-6-4-12(5-7-13)19(20,21)22/h4-11H,1-3H3,(H2,25,26,30)
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n/an/an/an/a 150n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)

More data for this
Ligand-Target Pair
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