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Compile Data Set for Download or QSAR

Found 139 hits of ec50 data for polymerid = 2200   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295513
PNG
((S)-6-amino-2-((S)-2-amino-3-(1H-indol-3-yl)propan...)
Show SMILES CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O
Show InChI InChI=1S/C41H61N9O7S2/c1-24(2)35(41(57)46-31(36(44)52)16-19-58-3)50-39(55)33(17-20-59-4)48-40(56)34(21-25-12-14-27(51)15-13-25)49-38(54)32(11-7-8-18-42)47-37(53)29(43)22-26-23-45-30-10-6-5-9-28(26)30/h5-6,9-10,12-15,23-24,29,31-35,45,51H,7-8,11,16-22,42-43H2,1-4H3,(H2,44,52)(H,46,57)(H,47,53)(H,48,56)(H,49,54)(H,50,55)/t29-,31+,32-,33-,34-,35-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098174
PNG
(CHEMBL3588929)
Show SMILES Brc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)NN2CCCCNC2=O)cc1
Show InChI InChI=1S/C18H29NO2/c1-13(2)16-11-15(12-17(14(3)4)18(16)20)5-6-19-7-9-21-10-8-19/h11-14,20H,5-10H2,1-4H3
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Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295514
PNG
(CHEMBL556625 | N-(4-Chlorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295526
PNG
(CHEMBL564392 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-14-11-17(12-16-5-4-6-20(13-16)29-3)22(28)26(25-14)15(2)21(27)24-19-9-7-18(23)8-10-19/h4-11,13,15H,12H2,1-3H3,(H,24,27)
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n/an/an/an/a 6n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295527
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1
Show InChI InChI=1S/C21H21N3O3/c1-15-11-17(12-16-7-6-10-19(13-16)27-2)21(26)24(23-15)14-20(25)22-18-8-4-3-5-9-18/h3-11,13H,12,14H2,1-2H3,(H,22,25)
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n/an/an/an/a 6n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098173
PNG
(CHEMBL3590206)
Show SMILES CCOC(=O)C1CCCN(C1)C(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C17H28N2O/c1-12(2)15-9-14(10-16(13(3)4)17(15)18)11-19-5-7-20-8-6-19/h9-10,12-13H,5-8,11,18H2,1-4H3
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n/an/an/an/a 7n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295517
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C22H23N3O3/c1-15-7-9-19(10-8-15)23-21(26)14-25-22(27)18(11-16(2)24-25)12-17-5-4-6-20(13-17)28-3/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295517
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1
Show InChI InChI=1S/C22H23N3O3/c1-15-7-9-19(10-8-15)23-21(26)14-25-22(27)18(11-16(2)24-25)12-17-5-4-6-20(13-17)28-3/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295518
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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n/an/an/an/a 11n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295518
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-15-11-17(12-16-5-4-6-20(13-16)29-3)22(27)25(24-15)14-21(26)23-18-7-9-19(28-2)10-8-18/h4-11,13H,12,14H2,1-3H3,(H,23,26)
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Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295519
PNG
(CHEMBL554291 | N-(3,4-Dimethoxyphenyl)-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1
Show InChI InChI=1S/C23H25N3O5/c1-15-10-17(11-16-6-5-7-19(12-16)29-2)23(28)26(25-15)14-22(27)24-18-8-9-20(30-3)21(13-18)31-4/h5-10,12-13H,11,14H2,1-4H3,(H,24,27)
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n/an/an/an/a 12n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295514
PNG
(CHEMBL556625 | N-(4-Chlorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1
Show InChI InChI=1S/C21H20ClN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 16n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295515
PNG
(CHEMBL560780 | N-(4-Iodophenyl)-2-[5-(3-methoxyben...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
Show InChI InChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 18n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295515
PNG
(CHEMBL560780 | N-(4-Iodophenyl)-2-[5-(3-methoxyben...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1
Show InChI InChI=1S/C21H20IN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 18n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295521
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(cc3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-14-10-16(11-15-4-3-5-19(12-15)31-2)21(30)28(27-14)13-20(29)26-18-8-6-17(7-9-18)22(23,24)25/h3-10,12H,11,13H2,1-2H3,(H,26,29)
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n/an/an/an/a 19n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295524
PNG
(CHEMBL551589 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 21n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186957
PNG
(1-(3-tert-butyl-2-methyl-5-oxo-1-phenyl-2,5-dihydr...)
Show SMILES Cn1c(c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1)C(C)(C)C
Show InChI InChI=1S/C21H23ClN4O2/c1-21(2,3)18-17(24-20(28)23-15-12-10-14(22)11-13-15)19(27)26(25(18)4)16-8-6-5-7-9-16/h5-13H,1-4H3,(H2,23,24,28)
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n/an/an/an/a 23n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186961
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,...)
Show SMILES CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cnc4ccccc4c3)c2=O)cc1
Show InChI InChI=1S/C24H25N5O2S/c1-15(2)22-21(27-24(31)26-17-9-11-19(32-4)12-10-17)23(30)29(28(22)3)18-13-16-7-5-6-8-20(16)25-14-18/h5-15H,1-4H3,(H2,26,27,31)
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n/an/an/an/a 30n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186952
PNG
(1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyra...)
Show SMILES Cc1c(NC(=O)Nc2ccc(I)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C18H17IN4O2/c1-12-16(21-18(25)20-14-10-8-13(19)9-11-14)17(24)23(22(12)2)15-6-4-3-5-7-15/h3-11H,1-2H3,(H2,20,21,25)
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n/an/an/an/a 30n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21702
PNG
(2-ethyl-1-[(3R)-1-[(5-methoxy-1H-indol-2-yl)carbon...)
Show SMILES CCc1nc2ccccc2n1[C@@H]1CCN(C1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C23H24N4O2/c1-3-22-25-19-6-4-5-7-21(19)27(22)16-10-11-26(14-16)23(28)20-13-15-12-17(29-2)8-9-18(15)24-20/h4-9,12-13,16,24H,3,10-11,14H2,1-2H3/t16-/m1/s1
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n/an/an/an/a 34n/an/a7.237



Amgen



Assay Description
hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295524
PNG
(CHEMBL551589 | N-(4-Bromophenyl)-2-[5-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 38n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098177
PNG
(CHEMBL3588926)
Show SMILES Brc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C19H30N2O2/c1-13(2)17-10-16(11-18(14(3)4)19(17)23)12-20-6-8-21(9-7-20)15(5)22/h10-11,13-14,23H,6-9,12H2,1-5H3
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n/an/an/an/a 40n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186968
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2...)
Show SMILES CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1
Show InChI InChI=1S/C19H22N6O2S/c1-12(2)17-16(18(26)25(24(17)3)14-9-20-11-21-10-14)23-19(27)22-13-5-7-15(28-4)8-6-13/h5-12H,1-4H3,(H2,22,23,27)
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n/an/an/an/a 43n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21692
PNG
(1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(p...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
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n/an/an/an/a 44n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186953
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(quinolin-3-yl)-2,...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2cnc3ccccc3c2)n1C
Show InChI InChI=1S/C24H22F3N5O2/c1-14(2)21-20(30-23(34)29-17-10-8-16(9-11-17)24(25,26)27)22(33)32(31(21)3)18-12-15-6-4-5-7-19(15)28-13-18/h4-14H,1-3H3,(H2,29,30,34)
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n/an/an/an/a 44n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21692
PNG
(1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(p...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
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n/an/an/an/a 44n/an/a7.237



Amgen



Assay Description
hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295520
PNG
(CHEMBL556485 | N-Benzo[1,3]dioxol-5-yl-2-[5-(3-met...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4OCOc4c3)c2=O)c1
Show InChI InChI=1S/C22H21N3O5/c1-14-8-16(9-15-4-3-5-18(10-15)28-2)22(27)25(24-14)12-21(26)23-17-6-7-19-20(11-17)30-13-29-19/h3-8,10-11H,9,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 45n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098176
PNG
(CHEMBL3588927)
Show SMILES Clc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C17H27NO/c1-13(2)16-9-15(10-17(11-16)14(3)4)12-18-5-7-19-8-6-18/h9-11,13-14H,5-8,12H2,1-4H3
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n/an/an/an/a 50n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/an/an/a 60n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probene...


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/an/an/a 64n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenec...


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186963
PNG
(1-(4-chlorophenyl)-3-(3-isopropyl-2-methyl-5-oxo-1...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C
Show InChI InChI=1S/C23H22ClN5O2/c1-14(2)21-20(27-23(31)26-17-10-8-16(24)9-11-17)22(30)29(28(21)3)18-12-15-6-4-5-7-19(15)25-13-18/h4-14H,1-3H3,(H2,26,27,31)
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n/an/an/an/a 80n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186942
PNG
(1-(3-fluoro-4-methylphenyl)-3-(3-isopropyl-2-methy...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C21H23FN4O2/c1-13(2)19-18(20(27)26(25(19)4)16-8-6-5-7-9-16)24-21(28)23-15-11-10-14(3)17(22)12-15/h5-13H,1-4H3,(H2,23,24,28)
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n/an/an/an/a 81n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295516
PNG
(CHEMBL552396 | N-(4-Fluorophenyl)-2-[5-(3-methoxyb...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1
Show InChI InChI=1S/C21H20FN3O3/c1-14-10-16(11-15-4-3-5-19(12-15)28-2)21(27)25(24-14)13-20(26)23-18-8-6-17(22)7-9-18/h3-10,12H,11,13H2,1-2H3,(H,23,26)
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n/an/an/an/a 82n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186938
PNG
(1-(3-tert-butyl-2-methyl-5-oxo-1-phenyl-2,5-dihydr...)
Show SMILES Cc1ccc(NC(=O)Nc2c(n(C)n(-c3ccccc3)c2=O)C(C)(C)C)cc1F
Show InChI InChI=1S/C22H25FN4O2/c1-14-11-12-15(13-17(14)23)24-21(29)25-18-19(22(2,3)4)26(5)27(20(18)28)16-9-7-6-8-10-16/h6-13H,1-5H3,(H2,24,25,29)
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n/an/an/an/a 83n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295521
PNG
(2-[5-(3-Methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin...)
Show SMILES COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(cc3)C(F)(F)F)c2=O)c1
Show InChI InChI=1S/C22H20F3N3O3/c1-14-10-16(11-15-4-3-5-19(12-15)31-2)21(30)28(27-14)13-20(29)26-18-8-6-17(7-9-18)22(23,24)25/h3-10,12H,11,13H2,1-2H3,(H,26,29)
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n/an/an/an/a 88n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186943
PNG
(1-(4-bromophenyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2...)
Show SMILES Cc1c(NC(=O)Nc2ccc(Br)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C18H17BrN4O2/c1-12-16(21-18(25)20-14-10-8-13(19)9-11-14)17(24)23(22(12)2)15-6-4-3-5-7-15/h3-11H,1-2H3,(H2,20,21,25)
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n/an/an/an/a 90n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50097567
PNG
(CHEMBL3588871)
Show SMILES COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(CCCCC2)c2ccc(OC)cn2)cc1
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/an/an/a 96n/an/an/an/a



Universit£ degli Studi di Bari 'Aldo Moro'

Curated by ChEMBL


Assay Description
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR ass...


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186970
PNG
(1-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyra...)
Show SMILES Cc1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C19H17F3N4O2/c1-12-16(17(27)26(25(12)2)15-6-4-3-5-7-15)24-18(28)23-14-10-8-13(9-11-14)19(20,21)22/h3-11H,1-2H3,(H2,23,24,28)
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n/an/an/an/a 100n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098181
PNG
(CHEMBL1289381)
Show SMILES COc1ccc(CCNC(=O)Nc2ccc(Br)cc2)cc1
Show InChI InChI=1S/C21H33NO3/c1-6-25-21(24)17-7-9-22(10-8-17)13-16-11-18(14(2)3)20(23)19(12-16)15(4)5/h11-12,14-15,17,23H,6-10,13H2,1-5H3
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n/an/an/an/a 100n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186958
PNG
(1-(2-ethyl-3-isopropyl-5-oxo-1-phenyl-2,5-dihydro-...)
Show SMILES CCn1c(C(C)C)c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n1-c1ccccc1
Show InChI InChI=1S/C22H25FN4O2/c1-5-26-20(14(2)3)19(21(28)27(26)17-9-7-6-8-10-17)25-22(29)24-16-12-11-15(4)18(23)13-16/h6-14H,5H2,1-4H3,(H2,24,25,29)
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n/an/an/an/a 100n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295525
PNG
(CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)
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n/an/an/an/a 118n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295525
PNG
(CHEMBL551590 | N-(4-Bromophenyl)-3-[3-(3-methoxybe...)
Show SMILES COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1
Show InChI InChI=1S/C22H22BrN3O3/c1-15-12-17(13-16-4-3-5-20(14-16)29-2)22(28)26(25-15)11-10-21(27)24-19-8-6-18(23)7-9-19/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,27)
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n/an/an/an/a 118n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM21701
PNG
(2-ethyl-1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]py...)
Show SMILES CCc1nc2ccccc2n1C1CCN(C1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C23H24N4O2/c1-3-22-25-19-6-4-5-7-21(19)27(22)16-10-11-26(14-16)23(28)20-13-15-12-17(29-2)8-9-18(15)24-20/h4-9,12-13,16,24H,3,10-11,14H2,1-2H3
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n/an/an/an/a 130n/an/a7.237



Amgen



Assay Description
hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098180
PNG
(CHEMBL3588923)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Nc1ccc(Br)cc1
Show InChI InChI=1S/C17H27NO2/c1-12(2)15-9-14(10-16(13(3)4)17(15)19)11-18-5-7-20-8-6-18/h9-10,12-13,19H,5-8,11H2,1-4H3
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n/an/an/an/a 130n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295523
PNG
(CHEMBL562380 | N-(4-Bromophenyl)-2-[5-(4-methoxybe...)
Show SMILES COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-11-16(12-15-3-9-19(28-2)10-4-15)21(27)25(24-14)13-20(26)23-18-7-5-17(22)6-8-18/h3-11H,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 131n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50295523
PNG
(CHEMBL562380 | N-(4-Bromophenyl)-2-[5-(4-methoxybe...)
Show SMILES COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1
Show InChI InChI=1S/C21H20BrN3O3/c1-14-11-16(12-15-3-9-19(28-2)10-4-15)21(27)25(24-14)13-20(26)23-18-7-5-17(22)6-8-18/h3-11H,12-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 131n/an/an/an/a



Universita degli Studi di Firenze

Curated by ChEMBL


Assay Description
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098000
PNG
(CHEMBL3588922)
Show SMILES CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](Cc1ccc2ccccc2c1)N1C[C@@H](Cc2ccc(O)cc2)N(CC2CCCCC2)C(=O)C1=O
Show InChI InChI=1/C43H55N5O5/c1-2-9-35-25-44-40(50)41(51)47(35)28-36-14-8-21-45(36)27-37(24-32-15-18-33-12-6-7-13-34(33)22-32)48-29-38(23-30-16-19-39(49)20-17-30)46(42(52)43(48)53)26-31-10-4-3-5-11-31/h6-7,12-13,15-20,22,31,35-38,49H,2-5,8-11,14,21,23-29H2,1H3,(H,44,50)/t35-,36-,37+,38+/s2
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n/an/an/an/a 140n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50098178
PNG
(CHEMBL3588925)
Show SMILES Brc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C21H29NO/c1-15(2)19-11-18(12-20(16(3)4)21(19)23)14-22(5)13-17-9-7-6-8-10-17/h6-12,15-16,23H,13-14H2,1-5H3
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n/an/an/an/a 140n/an/an/an/a



Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland; Faculty of Horticulture, Biotechnology and Landscape Architecture, Warsaw U

Curated by ChEMBL


Assay Description
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186954
PNG
(1-(4-chlorophenyl)-3-(3-ethyl-2-methyl-5-oxo-1-phe...)
Show SMILES CCc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C19H19ClN4O2/c1-3-16-17(22-19(26)21-14-11-9-13(20)10-12-14)18(25)24(23(16)2)15-7-5-4-6-8-15/h4-12H,3H2,1-2H3,(H2,21,22,26)
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n/an/an/an/a 140n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
fMet-Leu-Phe receptor 1/2


(Homo sapiens (human))
BDBM50186956
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2...)
Show SMILES CC(C)c1c(NC(=O)Nc2ccc(cc2)C(F)(F)F)c(=O)n(-c2cncnc2)n1C
Show InChI InChI=1S/C19H19F3N6O2/c1-11(2)16-15(17(29)28(27(16)3)14-8-23-10-24-9-14)26-18(30)25-13-6-4-12(5-7-13)19(20,21)22/h4-11H,1-3H3,(H2,25,26,30)
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n/an/an/an/a 150n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
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