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Compile Data Set for Download or QSAR

Found 54 hits of ec50 data for polymerid = 2266   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22376
PNG
((3aS,6aR)-4-cyclohexyl-5-[(4E)-oct-4-en-4-yl]-N-ph...)
Show SMILES CCC\C=C(/CCC)C1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H41N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h7,10-11,14,18-19,23-24,29H,3-6,8-9,12-13,15-17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 12n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22375
PNG
((3aS,6aR)-4-butyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl-...)
Show SMILES CCCCC1=C(C[C@H]2CCC[C@@]12Nc1ccccc1)C(\CCC)=C\CCC
Show InChI InChI=1S/C26H39N/c1-4-7-14-21(13-6-3)24-20-22-15-12-19-26(22,25(24)18-8-5-2)27-23-16-10-9-11-17-23/h9-11,14,16-17,22,27H,4-8,12-13,15,18-20H2,1-3H3/b21-14+/t22-,26+/m1/s1
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n/an/an/an/a 22n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22391
PNG
((3aS,6aR)-N-(2,3-dimethylphenyl)-5-hexyl-4-phenyl-...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(C)c1C
Show InChI InChI=1S/C28H37N/c1-4-5-6-8-16-24-20-25-17-12-19-28(25,27(24)23-14-9-7-10-15-23)29-26-18-11-13-21(2)22(26)3/h7,9-11,13-15,18,25,29H,4-6,8,12,16-17,19-20H2,1-3H3/t25-,28+/m1/s1
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n/an/an/an/a 30n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22385
PNG
((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 31.6n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22385
PNG
((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 34n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22379
PNG
((3aS,6aR)-4-(naphthalen-2-yl)-5-[(4E)-oct-4-en-4-y...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccc3ccccc3c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C32H37N/c1-3-5-13-25(12-4-2)30-23-28-16-11-21-32(28,33-29-17-7-6-8-18-29)31(30)27-20-19-24-14-9-10-15-26(24)22-27/h6-10,13-15,17-20,22,28,33H,3-5,11-12,16,21,23H2,1-2H3/b25-13+/t28-,32+/m1/s1
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n/an/an/an/a 60n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22382
PNG
((3aS,6aR)-5-(hexan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...)
Show SMILES CCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-3-4-12-20(2)24-19-22-15-11-18-26(22,27-23-16-9-6-10-17-23)25(24)21-13-7-5-8-14-21/h5-10,13-14,16-17,20,22,27H,3-4,11-12,15,18-19H2,1-2H3/t20?,22-,26+/m1/s1
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n/an/an/an/a 70n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22374
PNG
((3aS,6aR)-4-methyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl...)
Show SMILES CCC\C=C(/CCC)C1=C(C)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C23H33N/c1-4-6-12-19(11-5-2)22-17-20-13-10-16-23(20,18(22)3)24-21-14-8-7-9-15-21/h7-9,12,14-15,20,24H,4-6,10-11,13,16-17H2,1-3H3/b19-12+/t20-,23-/m1/s1
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n/an/an/an/a 90n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418312
PNG
(CHEMBL1765932)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCc1ccccc1
Show InChI InChI=1S/C27H34O/c1-2-3-4-9-17-24-20-25-18-12-19-27(25,26(24)23-15-10-6-11-16-23)28-21-22-13-7-5-8-14-22/h5-8,10-11,13-16,25H,2-4,9,12,17-21H2,1H3/t25-,27+/m1/s1
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n/an/an/an/a 100n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22378
PNG
((3aS,6aR)-4-(3-methoxyphenyl)-5-[(4E)-oct-4-en-4-y...)
Show SMILES CCC\C=C(/CCC)C1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C29H37NO/c1-4-6-13-22(12-5-2)27-21-24-15-11-19-29(24,30-25-16-8-7-9-17-25)28(27)23-14-10-18-26(20-23)31-3/h7-10,13-14,16-18,20,24,30H,4-6,11-12,15,19,21H2,1-3H3/b22-13+/t24-,29+/m1/s1
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n/an/an/an/a 100n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22388
PNG
((3aS,6aR)-N,4,5-triphenyl-1,2,3,3a,6,6a-hexahydrop...)
Show SMILES C1C[C@@H]2CC(=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H25N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h1-9,11-14,16-17,22,27H,10,15,18-19H2/t22-,26+/m1/s1
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n/an/an/an/a 150n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418306
PNG
(CHEMBL1765955)
Show SMILES C[Si](C)(C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H32Si/c1-23(24-14-7-4-8-15-24)30-21-13-18-26(30)22-28(29(30)25-16-9-5-10-17-25)31(2,3)27-19-11-6-12-20-27/h4-12,14-17,19-20,26H,1,13,18,21-22H2,2-3H3/t26-,30+/m1/s1
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n/an/an/an/a 158n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22377
PNG
((3aS,6aR)-4-(4-bromophenyl)-5-[(4E)-oct-4-en-4-yl]...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccc(Br)cc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H34BrN/c1-3-5-11-21(10-4-2)26-20-23-12-9-19-28(23,30-25-13-7-6-8-14-25)27(26)22-15-17-24(29)18-16-22/h6-8,11,13-18,23,30H,3-5,9-10,12,19-20H2,1-2H3/b21-11+/t23-,28+/m1/s1
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n/an/an/an/a 160n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418304
PNG
(CHEMBL1765953)
Show SMILES CCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C26H30/c1-3-4-12-23-19-24-17-11-18-26(24,20(2)21-13-7-5-8-14-21)25(23)22-15-9-6-10-16-22/h5-10,13-16,24H,2-4,11-12,17-19H2,1H3/t24-,26+/m1/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22386
PNG
((3aS,6aR)-5-cyclohexyl-N,4-diphenyl-1,2,3,3a,6,6a-...)
Show SMILES C1C[C@@H]2CC(C3CCCCC3)=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1
Show InChI InChI=1S/C26H31N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h2-3,6-9,13-14,16-17,20,22,27H,1,4-5,10-12,15,18-19H2/t22-,26+/m1/s1
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n/an/an/an/a 230n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418313
PNG
(CHEMBL1765945)
Show SMILES CCCCCCC1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-24-20-26-17-12-19-29(26,22(2)23-13-9-7-10-14-23)28(24)25-16-11-18-27(21-25)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418309
PNG
(CHEMBL1765956)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36/c1-3-4-5-8-19-26-22-27-20-13-14-21-29(27,23(2)24-15-9-6-10-16-24)28(26)25-17-11-7-12-18-25/h6-7,9-12,15-18,27H,2-5,8,13-14,19-22H2,1H3/t27-,29+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418308
PNG
(CHEMBL1765933)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6-7,9-12,14-17,26H,2-5,8,13,18-21H2,1H3/t26-,28+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418303
PNG
(CHEMBL1765959)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418310
PNG
(CHEMBL1765962)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28-,30-/m0/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418307
PNG
(CHEMBL1765934)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1cccc(OC)c1
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-25-20-26-17-12-19-29(26,28(25)23-13-9-7-10-14-23)22(2)24-16-11-18-27(21-24)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1
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n/an/an/an/a 316n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418325
PNG
(CHEMBL1765958)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CN(Cc3ccccc3)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C34H39N/c1-3-4-5-11-22-31-23-32-25-35(24-28-16-9-6-10-17-28)26-34(32,27(2)29-18-12-7-13-19-29)33(31)30-20-14-8-15-21-30/h6-10,12-21,32H,2-5,11,22-26H2,1H3/t32-,34-/m0/s1
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n/an/an/an/a 316n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22383
PNG
((3aS,6aR)-5-(decan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...)
Show SMILES CCCCCCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C30H41N/c1-3-4-5-6-7-10-16-24(2)28-23-26-19-15-22-30(26,31-27-20-13-9-14-21-27)29(28)25-17-11-8-12-18-25/h8-9,11-14,17-18,20-21,24,26,31H,3-7,10,15-16,19,22-23H2,1-2H3/t24?,26-,30+/m1/s1
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n/an/an/an/a 320n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22389
PNG
((3aS,6aR)-N-(3-fluorophenyl)-5-hexyl-4-phenyl-1,2,...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(F)c1
Show InChI InChI=1S/C26H32FN/c1-2-3-4-6-13-21-18-22-14-10-17-26(22,25(21)20-11-7-5-8-12-20)28-24-16-9-15-23(27)19-24/h5,7-9,11-12,15-16,19,22,28H,2-4,6,10,13-14,17-18H2,1H3/t22-,26+/m1/s1
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n/an/an/an/a 330n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418326
PNG
(CHEMBL1765961)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1
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n/an/an/an/a 398n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418305
PNG
(CHEMBL1765960)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1
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n/an/an/an/a 398n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22373
PNG
((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 430n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418316
PNG
(CHEMBL1765966)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](C[C@@H]2C1)OC(C)=O)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-19-27-20-28(32-23(3)31)21-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1
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n/an/an/an/a 501n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22373
PNG
((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 631n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418311
PNG
(CHEMBL1765931)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OC1CCCCC1
Show InChI InChI=1S/C26H38O/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5,8-9,13-14,23-24H,2-4,6-7,10-12,15-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 794n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418329
PNG
(CHEMBL1765951)
Show SMILES CCCCCCC1=C(CCCO)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C25H36O/c1-3-4-5-7-14-22-19-23-15-10-17-25(23,24(22)16-11-18-26)20(2)21-12-8-6-9-13-21/h6,8-9,12-13,23,26H,2-5,7,10-11,14-19H2,1H3/t23-,25+/m1/s1
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n/an/an/an/a 794n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418321
PNG
(CHEMBL1765963)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](O)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-18-25-19-26(29)20-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418330
PNG
(CHEMBL1765938)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccc(CCCC)cc1
Show InChI InChI=1S/C32H42/c1-4-6-8-10-17-29-24-30-18-13-23-32(30,31(29)28-15-11-9-12-16-28)25(3)27-21-19-26(20-22-27)14-7-5-2/h9,11-12,15-16,19-22,30H,3-8,10,13-14,17-18,23-24H2,1-2H3/t30-,32+/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22390
PNG
((3aS,6aR)-N-(4-chlorophenyl)-5-hexyl-4-phenyl-1,2,...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C26H32ClN/c1-2-3-4-6-12-21-19-22-13-9-18-26(22,25(21)20-10-7-5-8-11-20)28-24-16-14-23(27)15-17-24/h5,7-8,10-11,14-17,22,28H,2-4,6,9,12-13,18-19H2,1H3/t22-,26+/m1/s1
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n/an/an/an/a 1.00E+3n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22395
PNG
(N-[(3aS,6aR)-5-hexyl-4-phenyl-1,2,3,3a,6,6a-hexahy...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H35N/c1-2-3-4-6-16-25-22-26-18-12-21-30(26,29(25)24-14-7-5-8-15-24)31-28-20-11-17-23-13-9-10-19-27(23)28/h5,7-11,13-15,17,19-20,26,31H,2-4,6,12,16,18,21-22H2,1H3/t26-,30+/m1/s1
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n/an/an/an/a 1.20E+3n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418317
PNG
(CHEMBL1765950)
Show SMILES CCCCCCC1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H40/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6,9-10,14-15,24,26H,2-5,7-8,11-13,16-21H2,1H3/t26-,28+/m1/s1
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n/an/an/an/a 1.26E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418324
PNG
(CHEMBL1765957)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CN(C)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H35N/c1-4-5-6-9-18-25-19-26-20-29(3)21-28(26,22(2)23-14-10-7-11-15-23)27(25)24-16-12-8-13-17-24/h7-8,10-17,26H,2,4-6,9,18-21H2,1,3H3/t26-,28-/m0/s1
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n/an/an/an/a 1.26E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22380
PNG
((3aS,6aR)-5-[(3E)-hex-3-en-3-yl]-N,4-diphenyl-1,2,...)
Show SMILES CC\C=C(/CC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H31N/c1-3-12-20(4-2)24-19-22-15-11-18-26(22,27-23-16-9-6-10-17-23)25(24)21-13-7-5-8-14-21/h5-10,12-14,16-17,22,27H,3-4,11,15,18-19H2,1-2H3/b20-12+/t22-,26+/m1/s1
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n/an/an/an/a 1.40E+3n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418314
PNG
(CHEMBL1765954)
Show SMILES CCCCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H38/c1-3-4-5-6-7-10-20-27-23-28-21-15-22-30(28,24(2)25-16-11-8-12-17-25)29(27)26-18-13-9-14-19-26/h8-9,11-14,16-19,28H,2-7,10,15,20-23H2,1H3/t28-,30+/m1/s1
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n/an/an/an/a 1.58E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418323
PNG
(CHEMBL1765964)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@H](O)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-18-25-19-26(29)20-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
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n/an/an/an/a 1.58E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418315
PNG
(CHEMBL1765936)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccc(C)cc1
Show InChI InChI=1S/C29H36/c1-4-5-6-8-14-26-21-27-15-11-20-29(27,28(26)25-12-9-7-10-13-25)23(3)24-18-16-22(2)17-19-24/h7,9-10,12-13,16-19,27H,3-6,8,11,14-15,20-21H2,1-2H3/t27-,29+/m1/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22384
PNG
((3aS,6aR)-5-methyl-N,4-diphenyl-1,2,3,3a,6,6a-hexa...)
Show SMILES CC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C21H23N/c1-16-15-18-11-8-14-21(18,22-19-12-6-3-7-13-19)20(16)17-9-4-2-5-10-17/h2-7,9-10,12-13,18,22H,8,11,14-15H2,1H3/t18-,21+/m1/s1
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n/an/an/an/a 2.10E+3n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418299
PNG
(CHEMBL1765926)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCC
Show InChI InChI=1S/C22H32O/c1-3-5-6-8-14-19-17-20-15-11-16-22(20,23-4-2)21(19)18-12-9-7-10-13-18/h7,9-10,12-13,20H,3-6,8,11,14-17H2,1-2H3/t20-,22+/m1/s1
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n/an/an/an/a 2.51E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418319
PNG
(CHEMBL1765930)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCC(C)CC
Show InChI InChI=1S/C25H38O/c1-4-6-7-9-15-22-18-23-16-12-17-25(23,26-19-20(3)5-2)24(22)21-13-10-8-11-14-21/h8,10-11,13-14,20,23H,4-7,9,12,15-19H2,1-3H3/t20?,23-,25+/m1/s1
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n/an/an/an/a 2.51E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418320
PNG
(CHEMBL1765927)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCCC
Show InChI InChI=1S/C23H34O/c1-3-5-6-8-14-20-18-21-15-11-16-23(21,24-17-4-2)22(20)19-12-9-7-10-13-19/h7,9-10,12-13,21H,3-6,8,11,14-18H2,1-2H3/t21-,23+/m1/s1
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n/an/an/an/a 2.51E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418318
PNG
(CHEMBL1765942)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)CCCC
Show InChI InChI=1S/C26H38/c1-4-6-8-10-17-23-20-24-18-13-19-26(24,21(3)14-7-5-2)25(23)22-15-11-9-12-16-22/h9,11-12,15-16,24H,3-8,10,13-14,17-20H2,1-2H3/t24-,26+/m1/s1
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n/an/an/an/a 2.51E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418300
PNG
(CHEMBL1765941)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)CCC
Show InChI InChI=1S/C25H36/c1-4-6-7-9-16-22-19-23-17-12-18-25(23,20(3)13-5-2)24(22)21-14-10-8-11-15-21/h8,10-11,14-15,23H,3-7,9,12-13,16-19H2,1-2H3/t23-,25+/m1/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418301
PNG
(CHEMBL1765928)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OC(C)C
Show InChI InChI=1S/C23H34O/c1-4-5-6-8-14-20-17-21-15-11-16-23(21,24-18(2)3)22(20)19-12-9-7-10-13-19/h7,9-10,12-13,18,21H,4-6,8,11,14-17H2,1-3H3/t21-,23+/m1/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM50418302
PNG
(CHEMBL1765929)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCCCC
Show InChI InChI=1S/C24H36O/c1-3-5-7-9-15-21-19-22-16-12-17-24(22,25-18-6-4-2)23(21)20-13-10-8-11-14-20/h8,10-11,13-14,22H,3-7,9,12,15-19H2,1-2H3/t22-,24+/m1/s1
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n/an/an/an/a 5.01E+3n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control


Citation and Details
More data for this
Ligand-Target Pair
Liver Receptor Homolog 1


(Homo sapiens (human))
BDBM22392
PNG
((3aS,6aR)-5-hexyl-4-phenyl-N-[4-(trifluoromethoxy)...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C27H32F3NO/c1-2-3-4-6-12-21-19-22-13-9-18-26(22,25(21)20-10-7-5-8-11-20)31-23-14-16-24(17-15-23)32-27(28,29)30/h5,7-8,10-11,14-17,22,31H,2-4,6,9,12-13,18-19H2,1H3/t22-,26+/m1/s1
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n/an/an/an/a>1.00E+4n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human LRH1 and a TIF2-deriv...


Citation and Details
More data for this
Ligand-Target Pair
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