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Compile Data Set for Download or QSAR

Found 245 hits of ec50 data for polymerid = 2268   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22376
PNG
((3aS,6aR)-4-cyclohexyl-5-[(4E)-oct-4-en-4-yl]-N-ph...)
Show SMILES CCC\C=C(/CCC)C1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H41N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h7,10-11,14,18-19,23-24,29H,3-6,8-9,12-13,15-17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 10n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22391
PNG
((3aS,6aR)-N-(2,3-dimethylphenyl)-5-hexyl-4-phenyl-...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1cccc(C)c1C
Show InChI InChI=1S/C28H37N/c1-4-5-6-8-16-24-20-25-17-12-19-28(25,27(24)23-14-9-7-10-15-23)29-26-18-11-13-21(2)22(26)3/h7,9-11,13-15,18,25,29H,4-6,8,12,16-17,19-20H2,1-3H3/t25-,28+/m1/s1
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n/an/an/an/a 11n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22381
PNG
((3aS,6aR)-5-[(6E)-dodec-6-en-6-yl]-N,4-diphenyl-1,...)
Show SMILES CCCCC\C=C(/CCCCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C32H43N/c1-3-5-7-11-18-26(17-10-6-4-2)30-25-28-21-16-24-32(28,33-29-22-14-9-15-23-29)31(30)27-19-12-8-13-20-27/h8-9,12-15,18-20,22-23,28,33H,3-7,10-11,16-17,21,24-25H2,1-2H3/b26-18+/t28-,32+/m1/s1
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n/an/an/an/a 14n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22375
PNG
((3aS,6aR)-4-butyl-5-[(4E)-oct-4-en-4-yl]-N-phenyl-...)
Show SMILES CCCCC1=C(C[C@H]2CCC[C@@]12Nc1ccccc1)C(\CCC)=C\CCC
Show InChI InChI=1S/C26H39N/c1-4-7-14-21(13-6-3)24-20-22-15-12-19-26(22,25(24)18-8-5-2)27-23-16-10-9-11-17-23/h9-11,14,16-17,22,27H,4-8,12-13,15,18-20H2,1-3H3/b21-14+/t22-,26+/m1/s1
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n/an/an/an/a 30n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418303
PNG
(CHEMBL1765959)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26+,28-/m0/s1
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n/an/an/an/a 31.6n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22385
PNG
((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 39.8n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418304
PNG
(CHEMBL1765953)
Show SMILES CCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C26H30/c1-3-4-12-23-19-24-17-11-18-26(24,20(2)21-13-7-5-8-14-21)25(23)22-15-9-6-10-16-22/h5-10,13-16,24H,2-4,11-12,17-19H2,1H3/t24-,26+/m1/s1
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n/an/an/an/a 39.8n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22385
PNG
((3aS,6aR)-5-hexyl-N,4-diphenyl-1,2,3,3a,6,6a-hexah...)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5-6,8-11,13-14,17-18,23,27H,2-4,7,12,15-16,19-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 43n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22373
PNG
((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 54n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418305
PNG
(CHEMBL1765960)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-20-25-26(29)18-19-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1
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n/an/an/an/a 63.1n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418306
PNG
(CHEMBL1765955)
Show SMILES C[Si](C)(C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C30H32Si/c1-23(24-14-7-4-8-15-24)30-21-13-18-26(30)22-28(29(30)25-16-9-5-10-17-25)31(2,3)27-19-11-6-12-20-27/h4-12,14-17,19-20,26H,1,13,18,21-22H2,2-3H3/t26-,30+/m1/s1
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n/an/an/an/a 63.1n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418307
PNG
(CHEMBL1765934)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1cccc(OC)c1
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-25-20-26-17-12-19-29(26,28(25)23-13-9-7-10-14-23)22(2)24-16-11-18-27(21-24)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1
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n/an/an/an/a 63.1n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418308
PNG
(CHEMBL1765933)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6-7,9-12,14-17,26H,2-5,8,13,18-21H2,1H3/t26-,28+/m1/s1
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n/an/an/an/a 63.1n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418309
PNG
(CHEMBL1765956)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36/c1-3-4-5-8-19-26-22-27-20-13-14-21-29(27,23(2)24-15-9-6-10-16-24)28(26)25-17-11-7-12-18-25/h6-7,9-12,15-18,27H,2-5,8,13-14,19-22H2,1H3/t27-,29+/m1/s1
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n/an/an/an/a 63.1n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418310
PNG
(CHEMBL1765962)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@H](OC(C)=O)[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-21-27-28(32-23(3)31)19-20-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28-,30-/m0/s1
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n/an/an/an/a 79.4n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418311
PNG
(CHEMBL1765931)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OC1CCCCC1
Show InChI InChI=1S/C26H38O/c1-2-3-4-7-15-22-20-23-16-12-19-26(23,27-24-17-10-6-11-18-24)25(22)21-13-8-5-9-14-21/h5,8-9,13-14,23-24H,2-4,6-7,10-12,15-20H2,1H3/t23-,26+/m1/s1
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n/an/an/an/a 79.4n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM28650
PNG
(ethyl 2-[(2-{[(4-ethylphenyl)carbamoyl]methyl}-1-o...)
Show SMILES CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(CC)cc1)c2=O
Show InChI InChI=1S/C24H26N2O5/c1-4-17-9-11-18(12-10-17)25-22(27)15-26-14-13-19-20(23(26)28)7-6-8-21(19)31-16(3)24(29)30-5-2/h6-14,16H,4-5,15H2,1-3H3,(H,25,27)
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n/an/an/an/a 110n/an/an/an/a



Scripps Florida



Assay Description
The assay was to monitor the SF-1 activation state via co-transfection of CHO-K1 cells with a plasmid encoding a Gal4-SF-1 chimerical transcription f...


Bioorg Med Chem Lett 18: 2628-32 (2008)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22388
PNG
((3aS,6aR)-N,4,5-triphenyl-1,2,3,3a,6,6a-hexahydrop...)
Show SMILES C1C[C@@H]2CC(=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H25N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h1-9,11-14,16-17,22,27H,10,15,18-19H2/t22-,26+/m1/s1
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n/an/an/an/a 120n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418313
PNG
(CHEMBL1765945)
Show SMILES CCCCCCC1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C29H36O/c1-4-5-6-8-15-24-20-26-17-12-19-29(26,22(2)23-13-9-7-10-14-23)28(24)25-16-11-18-27(21-25)30-3/h7,9-11,13-14,16,18,21,26H,2,4-6,8,12,15,17,19-20H2,1,3H3/t26-,29+/m1/s1
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n/an/an/an/a 126n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39548
PNG
((2-phenyl-1,3-thiazol-4-yl)methyl 1-methylpyrrole-...)
Show SMILES Cn1cccc1C(=O)OCc1csc(n1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O2S/c1-18-9-5-8-14(18)16(19)20-10-13-11-21-15(17-13)12-6-3-2-4-7-12/h2-9,11H,10H2,1H3
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n/an/an/an/a 129n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22382
PNG
((3aS,6aR)-5-(hexan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...)
Show SMILES CCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C26H33N/c1-3-4-12-20(2)24-19-22-15-11-18-26(22,27-23-16-9-6-10-17-23)25(24)21-13-7-5-8-14-21/h5-10,13-14,16-17,20,22,27H,3-4,11-12,15,18-19H2,1-2H3/t20?,22-,26+/m1/s1
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n/an/an/an/a 130n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22379
PNG
((3aS,6aR)-4-(naphthalen-2-yl)-5-[(4E)-oct-4-en-4-y...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccc3ccccc3c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C32H37N/c1-3-5-13-25(12-4-2)30-23-28-16-11-21-32(28,33-29-17-7-6-8-18-29)31(30)27-20-19-24-14-9-10-15-26(24)22-27/h6-10,13-15,17-20,22,28,33H,3-5,11-12,16,21,23H2,1-2H3/b25-13+/t28-,32+/m1/s1
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n/an/an/an/a 130n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22383
PNG
((3aS,6aR)-5-(decan-2-yl)-N,4-diphenyl-1,2,3,3a,6,6...)
Show SMILES CCCCCCCCC(C)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C30H41N/c1-3-4-5-6-7-10-16-24(2)28-23-26-19-15-22-30(26,31-27-20-13-9-14-21-27)29(28)25-17-11-8-12-18-25/h8-9,11-14,17-18,20-21,24,26,31H,3-7,10,15-16,19,22-23H2,1-2H3/t24?,26-,30+/m1/s1
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n/an/an/an/a 130n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39480
PNG
(2-(1-tert-butyl-4-keto-pyrazolo[3,4-d]pyrimidin-5-...)
Show SMILES CC(C)(C)n1ncc2c1ncn(CC(=O)NCc1ccccc1Cl)c2=O
Show InChI InChI=1S/C18H20ClN5O2/c1-18(2,3)24-16-13(9-22-24)17(26)23(11-21-16)10-15(25)20-8-12-6-4-5-7-14(12)19/h4-7,9,11H,8,10H2,1-3H3,(H,20,25)
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n/an/an/an/a 138n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22378
PNG
((3aS,6aR)-4-(3-methoxyphenyl)-5-[(4E)-oct-4-en-4-y...)
Show SMILES CCC\C=C(/CCC)C1=C(c2cccc(OC)c2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C29H37NO/c1-4-6-13-22(12-5-2)27-21-24-15-11-19-29(24,30-25-16-8-7-9-17-25)28(27)23-14-10-18-26(20-23)31-3/h7-10,13-14,16-18,20,24,30H,4-6,11-12,15,19,21H2,1-3H3/b22-13+/t24-,29+/m1/s1
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n/an/an/an/a 140n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39527
PNG
(MLS000070707 | N-(6-ethoxy-1,3-benzothiazol-2-yl)-...)
Show SMILES CCOc1ccc2nc(NC(=O)c3cnccn3)sc2c1
Show InChI InChI=1S/C14H12N4O2S/c1-2-20-9-3-4-10-12(7-9)21-14(17-10)18-13(19)11-8-15-5-6-16-11/h3-8H,2H2,1H3,(H,17,18,19)
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n/an/an/an/a 140n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418315
PNG
(CHEMBL1765936)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccc(C)cc1
Show InChI InChI=1S/C29H36/c1-4-5-6-8-14-26-21-27-15-11-20-29(27,28(26)25-12-9-7-10-13-25)23(3)24-18-16-22(2)17-19-24/h7,9-10,12-13,16-19,27H,3-6,8,11,14-15,20-21H2,1-2H3/t27-,29+/m1/s1
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n/an/an/an/a 158n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418314
PNG
(CHEMBL1765954)
Show SMILES CCCCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C30H38/c1-3-4-5-6-7-10-20-27-23-28-21-15-22-30(28,24(2)25-16-11-8-12-17-25)29(27)26-18-13-9-14-19-26/h8-9,11-14,16-19,28H,2-7,10,15,20-23H2,1H3/t28-,30+/m1/s1
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n/an/an/an/a 158n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418300
PNG
(CHEMBL1765941)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)CCC
Show InChI InChI=1S/C25H36/c1-4-6-7-9-16-22-19-23-17-12-18-25(23,20(3)13-5-2)24(22)21-14-10-8-11-15-21/h8,10-11,14-15,23H,3-7,9,12-13,16-19H2,1-2H3/t23-,25+/m1/s1
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n/an/an/an/a 158n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22373
PNG
((3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-1,2,...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H35N/c1-3-5-14-22(13-4-2)26-21-24-17-12-20-28(24,29-25-18-10-7-11-19-25)27(26)23-15-8-6-9-16-23/h6-11,14-16,18-19,24,29H,3-5,12-13,17,20-21H2,1-2H3/b22-14+/t24-,28+/m1/s1
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n/an/an/an/a 158n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39428
PNG
(5-Methyl-furan-2-carboxylic acid (5-benzyl-thiazol...)
Show SMILES Cc1ccc(o1)C(=O)Nc1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C16H14N2O2S/c1-11-7-8-14(20-11)15(19)18-16-17-10-13(21-16)9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,17,18,19)
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n/an/an/an/a 168n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22377
PNG
((3aS,6aR)-4-(4-bromophenyl)-5-[(4E)-oct-4-en-4-yl]...)
Show SMILES CCC\C=C(/CCC)C1=C(c2ccc(Br)cc2)[C@@]2(CCC[C@@H]2C1)Nc1ccccc1
Show InChI InChI=1S/C28H34BrN/c1-3-5-11-21(10-4-2)26-20-23-12-9-19-28(23,30-25-13-7-6-8-14-25)27(26)22-15-17-24(29)18-16-22/h6-8,11,13-18,23,30H,3-5,9-10,12,19-20H2,1-2H3/b21-11+/t23-,28+/m1/s1
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n/an/an/an/a 170n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM22386
PNG
((3aS,6aR)-5-cyclohexyl-N,4-diphenyl-1,2,3,3a,6,6a-...)
Show SMILES C1C[C@@H]2CC(C3CCCCC3)=C(c3ccccc3)[C@@]2(C1)Nc1ccccc1
Show InChI InChI=1S/C26H31N/c1-4-11-20(12-5-1)24-19-22-15-10-18-26(22,27-23-16-8-3-9-17-23)25(24)21-13-6-2-7-14-21/h2-3,6-9,13-14,16-17,20,22,27H,1,4-5,10-12,15,18-19H2/t22-,26+/m1/s1
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n/an/an/an/a 180n/an/a7.522



University of Southampton



Assay Description
The screen utilizes a ligand mediated co-factor interaction between purified bacterial expressed ligand binding domain of human SF1 and a peptide der...


J Med Chem 49: 6652-5 (2006)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39426
PNG
(7-amino-3-phenyl-6-pyrazolo[1,5-a]pyrimidinecarbox...)
Show SMILES CCOC(=O)c1cnc2c(cnn2c1N)-c1ccccc1
Show InChI InChI=1S/C15H14N4O2/c1-2-21-15(20)12-8-17-14-11(9-18-19(14)13(12)16)10-6-4-3-5-7-10/h3-9H,2,16H2,1H3
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n/an/an/an/a 183n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM28649
PNG
(ethyl 2-[(2-{[(4-ethoxyphenyl)carbamoyl]methyl}-1-...)
Show SMILES CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OCC)cc1)c2=O
Show InChI InChI=1S/C24H26N2O6/c1-4-30-18-11-9-17(10-12-18)25-22(27)15-26-14-13-19-20(23(26)28)7-6-8-21(19)32-16(3)24(29)31-5-2/h6-14,16H,4-5,15H2,1-3H3,(H,25,27)
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n/an/an/an/a 190n/an/an/an/a



Scripps Florida



Assay Description
The assay was to monitor the SF-1 activation state via co-transfection of CHO-K1 cells with a plasmid encoding a Gal4-SF-1 chimerical transcription f...


Bioorg Med Chem Lett 18: 2628-32 (2008)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39531
PNG
(8-methyl-2-phenyl-imidazo[1,2-a]pyridine | 8-methy...)
Show SMILES Cc1cccn2cc(nc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2/c1-11-6-5-9-16-10-13(15-14(11)16)12-7-3-2-4-8-12/h2-10H,1H3
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n/an/an/an/a 190n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418320
PNG
(CHEMBL1765927)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCCC
Show InChI InChI=1S/C23H34O/c1-3-5-6-8-14-20-18-21-15-11-16-23(21,24-17-4-2)22(20)19-12-9-7-10-13-19/h7,9-10,12-13,21H,3-6,8,11,14-18H2,1-2H3/t21-,23+/m1/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM28648
PNG
(ethyl 2-{[1-oxo-2-({[4-(trifluoromethoxy)phenyl]ca...)
Show SMILES CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OC(F)(F)F)cc1)c2=O
Show InChI InChI=1S/C23H21F3N2O6/c1-3-32-22(31)14(2)33-19-6-4-5-18-17(19)11-12-28(21(18)30)13-20(29)27-15-7-9-16(10-8-15)34-23(24,25)26/h4-12,14H,3,13H2,1-2H3,(H,27,29)
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n/an/an/an/a 200n/an/an/an/a



Scripps Florida



Assay Description
The assay was to monitor the SF-1 activation state via co-transfection of CHO-K1 cells with a plasmid encoding a Gal4-SF-1 chimerical transcription f...


Bioorg Med Chem Lett 18: 2628-32 (2008)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418316
PNG
(CHEMBL1765966)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](C[C@@H]2C1)OC(C)=O)C(=C)c1ccccc1
Show InChI InChI=1S/C30H36O2/c1-4-5-6-9-18-26-19-27-20-28(32-23(3)31)21-30(27,22(2)24-14-10-7-11-15-24)29(26)25-16-12-8-13-17-25/h7-8,10-17,27-28H,2,4-6,9,18-21H2,1,3H3/t27-,28+,30-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418317
PNG
(CHEMBL1765950)
Show SMILES CCCCCCC1=C(C2CCCCC2)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H40/c1-3-4-5-8-18-25-21-26-19-13-20-28(26,22(2)23-14-9-6-10-15-23)27(25)24-16-11-7-12-17-24/h6,9-10,14-15,24,26H,2-5,7-8,11-13,16-21H2,1H3/t26-,28+/m1/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418318
PNG
(CHEMBL1765942)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)C(=C)CCCC
Show InChI InChI=1S/C26H38/c1-4-6-8-10-17-23-20-24-18-13-19-26(24,21(3)14-7-5-2)25(23)22-15-11-9-12-16-22/h9,11-12,15-16,24H,3-8,10,13-14,17-20H2,1-2H3/t24-,26+/m1/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418319
PNG
(CHEMBL1765930)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCC(C)CC
Show InChI InChI=1S/C25H38O/c1-4-6-7-9-15-22-18-23-16-12-17-25(23,26-19-20(3)5-2)24(22)21-13-10-8-11-14-21/h8,10-11,13-14,20,23H,4-7,9,12,15-19H2,1-3H3/t20?,23-,25+/m1/s1
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n/an/an/an/a 200n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM28647
PNG
(ethyl 2-[(2-{[(4-methoxyphenyl)carbamoyl]methyl}-1...)
Show SMILES CCOC(=O)C(C)Oc1cccc2c1ccn(CC(=O)Nc1ccc(OC)cc1)c2=O
Show InChI InChI=1S/C23H24N2O6/c1-4-30-23(28)15(2)31-20-7-5-6-19-18(20)12-13-25(22(19)27)14-21(26)24-16-8-10-17(29-3)11-9-16/h5-13,15H,4,14H2,1-3H3,(H,24,26)
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n/an/an/an/a 200n/an/an/an/a



Scripps Florida



Assay Description
The assay was to monitor the SF-1 activation state via co-transfection of CHO-K1 cells with a plasmid encoding a Gal4-SF-1 chimerical transcription f...


Bioorg Med Chem Lett 18: 2628-32 (2008)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39543
PNG
(3-(3-methoxyphenyl)-5-(2-thienyl)-1,2,4-oxadiazole...)
Show SMILES COc1cccc(c1)-c1noc(n1)-c1cccs1
Show InChI InChI=1S/C13H10N2O2S/c1-16-10-5-2-4-9(8-10)12-14-13(17-15-12)11-6-3-7-18-11/h2-8H,1H3
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n/an/an/an/a 226n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39565
PNG
(2-(2-chlorophenyl)-5-(4-chlorophenyl)-1,3,4-oxadia...)
Show SMILES Clc1ccc(cc1)-c1nnc(o1)-c1ccccc1Cl
Show InChI InChI=1S/C14H8Cl2N2O/c15-10-7-5-9(6-8-10)13-17-18-14(19-13)11-3-1-2-4-12(11)16/h1-8H
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n/an/an/an/a 233n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418322
PNG
(CHEMBL1765948)
Show SMILES CCCCCCC1=C(CCCC)[C@@]2(CCC[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C26H38/c1-4-6-8-10-16-23-20-24-17-13-19-26(24,25(23)18-7-5-2)21(3)22-14-11-9-12-15-22/h9,11-12,14-15,24H,3-8,10,13,16-20H2,1-2H3/t24-,26+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418302
PNG
(CHEMBL1765929)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(CCC[C@@H]2C1)OCCCC
Show InChI InChI=1S/C24H36O/c1-3-5-7-9-15-21-19-22-16-12-17-24(22,25-18-6-4-2)23(21)20-13-10-8-11-14-20/h8,10-11,13-14,22H,3-7,9,12,15-19H2,1-2H3/t22-,24+/m1/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM50418321
PNG
(CHEMBL1765963)
Show SMILES CCCCCCC1=C(c2ccccc2)[C@@]2(C[C@@H](O)C[C@@H]2C1)C(=C)c1ccccc1
Show InChI InChI=1S/C28H34O/c1-3-4-5-8-17-24-18-25-19-26(29)20-28(25,21(2)22-13-9-6-10-14-22)27(24)23-15-11-7-12-16-23/h6-7,9-16,25-26,29H,2-5,8,17-20H2,1H3/t25-,26-,28-/m0/s1
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n/an/an/an/a 251n/an/an/an/a



University of Southampton

Curated by ChEMBL


Assay Description
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control


J Med Chem 54: 2266-81 (2011)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39534
PNG
(1-azepanyl-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)pheny...)
Show SMILES O=C(N1CCCCCC1)c1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C21H21N3O2/c25-21(24-14-6-1-2-7-15-24)18-12-10-17(11-13-18)20-23-22-19(26-20)16-8-4-3-5-9-16/h3-5,8-13H,1-2,6-7,14-15H2
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n/an/an/an/a 252n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Steroidogenic Factor 1


(Homo sapiens (human))
BDBM39537
PNG
(MLS000077996 | N-[5-(1-adamantyl)-1,3,4-thiadiazol...)
Show SMILES O=C(Nc1nnc(s1)C12CC3CC(CC(C3)C1)C2)c1ccco1
Show InChI InChI=1S/C17H19N3O2S/c21-14(13-2-1-3-22-13)18-16-20-19-15(23-16)17-7-10-4-11(8-17)6-12(5-10)9-17/h1-3,10-12H,4-9H2,(H,18,20,21)
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n/an/an/an/a 257n/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
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