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Compile Data Set for Download or QSAR

Found 76 hits of ec50 data for polymerid = 2444   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50101853
PNG
((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 1.80n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103391
PNG
(CHEMBL3398233)
Show SMILES COc1ccc(cc1)-c1c(cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c1=O)-c1ccccc1
Show InChI InChI=1/C30H28N2O5/c1-36-24-13-11-22(12-14-24)29-26(21-6-3-2-4-7-21)17-31-32(30(29)35)18-20-10-15-25-23(16-20)8-5-9-27(25)37-19-28(33)34/h2-9,11-14,17,20H,10,15-16,18-19H2,1H3,(H,33,34)
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n/an/an/an/a 4n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103396
PNG
(CHEMBL3398236)
Show SMILES OC(=O)COc1cccc2C[C@H](Cn3ncc(-c4cccc(F)c4F)c(-c4ccc(F)cc4)c3=O)CCc12
Show InChI InChI=1/C29H23F3N2O4/c30-20-10-8-18(9-11-20)27-23(22-4-2-5-24(31)28(22)32)14-33-34(29(27)37)15-17-7-12-21-19(13-17)3-1-6-25(21)38-16-26(35)36/h1-6,8-11,14,17H,7,12-13,15-16H2,(H,35,36)/t17-/s2
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n/an/an/an/a 6n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103405
PNG
(CHEMBL3398215)
Show SMILES COc1ccc(cc1)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1/C30H28N2O5/c1-36-24-13-11-22(12-14-24)30-26(21-6-3-2-4-7-21)17-28(33)32(31-30)18-20-10-15-25-23(16-20)8-5-9-27(25)37-19-29(34)35/h2-9,11-14,17,20H,10,15-16,18-19H2,1H3,(H,34,35)
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n/an/an/an/a 8.5n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103408
PNG
(CHEMBL3398220)
Show SMILES COc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccc(C)cc1
Show InChI InChI=1/C31H30N2O5/c1-20-9-12-22(13-10-20)31-27(24-5-3-7-25(16-24)37-2)17-29(34)33(32-31)18-21-11-14-26-23(15-21)6-4-8-28(26)38-19-30(35)36/h3-10,12-13,16-17,21H,11,14-15,18-19H2,1-2H3,(H,35,36)
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n/an/an/an/a 9.5n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103407
PNG
(CHEMBL3398219)
Show SMILES COc1ccc(cc1F)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1/C30H27FN2O5/c1-37-27-13-11-22(15-25(27)31)30-24(20-6-3-2-4-7-20)16-28(34)33(32-30)17-19-10-12-23-21(14-19)8-5-9-26(23)38-18-29(35)36/h2-9,11,13,15-16,19H,10,12,14,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103394
PNG
(CHEMBL3398229)
Show SMILES COc1cccc(c1F)-c1cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)c1-c1ccccc1
Show InChI InChI=1/C30H27FN2O5/c1-37-26-12-6-10-23(29(26)31)24-16-32-33(30(36)28(24)20-7-3-2-4-8-20)17-19-13-14-22-21(15-19)9-5-11-25(22)38-18-27(34)35/h2-12,16,19H,13-15,17-18H2,1H3,(H,34,35)
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n/an/an/an/a 10n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES COCCOc1ccc(cc1)N1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 11n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23963
PNG
((2S)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@@H](Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C28H25N3O5/c1-18(32)30-23-9-5-8-22(16-23)21-12-10-20(11-13-21)15-25-26(29-17-36-25)27(33)31-24(28(34)35)14-19-6-3-2-4-7-19/h2-13,16-17,24H,14-15H2,1H3,(H,30,32)(H,31,33)(H,34,35)/t24-/m0/s1
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n/an/a 476n/a 16n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103406
PNG
(CHEMBL3398218)
Show SMILES COc1ccc(c(F)c1)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1/C30H27FN2O5/c1-37-22-11-13-24(26(31)15-22)30-25(20-6-3-2-4-7-20)16-28(34)33(32-30)17-19-10-12-23-21(14-19)8-5-9-27(23)38-18-29(35)36/h2-9,11,13,15-16,19H,10,12,14,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 20n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103392
PNG
(CHEMBL3398232)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4ccc(F)cc4)c3=O)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-23-12-10-21(11-13-23)28-25(20-5-2-1-3-6-20)16-31-32(29(28)35)17-19-9-14-24-22(15-19)7-4-8-26(24)36-18-27(33)34/h1-8,10-13,16,19H,9,14-15,17-18H2,(H,33,34)
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n/an/an/an/a 20n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103431
PNG
(CHEMBL3398216)
Show SMILES Cc1ccc(cc1)-c1nn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)cc1-c1ccccc1
Show InChI InChI=1/C30H28N2O4/c1-20-10-13-23(14-11-20)30-26(22-6-3-2-4-7-22)17-28(33)32(31-30)18-21-12-15-25-24(16-21)8-5-9-27(25)36-19-29(34)35/h2-11,13-14,17,21H,12,15-16,18-19H2,1H3,(H,34,35)
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n/an/an/an/a 24n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50101829
PNG
(7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...)
Show SMILES CCCC1(CCC1)[C@@H](O)C\C=C\C1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18?,20-,21+/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103395
PNG
(CHEMBL3398235)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(F)c4F)c(-c4ccc(F)cc4)c3=O)CCc12
Show InChI InChI=1/C29H23F3N2O4/c30-20-10-8-18(9-11-20)27-23(22-4-2-5-24(31)28(22)32)14-33-34(29(27)37)15-17-7-12-21-19(13-17)3-1-6-25(21)38-16-26(35)36/h1-6,8-11,14,17H,7,12-13,15-16H2,(H,35,36)
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n/an/an/an/a 33n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50101824
PNG
(7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-pro...)
Show SMILES CCCC1(CCC1)[C@@H](O)C\C=C\C1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC
Show InChI InChI=1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19?,21-,22+/m1/s1
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n/an/an/an/a 37n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103403
PNG
(CHEMBL3398212)
Show SMILES COc1cccc(c1F)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccccc1
Show InChI InChI=1/C30H27FN2O5/c1-37-26-12-6-10-23(29(26)31)24-16-27(34)33(32-30(24)20-7-3-2-4-8-20)17-19-13-14-22-21(15-19)9-5-11-25(22)38-18-28(35)36/h2-12,16,19H,13-15,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 37n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103404
PNG
(CHEMBL3398228)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(F)c4F)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1/C29H24F2N2O4/c30-24-10-5-9-22(28(24)31)23-15-32-33(29(36)27(23)19-6-2-1-3-7-19)16-18-12-13-21-20(14-18)8-4-11-25(21)37-17-26(34)35/h1-11,15,18H,12-14,16-17H2,(H,34,35)
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n/an/an/an/a 38n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50169551
PNG
(CHEMBL3805134)
Show SMILES CC(C)S(=O)(=O)N1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C22H25N7O3S/c1-15(2)33(30,31)28-10-8-27(9-11-28)17-6-3-5-16(13-17)18-14-20-25-21(19-7-4-12-32-19)26-29(20)22(23)24-18/h3-7,12-15H,8-11H2,1-2H3,(H2,23,24)
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n/an/an/an/a 47n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23960
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g | 5-{[...)
Show SMILES C[C@@H](CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1
Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)/t19-/m0/s1
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n/an/a 53n/a 51n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103402
PNG
(CHEMBL3398211)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccccc4)c(cc3=O)-c3cccc(Cl)c3)CCc12
Show InChI InChI=1/C29H25ClN2O4/c30-23-10-4-8-22(15-23)25-16-27(33)32(31-29(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-28(34)35/h1-11,15-16,19H,12-14,17-18H2,(H,34,35)
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n/an/an/an/a 60n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103399
PNG
(CHEMBL3398208)
Show SMILES COc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccccc1
Show InChI InChI=1/C30H28N2O5/c1-36-24-11-5-9-23(16-24)26-17-28(33)32(31-30(26)21-7-3-2-4-8-21)18-20-13-14-25-22(15-20)10-6-12-27(25)37-19-29(34)35/h2-12,16-17,20H,13-15,18-19H2,1H3,(H,34,35)
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n/an/an/an/a 60n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103412
PNG
(CHEMBL3398224)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(F)c4)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-23-10-4-8-22(15-23)25-16-31-32(29(35)28(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-27(33)34/h1-11,15-16,19H,12-14,17-18H2,(H,33,34)
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Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103409
PNG
(CHEMBL3398221)
Show SMILES COc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccc(F)cc1
Show InChI InChI=1/C30H27FN2O5/c1-37-24-6-2-4-22(15-24)26-16-28(34)33(32-30(26)20-9-11-23(31)12-10-20)17-19-8-13-25-21(14-19)5-3-7-27(25)38-18-29(35)36/h2-7,9-12,15-16,19H,8,13-14,17-18H2,1H3,(H,35,36)
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n/an/an/an/a 62n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23955
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b | N-be...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C26H23N3O3/c1-18(30)29-23-9-5-8-22(15-23)21-12-10-19(11-13-21)14-24-25(28-17-32-24)26(31)27-16-20-6-3-2-4-7-20/h2-13,15,17H,14,16H2,1H3,(H,27,31)(H,29,30)
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n/an/a 561n/a 66n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103397
PNG
(CHEMBL3398237)
Show SMILES OC(=O)COc1cccc2C(CCON=C(c3ccccc3)c3ccccc3)=CCCc12
Show InChI InChI=1S/C27H25NO4/c29-26(30)19-31-25-16-8-14-23-20(13-7-15-24(23)25)17-18-32-28-27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-6,8-14,16H,7,15,17-19H2,(H,29,30)
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n/an/an/an/a 79n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103390
PNG
(CHEMBL3398234)
Show SMILES COc1ccc(cc1F)-c1c(cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c1=O)-c1ccccc1
Show InChI InChI=1/C30H27FN2O5/c1-37-27-13-11-22(15-25(27)31)29-24(20-6-3-2-4-7-20)16-32-33(30(29)36)17-19-10-12-23-21(14-19)8-5-9-26(23)38-18-28(34)35/h2-9,11,13,15-16,19H,10,12,14,17-18H2,1H3,(H,34,35)
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n/an/an/an/a 85n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103422
PNG
(CHEMBL3398225)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4cccc(Cl)c4)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1/C29H25ClN2O4/c30-23-10-4-8-22(15-23)25-16-31-32(29(35)28(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-27(33)34/h1-11,15-16,19H,12-14,17-18H2,(H,33,34)
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n/an/an/an/a 86n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103410
PNG
(CHEMBL3398222)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1/C29H26N2O4/c32-27(33)19-35-26-13-7-12-23-16-20(14-15-24(23)26)18-31-29(34)28(22-10-5-2-6-11-22)25(17-30-31)21-8-3-1-4-9-21/h1-13,17,20H,14-16,18-19H2,(H,32,33)
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n/an/an/an/a 100n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103423
PNG
(CHEMBL3398217)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccc(F)cc4)c(cc3=O)-c3ccccc3)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-23-12-10-21(11-13-23)29-25(20-5-2-1-3-6-20)16-27(33)32(31-29)17-19-9-14-24-22(15-19)7-4-8-26(24)36-18-28(34)35/h1-8,10-13,16,19H,9,14-15,17-18H2,(H,34,35)
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n/an/an/an/a 114n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103413
PNG
(CHEMBL3398227)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4F)c(-c4ccccc4)c3=O)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-25-11-5-4-10-23(25)24-16-31-32(29(35)28(24)20-7-2-1-3-8-20)17-19-13-14-22-21(15-19)9-6-12-26(22)36-18-27(33)34/h1-12,16,19H,13-15,17-18H2,(H,33,34)
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23956
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccccc2)cc1
Show InChI InChI=1S/C27H25N3O3/c1-19(31)30-24-9-5-8-23(17-24)22-12-10-21(11-13-22)16-25-26(29-18-33-25)27(32)28-15-14-20-6-3-2-4-7-20/h2-13,17-18H,14-16H2,1H3,(H,28,32)(H,30,31)
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n/an/a 721n/a 138n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103411
PNG
(CHEMBL3398223)
Show SMILES COc1cccc(c1)-c1cnn(CC2CCc3c(C2)cccc3OCC(O)=O)c(=O)c1-c1ccccc1
Show InChI InChI=1/C30H28N2O5/c1-36-24-11-5-9-23(16-24)26-17-31-32(30(35)29(26)21-7-3-2-4-8-21)18-20-13-14-25-22(15-20)10-6-12-27(25)37-19-28(33)34/h2-12,16-17,20H,13-15,18-19H2,1H3,(H,33,34)
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n/an/an/an/a 140n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103416
PNG
(CHEMBL3398230)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4ccccc4F)c3=O)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-25-11-5-4-10-23(25)28-24(20-7-2-1-3-8-20)16-31-32(29(28)35)17-19-13-14-22-21(15-19)9-6-12-26(22)36-18-27(33)34/h1-12,16,19H,13-15,17-18H2,(H,33,34)
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n/an/an/an/a 140n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103400
PNG
(CHEMBL3398209)
Show SMILES Cc1cccc(c1)-c1cc(=O)n(CC2CCc3c(C2)cccc3OCC(O)=O)nc1-c1ccccc1
Show InChI InChI=1/C30H28N2O4/c1-20-7-5-10-23(15-20)26-17-28(33)32(31-30(26)22-8-3-2-4-9-22)18-21-13-14-25-24(16-21)11-6-12-27(25)36-19-29(34)35/h2-12,15,17,21H,13-14,16,18-19H2,1H3,(H,34,35)
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n/an/an/an/a 180n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50101822
PNG
((Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Show SMILES CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17-,19-/m1/s1
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n/an/an/an/a 260n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in human Prostanoid IP receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103393
PNG
(CHEMBL3398231)
Show SMILES OC(=O)COc1cccc2CC(Cn3ncc(-c4ccccc4)c(-c4cccc(F)c4)c3=O)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-23-10-4-9-22(15-23)28-25(20-6-2-1-3-7-20)16-31-32(29(28)35)17-19-12-13-24-21(14-19)8-5-11-26(24)36-18-27(33)34/h1-11,15-16,19H,12-14,17-18H2,(H,33,34)
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Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23957
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d | 5-{[...)
Show SMILES CC(NC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-18(21-7-4-3-5-8-21)29-27(32)26-25(33-17-28-26)15-20-11-13-22(14-12-20)23-9-6-10-24(16-23)30-19(2)31/h3-14,16-18H,15H2,1-2H3,(H,29,32)(H,30,31)
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n/an/a 1.23E+3n/a 278n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM240747
PNG
(US9422273, 12e)
Show SMILES CCCCCCCCNC(=O)c1coc(n1)[C@@H]1CCCN1Cc1cc(F)ccc1CCC(=O)NS(=O)(=O)C(F)(F)F
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US Patent
n/an/an/an/a 290n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23961
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h | 5-{[...)
Show SMILES C[C@H](CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1
Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)/t19-/m1/s1
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n/an/a 916n/a 296n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 347n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23959
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1
Show InChI InChI=1S/C28H25N3O3/c1-18(32)30-23-9-5-8-22(15-23)20-12-10-19(11-13-20)14-26-27(29-17-34-26)28(33)31-25-16-24(25)21-6-3-2-4-7-21/h2-13,15,17,24-25H,14,16H2,1H3,(H,30,32)(H,31,33)/t24-,25+/m1/s1
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Article
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n/an/a 331n/a 358n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103401
PNG
(CHEMBL3398210)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccccc4)c(cc3=O)-c3cccc(F)c3)CCc12
Show InChI InChI=1/C29H25FN2O4/c30-23-10-4-8-22(15-23)25-16-27(33)32(31-29(25)20-6-2-1-3-7-20)17-19-12-13-24-21(14-19)9-5-11-26(24)36-18-28(34)35/h1-11,15-16,19H,12-14,17-18H2,(H,34,35)
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n/an/an/an/a 380n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23966
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccncc2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-4-2-3-22(16-23)21-7-5-20(6-8-21)15-24-25(29-17-33-24)26(32)28-14-11-19-9-12-27-13-10-19/h2-10,12-13,16-17H,11,14-15H2,1H3,(H,28,32)(H,30,31)
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n/an/a 4.71E+3n/a 476n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM240744
PNG
(US9422273, 12a)
Show SMILES Fc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
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US Patent
n/an/an/an/a 550n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23965
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2cccnc2)cc1
Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-6-2-5-22(15-23)21-9-7-19(8-10-21)14-24-25(29-17-33-24)26(32)28-13-11-20-4-3-12-27-16-20/h2-10,12,15-17H,11,13-14H2,1H3,(H,28,32)(H,30,31)
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n/an/a 4.95E+3n/a 741n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23967
PNG
(5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n | 5-{[...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C25H21N3O3/c1-17(29)27-22-9-5-6-20(15-22)19-12-10-18(11-13-19)14-23-24(26-16-31-23)25(30)28-21-7-3-2-4-8-21/h2-13,15-16H,14H2,1H3,(H,27,29)(H,28,30)
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n/an/a 3.48E+3n/a 828n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM23962
PNG
((2R)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@H](Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1S/C28H25N3O5/c1-18(32)30-23-9-5-8-22(16-23)21-12-10-20(11-13-21)15-25-26(29-17-36-25)27(33)31-24(28(34)35)14-19-6-3-2-4-7-19/h2-13,16-17,24H,14-15H2,1H3,(H,30,32)(H,31,33)(H,34,35)/t24-/m1/s1
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n/an/a 4.20E+3n/a 831n/an/a7.422



Pharmacopeia Drug Discovery Inc.



Assay Description
IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM62356
PNG
(US9422273, 12b)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
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US Patent
n/an/an/an/a 860n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM50103398
PNG
(CHEMBL3398206)
Show SMILES OC(=O)COc1cccc2CC(Cn3nc(-c4ccccc4)c(cc3=O)-c3ccccc3)CCc12
Show InChI InChI=1/C29H26N2O4/c32-27-17-25(21-8-3-1-4-9-21)29(22-10-5-2-6-11-22)30-31(27)18-20-14-15-24-23(16-20)12-7-13-26(24)35-19-28(33)34/h1-13,17,20H,14-16,18-19H2,(H,33,34)
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n/an/an/an/a 969n/an/an/an/a



Arena Pharmaceuticals, 6154, Nancy Ridge Drive, San Diego, CA 92121, USA.

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant IP receptor expressed in CHO-K1 cells incubated for 1 hr by HTRF cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid IP receptor


(Homo sapiens (human))
BDBM240746
PNG
(US9422273, 12d)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1cc2OCOc2cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
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US Patent
n/an/an/an/a 1.00E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
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