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Compile Data Set for Download or QSAR

Found 67 hits of ec50 data for polymerid = 3427,50006525,5786   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054973
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(3-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)NCCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C27H34N6O4/c28-8-6-18-14-32-24-4-2-20(12-22(18)24)36-16-26(34)30-10-1-11-31-27(35)17-37-21-3-5-25-23(13-21)19(7-9-29)15-33-25/h2-5,12-15,32-33H,1,6-11,16-17,28-29H2,(H,30,34)(H,31,35)
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n/an/an/an/a 0.0900n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054985
PNG
(Biphenyl-4,4'-disulfonic acid bis-({6-[3-(2-amino-...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCCNS(=O)(=O)c3ccc(cc3)-c3ccc(cc3)S(=O)(=O)NCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C44H56N6O6S2/c45-23-21-35-31-47-43-19-13-37(29-41(35)43)55-27-7-3-1-5-25-49-57(51,52)39-15-9-33(10-16-39)34-11-17-40(18-12-34)58(53,54)50-26-6-2-4-8-28-56-38-14-20-44-42(30-38)36(22-24-46)32-48-44/h9-20,29-32,47-50H,1-8,21-28,45-46H2
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n/an/an/an/a 0.100n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054979
PNG
(2-{5-[2-(4-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]...)
Show SMILES NCCc1c[nH]c2ccc(OCCN3CCN(CCOc4ccc5[nH]cc(CCN)c5c4)CC3)cc12
Show InChI InChI=1S/C28H38N6O2/c29-7-5-21-19-31-27-3-1-23(17-25(21)27)35-15-13-33-9-11-34(12-10-33)14-16-36-24-2-4-28-26(18-24)22(6-8-30)20-32-28/h1-4,17-20,31-32H,5-16,29-30H2
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n/an/an/an/a 0.190n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054987
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCCN3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H36N6O3/c29-7-5-20-17-31-26-3-1-22(15-24(20)26)36-14-13-33-9-11-34(12-10-33)28(35)19-37-23-2-4-27-25(16-23)21(6-8-30)18-32-27/h1-4,15-18,31-32H,5-14,19,29-30H2
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n/an/an/an/a 0.220n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054980
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(1'-{2-[3...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCC(CC3)C3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C34H44N6O4/c35-11-5-25-19-37-31-3-1-27(17-29(25)31)43-21-33(41)39-13-7-23(8-14-39)24-9-15-40(16-10-24)34(42)22-44-28-2-4-32-30(18-28)26(6-12-36)20-38-32/h1-4,17-20,23-24,37-38H,5-16,21-22,35-36H2
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n/an/an/an/a 0.260n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054986
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H34N6O4/c29-7-5-19-15-31-25-3-1-21(13-23(19)25)37-17-27(35)33-9-11-34(12-10-33)28(36)18-38-22-2-4-26-24(14-22)20(6-8-30)16-32-26/h1-4,13-16,31-32H,5-12,17-18,29-30H2
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n/an/an/an/a 0.280n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054981
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(NC(=O)COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
Show InChI InChI=1S/C30H32N6O4/c31-11-9-19-15-33-27-7-5-23(13-25(19)27)39-17-29(37)35-21-1-2-22(4-3-21)36-30(38)18-40-24-6-8-28-26(14-24)20(10-12-32)16-34-28/h1-8,13-16,33-34H,9-12,17-18,31-32H2,(H,35,37)(H,36,38)
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n/an/an/an/a 0.300n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054988
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-...)
Show SMILES NCCc1c[nH]c2ccc(OCC(=O)Nc3ccc(cc3)N3CCN(CC3)C(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C34H39N7O4/c35-11-9-23-19-37-31-7-5-27(17-29(23)31)44-21-33(42)39-25-1-3-26(4-2-25)40-13-15-41(16-14-40)34(43)22-45-28-6-8-32-30(18-28)24(10-12-36)20-38-32/h1-8,17-20,37-38H,9-16,21-22,35-36H2,(H,39,42)
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n/an/an/an/a 0.400n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054976
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-...)
Show SMILES NCCc1c[nH]c2ccc(OCCNC(=O)COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C24H29N5O3/c25-7-5-16-13-28-22-3-1-18(11-20(16)22)31-10-9-27-24(30)15-32-19-2-4-23-21(12-19)17(6-8-26)14-29-23/h1-4,11-14,28-29H,5-10,15,25-26H2,(H,27,30)
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n/an/an/an/a 0.440n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50069315
PNG
(C-[3-(2-Dimethylamino-ethyl)-1H-indol-5-yl]-N-[4-(...)
Show SMILES CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N(C)Cc3ccc(CN(C)S(=O)(=O)Cc4ccc5[nH]cc(CCN(C)C)c5c4)cc3)cc12
Show InChI InChI=1S/C36H48N6O4S2/c1-39(2)17-15-31-21-37-35-13-11-29(19-33(31)35)25-47(43,44)41(5)23-27-7-9-28(10-8-27)24-42(6)48(45,46)26-30-12-14-36-34(20-30)32(22-38-36)16-18-40(3)4/h7-14,19-22,37-38H,15-18,23-26H2,1-6H3
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n/an/an/an/a 0.580n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Effective concentration of the compound determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor...


Bioorg Med Chem Lett 8: 675-80 (1999)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054977
PNG
(2-(5-{6-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-hexyl...)
Show SMILES NCCc1c[nH]c2ccc(OCCCCCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C26H34N4O2/c27-11-9-19-17-29-25-7-5-21(15-23(19)25)31-13-3-1-2-4-14-32-22-6-8-26-24(16-22)20(10-12-28)18-30-26/h5-8,15-18,29-30H,1-4,9-14,27-28H2
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n/an/an/an/a 0.600n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054978
PNG
(2-(5-{3-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Show SMILES NCCc1c[nH]c2ccc(OCc3cccc(COc4ccc5[nH]cc(CCN)c5c4)c3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-10-8-21-15-31-27-6-4-23(13-25(21)27)33-17-19-2-1-3-20(12-19)18-34-24-5-7-28-26(14-24)22(9-11-30)16-32-28/h1-7,12-16,31-32H,8-11,17-18,29-30H2
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n/an/an/an/a 0.850n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054983
PNG
(1,3-Bis-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-et...)
Show SMILES NCCc1c[nH]c2ccc(OCCNC(=O)NCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C25H32N6O3/c26-7-5-17-15-30-23-3-1-19(13-21(17)23)33-11-9-28-25(32)29-10-12-34-20-2-4-24-22(14-20)18(6-8-27)16-31-24/h1-4,13-16,30-31H,5-12,26-27H2,(H2,28,29,32)
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n/an/an/an/a 1.60n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50290912
PNG
(4-(2,4-Dimethyl-phenyl)-piperazine-1-carboxylic ac...)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2ccc(C)cc2C)cc1N1CCN(C)CC1
Show InChI InChI=1S/C25H35N5O2/c1-19-5-7-22(20(2)17-19)28-13-15-30(16-14-28)25(31)26-21-6-8-24(32-4)23(18-21)29-11-9-27(3)10-12-29/h5-8,17-18H,9-16H2,1-4H3,(H,26,31)
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n/an/an/an/a 1.90n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was evaluated for intrinsic activity against human cloned 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054984
PNG
(2-(5-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Show SMILES NCCc1c[nH]c2ccc(OCc3ccccc3COc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-11-9-19-15-31-27-7-5-23(13-25(19)27)33-17-21-3-1-2-4-22(21)18-34-24-6-8-28-26(14-24)20(10-12-30)16-32-28/h1-8,13-16,31-32H,9-12,17-18,29-30H2
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n/an/an/an/a 2.07n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50033447
PNG
(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-o-toly...)
Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)COc1ccc2[nH]cc(CCN)c2c1
Show InChI InChI=1S/C23H28N4O2/c1-17-4-2-3-5-22(17)26-10-12-27(13-11-26)23(28)16-29-19-6-7-21-20(14-19)18(8-9-24)15-25-21/h2-7,14-15,25H,8-13,16,24H2,1H3
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n/an/an/an/a 2.10n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was evaluated for intrinsic activity against human cloned 5-hydroxytryptamine 1B receptor; full agonist


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054974
PNG
(2-(5-((4-((3-(2-aminoethyl)-1H-indol-5-yloxy)methy...)
Show SMILES NCCc1c[nH]c2ccc(OCc3ccc(COc4ccc5[nH]cc(CCN)c5c4)cc3)cc12
Show InChI InChI=1S/C28H30N4O2/c29-11-9-21-15-31-27-7-5-23(13-25(21)27)33-17-19-1-2-20(4-3-19)18-34-24-6-8-28-26(14-24)22(10-12-30)16-32-28/h1-8,13-16,31-32H,9-12,17-18,29-30H2
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n/an/an/an/a 3n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50054982
PNG
(2-(5-{2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-ethox...)
Show SMILES NCCc1c[nH]c2ccc(OCCOc3ccc4[nH]cc(CCN)c4c3)cc12
Show InChI InChI=1S/C22H26N4O2/c23-7-5-15-13-25-21-3-1-17(11-19(15)21)27-9-10-28-18-2-4-22-20(12-18)16(6-8-24)14-26-22/h1-4,11-14,25-26H,5-10,23-24H2
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n/an/an/an/a 4n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 4.67n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
The intrinsic activity of the compound was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryp...


Bioorg Med Chem Lett 8: 1407-12 (1999)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 4.82n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50413552
PNG
(CHEMBL472289)
Show SMILES CN1C(=O)COc2cc(CCN3CCN(CC3)c3cccc4nc(C)ccc34)ccc12
Show InChI InChI=1S/C25H28N4O2/c1-18-6-8-20-21(26-18)4-3-5-22(20)29-14-12-28(13-15-29)11-10-19-7-9-23-24(16-19)31-17-25(30)27(23)2/h3-9,16H,10-15,17H2,1-2H3
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n/an/an/an/a 6.31n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50290915
PNG
(4-(2,6-Dimethyl-phenyl)-piperazine-1-carboxylic ac...)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2c(C)cccc2C)cc1N1CCN(C)CC1
Show InChI InChI=1S/C25H35N5O2/c1-19-6-5-7-20(2)24(19)29-14-16-30(17-15-29)25(31)26-21-8-9-23(32-4)22(18-21)28-12-10-27(3)11-13-28/h5-9,18H,10-17H2,1-4H3,(H,26,31)
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n/an/an/an/a 10n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The compound was evaluated for intrinsic activity against human cloned 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50413566
PNG
(CHEMBL470849)
Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCCc2cccc3NC(=O)COc23)CC1
Show InChI InChI=1S/C25H28N4O2/c1-18-10-11-20-21(26-18)7-3-9-23(20)29-15-13-28(14-16-29)12-4-6-19-5-2-8-22-25(19)31-17-24(30)27-22/h2-3,5,7-11H,4,6,12-17H2,1H3,(H,27,30)
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n/an/an/an/a 15.8n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50033383
PNG
((S)-4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)m...)
Show SMILES CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12
Show InChI InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
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n/an/an/an/a 16n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Effective concentration of the compound determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor...


Bioorg Med Chem Lett 8: 675-80 (1999)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50061297
PNG
(1-[4-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazin...)
Show SMILES CN1CCN(CC1)c1cccc2ccc(OCC(=O)N3CCN(CC3)c3cccc4OCCOc34)cc12
Show InChI InChI=1S/C29H34N4O4/c1-30-10-12-31(13-11-30)25-5-2-4-22-8-9-23(20-24(22)25)37-21-28(34)33-16-14-32(15-17-33)26-6-3-7-27-29(26)36-19-18-35-27/h2-9,20H,10-19,21H2,1H3
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n/an/an/an/a 25n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50061304
PNG
(2-[8-(4-Methyl-piperazin-1-yl)-naphthalen-2-yloxy]...)
Show SMILES CN1CCN(CC1)c1cccc2ccc(OCC(=O)N3CCN(CC3)c3c(C)cc(C)cc3C)cc12
Show InChI InChI=1S/C30H38N4O2/c1-22-18-23(2)30(24(3)19-22)34-16-14-33(15-17-34)29(35)21-36-26-9-8-25-6-5-7-28(27(25)20-26)32-12-10-31(4)11-13-32/h5-9,18-20H,10-17,21H2,1-4H3
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n/an/an/an/a 25n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50413563
PNG
(CHEMBL469376)
Show SMILES C[C@@H]1CN(CCN1CCCc1cccc2N(C)C(=O)COc12)c1cccc2nc(C)ccc12
Show InChI InChI=1S/C27H32N4O2/c1-19-12-13-22-23(28-19)9-5-10-24(22)31-16-15-30(20(2)17-31)14-6-8-21-7-4-11-25-27(21)33-18-26(32)29(25)3/h4-5,7,9-13,20H,6,8,14-18H2,1-3H3/t20-/m1/s1
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n/an/an/an/a 25.1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 26n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1B receptor of rat substantia nigra


J Med Chem 33: 2087-93 (1990)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50454685
PNG
(CHEMBL2112660)
Show SMILES CN1CCN(CC1)c1cccc2ccc(OCC(=O)N3CCN(CC3)c3ccccc3C#N)cc12
Show InChI InChI=1S/C28H31N5O2/c1-30-11-13-32(14-12-30)27-8-4-6-22-9-10-24(19-25(22)27)35-21-28(34)33-17-15-31(16-18-33)26-7-3-2-5-23(26)20-29/h2-10,19H,11-18,21H2,1H3
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n/an/an/an/a 28n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50061296
PNG
(1-[4-(2,3-Dimethoxy-phenyl)-piperazin-1-yl]-2-[8-(...)
Show SMILES COc1cccc(N2CCN(CC2)C(=O)COc2ccc3cccc(N4CCN(C)CC4)c3c2)c1OC
Show InChI InChI=1S/C29H36N4O4/c1-30-12-14-31(15-13-30)25-7-4-6-22-10-11-23(20-24(22)25)37-21-28(34)33-18-16-32(17-19-33)26-8-5-9-27(35-2)29(26)36-3/h4-11,20H,12-19,21H2,1-3H3
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n/an/an/an/a 30n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formation


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/an/an/a 30n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1A receptor of guinea pig hippocampus


J Med Chem 33: 2087-93 (1990)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50005835
PNG
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
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n/an/an/an/a 38n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
Effective concentration of the compound determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor...


Bioorg Med Chem Lett 8: 675-80 (1999)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50070407
PNG
(2N,2N-dipropyl-8-[6-(3-dipropylamino-1,2,3,4-tetra...)
Show SMILES CCCN(CCC)C1CCc2cccc(OCCCCCCOc3cccc4CCC(Cc34)N(CCC)CCC)c2C1
Show InChI InChI=1S/C38H60N2O2/c1-5-23-39(24-6-2)33-21-19-31-15-13-17-37(35(31)29-33)41-27-11-9-10-12-28-42-38-18-14-16-32-20-22-34(30-36(32)38)40(25-7-3)26-8-4/h13-18,33-34H,5-12,19-30H2,1-4H3
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n/an/an/an/a 50n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
The intrinsic activity of the compound was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryp...


Bioorg Med Chem Lett 8: 1407-12 (1999)

More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM84737
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1,4-dihydro-py...)
Show SMILES O=c1ccc2[nH]cc(C3=CCNCC3)c2[nH]1
Show InChI InChI=1S/C12H11N3O/c16-11-2-1-10-12(15-11)9(7-14-10)8-3-5-13-6-4-8/h1-3,7,13H,4-6H2
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n/an/an/an/a 56n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Forskolin-stimulated adenylate cyclase activity against 5-hydroxytryptamine 1B receptor of rat substantia nigra


J Med Chem 33: 2087-93 (1990)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50413562
PNG
(CHEMBL469375)
Show SMILES CN1C(=O)COc2c(CCCN3CCN(CC3)c3cccc4nc(C)ccc34)cccc12
Show InChI InChI=1S/C26H30N4O2/c1-19-11-12-21-22(27-19)8-4-9-23(21)30-16-14-29(15-17-30)13-5-7-20-6-3-10-24-26(20)32-18-25(31)28(24)2/h3-4,6,8-12H,5,7,13-18H2,1-2H3
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n/an/an/an/a 63.1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5HT1B assessed as GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50417422
PNG
(CHEMBL1289048)
Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3n(C)c(=O)ccc23)CC1
Show InChI InChI=1S/C27H30N4O/c1-19-7-11-25-22(10-12-27(32)29(25)3)21(19)13-14-30-15-17-31(18-16-30)26-6-4-5-24-23(26)9-8-20(2)28-24/h4-12H,13-18H2,1-3H3
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n/an/an/an/a 63.1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50065417
PNG
(3-[3-(4-Benzyl-4-fluoro-piperidin-1-yl)-propyl]-5-...)
Show SMILES FC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C25H28FN5/c26-25(16-20-5-2-1-3-6-20)10-13-30(14-11-25)12-4-7-21-17-27-24-9-8-22(15-23(21)24)31-18-28-29-19-31/h1-3,5-6,8-9,15,17-19,27H,4,7,10-14,16H2
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n/an/an/an/a 66n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50005835
PNG
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
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n/an/an/an/a 77n/an/an/an/a



Centre de Recherche Pierre Fabre

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cells


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50400902
PNG
(CHEMBL2204360)
Show SMILES Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1
Show InChI InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
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n/an/an/an/a 120n/an/an/an/a



H. Lundbeck A/S

Curated by ChEMBL


Assay Description
Partial agonist activity at human 5HT1B receptor expressed in CHO cells assessed as [35S]GTPgammaS binding


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50065419
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-5-[1,2,4]tr...)
Show SMILES C(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H29N5/c1-2-5-20(6-3-1)15-21-10-13-29(14-11-21)12-4-7-22-17-26-25-9-8-23(16-24(22)25)30-18-27-28-19-30/h1-3,5-6,8-9,16-19,21,26H,4,7,10-15H2
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n/an/an/an/a 120n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50417410
PNG
(CHEMBL1290596)
Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3NC(=O)CCc23)CC1
Show InChI InChI=1S/C26H30N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-8,10H,9,11-17H2,1-2H3,(H,28,31)
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n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/an/an/a 260n/an/an/an/a



Centre de Recherche Pierre FABRE

Curated by ChEMBL


Assay Description
The intrinsic activity of the compound was evaluated for its ability to inhibit forskolin-stimulated c-AMP formation mediated by cloned 5-hydroxytryp...


Bioorg Med Chem Lett 8: 1407-12 (1999)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50077814
PNG
(3-{3-[4-Fluoro-4-(2-trifluoromethyl-benzyl)-piperi...)
Show SMILES FC(F)(F)c1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1
Show InChI InChI=1S/C26H27F4N5/c27-25(15-19-4-1-2-6-23(19)26(28,29)30)9-12-34(13-10-25)11-3-5-20-16-31-24-8-7-21(14-22(20)24)35-17-32-33-18-35/h1-2,4,6-8,14,16-18,31H,3,5,9-13,15H2
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n/an/an/an/a 290n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50417423
PNG
(CHEMBL1289164)
Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(Cl)ccc3n(C)c(=O)ccc23)CC1
Show InChI InChI=1S/C26H27ClN4O/c1-18-6-7-21-23(28-18)4-3-5-25(21)31-16-14-30(15-17-31)13-12-19-20-8-11-26(32)29(2)24(20)10-9-22(19)27/h3-11H,12-17H2,1-2H3
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n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50417421
PNG
(CHEMBL1290597)
Show SMILES CN1C(=O)CCc2c(CCN3CCN(CC3)c3cccc4nc(C)ccc34)c(C)ccc12
Show InChI InChI=1S/C27H32N4O/c1-19-7-11-25-22(10-12-27(32)29(25)3)21(19)13-14-30-15-17-31(18-16-30)26-6-4-5-24-23(26)9-8-20(2)28-24/h4-9,11H,10,12-18H2,1-3H3
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n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50060437
PNG
(3-(3-{4-[2-(3-Fluoro-phenyl)-ethyl]-piperazin-1-yl...)
Show SMILES Fc1cccc(CCN2CCN(CCCc3c[nH]c4ccc(cc34)-n3cnnc3)CC2)c1
Show InChI InChI=1S/C25H29FN6/c26-22-5-1-3-20(15-22)8-10-31-13-11-30(12-14-31)9-2-4-21-17-27-25-7-6-23(16-24(21)25)32-18-28-29-19-32/h1,3,5-7,15-19,27H,2,4,8-14H2
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n/an/an/an/a 430n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50065421
PNG
(3-(3-{4-Fluoro-4-[2-(3-fluoro-phenyl)-ethyl]-piper...)
Show SMILES Fc1cccc(CCC2(F)CCN(CCCc3c[nH]c4ccc(cc34)-n3cnnc3)CC2)c1
Show InChI InChI=1S/C26H29F2N5/c27-22-5-1-3-20(15-22)8-9-26(28)10-13-32(14-11-26)12-2-4-21-17-29-25-7-6-23(16-24(21)25)33-18-30-31-19-33/h1,3,5-7,15-19,29H,2,4,8-14H2
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n/an/an/an/a 440n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50065418
PNG
(3-[3-(4-Benzyl-piperidin-1-yl)-2-fluoro-propyl]-5-...)
Show SMILES FC(CN1CCC(Cc2ccccc2)CC1)Cc1c[nH]c2ccc(cc12)-n1cnnc1
Show InChI InChI=1S/C25H28FN5/c26-22(16-30-10-8-20(9-11-30)12-19-4-2-1-3-5-19)13-21-15-27-25-7-6-23(14-24(21)25)31-17-28-29-18-31/h1-7,14-15,17-18,20,22,27H,8-13,16H2
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n/an/an/an/a 450n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50417412
PNG
(CHEMBL1289047)
Show SMILES Cc1ccc2c(cccc2n1)N1CCN(CCc2c(C)ccc3[nH]c(=O)ccc23)CC1
Show InChI InChI=1S/C26H28N4O/c1-18-6-10-24-21(9-11-26(31)28-24)20(18)12-13-29-14-16-30(17-15-29)25-5-3-4-23-22(25)8-7-19(2)27-23/h3-11H,12-17H2,1-2H3,(H,28,31)
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n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human 5-HT1B receptor expressed in CHO cells assessed as stimulation of GTPgammaS binding by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50077806
PNG
(3-{3-[4-Fluoro-4-(2-phenyl-propyl)-piperidin-1-yl]...)
Show SMILES CC(CC1(F)CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)c1ccccc1
Show InChI InChI=1S/C27H32FN5/c1-21(22-6-3-2-4-7-22)17-27(28)11-14-32(15-12-27)13-5-8-23-18-29-26-10-9-24(16-25(23)26)33-19-30-31-20-33/h2-4,6-7,9-10,16,18-21,29H,5,8,11-15,17H2,1H3
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n/an/an/an/a 510n/an/an/an/a



Merck, Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Agonist-induced [35S]-GTP-gammaS, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1B receptor


Citation and Details
More data for this
Ligand-Target Pair
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