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Compile Data Set for Download or QSAR

Found 237 hits of ec50 data for polymerid = 4344,6096   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156541
PNG
(CHEMBL3794302)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(c1)C(F)(F)F)c1nc(cs1)C(O)=O
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n/an/an/an/a 0.110n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156474
PNG
(CHEMBL3793515)
Show SMILES Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
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n/an/an/an/a 0.140n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156533
PNG
(CHEMBL3794016)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)cc(C)c1Cl
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n/an/an/an/a 0.170n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156532
PNG
(CHEMBL3793862)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cc(Cl)c(Cl)cc1Cl)c1nc(cs1)C(O)=O
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n/an/an/an/a 0.200n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156531
PNG
(CHEMBL3792632)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(Cl)c1Cl)c1nc(cs1)C(O)=O
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n/an/an/an/a 0.210n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50138101
PNG
(CHEMBL3754586)
Show SMILES CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
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n/an/an/an/a 0.390n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169613
PNG
(CHEMBL3806284)
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n/an/an/an/a 0.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156540
PNG
(CHEMBL3793802)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(Cl)c1)c1nc(cs1)C(O)=O
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n/an/an/an/a 0.570n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156538
PNG
(CHEMBL3794466)
Show SMILES CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
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n/an/an/an/a 0.680n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156539
PNG
(CHEMBL3793892)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
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n/an/an/an/a 0.690n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204978
PNG
(US9249085, I(al))
Show SMILES COc1c(C)cc(cc1CNc1c(C)ccc(OCC(O)=O)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO4/c1-15-8-9-22(31-14-23(28)29)17(3)24(15)27-13-20-11-19(10-16(2)25(20)30-4)18-6-5-7-21(26)12-18/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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n/an/an/an/a 0.900n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156543
PNG
(CHEMBL3793045)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cccc(c1)C(F)(F)F)c1nc(cs1)C(O)=O
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156543
PNG
(CHEMBL3793045)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cccc(c1)C(F)(F)F)c1nc(cs1)C(O)=O
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169609
PNG
(CHEMBL3805981)
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n/an/an/an/a 0.900n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50138102
PNG
(CHEMBL3752377)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
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n/an/an/an/a 0.910n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204973
PNG
(US9249085, I(ag))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-21(30-13-22(28)29)16(3)24(14)27-12-19-10-18(9-15(2)23(19)26)17-5-4-6-20(25)11-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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n/an/an/an/a<1n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204981
PNG
(US9249085, I(ao))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(O)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H22FNO4/c1-14-6-7-21(29-13-22(27)28)15(2)23(14)25-12-16-8-18(11-20(26)9-16)17-4-3-5-19(24)10-17/h3-11,25-26H,12-13H2,1-2H3,(H,27,28)
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n/an/an/an/a 1n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES CC(C)(C)CNC1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 1.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156536
PNG
(CHEMBL3794585)
Show SMILES COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
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n/an/an/an/a 1.80n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50016952
PNG
(CHEMBL3286796)
Show SMILES O[C@@H](C\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1C\C=C/CCCC(O)=O)C1(CC=C)CCC1
Show InChI InChI=1S/C23H35ClO4/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h2-3,5,7,10,17-21,25-26H,1,4,6,8-9,11-16H2,(H,27,28)/b5-3-,10-7+/t17-,18-,19-,20-,21+/m1/s1
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n/an/an/an/a 1.80n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 1.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204977
PNG
(US9249085, I(ak))
Show SMILES Cc1cc(cc(CNc2c(C)ccc(OCC(O)=O)c2C)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C25H26FNO3/c1-15-8-9-23(30-14-24(28)29)18(4)25(15)27-13-21-11-20(10-16(2)17(21)3)19-6-5-7-22(26)12-19/h5-12,27H,13-14H2,1-4H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204962
PNG
(US9249085, I(v))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(14(13)2)11-27-23-19(25)6-7-20(22(23)26)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204983
PNG
(US9249085, I(aq))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2F)c1C)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C23H19F4NO3/c1-12-7-15(14-3-4-17(24)19(26)9-14)8-16(13(12)2)10-28-23-18(25)5-6-20(22(23)27)31-11-21(29)30/h3-9,28H,10-11H2,1-2H3,(H,29,30)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156537
PNG
(CHEMBL3793020)
Show SMILES CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
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n/an/an/an/a 2n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204970
PNG
(US9249085, I(ad))
Show SMILES Cc1cc(cc(CNc2c(F)ccc(OCC(O)=O)c2C)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C23H20F3NO3/c1-13-8-16(15-4-3-5-18(24)10-15)9-17(22(13)26)11-27-23-14(2)20(7-6-19(23)25)30-12-21(28)29/h3-10,27H,11-12H2,1-2H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.10n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid EP2 Receptor


(Mus musculus (Mouse))
BDBM50101822
PNG
((Z)-7-[(1R,2R,3R)-3-Hydroxy-2-((E)-(R)-3-hydroxy-o...)
Show SMILES CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16-,17-,19-/m1/s1
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n/an/an/an/a 2.10n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156529
PNG
(CHEMBL3794226)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2ccc(o2)C(O)=O)ccc1Cl
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n/an/an/an/a 2.20n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156533
PNG
(CHEMBL3794016)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)cc(C)c1Cl
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n/an/an/an/a 2.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156531
PNG
(CHEMBL3792632)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(Cl)c1Cl)c1nc(cs1)C(O)=O
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n/an/an/an/a 2.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay


Citation and Details
More data for this
Ligand-Target Pair
Prostanoid EP2 Receptor


(Mus musculus (Mouse))
BDBM50101853
PNG
((11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostanoid EP2 Receptor


(Mus musculus (Mouse))
BDBM50101830
PNG
((Z)-7-{(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-4-(1-ethy...)
Show SMILES CCC1(CCC1)[C@@H](O)C\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H35ClO4/c1-2-22(13-8-14-22)20(25)11-7-10-17-16(18(23)15-19(17)24)9-5-3-4-6-12-21(26)27/h3,5,7,10,16-20,24-25H,2,4,6,8-9,11-15H2,1H3,(H,26,27)/b5-3-,10-7+/t16-,17-,18-,19-,20+/m1/s1
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n/an/an/an/a 2.80n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor


Bioorg Med Chem Lett 11: 2025-8 (2001)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50016953
PNG
(TAPRENEPAG | Taprenepag)
Show SMILES OC(=O)COc1cccc(CN(Cc2ccc(cc2)-n2cccn2)S(=O)(=O)c2cccnc2)c1
Show InChI InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)
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n/an/an/an/a 2.80n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50138052
PNG
(CHEMBL3751951)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCCCF)CCC1
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n/an/an/an/a 2.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50138051
PNG
(CHEMBL3753221)
Show SMILES CCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
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n/an/an/an/a 2.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156535
PNG
(CHEMBL3793797)
Show SMILES Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)cc1C
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n/an/an/an/a 2.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204989
PNG
(US9249085, I(aw))
Show SMILES Cc1ccc(OCC(O)=O)c(C)c1NCc1cc(cc(F)c1C)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-7-8-22(30-13-23(28)29)16(3)24(14)27-12-19-9-18(11-21(26)15(19)2)17-5-4-6-20(25)10-17/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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US Patent
n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204982
PNG
(US9249085, I(ap))
Show SMILES COc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H24FNO4/c1-15-7-8-22(30-14-23(27)28)16(2)24(15)26-13-17-9-19(12-21(10-17)29-3)18-5-4-6-20(25)11-18/h4-12,26H,13-14H2,1-3H3,(H,27,28)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50373944
PNG
(CHEMBL272277)
Show SMILES CCCCC1(CCC1)[C@@H](O)\C=C\[C@H]1CCC(=O)N1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H33NO4/c1-2-3-14-24(15-4-16-24)21(26)11-9-20-10-12-22(27)25(20)17-13-18-5-7-19(8-6-18)23(28)29/h5-9,11,20-21,26H,2-4,10,12-17H2,1H3,(H,28,29)/b11-9+/t20-,21-/m0/s1
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n/an/an/an/a 3n/an/an/an/a



EMD-Serono Research Institute, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor by cAMP assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204979
PNG
(US9249085, I(am))
Show SMILES Cc1cc(CNc2c(C)ccc(OCC(O)=O)c2C)c(F)c(c1)-c1cccc(F)c1
Show InChI InChI=1S/C24H23F2NO3/c1-14-9-18(23(26)20(10-14)17-5-4-6-19(25)11-17)12-27-24-15(2)7-8-21(16(24)3)30-13-22(28)29/h4-11,27H,12-13H2,1-3H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204971
PNG
(US9249085, I(ae))
Show SMILES Cc1cc(CNc2c(F)ccc(OCC(O)=O)c2C)cc(c1)-c1cccc(F)c1
Show InChI InChI=1S/C23H21F2NO3/c1-14-8-16(10-18(9-14)17-4-3-5-19(24)11-17)12-26-23-15(2)21(7-6-20(23)25)29-13-22(27)28/h3-11,26H,12-13H2,1-2H3,(H,27,28)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM204967
PNG
(US9249085, I(aa))
Show SMILES Cc1c(F)cc(cc1CNc1c(F)ccc(OCC(O)=O)c1F)-c1cccc(F)c1
Show InChI InChI=1S/C22H17F4NO3/c1-12-15(7-14(9-18(12)25)13-3-2-4-16(23)8-13)10-27-22-17(24)5-6-19(21(22)26)30-11-20(28)29/h2-9,27H,10-11H2,1H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



FOVEA PHARMACEUTICALS

US Patent


Assay Description
Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HE...


US Patent US9249085 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169614
PNG
(CHEMBL3805767)
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n/an/an/an/a 3.30n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169611
PNG
(CHEMBL3805554)
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n/an/an/an/a 3.60n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156532
PNG
(CHEMBL3793862)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1cc(Cl)c(Cl)cc1Cl)c1nc(cs1)C(O)=O
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n/an/an/an/a 3.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)-c1cccc(c1)N1CCC(=O)CC1
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a 3.80n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50101830
PNG
((Z)-7-{(1R,2R,3R,5R)-5-Chloro-2-[(E)-(S)-4-(1-ethy...)
Show SMILES CCC1(CCC1)[C@@H](O)C\C=C\[C@H]1[C@H](O)C[C@@H](Cl)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H35ClO4/c1-2-22(13-8-14-22)20(25)11-7-10-17-16(18(23)15-19(17)24)9-5-3-4-6-12-21(26)27/h3,5,7,10,16-20,24-25H,2,4,6,8-9,11-15H2,1H3,(H,26,27)/b5-3-,10-7+/t16-,17-,18-,19-,20+/m1/s1
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n/an/an/an/a 3.80n/an/an/an/a



Emory University School of Medicine

Curated by ChEMBL


Assay Description
Agonist activity at EP2 receptor (unknown origin) by functional assay


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50156542
PNG
(CHEMBL3793786)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)cc1)c1nc(cs1)C(O)=O
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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (EP2)


(Homo sapiens (Human))
BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)-c1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
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