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Compile Data Set for Download or QSAR

Found 19 hits of ec50 data for polymerid = 4424   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193650
PNG
(US9199949, 8)
Show SMILES CNC1=N[C@H]2[C@H](C[C@H](C(F)F)[C@@H](O)[C@@H]2O)O1
Show InChI InChI=1/C9H14F2N2O3/c1-12-9-13-5-4(16-9)2-3(8(10)11)6(14)7(5)15/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5-,6+,7+/s2
PDB

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US Patent
n/an/an/an/a 4.70n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4 C. with 100 μL/well of the cell l...


US Patent US9199949 (2015)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193649
PNG
(US9199949, 6)
Show SMILES O[C@@H]1[C@H]2N=C(O[C@H]2C[C@H](C(F)F)[C@H]1O)N1CCC1
Show InChI InChI=1/C11H16F2N2O3/c12-10(13)5-4-6-7(9(17)8(5)16)14-11(18-6)15-2-1-3-15/h5-10,16-17H,1-4H2/t5-,6-,7-,8+,9+/s2
PDB

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n/an/an/an/a 5.10n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4 C. with 100 μL/well of the cell l...


US Patent US9199949 (2015)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193648
PNG
(US9199949, 4)
Show SMILES O[C@@H]1[C@H]2N=C(O[C@H]2C[C@H](CF)[C@H]1O)N1CCC1
Show InChI InChI=1/C11H17FN2O3/c12-5-6-4-7-8(10(16)9(6)15)13-11(17-7)14-2-1-3-14/h6-10,15-16H,1-5H2/t6-,7+,8+,9-,10-/s2
PDB

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n/an/an/an/a 5.20n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4 C. with 100 μL/well of the cell l...


US Patent US9199949 (2015)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240657
PNG
(US9409924, 34)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@H]2F)S1
PDB

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n/an/an/an/a 5.20n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205425
PNG
(US9243020, 20)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1/C9H14F2N2O3S/c1-13(2)9-12-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,1-2H3/t3-,4-,5+,6+,8-/s2
PDB

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n/an/an/an/a 6n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193647
PNG
(US9199949, 2)
Show SMILES CNC1=N[C@H]2[C@H](C[C@H](CF)[C@@H](O)[C@@H]2O)O1
Show InChI InChI=1/C9H15FN2O3/c1-11-9-12-6-5(15-9)2-4(3-10)7(13)8(6)14/h4-8,13-14H,2-3H2,1H3,(H,11,12)/t4-,5+,6+,7-,8-/s2
PDB

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n/an/an/an/a 8.80n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4 C. with 100 μL/well of the cell l...


US Patent US9199949 (2015)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240659
PNG
(US9409924, 38)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@H]2F)S1
PDB

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UniProtKB/SwissProt

antibodypedia
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n/an/an/an/a 9.10n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240645
PNG
(US9409924, (3aR,5R,6R,7S,7aR)-2-(dimethylamino)-7-...)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1
PDB

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n/an/an/an/a 10n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205418
PNG
(US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1/C9H16N2O4S/c1-11(2)9-10-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,3H2,1-2H3/t4-,5-,6-,7-,8-/s2
PDB

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n/an/an/an/a 10n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240646
PNG
(US9409924, 1)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@@H]2F)S1
PDB

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n/an/an/an/a 13n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240644
PNG
(US9409924, (3aR,5R,6R,7S,7aR)-2-(ethylamino)-7-flu...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1
PDB

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UniProtKB/SwissProt

antibodypedia
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AffyNet 
US Patent
n/an/an/an/a 13n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM50323697
PNG
((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
PDB

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n/an/an/an/a 13n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205423
PNG
(US9243020, 17)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CF)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1/C8H13FN2O3S/c1-10-8-11-4-6(13)5(12)3(2-9)14-7(4)15-8/h3-7,12-13H,2H2,1H3,(H,10,11)/t3-,4-,5-,6-,7-/s2
PDB

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UniProtKB/SwissProt

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n/an/an/an/a 34n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240654
PNG
(US9409924, 20)
Show SMILES CNC1=N[C@@H]2C[C@H](O)[C@H](O[C@@H]2S1)[C@@H](O)C(F)(F)F
PDB

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n/an/an/an/a 50n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205424
PNG
(US9243020, 19)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1/C9H14F2N2O3S/c1-2-12-9-13-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5+,6+,8-/s2
PDB

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US Patent
n/an/an/an/a 53n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240650
PNG
(US9409924, 9)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2F)S1
PDB

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UniProtKB/SwissProt

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n/an/an/an/a 74n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Inhibition of O-GlcNAcase, which removes O-GlcNAc from cellular proteins, results in an increase in the level of O-GlcNAcylated protein in cells. An ...


US Patent US9409924 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205422
PNG
(US9243020, 9)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2F)S1
Show InChI InChI=1/C8H13FN2O3S/c1-10-8-11-5-4(9)6(13)3(2-12)14-7(5)15-8/h3-7,12-13H,2H2,1H3,(H,10,11)/t3-,4-,5-,6-,7-/s2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
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PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 307n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205421
PNG
(US9243020, 4)
Show SMILES CN(C)C1=N[C@@H]2C[C@H](O)[C@@H](CO)O[C@@H]2S1
Show InChI InChI=1/C9H16N2O3S/c1-11(2)9-10-5-3-6(13)7(4-12)14-8(5)15-9/h5-8,12-13H,3-4H2,1-2H3/t5-,6+,7-,8-/s2
PDB

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UniProtKB/SwissProt

antibodypedia
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PC sid
UniChem
AffyNet 
US Patent
n/an/an/an/a 358n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205420
PNG
(US9243020, 2)
Show SMILES CCNC1=N[C@@H]2C[C@H](O)[C@@H](CO)O[C@@H]2S1
Show InChI InChI=1/C9H16N2O3S/c1-2-10-9-11-5-3-6(13)7(4-12)14-8(5)15-9/h5-8,12-13H,2-4H2,1H3,(H,10,11)/t5-,6+,7-,8-/s2
PDB

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antibodypedia
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AffyNet 
US Patent
n/an/an/an/a 365n/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly...


US Patent US9243020 (2016)

More data for this
Ligand-Target Pair