BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 130 hits of ec50 data for polymerid = 49000358,49000359,49000360,49000362   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448377
PNG
(CHEMBL3121473)
Show SMILES C[N+](C)(C)CC#CCOC1=NOCC1
Show InChI InChI=1S/C10H17N2O2/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10/h6-9H2,1-3H3/q+1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/an/an/a 0.0794n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448377
PNG
(CHEMBL3121473)
Show SMILES C[N+](C)(C)CC#CCOC1=NOCC1
Show InChI InChI=1S/C10H17N2O2/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10/h6-9H2,1-3H3/q+1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem
AffyNet 
PDB
Article
PubMed
n/an/an/an/a 0.166n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50225215
PNG
(N,N,N-triethyl-2-(3-(((6-(2-(1,2,3,4-tetrahydroacr...)
Show SMILES CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(c1)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C42H64N6O4/c1-7-47(8-2,9-3)26-28-51-34-30-33(31-35(32-34)52-29-27-48(10-4,11-5)12-6)42(50)43-25-19-13-14-24-40(49)45-46-41-36-20-15-17-22-38(36)44-39-23-18-16-21-37(39)41/h15,17,20,22,30-32H,7-14,16,18-19,21,23-29H2,1-6H3,(H-2,43,44,45,46,49,50)/p+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.900n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50371197
PNG
(CHEMBL555247)
Show SMILES CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(cc1OCC[N+](CC)(CC)CC)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2cc(Cl)ccc12
Show InChI InChI=1S/C50H81ClN7O5/c1-10-56(11-2,12-3)30-33-61-45-38-47(63-35-32-58(16-7,17-8)18-9)46(62-34-31-57(13-4,14-5)15-6)37-42(45)50(60)52-29-23-19-20-26-48(59)54-55-49-40-24-21-22-25-43(40)53-44-36-39(51)27-28-41(44)49/h27-28,36-38H,10-26,29-35H2,1-9H3,(H-2,52,53,54,55,59,60)/q+1/p+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50225209
PNG
(N,N,N-triethyl-2-(4-(((6-(2-(1,2,3,4-tetrahydroacr...)
Show SMILES CC[N+](CC)(CC)CCOc1ccc(cc1)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C34H47N5O3/c1-4-39(5-2,6-3)24-25-42-27-21-19-26(20-22-27)34(41)35-23-13-7-8-18-32(40)37-38-33-28-14-9-11-16-30(28)36-31-17-12-10-15-29(31)33/h9,11,14,16,19-22H,4-8,10,12-13,15,17-18,23-25H2,1-3H3,(H2-,35,36,37,38,40,41)/p+1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.30n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50225210
PNG
(N,N,N-triethyl-2-(5-(((6-(2-(1,2,3,4-tetrahydroacr...)
Show SMILES CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(cc1OCC[N+](CC)(CC)CC)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C50H82N7O5/c1-10-55(11-2,12-3)32-35-60-45-39-47(62-37-34-57(16-7,17-8)18-9)46(61-36-33-56(13-4,14-5)15-6)38-42(45)50(59)51-31-25-19-20-30-48(58)53-54-49-40-26-21-23-28-43(40)52-44-29-24-22-27-41(44)49/h21,23,26,28,38-39H,10-20,22,24-25,27,29-37H2,1-9H3,(H-2,51,52,53,54,58,59)/q+1/p+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.40n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50371199
PNG
(CHEMBL540132)
Show SMILES CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(c1)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2cc(Cl)ccc12
Show InChI InChI=1S/C42H63ClN6O4/c1-7-48(8-2,9-3)24-26-52-34-28-32(29-35(31-34)53-27-25-49(10-4,11-5)12-6)42(51)44-23-17-13-14-20-40(50)46-47-41-36-18-15-16-19-38(36)45-39-30-33(43)21-22-37(39)41/h21-22,28-31H,7-20,23-27H2,1-6H3,(H-2,44,45,46,47,50,51)/p+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025038
PNG
(ALCURONIUM | Alcuronium)
Show SMILES OCC=C1C[N+]2(CC=C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N@@+]3(CC=C)CC1=CCO)c1ccccc21
Show InChI InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50093896
PNG
(CHEMBL311649 | Caracurine V derivative)
Show SMILES C=CC[N+]12CCC34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N+]7(CC=C)CCC89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OCC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-31-9-5-7-11-33(31)45-39(43)37-29(23-35(43)47)27(25-47)13-21-49-41(37)46-34-12-8-6-10-32(34)44-16-20-48(18-4-2)26-28-14-22-50-42(45)38(40(44)46)30(28)24-36(44)48/h3-14,29-30,35-42H,1-2,15-26H2/q+2/t29-,30-,35-,36-,37+,38+,39-,40-,41+,42+,43?,44?,47?,48?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 3n/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Allosteric inhibition of [3H]-NMS (N-methylscopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2


Bioorg Med Chem Lett 10: 2529-32 (2001)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50093893
PNG
(CHEMBL433343 | Caracurine V derivative)
Show SMILES C#CC[N+]12CCC34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N+]7(CC#C)CCC89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OCC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1S/C44H46N4O2/c1-3-17-47-19-15-43-31-9-5-7-11-33(31)45-39(43)37-29(23-35(43)47)27(25-47)13-21-49-41(37)46-34-12-8-6-10-32(34)44-16-20-48(18-4-2)26-28-14-22-50-42(45)38(40(44)46)30(28)24-36(44)48/h1-2,5-14,29-30,35-42H,15-26H2/q+2/t29-,30-,35-,36-,37+,38+,39-,40-,41+,42+,43?,44?,47?,48?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 4n/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Allosteric inhibition of [3H]-NMS (N-methylscopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2


Bioorg Med Chem Lett 10: 2529-32 (2001)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50371198
PNG
(CHEMBL540131)
Show SMILES CC[N+](CC)(CC)CCOc1ccc(cc1)C(=O)NCCCCCC(=O)NNc1c2CCCCc2nc2cc(Cl)ccc12
Show InChI InChI=1S/C34H46ClN5O3/c1-4-40(5-2,6-3)22-23-43-27-18-15-25(16-19-27)34(42)36-21-11-7-8-14-32(41)38-39-33-28-12-9-10-13-30(28)37-31-24-26(35)17-20-29(31)33/h15-20,24H,4-14,21-23H2,1-3H3,(H2-,36,37,38,39,41,42)/p+1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 5n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448375
PNG
(CHEMBL3121479)
Show SMILES C[N+](C)(CCCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C34H48N4O4/c1-37(2,24-11-12-26-41-31-20-27-42-35-31)22-9-7-5-6-8-10-23-38(3,4)25-15-21-36-33(39)29-18-13-16-28-17-14-19-30(32(28)29)34(36)40/h13-14,16-19H,5-10,15,20-27H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 7.10n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448374
PNG
(CHEMBL3121478)
Show SMILES C[N+](C)(CCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C32H44N4O4/c1-35(2,22-9-10-24-39-29-18-25-40-33-29)20-7-5-6-8-21-36(3,4)23-13-19-34-31(37)27-16-11-14-26-15-12-17-28(30(26)27)32(34)38/h11-12,14-17H,5-8,13,18-25H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 7.80n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025036
PNG
(CHEMBL3337858)
Show SMILES [I-].[I-].C[N+]12CC[C@@]34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N+]7(C)CC[C@@]89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1/C39H44N4O2/c1-42-14-12-38-27-8-4-6-10-29(27)41-34(38)32-24(17-30(38)42)22(19-42)11-16-44-36(32)40-28-9-5-3-7-26(28)39-13-15-43(2)20-23-21-45-37(41)33(35(39)40)25(23)18-31(39)43/h3-11,21,24-25,30-37H,12-20H2,1-2H3/q+2/t24-,25-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39+,42?,43?/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 8n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50093891
PNG
(CHEMBL315340 | Caracurine V derivative)
Show SMILES C[N+]12CCC34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N+]7(C)CCC89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OCC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1S/C40H46N4O2/c1-43-15-13-39-27-7-3-5-9-29(27)41-35(39)33-25(19-31(39)43)23(21-43)11-17-45-37(33)42-30-10-6-4-8-28(30)40-14-16-44(2)22-24-12-18-46-38(41)34(36(40)42)26(24)20-32(40)44/h3-12,25-26,31-38H,13-22H2,1-2H3/q+2/t25-,26-,31-,32-,33+,34+,35-,36-,37+,38+,39?,40?,43?,44?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 8n/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Allosteric inhibition of [3H]-NMS (N-methylscopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2


Bioorg Med Chem Lett 10: 2529-32 (2001)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025035
PNG
(CHEMBL3337859)
Show SMILES [Br-].[Br-].C=CC[N+]12CC[C@@]34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N+]7(CC=C)CC[C@@]89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1/C43H48N4O2/c1-3-16-46-18-14-42-31-10-6-8-12-33(31)45-38(42)36-28(21-34(42)46)26(23-46)13-20-48-40(36)44-32-11-7-5-9-30(32)43-15-19-47(17-4-2)24-27-25-49-41(45)37(39(43)44)29(27)22-35(43)47/h3-13,25,28-29,34-41H,1-2,14-24H2/q+2/t28-,29-,34-,35-,36+,37+,38-,39-,40+,41+,42+,43+,46?,47?/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 11n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448375
PNG
(CHEMBL3121479)
Show SMILES C[N+](C)(CCCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C34H48N4O4/c1-37(2,24-11-12-26-41-31-20-27-42-35-31)22-9-7-5-6-8-10-23-38(3,4)25-15-21-36-33(39)29-18-13-16-28-17-14-19-30(32(28)29)34(36)40/h13-14,16-19H,5-10,15,20-27H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025031
PNG
(CHEMBL3337863)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(CC=C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(CC=C)C[C@H]1CCO)c1ccccc21
Show InChI InChI=1/C44H54N4O.2BrH/c1-4-18-47-20-16-43-35-11-7-10-14-38(35)46-26-34-32-24-40-44(17-21-48(40,19-5-2)28-30(32)15-22-49)36-12-8-9-13-37(36)45(42(34)44)25-33(41(43)46)31(23-39(43)47)29(6-3)27-47;;/h4-5,7-14,25-26,29-32,39-42,49H,1-2,6,15-24,27-28H2,3H3;2*1H/q+2;;/p-2/b33-25-,34-26-;;/t29-,30-,31+,32+,39+,40+,41+,42+,43-,44-,47?,48?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025031
PNG
(CHEMBL3337863)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(CC=C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(CC=C)C[C@H]1CCO)c1ccccc21
Show InChI InChI=1/C44H54N4O.2BrH/c1-4-18-47-20-16-43-35-11-7-10-14-38(35)46-26-34-32-24-40-44(17-21-48(40,19-5-2)28-30(32)15-22-49)36-12-8-9-13-37(36)45(42(34)44)25-33(41(43)46)31(23-39(43)47)29(6-3)27-47;;/h4-5,7-14,25-26,29-32,39-42,49H,1-2,6,15-24,27-28H2,3H3;2*1H/q+2;;/p-2/b33-25-,34-26-;;/t29-,30-,31+,32+,39+,40+,41+,42+,43-,44-,47?,48?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448372
PNG
(CHEMBL3121475)
Show SMILES C[N+](C)(CCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C29H44N4O4/c1-32(2,21-12-13-23-36-27-17-24-37-30-27)19-10-6-5-7-11-20-33(3,4)22-14-18-31-28(34)25-15-8-9-16-26(25)29(31)35/h8-9,15-16H,5-7,10-11,14,17-24H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448369
PNG
(CHEMBL3121476)
Show SMILES C[N+](C)(CCCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C30H46N4O4/c1-33(2,22-13-14-24-37-28-18-25-38-31-28)20-11-7-5-6-8-12-21-34(3,4)23-15-19-32-29(35)26-16-9-10-17-27(26)30(32)36/h9-10,16-17H,5-8,11-12,15,18-25H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 14n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448370
PNG
(CHEMBL3120178)
Show SMILES C[N+](C)(CCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C33H46N4O4/c1-36(2,23-10-11-25-40-30-19-26-41-34-30)21-8-6-5-7-9-22-37(3,4)24-14-20-35-32(38)28-17-12-15-27-16-13-18-29(31(27)28)33(35)39/h12-13,15-18H,5-9,14,19-26H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 19n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448371
PNG
(CHEMBL3121480)
Show SMILES C[N+](C)(CCCCCC[N+]1(C)CCC(CC1)N1C(=O)c2cccc3cccc(C1=O)c23)CC#CCOC1=NOCC1
Show InChI InChI=1S/C33H44N4O4/c1-36(2,20-8-9-24-40-30-18-25-41-34-30)19-6-4-5-7-21-37(3)22-16-27(17-23-37)35-32(38)28-14-10-12-26-13-11-15-29(31(26)28)33(35)39/h10-15,27H,4-7,16-25H2,1-3H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448374
PNG
(CHEMBL3121478)
Show SMILES C[N+](C)(CCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C32H44N4O4/c1-35(2,22-9-10-24-39-29-18-25-40-33-29)20-7-5-6-8-21-36(3,4)23-13-19-34-31(37)27-16-11-14-26-15-12-17-28(30(26)27)32(34)38/h11-12,14-17H,5-8,13,18-25H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 21n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50093899
PNG
(CHEMBL314491 | Caracurine V derivative)
Show SMILES CCC[N+]12CCC34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N+]7(CCC)CCC89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OCC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1S/C44H54N4O2/c1-3-17-47-19-15-43-31-9-5-7-11-33(31)45-39(43)37-29(23-35(43)47)27(25-47)13-21-49-41(37)46-34-12-8-6-10-32(34)44-16-20-48(18-4-2)26-28-14-22-50-42(45)38(40(44)46)30(28)24-36(44)48/h5-14,29-30,35-42H,3-4,15-26H2,1-2H3/q+2/t29-,30-,35-,36-,37+,38+,39-,40-,41+,42+,43?,44?,47?,48?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 30n/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Allosteric inhibition of [3H]-NMS (N-methylscopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2


Bioorg Med Chem Lett 10: 2529-32 (2001)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025030
PNG
(CHEMBL3355097)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(Cc3ccc(cc3)[N+]([O-])=O)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(Cc3ccc(cc3)[N+]([O-])=O)C[C@H]1CCO)c1ccccc21
Show InChI InChI=1/C52H56N6O5.2BrH/c1-2-35-31-57(29-33-11-15-37(16-12-33)55(60)61)22-20-51-43-7-3-6-10-46(43)54-28-42-40-26-48-52(21-23-58(48,32-36(40)19-24-59)30-34-13-17-38(18-14-34)56(62)63)44-8-4-5-9-45(44)53(50(42)52)27-41(49(51)54)39(35)25-47(51)57;;/h3-18,27-28,35-36,39-40,47-50,59H,2,19-26,29-32H2,1H3;2*1H/q+2;;/p-2/b41-27-,42-28-;;/t35-,36-,39+,40+,47+,48+,49+,50+,51-,52-,57?,58?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 32n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025030
PNG
(CHEMBL3355097)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(Cc3ccc(cc3)[N+]([O-])=O)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(Cc3ccc(cc3)[N+]([O-])=O)C[C@H]1CCO)c1ccccc21
Show InChI InChI=1/C52H56N6O5.2BrH/c1-2-35-31-57(29-33-11-15-37(16-12-33)55(60)61)22-20-51-43-7-3-6-10-46(43)54-28-42-40-26-48-52(21-23-58(48,32-36(40)19-24-59)30-34-13-17-38(18-14-34)56(62)63)44-8-4-5-9-45(44)53(50(42)52)27-41(49(51)54)39(35)25-47(51)57;;/h3-18,27-28,35-36,39-40,47-50,59H,2,19-26,29-32H2,1H3;2*1H/q+2;;/p-2/b41-27-,42-28-;;/t35-,36-,39+,40+,47+,48+,49+,50+,51-,52-,57?,58?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 32n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025027
PNG
(CHEMBL3337867)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(CC=C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(CC=C)C[C@H]1CC)c1ccccc21
Show InChI InChI=1/C44H54N4.2BrH/c1-5-19-47-21-17-43-35-13-9-11-15-37(35)45-26-34-32-24-40-44(18-22-48(40,20-6-2)28-30(32)8-4)36-14-10-12-16-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(7-3)27-47;;/h5-6,9-16,25-26,29-32,39-42H,1-2,7-8,17-24,27-28H2,3-4H3;2*1H/q+2;;/p-2/b33-25-,34-26-;;/t29-,30-,31+,32+,39+,40+,41+,42+,43-,44-,47?,48?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 36n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025027
PNG
(CHEMBL3337867)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(CC=C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(CC=C)C[C@H]1CC)c1ccccc21
Show InChI InChI=1/C44H54N4.2BrH/c1-5-19-47-21-17-43-35-13-9-11-15-37(35)45-26-34-32-24-40-44(18-22-48(40,20-6-2)28-30(32)8-4)36-14-10-12-16-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(7-3)27-47;;/h5-6,9-16,25-26,29-32,39-42H,1-2,7-8,17-24,27-28H2,3-4H3;2*1H/q+2;;/p-2/b33-25-,34-26-;;/t29-,30-,31+,32+,39+,40+,41+,42+,43-,44-,47?,48?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 36n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448373
PNG
(CHEMBL3121477)
Show InChI InChI=1S/C29H42N4O4.2BrH/c1-32(2,18-10-11-22-36-27-16-23-37-30-27)17-8-4-5-9-19-33(3)20-14-24(15-21-33)31-28(34)25-12-6-7-13-26(25)29(31)35;;/h6-7,12-13,24H,4-5,8-9,14-23H2,1-3H3;2*1H/q+2;;/p-2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 38n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448371
PNG
(CHEMBL3121480)
Show SMILES C[N+](C)(CCCCCC[N+]1(C)CCC(CC1)N1C(=O)c2cccc3cccc(C1=O)c23)CC#CCOC1=NOCC1
Show InChI InChI=1S/C33H44N4O4/c1-36(2,20-8-9-24-40-30-18-25-41-34-30)19-6-4-5-7-21-37(3)22-16-27(17-23-37)35-32(38)28-14-10-12-26-13-11-15-29(31(26)28)33(35)39/h10-15,27H,4-7,16-25H2,1-3H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 47n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025040
PNG
(CHEMBL3355098)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(Cc3ccc(cc3)[N+]([O-])=O)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(Cc3ccc(cc3)[N+]([O-])=O)C[C@H]1CC)c1ccccc21
Show InChI InChI=1/C52H56N6O4/c1-3-35-31-57(29-33-13-17-37(18-14-33)55(59)60)23-21-51-43-9-5-8-12-46(43)54-28-42-40-26-48-52(22-24-58(48,32-36(40)4-2)30-34-15-19-38(20-16-34)56(61)62)44-10-6-7-11-45(44)53(50(42)52)27-41(49(51)54)39(35)25-47(51)57/h5-20,27-28,35-36,39-40,47-50H,3-4,21-26,29-32H2,1-2H3/q+2/b41-27-,42-28-/t35-,36-,39+,40+,47+,48+,49+,50+,51-,52-,57?,58?/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 49n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025040
PNG
(CHEMBL3355098)
Show SMILES [Br-].[Br-].CC[C@@H]1C[N+]2(Cc3ccc(cc3)[N+]([O-])=O)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(Cc3ccc(cc3)[N+]([O-])=O)C[C@H]1CC)c1ccccc21
Show InChI InChI=1/C52H56N6O4/c1-3-35-31-57(29-33-13-17-37(18-14-33)55(59)60)23-21-51-43-9-5-8-12-46(43)54-28-42-40-26-48-52(22-24-58(48,32-36(40)4-2)30-34-15-19-38(20-16-34)56(61)62)44-10-6-7-11-45(44)53(50(42)52)27-41(49(51)54)39(35)25-47(51)57/h5-20,27-28,35-36,39-40,47-50H,3-4,21-26,29-32H2,1-2H3/q+2/b41-27-,42-28-/t35-,36-,39+,40+,47+,48+,49+,50+,51-,52-,57?,58?/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 49n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448370
PNG
(CHEMBL3120178)
Show SMILES C[N+](C)(CCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C33H46N4O4/c1-36(2,23-10-11-25-40-30-19-26-41-34-30)21-8-6-5-7-9-22-37(3,4)24-14-20-35-32(38)28-17-12-15-27-16-13-18-29(31(27)28)33(35)39/h12-13,15-18H,5-9,14,19-26H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 50n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448378
PNG
(CHEMBL3121474)
Show SMILES C[N+](C)(CCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C28H42N4O4/c1-31(2,20-11-12-22-35-26-16-23-36-29-26)18-9-5-6-10-19-32(3,4)21-13-17-30-27(33)24-14-7-8-15-25(24)28(30)34/h7-8,14-15H,5-6,9-10,13,16-23H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 66n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50408910
PNG
(CHEMBL2111531)
Show SMILES C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2\C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2\C1=C\c1ccccc1
Show InChI InChI=1S/C46H56N4O2/c1-49(2,33-19-29-47-43(35-37-21-9-7-10-22-37)39-25-13-15-27-41(39)45(47)51)31-17-5-6-18-32-50(3,4)34-20-30-48-44(36-38-23-11-8-12-24-38)40-26-14-16-28-42(40)46(48)52/h7-16,21-28,35-36H,5-6,17-20,29-34H2,1-4H3/q+2/b43-35-,44-36-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 66.1n/an/an/an/a



University of W�rzburg

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors


J Med Chem 43: 2155-64 (2000)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50421416
PNG
(CHEMBL2311018)
Show SMILES C(c1ccccc1)[N@@+]12CC[C@@]34[C@@H]1C[C@@H]1[C@@H]5[C@@H]3N([C@@H]3OCC=C6C[N@+]7(Cc8ccccc8)CC[C@@]89[C@@H]7C[C@@H]6[C@@H]3[C@@H]8N([C@@H]5OCC=C1C2)c1ccccc91)c1ccccc41
Show InChI InChI=1S/C52H54N4O2/c1-3-11-33(12-4-1)29-55-23-21-51-39-15-7-9-17-41(39)53-47(51)45-37(27-43(51)55)35(31-55)19-25-57-49(45)54-42-18-10-8-16-40(42)52-22-24-56(30-34-13-5-2-6-14-34)32-36-20-26-58-50(53)46(48(52)54)38(36)28-44(52)56/h1-20,37-38,43-50H,21-32H2/q+2/t37-,38-,43-,44-,45+,46+,47-,48-,49+,50+,51+,52+,55+,56+/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 69n/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Allosteric inhibition of [3H]-NMS (N-methylscopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2


Bioorg Med Chem Lett 10: 2529-32 (2001)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448369
PNG
(CHEMBL3121476)
Show SMILES C[N+](C)(CCCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C30H46N4O4/c1-33(2,22-13-14-24-37-28-18-25-38-31-28)20-11-7-5-6-8-12-21-34(3,4)23-15-19-32-29(35)26-16-9-10-17-27(26)30(32)36/h9-10,16-17H,5-8,11-12,15,18-25H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 69n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448373
PNG
(CHEMBL3121477)
Show InChI InChI=1S/C29H42N4O4.2BrH/c1-32(2,18-10-11-22-36-27-16-23-37-30-27)17-8-4-5-9-19-33(3)20-14-24(15-21-33)31-28(34)25-12-6-7-13-26(25)29(31)35;;/h6-7,12-13,24H,4-5,8-9,14-23H2,1-3H3;2*1H/q+2;;/p-2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/an/an/a 69n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50408903
PNG
(CHEMBL68936)
Show SMILES C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2\C1=C/c1ccccc1)CCCN1C(=O)c2ccccc2\C1=C/c1ccccc1
Show InChI InChI=1S/C46H56N4O2/c1-49(2,33-19-29-47-43(35-37-21-9-7-10-22-37)39-25-13-15-27-41(39)45(47)51)31-17-5-6-18-32-50(3,4)34-20-30-48-44(36-38-23-11-8-12-24-38)40-26-14-16-28-42(40)46(48)52/h7-16,21-28,35-36H,5-6,17-20,29-34H2,1-4H3/q+2/b43-35+,44-36+
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 70.8n/an/an/an/a



University of W�rzburg

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors


J Med Chem 43: 2155-64 (2000)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50408910
PNG
(CHEMBL2111531)
Show SMILES C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2\C1=C\c1ccccc1)CCCN1C(=O)c2ccccc2\C1=C\c1ccccc1
Show InChI InChI=1S/C46H56N4O2/c1-49(2,33-19-29-47-43(35-37-21-9-7-10-22-37)39-25-13-15-27-41(39)45(47)51)31-17-5-6-18-32-50(3,4)34-20-30-48-44(36-38-23-11-8-12-24-38)40-26-14-16-28-42(40)46(48)52/h7-16,21-28,35-36H,5-6,17-20,29-34H2,1-4H3/q+2/b43-35-,44-36-
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 85.1n/an/an/an/a



University of W�rzburg

Curated by ChEMBL


Assay Description
Inhibition of [3H]- N-methyl-scopolamine ([3H]NMS) dissociation from porcine cardiac M2-receptors


J Med Chem 43: 2155-64 (2000)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025039
PNG
(CHEMBL3337857)
Show SMILES [Cl-].[Cl-].C[N+]12CC[C@@]34[C@@H]1C[C@@H](\C(C2)=C/CO)\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(C)C\C1=C\CO)c1ccccc21
Show InChI InChI=1/C40H46N4O2/c1-43-15-13-39-31-7-3-5-9-33(31)41-22-30-28-20-36-40(14-16-44(36,2)24-26(28)12-18-46)32-8-4-6-10-34(32)42(38(30)40)21-29(37(39)41)27(19-35(39)43)25(23-43)11-17-45/h3-12,21-22,27-28,35-38,45-46H,13-20,23-24H2,1-2H3/q+2/b25-11-,26-12-,29-21-,30-22-/t27-,28-,35-,36-,37-,38-,39+,40+,43?,44?/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 96n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50448372
PNG
(CHEMBL3121475)
Show SMILES C[N+](C)(CCCCCCC[N+](C)(C)CC#CCOC1=NOCC1)CCCN1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C29H44N4O4/c1-32(2,21-12-13-23-36-27-17-24-37-30-27)19-10-6-5-7-11-20-33(3,4)22-14-18-31-28(34)25-15-8-9-16-26(25)29(31)35/h8-9,15-16H,5-7,10-11,14,17-24H2,1-4H3/q+2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 105n/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced response


Eur J Med Chem 75: 222-32 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50149891
PNG
(2,2',2''-[1,2,3-BENZENE-TRIYLTRIS(OXY)]TRIS[N,N,N-...)
Show SMILES CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC
Show InChI InChI=1S/C30H60N3O3/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9/h19-21H,10-18,22-27H2,1-9H3/q+3
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 130n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor


J Med Chem 50: 5685-95 (2007)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025028
PNG
(CHEMBL3337866)
Show SMILES [I-].[I-].CC[C@@H]1C[N+]2(C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(C)C[C@H]1CC)c1ccccc21
Show InChI InChI=1/C40H50N4.2HI/c1-5-25-23-43(3)17-15-39-31-11-7-10-14-34(31)42-22-30-28-20-36-40(16-18-44(36,4)24-26(28)6-2)32-12-8-9-13-33(32)41(38(30)40)21-29(37(39)42)27(25)19-35(39)43;;/h7-14,21-22,25-28,35-38H,5-6,15-20,23-24H2,1-4H3;2*1H/q+2;;/p-2/b29-21-,30-22-;;/t25-,26-,27+,28+,35+,36+,37+,38+,39-,40-,43?,44?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 260n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025028
PNG
(CHEMBL3337866)
Show SMILES [I-].[I-].CC[C@@H]1C[N+]2(C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(C)C[C@H]1CC)c1ccccc21
Show InChI InChI=1/C40H50N4.2HI/c1-5-25-23-43(3)17-15-39-31-11-7-10-14-34(31)42-22-30-28-20-36-40(16-18-44(36,4)24-26(28)6-2)32-12-8-9-13-33(32)41(38(30)40)21-29(37(39)42)27(25)19-35(39)43;;/h7-14,21-22,25-28,35-38H,5-6,15-20,23-24H2,1-4H3;2*1H/q+2;;/p-2/b29-21-,30-22-;;/t25-,26-,27+,28+,35+,36+,37+,38+,39-,40-,43?,44?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 263n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(Mus musculus)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 270n/an/an/an/a



The University of Toledo

Curated by ChEMBL


Assay Description
Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line


J Med Chem 40: 1230-46 (1997)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50093888
PNG
(CHEMBL405691 | Caracurine V derivative)
Show SMILES [O-][N+](=O)c1ccc(C[N+]23CCC45[C@@H]2C[C@@H]2[C@@H]6[C@@H]4N([C@@H]4OCC=C7C[N+]8(Cc9ccc(cc9)[N+]([O-])=O)CCC9%10[C@@H]8C[C@@H]7[C@@H]4[C@@H]9N([C@@H]6OCC=C2C3)c2ccccc%102)c2ccccc52)cc1
Show InChI InChI=1S/C52H52N6O6/c59-55(60)35-13-9-31(10-14-35)27-57-21-19-51-39-5-1-3-7-41(39)53-47(51)45-37(25-43(51)57)33(29-57)18-24-64-50(45)54-42-8-4-2-6-40(42)52-20-22-58(28-32-11-15-36(16-12-32)56(61)62)30-34-17-23-63-49(53)46(48(52)54)38(34)26-44(52)58/h1-18,37-38,43-50H,19-30H2/q+2/t37-,38-,43-,44-,45+,46+,47-,48-,49+,50+,51?,52?,57?,58?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/an/a 315n/an/an/an/a



University of Würzburg

Curated by ChEMBL


Assay Description
Allosteric inhibition of [3H]-NMS (N-methylscopolamine) dissociation from porcine cardiac Muscarinic acetylcholine receptor M2


Bioorg Med Chem Lett 10: 2529-32 (2001)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025032
PNG
(CHEMBL3337862)
Show SMILES [I-].[I-].CC[C@@H]1C[N+]2(C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(C)C[C@H]1CCO)c1ccccc21
Show InChI InChI=1/C40H50N4O.2HI/c1-4-25-23-43(2)16-14-39-31-9-5-8-12-34(31)42-22-30-28-20-36-40(15-17-44(36,3)24-26(28)13-18-45)32-10-6-7-11-33(32)41(38(30)40)21-29(37(39)42)27(25)19-35(39)43;;/h5-12,21-22,25-28,35-38,45H,4,13-20,23-24H2,1-3H3;2*1H/q+2;;/p-2/b29-21-,30-22-;;/t25-,26-,27+,28+,35+,36+,37+,38+,39-,40-,43?,44?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 320n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Cholinergic, muscarinic


(GUINEA PIG)
BDBM50025032
PNG
(CHEMBL3337862)
Show SMILES [I-].[I-].CC[C@@H]1C[N+]2(C)CC[C@@]34[C@@H]2C[C@@H]1\C1=C\N2[C@H]5\C(=C/N([C@H]31)c1ccccc41)[C@H]1C[C@H]3[C@@]5(CC[N+]3(C)C[C@H]1CCO)c1ccccc21
Show InChI InChI=1/C40H50N4O.2HI/c1-4-25-23-43(2)16-14-39-31-9-5-8-12-34(31)42-22-30-28-20-36-40(15-17-44(36,3)24-26(28)13-18-45)32-10-6-7-11-33(32)41(38(30)40)21-29(37(39)42)27(25)19-35(39)43;;/h5-12,21-22,25-28,35-38,45H,4,13-20,23-24H2,1-3H3;2*1H/q+2;;/p-2/b29-21-,30-22-;;/t25-,26-,27+,28+,35+,36+,37+,38+,39-,40-,43?,44?;;/s2
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 324n/an/an/an/a



The German University in Cairo

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from pig muscarinic M2 receptor after 120 mins by liquid scintillation counting


J Nat Prod 77: 2006-13 (2014)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 130 total )  |  Next  |  Last  >>
Jump to: