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Compile Data Set for Download or QSAR

Found 63 hits of ec50 data for polymerid = 49000646   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414494
PNG
(CHEMBL564300)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccsc1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-5-13(16-15-12)17(6-10-1-3-20-8-10)7-11-2-4-21-9-11/h1-5,8-9H,6-7H2,(H,15,16)(H,18,19)
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n/an/an/an/a 3.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414492
PNG
(CHEMBL564914)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccccc1
Show InChI InChI=1S/C16H15N3O2S/c20-16(21)14-8-15(18-17-14)19(10-13-6-7-22-11-13)9-12-4-2-1-3-5-12/h1-8,11H,9-10H2,(H,17,18)(H,20,21)
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414513
PNG
(CHEMBL394468)
Show SMILES OC(=O)c1ccc(NCC=C)nc1
Show InChI InChI=1S/C9H10N2O2/c1-2-5-10-8-4-3-7(6-11-8)9(12)13/h2-4,6H,1,5H2,(H,10,11)(H,12,13)
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50384637
PNG
(CHEMBL2036951)
Show SMILES FC(F)CCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C11H10F2N2O4/c12-6(13)3-1-2-5-4-7(16)19-10-8(5)9(17)14-11(18)15-10/h4,6H,1-3H2,(H2,14,15,17,18)
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n/an/an/an/a 59n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50384640
PNG
(CHEMBL2036954)
Show SMILES O=c1cc(CCC2CCC2)c2c([nH]c(=O)[nH]c2=O)o1
Show InChI InChI=1S/C13H14N2O4/c16-9-6-8(5-4-7-2-1-3-7)10-11(17)14-13(18)15-12(10)19-9/h6-7H,1-5H2,(H2,14,15,17,18)
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TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50384612
PNG
(CHEMBL2036958)
Show SMILES CC1(CCCc2cc(=O)oc3[nH]c(=O)[nH]c(=O)c23)CC1
Show InChI InChI=1S/C14H16N2O4/c1-14(5-6-14)4-2-3-8-7-9(17)20-12-10(8)11(18)15-13(19)16-12/h7H,2-6H2,1H3,(H2,15,16,18,19)
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TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50384641
PNG
(CHEMBL2036955)
Show SMILES O=c1cc(CCCC2CC2)c2c([nH]c(=O)[nH]c2=O)o1
Show InChI InChI=1S/C13H14N2O4/c16-9-6-8(3-1-2-7-4-5-7)10-11(17)14-13(18)15-12(10)19-9/h6-7H,1-5H2,(H2,14,15,17,18)
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TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414491
PNG
(CHEMBL559204)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-6-13(16-15-12)17(7-10-3-5-20-9-10)8-11-2-1-4-21-11/h1-6,9H,7-8H2,(H,15,16)(H,18,19)
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n/an/an/an/a 141n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208135
PNG
((+)-5-methyl-5-(5-methyl-thiophen-3-yl)-4-oxo-4,5-...)
Show SMILES Cc1cc(cs1)C1(C)OC(=CC1=O)C(O)=O
Show InChI InChI=1S/C11H10O4S/c1-6-3-7(5-16-6)11(2)9(12)4-8(15-11)10(13)14/h3-5H,1-2H3,(H,13,14)
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n/an/an/an/a 180n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50384616
PNG
(CHEMBL2036813)
Show SMILES CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C11H12N2O4/c1-2-3-4-6-5-7(14)17-10-8(6)9(15)12-11(16)13-10/h5H,2-4H2,1H3,(H2,12,13,15,16)
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n/an/an/an/a 190n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414495
PNG
(CHEMBL562675)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1cccs1)Cc1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-7-13(16-15-12)17(8-10-3-1-5-20-10)9-11-4-2-6-21-11/h1-7H,8-9H2,(H,15,16)(H,18,19)
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n/an/an/an/a 257n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208140
PNG
(5-methyl-5-(5-methyl-thiophen-2-yl)-4-oxo-4,5-dihy...)
Show SMILES Cc1ccc(s1)C1(C)OC(=CC1=O)C(O)=O
Show InChI InChI=1S/C11H10O4S/c1-6-3-4-9(16-6)11(2)8(12)5-7(15-11)10(13)14/h3-5H,1-2H3,(H,13,14)
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n/an/an/an/a 270n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50337038
PNG
(5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyra...)
Show SMILES FC(F)c1nc2oc(=O)cc(CCCC3CC3)c2c(=O)[nH]1
Show InChI InChI=1S/C14H14F2N2O3/c15-11(16)12-17-13(20)10-8(3-1-2-7-4-5-7)6-9(19)21-14(10)18-12/h6-7,11H,1-5H2,(H,17,18,20)
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n/an/an/an/a 300n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208137
PNG
((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Br)c1
Show InChI InChI=1S/C10H7BrO4S/c1-10(5-2-8(11)16-4-5)7(12)3-6(15-10)9(13)14/h2-4H,1H3,(H,13,14)
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n/an/an/an/a 370n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50220833
PNG
(5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL...)
Show SMILES CCCc1cc(n[nH]1)-c1nnn[nH]1
Show InChI InChI=1S/C7H10N6/c1-2-3-5-4-6(9-8-5)7-10-12-13-11-7/h4H,2-3H2,1H3,(H,8,9)(H,10,11,12,13)
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n/an/an/an/a 724n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50220833
PNG
(5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL...)
Show SMILES CCCc1cc(n[nH]1)-c1nnn[nH]1
Show InChI InChI=1S/C7H10N6/c1-2-3-5-4-6(9-8-5)7-10-12-13-11-7/h4H,2-3H2,1H3,(H,8,9)(H,10,11,12,13)
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n/an/an/an/a 724n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414499
PNG
(CHEMBL561920)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c22-18(23)16-11-17(20-19-16)21(12-14-7-3-1-4-8-14)13-15-9-5-2-6-10-15/h1-11H,12-13H2,(H,19,20)(H,22,23)
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n/an/an/an/a 851n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50337024
PNG
(2-(difluoromethyl)-5-(3-(1-methylcyclopropyl)propy...)
Show SMILES CC1(CCCc2cc(=O)oc3nc([nH]c(=O)c23)C(F)F)CC1
Show InChI InChI=1S/C15H16F2N2O3/c1-15(5-6-15)4-2-3-8-7-9(20)22-14-10(8)13(21)18-12(19-14)11(16)17/h7,11H,2-6H2,1H3,(H,18,19,21)
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n/an/an/an/a 1.12E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50384634
PNG
(CHEMBL2036948)
Show SMILES CC(C)CCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C12H14N2O4/c1-6(2)3-4-7-5-8(15)18-11-9(7)10(16)13-12(17)14-11/h5-6H,3-4H2,1-2H3,(H2,13,14,16,17)
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n/an/an/an/a 1.30E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208137
PNG
((+)-5-(5-bromo-thiophen-3-yl)-5-methyl-4-oxo-4,5-d...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Br)c1
Show InChI InChI=1S/C10H7BrO4S/c1-10(5-2-8(11)16-4-5)7(12)3-6(15-10)9(13)14/h2-4H,1H3,(H,13,14)
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n/an/an/an/a 1.47E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208122
PNG
((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Cl)c1
Show InChI InChI=1S/C10H7ClO4S/c1-10(5-2-8(11)16-4-5)7(12)3-6(15-10)9(13)14/h2-4H,1H3,(H,13,14)
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n/an/an/an/a 1.70E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208122
PNG
((+)-5-(5-chloro-thiophen-3-yl)-5-methyl-4-oxo-4,5-...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1csc(Cl)c1
Show InChI InChI=1S/C10H7ClO4S/c1-10(5-2-8(11)16-4-5)7(12)3-6(15-10)9(13)14/h2-4H,1H3,(H,13,14)
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n/an/an/an/a 1.72E+3n/an/an/an/a



Arena Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Activity at GPR109b assessed as inhibition of forskolin-stimulated cAMP production


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208134
PNG
(5-methyl-5-(4-methyl-thiophen-2-yl)-4-oxo-4,5-dihy...)
Show SMILES Cc1csc(c1)C1(C)OC(=CC1=O)C(O)=O
Show InChI InChI=1S/C11H10O4S/c1-6-3-9(16-5-6)11(2)8(12)4-7(15-11)10(13)14/h3-5H,1-2H3,(H,13,14)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50220853
PNG
(5-(5-cyclopropyl-1H-pyrazol-3-yl)-1H-tetrazole | C...)
Show SMILES C1CC1c1cc(n[nH]1)-c1nnn[nH]1
Show InChI InChI=1S/C7H8N6/c1-2-4(1)5-3-6(9-8-5)7-10-12-13-11-7/h3-4H,1-2H2,(H,8,9)(H,10,11,12,13)
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n/an/an/an/a 3.60E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50220853
PNG
(5-(5-cyclopropyl-1H-pyrazol-3-yl)-1H-tetrazole | C...)
Show SMILES C1CC1c1cc(n[nH]1)-c1nnn[nH]1
Show InChI InChI=1S/C7H8N6/c1-2-4(1)5-3-6(9-8-5)7-10-12-13-11-7/h3-4H,1-2H2,(H,8,9)(H,10,11,12,13)
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n/an/an/an/a 3.60E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208116
PNG
(5-(5-chloro-thiophen-2-yl)-5-methyl-4-oxo-4,5-dihy...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccc(Cl)s1
Show InChI InChI=1S/C10H7ClO4S/c1-10(7-2-3-8(11)16-7)6(12)4-5(15-10)9(13)14/h2-4H,1H3,(H,13,14)
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n/an/an/an/a 3.70E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414502
PNG
(CHEMBL561720)
Show SMILES OC(=O)c1cc([nH]n1)N(CC1CC1)CC1CC1
Show InChI InChI=1S/C12H17N3O2/c16-12(17)10-5-11(14-13-10)15(6-8-1-2-8)7-9-3-4-9/h5,8-9H,1-4,6-7H2,(H,13,14)(H,16,17)
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n/an/an/an/a 3.98E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208110
PNG
(5-methyl-5-(4-bromo-thiophen-2-yl)-4-oxo-4,5-dihyd...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1cc(Br)cs1
Show InChI InChI=1S/C10H7BrO4S/c1-10(8-2-5(11)4-16-8)7(12)3-6(15-10)9(13)14/h2-4H,1H3,(H,13,14)
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n/an/an/an/a 4.10E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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n/an/an/an/a 4.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208139
PNG
(5-methyl-4-oxo-5-thiophen-3-yl-4,5-dihydro-furan-2...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccsc1
Show InChI InChI=1S/C10H8O4S/c1-10(6-2-3-15-5-6)8(11)4-7(14-10)9(12)13/h2-5H,1H3,(H,12,13)
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n/an/an/an/a 4.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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n/an/an/an/a 4.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414506
PNG
(CHEMBL553415)
Show SMILES CCC(C)Nc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C8H13N3O2/c1-3-5(2)9-7-4-6(8(12)13)10-11-7/h4-5H,3H2,1-2H3,(H,12,13)(H2,9,10,11)
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n/an/an/an/a 4.47E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208125
PNG
(5-ethyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxy...)
Show SMILES CCC1(OC(=CC1=O)C(O)=O)c1ccccc1
Show InChI InChI=1S/C13H12O4/c1-2-13(9-6-4-3-5-7-9)11(14)8-10(17-13)12(15)16/h3-8H,2H2,1H3,(H,15,16)
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n/an/an/an/a 4.80E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208115
PNG
((+)-5-(3-bromo-phenyl)-5-methyl-4-oxo-4,5-dihydro-...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1cccc(Br)c1
Show InChI InChI=1S/C12H9BrO4/c1-12(7-3-2-4-8(13)5-7)10(14)6-9(17-12)11(15)16/h2-6H,1H3,(H,15,16)
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n/an/an/an/a 4.90E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208120
PNG
(5-(3-iodo-phenyl)-5-methyl-4-oxo-4,5-dihydro-furan...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1cccc(I)c1
Show InChI InChI=1S/C12H9IO4/c1-12(7-3-2-4-8(13)5-7)10(14)6-9(17-12)11(15)16/h2-6H,1H3,(H,15,16)
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n/an/an/an/a 5.10E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208112
PNG
(5-cyclopent-1-enyl-5-methyl-4-oxo-4,5-dihydro-fura...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)C1=CCCC1
Show InChI InChI=1S/C11H12O4/c1-11(7-4-2-3-5-7)9(12)6-8(15-11)10(13)14/h4,6H,2-3,5H2,1H3,(H,13,14)
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n/an/an/an/a 5.10E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414500
PNG
(CHEMBL557298)
Show SMILES OC(=O)c1cc([nH]n1)N(CCc1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C20H21N3O2/c24-20(25)18-15-19(22-21-18)23(13-11-16-7-3-1-4-8-16)14-12-17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,21,22)(H,24,25)
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n/an/an/an/a 5.62E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208124
PNG
(5-(3-ethyl-phenyl)-5-methyl-4-oxo-4,5-dihydro-fura...)
Show SMILES CCc1cccc(c1)C1(C)OC(=CC1=O)C(O)=O
Show InChI InChI=1S/C14H14O4/c1-3-9-5-4-6-10(7-9)14(2)12(15)8-11(18-14)13(16)17/h4-8H,3H2,1-2H3,(H,16,17)
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n/an/an/an/a 6.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414505
PNG
(CHEMBL552399)
Show SMILES CCCC(C)Nc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H15N3O2/c1-3-4-6(2)10-8-5-7(9(13)14)11-12-8/h5-6H,3-4H2,1-2H3,(H,13,14)(H2,10,11,12)
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n/an/an/an/a 6.76E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50220834
PNG
(5-(5-butyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL3...)
Show SMILES CCCCc1cc(n[nH]1)-c1nnn[nH]1
Show InChI InChI=1S/C8H12N6/c1-2-3-4-6-5-7(10-9-6)8-11-13-14-12-8/h5H,2-4H2,1H3,(H,9,10)(H,11,12,13,14)
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n/an/an/an/a 7.59E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414504
PNG
(CHEMBL560254)
Show SMILES CCCN(CCC)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C10H17N3O2/c1-3-5-13(6-4-2)9-7-8(10(14)15)11-12-9/h7H,3-6H2,1-2H3,(H,11,12)(H,14,15)
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n/an/an/an/a 8.32E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414498
PNG
(CHEMBL550563)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccccc1F)Cc1ccccc1F
Show InChI InChI=1S/C18H15F2N3O2/c19-14-7-3-1-5-12(14)10-23(11-13-6-2-4-8-15(13)20)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a 8.71E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414493
PNG
(CHEMBL565055)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccoc1)Cc1ccoc1
Show InChI InChI=1S/C14H13N3O4/c18-14(19)12-5-13(16-15-12)17(6-10-1-3-20-8-10)7-11-2-4-21-9-11/h1-5,8-9H,6-7H2,(H,15,16)(H,18,19)
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n/an/an/an/a 8.91E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50208113
PNG
(5-(4-fluoro-phenyl)-5-methyl-4-oxo-4,5-dihydro-fur...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccc(F)cc1
Show InChI InChI=1S/C12H9FO4/c1-12(7-2-4-8(13)5-3-7)10(14)6-9(17-12)11(15)16/h2-6H,1H3,(H,15,16)
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n/an/an/an/a 9.90E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Activity at GPR109b in CHO cells assessed as inhibition of forskolin-induced cAMP generation


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414490
PNG
(CHEMBL550153)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccco1
Show InChI InChI=1S/C14H13N3O3S/c18-14(19)12-6-13(16-15-12)17(7-10-3-5-21-9-10)8-11-2-1-4-20-11/h1-6,9H,7-8H2,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414496
PNG
(CHEMBL564907)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccc(F)cc1)Cc1ccc(F)cc1
Show InChI InChI=1S/C18H15F2N3O2/c19-14-5-1-12(2-6-14)10-23(11-13-3-7-15(20)8-4-13)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414497
PNG
(CHEMBL564064)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1cccc(F)c1)Cc1cccc(F)c1
Show InChI InChI=1S/C18H15F2N3O2/c19-14-5-1-3-12(7-14)10-23(11-13-4-2-6-15(20)8-13)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM23515
PNG
(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Show SMILES OC(=O)c1cccnc1
Show InChI InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
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n/an/an/an/a>1.00E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM23515
PNG
(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Show SMILES OC(=O)c1cccnc1
Show InChI InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
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n/an/an/an/a>1.00E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at human GPR109b


Citation and Details
More data for this
Ligand-Target Pair
HM74 nicotinic acid GPCR


(HUMAN)
BDBM50414503
PNG
(CHEMBL553912)
Show SMILES CCCCCCN(CCCCCC)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C16H29N3O2/c1-3-5-7-9-11-19(12-10-8-6-4-2)15-13-14(16(20)21)17-18-15/h13H,3-12H2,1-2H3,(H,17,18)(H,20,21)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay


Citation and Details
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