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Compile Data Set for Download or QSAR

Found 1593 hits of ec50 data for polymerid = 49000742,50000109,50002136,5747,8283,8286   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(RAT)
BDBM50094843
PNG
((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
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n/an/an/an/a 0.570n/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50094843
PNG
((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
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n/an/an/an/a 1.26n/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50094843
PNG
((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1
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n/an/an/an/a 2.07n/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist potency against cloned Metabotropic glutamate receptor 3


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50138784
PNG
((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1
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n/an/an/an/a 4n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 2 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50138784
PNG
((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1
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n/an/an/an/a 5n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 2 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50138784
PNG
((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1
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n/an/an/an/a 7n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263355
PNG
(2-(((1R,5S)-6-((2,5-difluorophenoxy)methyl)-3-aza-...)
Show SMILES Cn1c(CN2C[C@H]3C(COc4cc(F)ccc4F)[C@H]3C2)nc2ccccc12
Show InChI InChI=1S/C21H21F2N3O/c1-25-19-5-3-2-4-18(19)24-21(25)11-26-9-14-15(10-26)16(14)12-27-20-8-13(22)6-7-17(20)23/h2-8,14-16H,9-12H2,1H3/t14-,15+,16?
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n/an/an/an/a 7n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50392432
PNG
(CHEMBL2151817)
Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C(C)(C)C
Show InChI InChI=1S/C19H23FN2O2/c1-13(19(2,3)4)22-18(23)15-8-9-17(21-11-15)24-12-14-6-5-7-16(20)10-14/h5-11,13H,12H2,1-4H3,(H,22,23)/t13-/m1/s1
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n/an/an/an/a 7.20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50392432
PNG
(CHEMBL2151817)
Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C(C)(C)C
Show InChI InChI=1S/C19H23FN2O2/c1-13(19(2,3)4)22-18(23)15-8-9-17(21-11-15)24-12-14-6-5-7-16(20)10-14/h5-11,13H,12H2,1-4H3,(H,22,23)/t13-/m1/s1
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n/an/an/an/a 7.24n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343305
PNG
(2-((4-(4-Chloro-2-fluorophenyl)piperidin-1-yl)meth...)
Show SMILES Cn1c(CN2CCC(CC2)c2ccc(Cl)cc2F)nc2ccccc12
Show InChI InChI=1S/C20H21ClFN3/c1-24-19-5-3-2-4-18(19)23-20(24)13-25-10-8-14(9-11-25)16-7-6-15(21)12-17(16)22/h2-7,12,14H,8-11,13H2,1H3
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n/an/an/an/a 7.60n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263391
PNG
(2-(((1R,5S)-6-((4-chloro-2-fluorophenoxy)methyl)-3...)
Show SMILES Cn1c(CN2C[C@H]3C(COc4ccc(Cl)cc4F)[C@H]3C2)nc2ccccc12
Show InChI InChI=1S/C21H21ClFN3O/c1-25-19-5-3-2-4-18(19)24-21(25)11-26-9-14-15(10-26)16(14)12-27-20-7-6-13(22)8-17(20)23/h2-8,14-16H,9-12H2,1H3/t14-,15+,16?
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n/an/an/an/a 8n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50138781
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1
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n/an/an/an/a 8n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 2 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50116515
PNG
(CHEMBL3609729)
Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
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n/an/an/an/a 9n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343325
PNG
(CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Show SMILES C[C@H]1CN(Cc2nc3ncccc3n2C)CC[C@H]1c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C21H22F4N4/c1-13-11-29(12-19-27-20-18(28(19)2)4-3-8-26-20)9-7-15(13)16-6-5-14(10-17(16)22)21(23,24)25/h3-6,8,10,13,15H,7,9,11-12H2,1-2H3/t13-,15+/m0/s1
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n/an/an/an/a 9n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50187644
PNG
(4-nitro-N-(1-(2-fluorophenyl)-3-phenyl-1H-pyrazol-...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C22H15FN4O3/c23-18-8-4-5-9-20(18)26-21(14-19(25-26)15-6-2-1-3-7-15)24-22(28)16-10-12-17(13-11-16)27(29)30/h1-14H,(H,24,28)
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n/an/an/an/a 9.60n/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50187615
PNG
(4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide ...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H16N4O3/c27-22(17-11-13-19(14-12-17)26(28)29)23-21-15-20(16-7-3-1-4-8-16)24-25(21)18-9-5-2-6-10-18/h1-15H,(H,23,27)
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n/an/an/an/a 10.7n/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM50138784
PNG
((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 3 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50397661
PNG
(EGLUMEGAD)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/an/an/a 11.1n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Agonist activity at mGLUR2 in rat cerebral cortex assessed as inhibition of forskolin-stimulated cAMP production


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor


(RAT)
BDBM50017211
PNG
(CHEMBL3287695)
Show SMILES COc1cc(ccc1OCCCCOc1ccc(C(=O)CC(C)C)c(O)c1C)C(O)=O
Show InChI InChI=1S/C24H30O7/c1-15(2)13-19(25)18-8-10-20(16(3)23(18)26)30-11-5-6-12-31-21-9-7-17(24(27)28)14-22(21)29-4/h7-10,14-15,26H,5-6,11-13H2,1-4H3,(H,27,28)
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n/an/an/an/a 12n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50187616
PNG
(3,4-dichloro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benza...)
Show SMILES Clc1ccc(cc1Cl)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H15Cl2N3O/c23-18-12-11-16(13-19(18)24)22(28)25-21-14-20(15-7-3-1-4-8-15)26-27(21)17-9-5-2-6-10-17/h1-14H,(H,25,28)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343312
PNG
(2-((4-(2-Methoxy-4-(trifluoromethyl)phenyl)piperid...)
Show SMILES COc1cc(ccc1C1CCN(Cc2nc3ncccc3n2C)CC1)C(F)(F)F
Show InChI InChI=1S/C21H23F3N4O/c1-27-17-4-3-9-25-20(17)26-19(27)13-28-10-7-14(8-11-28)16-6-5-15(21(22,23)24)12-18(16)29-2/h3-6,9,12,14H,7-8,10-11,13H2,1-2H3
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n/an/an/an/a 13n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50392447
PNG
(CHEMBL2151815)
Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C1CCCCC1
Show InChI InChI=1S/C21H25FN2O2/c1-15(17-7-3-2-4-8-17)24-21(25)18-10-11-20(23-13-18)26-14-16-6-5-9-19(22)12-16/h5-6,9-13,15,17H,2-4,7-8,14H2,1H3,(H,24,25)/t15-/m1/s1
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n/an/an/an/a 15n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50392447
PNG
(CHEMBL2151815)
Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C1CCCCC1
Show InChI InChI=1S/C21H25FN2O2/c1-15(17-7-3-2-4-8-17)24-21(25)18-10-11-20(23-13-18)26-14-16-6-5-9-19(22)12-16/h5-6,9-13,15,17H,2-4,7-8,14H2,1H3,(H,24,25)/t15-/m1/s1
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n/an/an/an/a 15.1n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50337958
PNG
(CHEMBL1684242 | N-cyclobutyl-6-((3-fluorophenyl)et...)
Show SMILES Fc1cccc(c1)C#Cc1ccc(cn1)C(=O)NC1CCC1
Show InChI InChI=1S/C18H15FN2O/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50094842
PNG
((+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)
Show SMILES N[C@]1(CC[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10FNO4/c9-8(6(13)14)3-1-2-7(10,4(3)8)5(11)12/h3-4H,1-2,10H2,(H,11,12)(H,13,14)/t3-,4-,7+,8-/m1/s1
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n/an/an/an/a 16.6n/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50187636
PNG
(4-trifluoromethoxy-N-(1,3-diphenyl-1H-pyrazol-5-yl...)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H16F3N3O2/c24-23(25,26)31-19-13-11-17(12-14-19)22(30)27-21-15-20(16-7-3-1-4-8-16)28-29(21)18-9-5-2-6-10-18/h1-15H,(H,27,30)
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n/an/an/an/a 18n/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/an/an/a 18.3n/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258185
PNG
(CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 19n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50398728
PNG
(CHEMBL2179646)
Show SMILES OC(=O)c1cc(ccc1Cl)-c1cccc(c1)-c1ccc2C(=O)N(Cc2c1)C1CCCC1
Show InChI InChI=1S/C26H22ClNO3/c27-24-11-9-19(14-23(24)26(30)31)17-5-3-4-16(12-17)18-8-10-22-20(13-18)15-28(25(22)29)21-6-1-2-7-21/h3-5,8-14,21H,1-2,6-7,15H2,(H,30,31)
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n/an/an/an/a 20n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50398742
PNG
(CHEMBL2179632)
Show SMILES OC(=O)c1cc(ccc1O)-c1cccc(COc2ccc3C(=O)N(Cc3c2)C2CCCC2)c1
Show InChI InChI=1S/C27H25NO5/c29-25-11-8-19(14-24(25)27(31)32)18-5-3-4-17(12-18)16-33-22-9-10-23-20(13-22)15-28(26(23)30)21-6-1-2-7-21/h3-5,8-14,21,29H,1-2,6-7,15-16H2,(H,31,32)
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n/an/an/an/a 20n/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50156068
PNG
(CHEMBL190326 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H16F3N3O/c24-23(25,26)18-13-11-17(12-14-18)22(30)27-21-15-20(16-7-3-1-4-8-16)28-29(21)19-9-5-2-6-10-19/h1-15H,(H,27,30)
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n/an/an/an/a 20n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 5 of rat


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258224
PNG
(CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 20n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50156071
PNG
(3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...)
Show SMILES O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)c1cccc(c1)C#N
Show InChI InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)
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n/an/an/an/a 20n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 5 of rat


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50187633
PNG
(3,4-dimethyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benza...)
Show SMILES Cc1ccc(cc1C)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H21N3O/c1-17-13-14-20(15-18(17)2)24(28)25-23-16-22(19-9-5-3-6-10-19)26-27(23)21-11-7-4-8-12-21/h3-16H,1-2H3,(H,25,28)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263434
PNG
(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Show SMILES Cn1c(CN2C[C@H]3C(COc4ccc(cc4)C(F)(F)F)[C@H]3C2)nc2ncccc12
Show InChI InChI=1S/C21H21F3N4O/c1-27-18-3-2-8-25-20(18)26-19(27)11-28-9-15-16(10-28)17(15)12-29-14-6-4-13(5-7-14)21(22,23)24/h2-8,15-17H,9-12H2,1H3/t15-,16+,17?
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n/an/an/an/a 20n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50156076
PNG
(CHEMBL191147 | N-(2,5-Diphenyl-2H-pyrazol-3-yl)-3,...)
Show SMILES Fc1ccc(cc1F)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C22H15F2N3O/c23-18-12-11-16(13-19(18)24)22(28)25-21-14-20(15-7-3-1-4-8-15)26-27(21)17-9-5-2-6-10-17/h1-14H,(H,25,28)
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n/an/an/an/a 20n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration against metabotropic glutamate receptor 5 of rat


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258223
PNG
(CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 21n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50094845
PNG
((+/-)-2-Amino-6-fluoro-4-hydroxy-bicyclo[3.1.0]hex...)
Show SMILES N[C@]1(CC(O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h2-4,11H,1,10H2,(H,12,13)(H,14,15)/t2?,3-,4-,7+,8-/m1/s1
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n/an/an/an/a 21n/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation


J Med Chem 43: 4893-909 (2000)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343323
PNG
(CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...)
Show SMILES COc1cc(ccc1[C@@H]1CCN(Cc2nc3ncccc3n2C)C[C@@H]1C)C(F)(F)F
Show InChI InChI=1S/C22H25F3N4O/c1-14-12-29(13-20-27-21-18(28(20)2)5-4-9-26-21)10-8-16(14)17-7-6-15(22(23,24)25)11-19(17)30-3/h4-7,9,11,14,16H,8,10,12-13H2,1-3H3/t14-,16+/m0/s1
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n/an/an/an/a 22n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343299
PNG
(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Show SMILES Cn1c(CN2CCC(CC2)c2ccccc2F)nc2ccccc12
Show InChI InChI=1S/C20H22FN3/c1-23-19-9-5-4-8-18(19)22-20(23)14-24-12-10-15(11-13-24)16-6-2-3-7-17(16)21/h2-9,15H,10-14H2,1H3
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n/an/an/an/a 22n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263426
PNG
(1-methyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyc...)
Show SMILES Cn1c(CN2C[C@H]3C(COc4ccccc4)[C@H]3C2)nc2ccccc12
Show InChI InChI=1S/C21H23N3O/c1-23-20-10-6-5-9-19(20)22-21(23)13-24-11-16-17(12-24)18(16)14-25-15-7-3-2-4-8-15/h2-10,16-18H,11-14H2,1H3/t16-,17+,18?
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n/an/an/an/a 24n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50145198
PNG
(CHEMBL3765778)
Show SMILES Cc1ccc(cc1-c1ccc2n(CC(C)(C)C)c(=O)n(C)c2n1)C(C)(C)O
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n/an/an/an/a 25n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Positive allosteric modulation of recombinant rat mGluR2 preincubated for 5 mins followed by stimulation with EC20 concentration of glutamate for 3 m...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258186
PNG
(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 25n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343314
PNG
(2-((4-(2-Fluoro-4-(trifluoromethoxy)phenyl)piperid...)
Show SMILES Cn1c(CN2CCC(CC2)c2ccc(OC(F)(F)F)cc2F)nc2ncccc12
Show InChI InChI=1S/C20H20F4N4O/c1-27-17-3-2-8-25-19(17)26-18(27)12-28-9-6-13(7-10-28)15-5-4-14(11-16(15)21)29-20(22,23)24/h2-5,8,11,13H,6-7,9-10,12H2,1H3
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n/an/an/an/a 25n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343313
PNG
(2-((4-(2-Fluoro-4-(trifluoromethyl)phenyl)piperidi...)
Show SMILES Cn1c(CN2CCC(CC2)c2ccc(cc2F)C(F)(F)F)nc2ncccc12
Show InChI InChI=1S/C20H20F4N4/c1-27-17-3-2-8-25-19(17)26-18(27)12-28-9-6-13(7-10-28)15-5-4-14(11-16(15)21)20(22,23)24/h2-5,8,11,13H,6-7,9-10,12H2,1H3
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n/an/an/an/a 25.1n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263389
PNG
(2-(((1R,5S)-6-((4-isopropylphenoxy)methyl)-3-aza-b...)
Show SMILES CC(C)c1ccc(OCC2[C@@H]3CN(Cc4nc5ccccc5n4C)C[C@H]23)cc1
Show InChI InChI=1S/C24H29N3O/c1-16(2)17-8-10-18(11-9-17)28-15-21-19-12-27(13-20(19)21)14-24-25-22-6-4-5-7-23(22)26(24)3/h4-11,16,19-21H,12-15H2,1-3H3/t19-,20+,21?
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n/an/an/an/a 26n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263431
PNG
(2-(((1R,5S)-6-((5-chloropyridin-2-yloxy)methyl)-3-...)
Show SMILES Cn1c(CN2C[C@H]3C(COc4ccc(Cl)cn4)[C@H]3C2)nc2ccccc12
Show InChI InChI=1S/C20H21ClN4O/c1-24-18-5-3-2-4-17(18)23-19(24)11-25-9-14-15(10-25)16(14)12-26-20-7-6-13(21)8-22-20/h2-8,14-16H,9-12H2,1H3/t14-,15+,16?
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n/an/an/an/a 26n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50263390
PNG
(2-(((1R,5S)-6-((4-chlorophenoxy)methyl)-3-aza-bicy...)
Show SMILES Cn1c(CN2C[C@H]3C(COc4ccc(Cl)cc4)[C@H]3C2)nc2ccccc12
Show InChI InChI=1S/C21H22ClN3O/c1-24-20-5-3-2-4-19(20)23-21(24)12-25-10-16-17(11-25)18(16)13-26-15-8-6-14(22)7-9-15/h2-9,16-18H,10-13H2,1H3/t16-,17+,18?
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n/an/an/an/a 26n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamate


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50343321
PNG
(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Show SMILES C[C@H]1CN(Cc2nc3ncccc3n2C)CC[C@H]1c1ccc(Cl)cc1F
Show InChI InChI=1S/C20H22ClFN4/c1-13-11-26(9-7-15(13)16-6-5-14(21)10-17(16)22)12-19-24-20-18(25(19)2)4-3-8-23-20/h3-6,8,10,13,15H,7,9,11-12H2,1-2H3/t13-,15+/m0/s1
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n/an/an/an/a 28n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic Glutamate Receptor 5 (mGluR5)


(Rattus norvegicus (Rat))
BDBM50392439
PNG
(CHEMBL2151806)
Show SMILES Fc1cccc(COc2ccc(cn2)C(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C19H21FN2O2/c20-16-6-4-5-14(11-16)13-24-18-10-9-15(12-21-18)19(23)22-17-7-2-1-3-8-17/h4-6,9-12,17H,1-3,7-8,13H2,(H,22,23)
PDB
MMDB

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n/an/an/an/a 28.8n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
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