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Compile Data Set for Download or QSAR

Found 158 hits of ec50 data for polymerid = 49000761,8285   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 55n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50138784
PNG
((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1
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n/an/an/an/a 147n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50004051
PNG
(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Show SMILES NC(CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
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n/an/an/an/a 280n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Metabotropic glutamate receptor 6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 340n/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Activity at rat recombinant mGluR6 expressed in CHO cells assessed as cAMP production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 340n/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Activity at rat mGluR6 by measuring cAMP formation in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50074749
PNG
((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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n/an/an/an/a 401n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human mGluR6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50159148
PNG
(CHEMBL3786667)
Show SMILES N[C@@H](C[C@@]1(C[C@H]1C(O)=O)C(O)=O)C(O)=O
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n/an/an/an/a 490n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 570n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50034504
PNG
((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Show SMILES N[C@@H]([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
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Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434137
PNG
(CHEMBL2381649)
Show SMILES CC(=O)N[C@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C10H14N2O5/c1-3(13)12-4-2-10(11,9(16)17)7-5(4)6(7)8(14)15/h4-7H,2,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t4-,5-,6-,7-,10-/m0/s1
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n/an/an/an/a 709n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50220011
PNG
(CHEMBL243925 | L-(+)-2-amino-4-thiophosphonobutyri...)
Show SMILES N[C@@H](CCP(O)(O)=S)C(O)=O
Show InChI InChI=1S/C4H10NO4PS/c5-3(4(6)7)1-2-10(8,9)11/h3H,1-2,5H2,(H,6,7)(H2,8,9,11)/t3-/m0/s1
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n/an/an/an/a 730n/an/an/an/a



Université Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434131
PNG
(CHEMBL2381644)
Show SMILES N[C@]1(C[C@@H](N=[N+]=[N-])[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10N4O4/c9-8(7(15)16)1-2(11-12-10)3-4(5(3)8)6(13)14/h2-5H,1,9H2,(H,13,14)(H,15,16)/t2-,3+,4+,5+,8+/m1/s1
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n/an/an/an/a 780n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 900n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50004051
PNG
(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Show SMILES NC(CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)
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n/an/an/an/a 1.00E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the agonistic activity against Metabotropic glutamate receptor 6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM82006
PNG
(D-AP4 | D-APB | US9212196, L-AP4)
Show SMILES N[C@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
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US Patent
n/an/an/an/a 1.03E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314796
PNG
((3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...)
Show SMILES OC(=O)CCP(O)(=O)CCC(=N)C(O)=O
Show InChI InChI=1S/C7H12NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h8H,1-4H2,(H,9,10)(H,11,12)(H,13,14)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50138781
PNG
((1S,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-methyl-c...)
Show SMILES C[C@@H]1[C@H]([C@H](N)C(O)=O)[C@H]1C(O)=O
Show InChI InChI=1S/C7H11NO4/c1-2-3(4(2)6(9)10)5(8)7(11)12/h2-5H,8H2,1H3,(H,9,10)(H,11,12)/t2-,3+,4+,5+/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434139
PNG
(CHEMBL2381650)
Show SMILES N[C@]1(C[C@@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9+,10+,11+,14+/m1/s1
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n/an/an/an/a 1.27E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434135
PNG
(CHEMBL2381652)
Show SMILES N[C@]1(C[C@@H](F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H10FNO4/c9-2-1-8(10,7(13)14)5-3(2)4(5)6(11)12/h2-5H,1,10H2,(H,11,12)(H,13,14)/t2-,3+,4+,5+,8+/m1/s1
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n/an/an/an/a 1.41E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 1.91E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50217031
PNG
((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m0/s1
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n/an/an/an/a 1.95E+3n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 2.08E+3n/an/an/an/a



Université Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50074750
PNG
((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Show SMILES N[C@]1(CS[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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n/an/an/an/a 2.43E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human mGluR6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM196932
PNG
(US9212196, Derivative 28)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1cc(F)c(OCC(O)=O)c(F)c1)C(O)=O
Show InChI InChI=1/C13H16F2NO8P/c14-7-3-6(4-8(15)11(7)24-5-10(17)18)13(21)25(22,23)2-1-9(16)12(19)20/h3-4,9,13,21H,1-2,5,16H2,(H,17,18)(H,19,20)(H,22,23)/t9-,13?/s2
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US Patent
n/an/an/an/a 2.50E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM17664
PNG
((2S)-2-amino-3-(phosphonooxy)propanoic acid | CHEM...)
Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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n/an/an/an/a 2.70E+3n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR6 in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/an/an/a 2.99E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human mGluR6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434138
PNG
(CHEMBL2381651)
Show SMILES N[C@]1(C[C@H](Sc2ccccc2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4S/c15-14(13(18)19)6-8(9-10(11(9)14)12(16)17)20-7-4-2-1-3-5-7/h1-5,8-11H,6,15H2,(H,16,17)(H,18,19)/t8-,9-,10-,11-,14-/m0/s1
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n/an/an/an/a 3.25E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 3.30E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50056272
PNG
((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/an/an/a 3.36E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50217030
PNG
((1S,2S)-1-amino-2-phosphonomethylcyclopropane-carb...)
Show SMILES N[C@]1(C[C@@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5+/m1/s1
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n/an/an/an/a 3.41E+3n/an/an/an/a



University Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50121643
PNG
(CHEMBL3616847)
Show SMILES N[C@]1(C[C@@H](Sc2nnc[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1/C10H12N4O4S/c11-10(8(17)18)1-3(19-9-12-2-13-14-9)4-5(6(4)10)7(15)16/h2-6H,1,11H2,(H,15,16)(H,17,18)(H,12,13,14)/t3-,4+,5+,6+,10+/s2
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n/an/an/an/a 3.45E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant mGlu6 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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n/an/an/an/a 3.45E+3n/an/an/an/a



Univ. Rouen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50138783
PNG
(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Show SMILES N[C@H](C(O)=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1
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n/an/an/an/a 3.60E+3n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM196915
PNG
(US9212196, Derivative 11)
Show SMILES N[C@H](CCP(O)(=O)C(O)c1ccc(\C=C\C(O)=O)cc1)C(O)=O
Show InChI InChI=1/C14H18NO7P/c15-11(13(18)19)7-8-23(21,22)14(20)10-4-1-9(2-5-10)3-6-12(16)17/h1-6,11,14,20H,7-8,15H2,(H,16,17)(H,18,19)(H,21,22)/b6-3+/t11-,14?/s2
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n/an/an/an/a 3.80E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM196906
PNG
(US9212196, Derivative 2)
Show SMILES N[C@@H](CCP(O)(=O)C(O)c1ccc(OCC(O)=O)cc1)C(O)=O
Show InChI InChI=1/C13H18NO8P/c14-10(12(17)18)5-6-23(20,21)13(19)8-1-3-9(4-2-8)22-7-11(15)16/h1-4,10,13,19H,5-7,14H2,(H,15,16)(H,17,18)(H,20,21)/t10-,13?/s2
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n/an/an/an/a 4.20E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434132
PNG
(CHEMBL2381642)
Show SMILES N[C@]1(C[C@@H](O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3+,4+,5+,8+/m1/s1
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n/an/an/an/a 4.37E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50004881
PNG
((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Show SMILES NC(C(O)=O)c1ccc(cc1)P(O)(O)=O
Show InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
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n/an/an/an/a 4.70E+3n/an/an/an/a



Lilly, SA

Curated by ChEMBL


Assay Description
Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat nonneuronal cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM196907
PNG
(US9212196, Derivative 3)
Show SMILES COc1cc(ccc1OCC(O)=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H20NO9P/c1-23-11-6-8(2-3-10(11)24-7-12(16)17)14(20)25(21,22)5-4-9(15)13(18)19/h2-3,6,9,14,20H,4-5,7,15H2,1H3,(H,16,17)(H,18,19)(H,21,22)/t9-,14?/s2
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n/an/an/an/a 4.70E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 4.90E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Metabotropic glutamate receptor 6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50064248
PNG
((1S,2S,4S,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dic...)
Show SMILES N[C@]1(C[C@@H]2C[C@H]1[C@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-3-1-4(8)5(3)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
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n/an/an/an/a 5.30E+3n/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of Metabotropic glutamate receptor 6


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50293743
PNG
(CHEMBL556667 | N-(3-chlorophenyl)picolinamide | ci...)
Show SMILES Clc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
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n/an/an/an/a 5.36E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM196909
PNG
(US9212196, Derivative 5)
Show SMILES COc1cc(cc(c1OCC(O)=O)[N+]([O-])=O)C(O)P(O)(=O)CC[C@@H](N)C(O)=O
Show InChI InChI=1/C14H19N2O11P/c1-26-10-5-7(4-9(16(22)23)12(10)27-6-11(17)18)14(21)28(24,25)3-2-8(15)13(19)20/h4-5,8,14,21H,2-3,6,15H2,1H3,(H,17,18)(H,19,20)(H,24,25)/t8-,14?/s2
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n/an/an/an/a 5.95E+3n/an/an/an/a



UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE

US Patent


Assay Description
Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...


US Patent US9212196 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50088290
PNG
(CHEMBL3427499)
Show SMILES NC1(CC1(F)CP(O)(O)=O)C(O)=O
Show InChI InChI=1/C5H9FNO5P/c6-4(2-13(10,11)12)1-5(4,7)3(8)9/h1-2,7H2,(H,8,9)(H2,10,11,12)
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n/an/an/an/a 6.01E+3n/an/an/an/a



Univ. Rouen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50434140
PNG
(CHEMBL2381648)
Show SMILES CC(=O)N[C@@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C10H14N2O5/c1-3(13)12-4-2-10(11,9(16)17)7-5(4)6(7)8(14)15/h4-7H,2,11H2,1H3,(H,12,13)(H,14,15)(H,16,17)/t4-,5+,6+,7+,10+/m1/s1
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n/an/an/an/a 6.69E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314793
PNG
((S)-3-amino-3-carboxypropyl-2'-carboxyethyl phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CCC(O)=O)C(O)=O
Show InChI InChI=1S/C7H14NO6P/c8-5(7(11)12)1-3-15(13,14)4-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14)/t5-/m0/s1
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n/an/an/an/a 6.70E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(HUMAN)
BDBM50167032
PNG
((1S,2S,4R,5R,6S)-2-Amino-4-methyl-bicyclo[3.1.0]he...)
Show SMILES C[C@@H]1C[C@](N)([C@H]2[C@@H]1[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h3-6H,2,10H2,1H3,(H,11,12)(H,13,14)/t3-,4+,5+,6+,9+/m1/s1
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n/an/an/an/a 7.54E+3n/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Agonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
UniProtKB/SwissProt

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PubMed
n/an/an/an/a 7.60E+3n/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Activity at rat mGluR6 by measuring cAMP formation in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
UniProtKB/SwissProt

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KEGG
MMDB
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UniChem

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Article
PubMed
n/an/an/an/a 7.60E+3n/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Activity at rat recombinant mGluR6 expressed in CHO cells assessed as cAMP production


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6)


(Rattus norvegicus (Rat))
BDBM50314797
PNG
((3S)-3-[((3-Amino-3-carboxy)propyl)(hydroxy)phosph...)
Show SMILES N[C@@H](CCP(O)(=O)CC(Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H13ClNO6P/c8-4(6(10)11)3-16(14,15)2-1-5(9)7(12)13/h4-5H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4?,5-/m0/s1
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PubMed
n/an/an/an/a 8.90E+3n/an/an/an/a



Universite Paris Descartes

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu6 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ...


Citation and Details
More data for this
Ligand-Target Pair
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