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Compile Data Set for Download or QSAR

Found 175 hits of ec50 data for polymerid = 49000839,49000840,49000841,49000842,49000843   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444592
PNG
(CHEMBL3099721)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)O[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)211-111(26-17-18-60-178)171(281)228-66-24-32-126(228)165(275)208-108(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-31-125(227)164(274)197-80-132(240)203-106(51-56-133(241)242)149(259)222-122(78-137(249)250)155(265)200-90(12)143(253)224-124(82-231)172(282)229-67-25-33-127(229)166(276)209-110(54-59-136(247)248)150(260)207-109(53-58-135(245)246)152(262)213-114(69-85(4)5)157(267)221-121(77-131(181)239)162(272)205-103(27-19-61-193-174(184)185)147(257)216-117(72-95-36-44-100(234)45-37-95)160(270)217-116(71-94-34-42-99(233)43-35-94)153(263)199-89(11)142(252)223-123(81-230)163(273)215-113(68-84(2)3)156(266)204-104(28-20-62-194-175(186)187)148(258)219-119(75-98-79-192-83-198-98)161(271)218-118(73-96-38-46-101(235)47-39-96)159(269)214-115(70-86(6)7)158(268)220-120(76-130(180)238)154(264)201-91(13)144(254)225-139(87(8)9)168(278)226-140(93(15)232)169(279)210-105(29-21-63-195-176(188)189)146(256)206-107(50-55-129(179)237)151(261)212-112(30-22-64-196-177(190)191)173(283)284-128(141(183)251)74-97-40-48-102(236)49-41-97/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,274)(H,199,263)(H,200,265)(H,201,264)(H,202,255)(H,203,240)(H,204,266)(H,205,272)(H,206,256)(H,207,260)(H,208,275)(H,209,276)(H,210,279)(H,211,277)(H,212,261)(H,213,262)(H,214,269)(H,215,273)(H,216,257)(H,217,270)(H,218,271)(H,219,258)(H,220,268)(H,221,267)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,278)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 0.300n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197025
PNG
(CHEMBL439904 | PYY(3-36))
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C180H279N53O54/c1-17-91(12)141(185)171(282)214-114(27-18-19-61-181)175(286)232-67-25-33-130(232)169(280)211-111(53-58-137(247)248)147(258)204-94(15)174(285)231-66-24-32-129(231)168(279)200-82-135(244)205-109(52-57-136(245)246)152(263)226-126(80-140(253)254)157(268)203-93(14)146(257)228-128(84-235)176(287)233-68-26-34-131(233)170(281)212-113(55-60-139(251)252)154(265)210-112(54-59-138(249)250)155(266)216-117(70-87(4)5)159(270)224-124(78-133(183)242)164(275)208-106(29-21-63-197-178(189)190)150(261)220-121(75-98-39-47-103(239)48-40-98)162(273)221-120(74-97-37-45-102(238)46-38-97)156(267)202-92(13)145(256)227-127(83-234)167(278)219-116(69-86(2)3)158(269)207-107(30-22-64-198-179(191)192)151(262)223-123(77-100-81-195-85-201-100)163(274)222-122(76-99-41-49-104(240)50-42-99)161(272)217-118(71-88(6)7)160(271)225-125(79-134(184)243)165(276)218-119(72-89(8)9)166(277)229-142(90(10)11)172(283)230-143(95(16)236)173(284)213-108(31-23-65-199-180(193)194)148(259)209-110(51-56-132(182)241)153(264)206-105(28-20-62-196-177(187)188)149(260)215-115(144(186)255)73-96-35-43-101(237)44-36-96/h35-50,81,85-95,105-131,141-143,234-240H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,241)(H2,183,242)(H2,184,243)(H2,186,255)(H,195,201)(H,200,279)(H,202,267)(H,203,268)(H,204,258)(H,205,244)(H,206,264)(H,207,269)(H,208,275)(H,209,259)(H,210,265)(H,211,280)(H,212,281)(H,213,284)(H,214,282)(H,215,260)(H,216,266)(H,217,272)(H,218,276)(H,219,278)(H,220,261)(H,221,273)(H,222,274)(H,223,262)(H,224,270)(H,225,271)(H,226,263)(H,227,256)(H,228,257)(H,229,277)(H,230,283)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.300n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089442
PNG
(CHEMBL3578012)
Show SMILES CC(C)C[C@H](NC(=O)C(CN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C84H137N29O20/c1-41(2)30-57(109-80(132)64(38-85)100-46(10)115)73(125)102-53(15-12-28-97-83(91)92)71(123)111-62(36-49-39-95-40-99-49)77(129)110-61(35-48-19-23-51(117)24-20-48)76(128)106-59(32-43(5)6)75(127)112-63(37-66(87)119)78(130)107-58(31-42(3)4)74(126)108-60(33-44(7)8)79(131)113-67(45(9)114)81(133)104-54(16-13-29-98-84(93)94)69(121)103-55(25-26-65(86)118)72(124)101-52(14-11-27-96-82(89)90)70(122)105-56(68(88)120)34-47-17-21-50(116)22-18-47/h17-24,39-45,52-64,67,114,116-117H,11-16,25-38,85H2,1-10H3,(H2,86,118)(H2,87,119)(H2,88,120)(H,95,99)(H,100,115)(H,101,124)(H,102,125)(H,103,121)(H,104,133)(H,105,122)(H,106,128)(H,107,130)(H,108,126)(H,109,132)(H,110,129)(H,111,123)(H,112,127)(H,113,131)(H4,89,90,96)(H4,91,92,97)(H4,93,94,98)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64?,67+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.398n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089442
PNG
(CHEMBL3578012)
Show SMILES CC(C)C[C@H](NC(=O)C(CN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C84H137N29O20/c1-41(2)30-57(109-80(132)64(38-85)100-46(10)115)73(125)102-53(15-12-28-97-83(91)92)71(123)111-62(36-49-39-95-40-99-49)77(129)110-61(35-48-19-23-51(117)24-20-48)76(128)106-59(32-43(5)6)75(127)112-63(37-66(87)119)78(130)107-58(31-42(3)4)74(126)108-60(33-44(7)8)79(131)113-67(45(9)114)81(133)104-54(16-13-29-98-84(93)94)69(121)103-55(25-26-65(86)118)72(124)101-52(14-11-27-96-82(89)90)70(122)105-56(68(88)120)34-47-17-21-50(116)22-18-47/h17-24,39-45,52-64,67,114,116-117H,11-16,25-38,85H2,1-10H3,(H2,86,118)(H2,87,119)(H2,88,120)(H,95,99)(H,100,115)(H,101,124)(H,102,125)(H,103,121)(H,104,133)(H,105,122)(H,106,128)(H,107,130)(H,108,126)(H,109,132)(H,110,129)(H,111,123)(H,112,127)(H,113,131)(H4,89,90,96)(H4,91,92,97)(H4,93,94,98)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64?,67+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.400n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089433
PNG
(CHEMBL3578011)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C87H143N29O20/c1-44(2)34-61(109-72(124)55(103-49(10)118)16-11-12-30-88)77(129)105-57(18-14-32-100-86(94)95)75(127)114-66(40-52-42-98-43-102-52)81(133)113-65(39-51-22-26-54(120)27-23-51)80(132)110-63(36-46(5)6)79(131)115-67(41-69(90)122)82(134)111-62(35-45(3)4)78(130)112-64(37-47(7)8)83(135)116-70(48(9)117)84(136)107-58(19-15-33-101-87(96)97)73(125)106-59(28-29-68(89)121)76(128)104-56(17-13-31-99-85(92)93)74(126)108-60(71(91)123)38-50-20-24-53(119)25-21-50/h20-27,42-48,55-67,70,117,119-120H,11-19,28-41,88H2,1-10H3,(H2,89,121)(H2,90,122)(H2,91,123)(H,98,102)(H,103,118)(H,104,128)(H,105,129)(H,106,125)(H,107,136)(H,108,126)(H,109,124)(H,110,132)(H,111,134)(H,112,130)(H,113,133)(H,114,127)(H,115,131)(H,116,135)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t48-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,70+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.5n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089433
PNG
(CHEMBL3578011)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C87H143N29O20/c1-44(2)34-61(109-72(124)55(103-49(10)118)16-11-12-30-88)77(129)105-57(18-14-32-100-86(94)95)75(127)114-66(40-52-42-98-43-102-52)81(133)113-65(39-51-22-26-54(120)27-23-51)80(132)110-63(36-46(5)6)79(131)115-67(41-69(90)122)82(134)111-62(35-45(3)4)78(130)112-64(37-47(7)8)83(135)116-70(48(9)117)84(136)107-58(19-15-33-101-87(96)97)73(125)106-59(28-29-68(89)121)76(128)104-56(17-13-31-99-85(92)93)74(126)108-60(71(91)123)38-50-20-24-53(119)25-21-50/h20-27,42-48,55-67,70,117,119-120H,11-19,28-41,88H2,1-10H3,(H2,89,121)(H2,90,122)(H2,91,123)(H,98,102)(H,103,118)(H,104,128)(H,105,129)(H,106,125)(H,107,136)(H,108,126)(H,109,124)(H,110,132)(H,111,134)(H,112,130)(H,113,133)(H,114,127)(H,115,131)(H,116,135)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t48-,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,70+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.501n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089441
PNG
(CHEMBL3578010)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C136H210N42O38/c1-65(2)50-90(168-128(212)100(63-180)175-110(194)70(11)156-118(202)94(55-73-25-33-78(183)34-26-73)170-123(207)95(56-74-27-35-79(184)36-28-74)169-113(197)83(19-14-46-152-134(144)145)159-125(209)98(59-103(139)187)173-120(204)91(51-66(3)4)165-117(201)87(40-43-105(189)190)161-116(200)88(41-44-106(191)192)162-129(213)101-22-17-49-178(101)132(216)81(137)62-179)119(203)158-84(20-15-47-153-135(146)147)114(198)172-97(58-76-61-150-64-155-76)124(208)171-96(57-75-29-37-80(185)38-30-75)122(206)166-92(52-67(5)6)121(205)174-99(60-104(140)188)126(210)167-93(53-68(7)8)127(211)176-107(69(9)10)130(214)177-108(71(12)181)131(215)163-85(21-16-48-154-136(148)149)111(195)160-86(39-42-102(138)186)115(199)157-82(18-13-45-151-133(142)143)112(196)164-89(109(141)193)54-72-23-31-77(182)32-24-72/h23-38,61,64-71,81-101,107-108,179-185H,13-22,39-60,62-63,137H2,1-12H3,(H2,138,186)(H2,139,187)(H2,140,188)(H2,141,193)(H,150,155)(H,156,202)(H,157,199)(H,158,203)(H,159,209)(H,160,195)(H,161,200)(H,162,213)(H,163,215)(H,164,196)(H,165,201)(H,166,206)(H,167,210)(H,168,212)(H,169,197)(H,170,207)(H,171,208)(H,172,198)(H,173,204)(H,174,205)(H,175,194)(H,176,211)(H,177,214)(H,189,190)(H,191,192)(H4,142,143,151)(H4,144,145,152)(H4,146,147,153)(H4,148,149,154)/t70-,71+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.600n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089441
PNG
(CHEMBL3578010)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C136H210N42O38/c1-65(2)50-90(168-128(212)100(63-180)175-110(194)70(11)156-118(202)94(55-73-25-33-78(183)34-26-73)170-123(207)95(56-74-27-35-79(184)36-28-74)169-113(197)83(19-14-46-152-134(144)145)159-125(209)98(59-103(139)187)173-120(204)91(51-66(3)4)165-117(201)87(40-43-105(189)190)161-116(200)88(41-44-106(191)192)162-129(213)101-22-17-49-178(101)132(216)81(137)62-179)119(203)158-84(20-15-47-153-135(146)147)114(198)172-97(58-76-61-150-64-155-76)124(208)171-96(57-75-29-37-80(185)38-30-75)122(206)166-92(52-67(5)6)121(205)174-99(60-104(140)188)126(210)167-93(53-68(7)8)127(211)176-107(69(9)10)130(214)177-108(71(12)181)131(215)163-85(21-16-48-154-136(148)149)111(195)160-86(39-42-102(138)186)115(199)157-82(18-13-45-151-133(142)143)112(196)164-89(109(141)193)54-72-23-31-77(182)32-24-72/h23-38,61,64-71,81-101,107-108,179-185H,13-22,39-60,62-63,137H2,1-12H3,(H2,138,186)(H2,139,187)(H2,140,188)(H2,141,193)(H,150,155)(H,156,202)(H,157,199)(H,158,203)(H,159,209)(H,160,195)(H,161,200)(H,162,213)(H,163,215)(H,164,196)(H,165,201)(H,166,206)(H,167,210)(H,168,212)(H,169,197)(H,170,207)(H,171,208)(H,172,198)(H,173,204)(H,174,205)(H,175,194)(H,176,211)(H,177,214)(H,189,190)(H,191,192)(H4,142,143,151)(H4,144,145,152)(H4,146,147,153)(H4,148,149,154)/t70-,71+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,107-,108-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.631n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197025
PNG
(CHEMBL439904 | PYY(3-36))
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C180H279N53O54/c1-17-91(12)141(185)171(282)214-114(27-18-19-61-181)175(286)232-67-25-33-130(232)169(280)211-111(53-58-137(247)248)147(258)204-94(15)174(285)231-66-24-32-129(231)168(279)200-82-135(244)205-109(52-57-136(245)246)152(263)226-126(80-140(253)254)157(268)203-93(14)146(257)228-128(84-235)176(287)233-68-26-34-131(233)170(281)212-113(55-60-139(251)252)154(265)210-112(54-59-138(249)250)155(266)216-117(70-87(4)5)159(270)224-124(78-133(183)242)164(275)208-106(29-21-63-197-178(189)190)150(261)220-121(75-98-39-47-103(239)48-40-98)162(273)221-120(74-97-37-45-102(238)46-38-97)156(267)202-92(13)145(256)227-127(83-234)167(278)219-116(69-86(2)3)158(269)207-107(30-22-64-198-179(191)192)151(262)223-123(77-100-81-195-85-201-100)163(274)222-122(76-99-41-49-104(240)50-42-99)161(272)217-118(71-88(6)7)160(271)225-125(79-134(184)243)165(276)218-119(72-89(8)9)166(277)229-142(90(10)11)172(283)230-143(95(16)236)173(284)213-108(31-23-65-199-180(193)194)148(259)209-110(51-56-132(182)241)153(264)206-105(28-20-62-196-177(187)188)149(260)215-115(144(186)255)73-96-35-43-101(237)44-36-96/h35-50,81,85-95,105-131,141-143,234-240H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,241)(H2,183,242)(H2,184,243)(H2,186,255)(H,195,201)(H,200,279)(H,202,267)(H,203,268)(H,204,258)(H,205,244)(H,206,264)(H,207,269)(H,208,275)(H,209,259)(H,210,265)(H,211,280)(H,212,281)(H,213,284)(H,214,282)(H,215,260)(H,216,266)(H,217,272)(H,218,276)(H,219,278)(H,220,261)(H,221,273)(H,222,274)(H,223,262)(H,224,270)(H,225,271)(H,226,263)(H,227,256)(H,228,257)(H,229,277)(H,230,283)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)(H4,193,194,199)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/an/an/a 1n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444587
PNG
(CHEMBL3099724)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H273N53O54/c1-16-88(10)138(182)168(279)212-112(26-17-18-60-178)172(283)229-66-24-32-127(229)166(277)209-109(52-57-134(244)245)145(256)202-92(14)171(282)228-65-23-31-126(228)165(276)197-80-132(241)203-107(51-56-133(242)243)150(261)223-123(78-137(250)251)156(267)200-90(12)143(254)225-125(82-232)173(284)230-67-25-33-128(230)167(278)210-111(54-59-136(248)249)152(263)208-110(53-58-135(246)247)153(264)214-115(69-85(4)5)158(269)222-122(77-131(181)240)163(274)206-104(28-20-62-194-175(186)187)148(259)217-118(73-96-38-46-101(236)47-39-96)161(272)218-117(72-95-36-44-100(235)45-37-95)154(265)199-89(11)142(253)224-124(81-231)164(275)216-114(68-84(2)3)157(268)205-105(29-21-63-195-176(188)189)149(260)220-120(75-98-79-192-83-198-98)162(273)219-119(74-97-40-48-102(237)49-41-97)160(271)215-116(70-86(6)7)159(270)221-121(76-130(180)239)155(266)201-91(13)144(255)226-139(87(8)9)169(280)227-140(93(15)233)170(281)211-106(30-22-64-196-177(190)191)146(257)207-108(50-55-129(179)238)151(262)204-103(27-19-61-193-174(184)185)147(258)213-113(141(183)252)71-94-34-42-99(234)43-35-94/h34-49,79,83-93,103-128,138-140,231-237H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,238)(H2,180,239)(H2,181,240)(H2,183,252)(H,192,198)(H,197,276)(H,199,265)(H,200,267)(H,201,266)(H,202,256)(H,203,241)(H,204,262)(H,205,268)(H,206,274)(H,207,257)(H,208,263)(H,209,277)(H,210,278)(H,211,281)(H,212,279)(H,213,258)(H,214,264)(H,215,271)(H,216,275)(H,217,259)(H,218,272)(H,219,273)(H,220,260)(H,221,270)(H,222,269)(H,223,261)(H,224,253)(H,225,254)(H,226,255)(H,227,280)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 1n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444587
PNG
(CHEMBL3099724)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H273N53O54/c1-16-88(10)138(182)168(279)212-112(26-17-18-60-178)172(283)229-66-24-32-127(229)166(277)209-109(52-57-134(244)245)145(256)202-92(14)171(282)228-65-23-31-126(228)165(276)197-80-132(241)203-107(51-56-133(242)243)150(261)223-123(78-137(250)251)156(267)200-90(12)143(254)225-125(82-232)173(284)230-67-25-33-128(230)167(278)210-111(54-59-136(248)249)152(263)208-110(53-58-135(246)247)153(264)214-115(69-85(4)5)158(269)222-122(77-131(181)240)163(274)206-104(28-20-62-194-175(186)187)148(259)217-118(73-96-38-46-101(236)47-39-96)161(272)218-117(72-95-36-44-100(235)45-37-95)154(265)199-89(11)142(253)224-124(81-231)164(275)216-114(68-84(2)3)157(268)205-105(29-21-63-195-176(188)189)149(260)220-120(75-98-79-192-83-198-98)162(273)219-119(74-97-40-48-102(237)49-41-97)160(271)215-116(70-86(6)7)159(270)221-121(76-130(180)239)155(266)201-91(13)144(255)226-139(87(8)9)169(280)227-140(93(15)233)170(281)211-106(30-22-64-196-177(190)191)146(257)207-108(50-55-129(179)238)151(262)204-103(27-19-61-193-174(184)185)147(258)213-113(141(183)252)71-94-34-42-99(234)43-35-94/h34-49,79,83-93,103-128,138-140,231-237H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,238)(H2,180,239)(H2,181,240)(H2,183,252)(H,192,198)(H,197,276)(H,199,265)(H,200,267)(H,201,266)(H,202,256)(H,203,241)(H,204,262)(H,205,268)(H,206,274)(H,207,257)(H,208,263)(H,209,277)(H,210,278)(H,211,281)(H,212,279)(H,213,258)(H,214,264)(H,215,271)(H,216,275)(H,217,259)(H,218,272)(H,219,273)(H,220,260)(H,221,270)(H,222,269)(H,223,261)(H,224,253)(H,225,254)(H,226,255)(H,227,280)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 1.30n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089436
PNG
(CHEMBL3578015)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C140H209N39O28/c1-75(2)60-102(169-121(191)95(161-81(12)181)37-21-23-55-154-116(187)53-59-155-120(190)99(49-51-113(143)184)164-127(197)103(61-76(3)4)171-133(203)110(69-87-72-159-94-36-19-18-34-92(87)94)176-131(201)107(66-82-28-14-13-15-29-82)174-132(202)109(168-119(189)93(142)35-20-22-54-141)68-86-32-24-31-85-30-16-17-33-91(85)86)126(196)163-97(39-26-57-157-139(149)150)124(194)177-111(70-88-73-153-74-160-88)134(204)175-108(67-84-43-47-90(183)48-44-84)130(200)170-105(63-78(7)8)129(199)178-112(71-115(145)186)135(205)172-104(62-77(5)6)128(198)173-106(64-79(9)10)136(206)179-117(80(11)180)137(207)166-98(40-27-58-158-140(151)152)122(192)165-100(50-52-114(144)185)125(195)162-96(38-25-56-156-138(147)148)123(193)167-101(118(146)188)65-83-41-45-89(182)46-42-83/h13-19,24,28-34,36,41-48,72-80,93,95-112,117,159,180,182-183H,20-23,25-27,35,37-40,49-71,141-142H2,1-12H3,(H2,143,184)(H2,144,185)(H2,145,186)(H2,146,188)(H,153,160)(H,154,187)(H,155,190)(H,161,181)(H,162,195)(H,163,196)(H,164,197)(H,165,192)(H,166,207)(H,167,193)(H,168,189)(H,169,191)(H,170,200)(H,171,203)(H,172,205)(H,173,198)(H,174,202)(H,175,204)(H,176,201)(H,177,194)(H,178,199)(H,179,206)(H4,147,148,156)(H4,149,150,157)(H4,151,152,158)/t80-,93+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109-,110-,111+,112+,117+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.60n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089436
PNG
(CHEMBL3578015)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C140H209N39O28/c1-75(2)60-102(169-121(191)95(161-81(12)181)37-21-23-55-154-116(187)53-59-155-120(190)99(49-51-113(143)184)164-127(197)103(61-76(3)4)171-133(203)110(69-87-72-159-94-36-19-18-34-92(87)94)176-131(201)107(66-82-28-14-13-15-29-82)174-132(202)109(168-119(189)93(142)35-20-22-54-141)68-86-32-24-31-85-30-16-17-33-91(85)86)126(196)163-97(39-26-57-157-139(149)150)124(194)177-111(70-88-73-153-74-160-88)134(204)175-108(67-84-43-47-90(183)48-44-84)130(200)170-105(63-78(7)8)129(199)178-112(71-115(145)186)135(205)172-104(62-77(5)6)128(198)173-106(64-79(9)10)136(206)179-117(80(11)180)137(207)166-98(40-27-58-158-140(151)152)122(192)165-100(50-52-114(144)185)125(195)162-96(38-25-56-156-138(147)148)123(193)167-101(118(146)188)65-83-41-45-89(182)46-42-83/h13-19,24,28-34,36,41-48,72-80,93,95-112,117,159,180,182-183H,20-23,25-27,35,37-40,49-71,141-142H2,1-12H3,(H2,143,184)(H2,144,185)(H2,145,186)(H2,146,188)(H,153,160)(H,154,187)(H,155,190)(H,161,181)(H,162,195)(H,163,196)(H,164,197)(H,165,192)(H,166,207)(H,167,193)(H,168,189)(H,169,191)(H,170,200)(H,171,203)(H,172,205)(H,173,198)(H,174,202)(H,175,204)(H,176,201)(H,177,194)(H,178,199)(H,179,206)(H4,147,148,156)(H4,149,150,157)(H4,151,152,158)/t80-,93+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109-,110-,111+,112+,117+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.70n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089440
PNG
(CHEMBL3578018)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)NCC(NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(N)=O
Show InChI InChI=1/C145H218N40O29/c1-77(2)60-103(122(150)194)172-131(203)106(62-79(5)6)175-137(209)113(70-90-73-162-96-37-21-20-36-95(90)96)182-135(207)110(67-85-30-16-15-17-31-85)179-136(208)112(69-89-34-26-33-88-32-18-19-35-94(88)89)181-127(199)98(39-23-25-56-147)167-124(196)97(38-22-24-55-146)166-120(193)54-53-119(192)163-75-116(165-84(14)187)141(213)178-105(61-78(3)4)130(202)169-100(41-28-58-160-144(154)155)128(200)183-114(71-91-74-158-76-164-91)138(210)180-111(68-87-45-49-93(189)50-46-87)134(206)174-108(64-81(9)10)133(205)184-115(72-118(149)191)139(211)176-107(63-80(7)8)132(204)177-109(65-82(11)12)140(212)185-121(83(13)186)142(214)171-101(42-29-59-161-145(156)157)125(197)170-102(51-52-117(148)190)129(201)168-99(40-27-57-159-143(152)153)126(198)173-104(123(151)195)66-86-43-47-92(188)48-44-86/h15-21,26,30-37,43-50,73-74,76-83,97-116,121,162,186,188-189H,22-25,27-29,38-42,51-72,75,146-147H2,1-14H3,(H2,148,190)(H2,149,191)(H2,150,194)(H2,151,195)(H,158,164)(H,163,192)(H,165,187)(H,166,193)(H,167,196)(H,168,201)(H,169,202)(H,170,197)(H,171,214)(H,172,203)(H,173,198)(H,174,206)(H,175,209)(H,176,211)(H,177,204)(H,178,213)(H,179,208)(H,180,210)(H,181,199)(H,182,207)(H,183,200)(H,184,205)(H,185,212)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t83-,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113-,114+,115+,116?,121+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089440
PNG
(CHEMBL3578018)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)NCC(NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(N)=O
Show InChI InChI=1/C145H218N40O29/c1-77(2)60-103(122(150)194)172-131(203)106(62-79(5)6)175-137(209)113(70-90-73-162-96-37-21-20-36-95(90)96)182-135(207)110(67-85-30-16-15-17-31-85)179-136(208)112(69-89-34-26-33-88-32-18-19-35-94(88)89)181-127(199)98(39-23-25-56-147)167-124(196)97(38-22-24-55-146)166-120(193)54-53-119(192)163-75-116(165-84(14)187)141(213)178-105(61-78(3)4)130(202)169-100(41-28-58-160-144(154)155)128(200)183-114(71-91-74-158-76-164-91)138(210)180-111(68-87-45-49-93(189)50-46-87)134(206)174-108(64-81(9)10)133(205)184-115(72-118(149)191)139(211)176-107(63-80(7)8)132(204)177-109(65-82(11)12)140(212)185-121(83(13)186)142(214)171-101(42-29-59-161-145(156)157)125(197)170-102(51-52-117(148)190)129(201)168-99(40-27-57-159-143(152)153)126(198)173-104(123(151)195)66-86-43-47-92(188)48-44-86/h15-21,26,30-37,43-50,73-74,76-83,97-116,121,162,186,188-189H,22-25,27-29,38-42,51-72,75,146-147H2,1-14H3,(H2,148,190)(H2,149,191)(H2,150,194)(H2,151,195)(H,158,164)(H,163,192)(H,165,187)(H,166,193)(H,167,196)(H,168,201)(H,169,202)(H,170,197)(H,171,214)(H,172,203)(H,173,198)(H,174,206)(H,175,209)(H,176,211)(H,177,204)(H,178,213)(H,179,208)(H,180,210)(H,181,199)(H,182,207)(H,183,200)(H,184,205)(H,185,212)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t83-,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113-,114+,115+,116?,121+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 2n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444588
PNG
(CHEMBL3099722)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)210-110(26-17-18-60-178)171(281)228-66-24-31-126(228)164(274)207-107(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-30-125(227)163(273)197-80-132(240)203-106(51-56-133(241)242)149(259)222-122(78-137(249)250)154(264)200-90(12)143(253)224-124(82-231)172(282)229-67-25-32-127(229)165(275)208-109(54-59-136(247)248)150(260)206-108(53-58-135(245)246)151(261)213-114(69-85(4)5)156(266)221-121(77-131(181)239)161(271)205-103(27-19-61-193-174(184)185)147(257)216-117(73-96-38-46-101(235)47-39-96)159(269)217-116(72-95-36-44-100(234)45-37-95)152(262)199-89(11)142(252)223-123(81-230)162(272)215-113(68-84(2)3)155(265)204-104(28-20-62-194-175(186)187)148(258)219-119(75-98-79-192-83-198-98)160(270)218-118(74-97-40-48-102(236)49-41-97)158(268)214-115(70-86(6)7)157(267)220-120(76-130(180)238)153(263)201-91(13)144(254)225-139(87(8)9)168(278)226-140(93(15)232)169(279)209-105(29-21-63-195-176(188)189)146(256)211-111(50-55-129(179)237)173(283)284-128(33-22-64-196-177(190)191)166(276)212-112(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,273)(H,199,262)(H,200,264)(H,201,263)(H,202,255)(H,203,240)(H,204,265)(H,205,271)(H,206,260)(H,207,274)(H,208,275)(H,209,279)(H,210,277)(H,211,256)(H,212,276)(H,213,261)(H,214,268)(H,215,272)(H,216,257)(H,217,269)(H,218,270)(H,219,258)(H,220,267)(H,221,266)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,278)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 2.20n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197019
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1cccc(N)c1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H121N27O18/c1-39(2)30-55(100-71(119)57(33-44-19-23-49(109)24-20-44)102-72(120)58(35-47-37-90-38-94-47)103-68(116)50(14-9-27-91-77(84)85)95-65(113)45-12-8-13-46(80)34-45)70(118)104-59(36-61(82)111)73(121)101-56(31-40(3)4)74(122)105-62(41(5)6)75(123)106-63(42(7)107)76(124)98-52(16-11-29-93-79(88)89)66(114)97-53(25-26-60(81)110)69(117)96-51(15-10-28-92-78(86)87)67(115)99-54(64(83)112)32-43-17-21-48(108)22-18-43/h8,12-13,17-24,34,37-42,50-59,62-63,107-109H,9-11,14-16,25-33,35-36,80H2,1-7H3,(H2,81,110)(H2,82,111)(H2,83,112)(H,90,94)(H,95,113)(H,96,117)(H,97,114)(H,98,124)(H,99,115)(H,100,119)(H,101,121)(H,102,120)(H,103,116)(H,104,118)(H,105,122)(H,106,123)(H4,84,85,91)(H4,86,87,92)(H4,88,89,93)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197023
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES COc1cc(ccc1N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C80H123N27O19/c1-39(2)30-55(101-72(120)57(33-44-17-22-48(110)23-18-44)103-73(121)58(35-46-37-91-38-95-46)104-69(117)50(12-9-27-92-78(85)86)96-66(114)45-19-24-49(81)60(34-45)126-8)71(119)105-59(36-62(83)112)74(122)102-56(31-40(3)4)75(123)106-63(41(5)6)76(124)107-64(42(7)108)77(125)99-52(14-11-29-94-80(89)90)67(115)98-53(25-26-61(82)111)70(118)97-51(13-10-28-93-79(87)88)68(116)100-54(65(84)113)32-43-15-20-47(109)21-16-43/h15-24,34,37-42,50-59,63-64,108-110H,9-14,25-33,35-36,81H2,1-8H3,(H2,82,111)(H2,83,112)(H2,84,113)(H,91,95)(H,96,114)(H,97,118)(H,98,115)(H,99,125)(H,100,116)(H,101,120)(H,102,122)(H,103,121)(H,104,117)(H,105,119)(H,106,123)(H,107,124)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,63+,64+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 3n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197010
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccccc1N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H121N27O18/c1-39(2)31-55(100-71(119)57(34-44-20-24-47(109)25-21-44)102-72(120)58(35-45-37-90-38-94-45)103-68(116)50(15-10-28-91-77(84)85)95-65(113)48-13-8-9-14-49(48)80)70(118)104-59(36-61(82)111)73(121)101-56(32-40(3)4)74(122)105-62(41(5)6)75(123)106-63(42(7)107)76(124)98-52(17-12-30-93-79(88)89)66(114)97-53(26-27-60(81)110)69(117)96-51(16-11-29-92-78(86)87)67(115)99-54(64(83)112)33-43-18-22-46(108)23-19-43/h8-9,13-14,18-25,37-42,50-59,62-63,107-109H,10-12,15-17,26-36,80H2,1-7H3,(H2,81,110)(H2,82,111)(H2,83,112)(H,90,94)(H,95,113)(H,96,117)(H,97,114)(H,98,124)(H,99,115)(H,100,119)(H,101,121)(H,102,120)(H,103,116)(H,104,118)(H,105,122)(H,106,123)(H4,84,85,91)(H4,86,87,92)(H4,88,89,93)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 3n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197020
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(N)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H121N27O18/c1-39(2)31-55(100-71(119)57(34-44-16-24-49(109)25-17-44)102-72(120)58(35-47-37-90-38-94-47)103-68(116)50(11-8-28-91-77(84)85)95-65(113)45-18-20-46(80)21-19-45)70(118)104-59(36-61(82)111)73(121)101-56(32-40(3)4)74(122)105-62(41(5)6)75(123)106-63(42(7)107)76(124)98-52(13-10-30-93-79(88)89)66(114)97-53(26-27-60(81)110)69(117)96-51(12-9-29-92-78(86)87)67(115)99-54(64(83)112)33-43-14-22-48(108)23-15-43/h14-25,37-42,50-59,62-63,107-109H,8-13,26-36,80H2,1-7H3,(H2,81,110)(H2,82,111)(H2,83,112)(H,90,94)(H,95,113)(H,96,117)(H,97,114)(H,98,124)(H,99,115)(H,100,119)(H,101,121)(H,102,120)(H,103,116)(H,104,118)(H,105,122)(H,106,123)(H4,84,85,91)(H4,86,87,92)(H4,88,89,93)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 3n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197010
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccccc1N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H121N27O18/c1-39(2)31-55(100-71(119)57(34-44-20-24-47(109)25-21-44)102-72(120)58(35-45-37-90-38-94-45)103-68(116)50(15-10-28-91-77(84)85)95-65(113)48-13-8-9-14-49(48)80)70(118)104-59(36-61(82)111)73(121)101-56(32-40(3)4)74(122)105-62(41(5)6)75(123)106-63(42(7)107)76(124)98-52(17-12-30-93-79(88)89)66(114)97-53(26-27-60(81)110)69(117)96-51(16-11-29-92-78(86)87)67(115)99-54(64(83)112)33-43-18-22-46(108)23-19-43/h8-9,13-14,18-25,37-42,50-59,62-63,107-109H,10-12,15-17,26-36,80H2,1-7H3,(H2,81,110)(H2,82,111)(H2,83,112)(H,90,94)(H,95,113)(H,96,117)(H,97,114)(H,98,124)(H,99,115)(H,100,119)(H,101,121)(H,102,120)(H,103,116)(H,104,118)(H,105,122)(H,106,123)(H4,84,85,91)(H4,86,87,92)(H4,88,89,93)/t42-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 3n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 by [35S]GTPgammaS cAMP accumulation assay


J Med Chem 50: 2264-8 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089439
PNG
(CHEMBL3578017)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)NCC(NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(N)=O
Show InChI InChI=1/C139H206N38O28/c1-73(2)56-98(117(143)186)164-125(194)101(58-75(5)6)167-131(200)108(66-86-69-155-92-35-21-20-34-91(86)92)174-129(198)105(63-81-28-16-15-17-29-81)171-130(199)107(65-85-32-24-31-84-30-18-19-33-90(84)85)173-119(188)93(36-22-23-52-140)159-115(185)51-50-114(184)156-71-111(158-80(14)179)135(204)170-100(57-74(3)4)124(193)161-95(38-26-54-153-138(147)148)122(191)175-109(67-87-70-151-72-157-87)132(201)172-106(64-83-42-46-89(181)47-43-83)128(197)166-103(60-77(9)10)127(196)176-110(68-113(142)183)133(202)168-102(59-76(7)8)126(195)169-104(61-78(11)12)134(203)177-116(79(13)178)136(205)163-96(39-27-55-154-139(149)150)120(189)162-97(48-49-112(141)182)123(192)160-94(37-25-53-152-137(145)146)121(190)165-99(118(144)187)62-82-40-44-88(180)45-41-82/h15-21,24,28-35,40-47,69-70,72-79,93-111,116,155,178,180-181H,22-23,25-27,36-39,48-68,71,140H2,1-14H3,(H2,141,182)(H2,142,183)(H2,143,186)(H2,144,187)(H,151,157)(H,156,184)(H,158,179)(H,159,185)(H,160,192)(H,161,193)(H,162,189)(H,163,205)(H,164,194)(H,165,190)(H,166,197)(H,167,200)(H,168,202)(H,169,195)(H,170,204)(H,171,199)(H,172,201)(H,173,188)(H,174,198)(H,175,191)(H,176,196)(H,177,203)(H4,145,146,152)(H4,147,148,153)(H4,149,150,154)/t79-,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107-,108-,109+,110+,111?,116+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
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UniChem

Similars

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PubMed
n/an/an/an/a 3.20n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089439
PNG
(CHEMBL3578017)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)NCC(NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(N)=O
Show InChI InChI=1/C139H206N38O28/c1-73(2)56-98(117(143)186)164-125(194)101(58-75(5)6)167-131(200)108(66-86-69-155-92-35-21-20-34-91(86)92)174-129(198)105(63-81-28-16-15-17-29-81)171-130(199)107(65-85-32-24-31-84-30-18-19-33-90(84)85)173-119(188)93(36-22-23-52-140)159-115(185)51-50-114(184)156-71-111(158-80(14)179)135(204)170-100(57-74(3)4)124(193)161-95(38-26-54-153-138(147)148)122(191)175-109(67-87-70-151-72-157-87)132(201)172-106(64-83-42-46-89(181)47-43-83)128(197)166-103(60-77(9)10)127(196)176-110(68-113(142)183)133(202)168-102(59-76(7)8)126(195)169-104(61-78(11)12)134(203)177-116(79(13)178)136(205)163-96(39-27-55-154-139(149)150)120(189)162-97(48-49-112(141)182)123(192)160-94(37-25-53-152-137(145)146)121(190)165-99(118(144)187)62-82-40-44-88(180)45-41-82/h15-21,24,28-35,40-47,69-70,72-79,93-111,116,155,178,180-181H,22-23,25-27,36-39,48-68,71,140H2,1-14H3,(H2,141,182)(H2,142,183)(H2,143,186)(H2,144,187)(H,151,157)(H,156,184)(H,158,179)(H,159,185)(H,160,192)(H,161,193)(H,162,189)(H,163,205)(H,164,194)(H,165,190)(H,166,197)(H,167,200)(H,168,202)(H,169,195)(H,170,204)(H,171,199)(H,172,201)(H,173,188)(H,174,198)(H,175,191)(H,176,196)(H,177,203)(H4,145,146,152)(H4,147,148,153)(H4,149,150,154)/t79-,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107-,108-,109+,110+,111?,116+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 3.20n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444590
PNG
(CHEMBL3099727)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)168(278)211-111(26-17-18-60-178)171(281)228-66-24-31-126(228)165(275)208-108(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-30-125(227)164(274)197-80-132(240)203-106(51-56-133(241)242)149(259)222-122(78-137(249)250)155(265)200-90(12)143(253)224-124(82-231)172(282)229-67-25-32-127(229)166(276)209-110(54-59-136(247)248)151(261)207-109(53-58-135(245)246)152(262)213-114(69-85(4)5)157(267)221-121(77-131(181)239)162(272)206-104(28-20-62-194-175(186)187)147(257)216-117(73-96-38-46-101(235)47-39-96)160(270)217-116(72-95-36-44-100(234)45-37-95)153(263)199-89(11)142(252)223-123(81-230)163(273)215-113(68-84(2)3)156(266)205-105(29-21-63-195-176(188)189)148(258)219-119(75-98-79-192-83-198-98)161(271)218-118(74-97-40-48-102(236)49-41-97)159(269)214-115(70-86(6)7)158(268)220-120(76-130(180)238)154(264)201-91(13)144(254)225-139(87(8)9)169(279)226-140(93(15)232)173(283)284-128(33-22-64-196-177(190)191)167(277)210-107(50-55-129(179)237)150(260)204-103(27-19-61-193-174(184)185)146(256)212-112(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,274)(H,199,263)(H,200,265)(H,201,264)(H,202,255)(H,203,240)(H,204,260)(H,205,266)(H,206,272)(H,207,261)(H,208,275)(H,209,276)(H,210,277)(H,211,278)(H,212,256)(H,213,262)(H,214,269)(H,215,273)(H,216,257)(H,217,270)(H,218,271)(H,219,258)(H,220,268)(H,221,267)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,279)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
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Article
n/an/an/an/a 3.60n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089438
PNG
(CHEMBL3578016)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C143H215N39O28/c1-78(2)63-105(172-124(194)98(164-84(12)184)40-23-26-58-157-119(190)44-17-14-25-59-158-123(193)102(53-55-116(146)187)167-130(200)106(64-79(3)4)174-136(206)113(72-90-75-162-97-39-21-20-37-95(90)97)179-134(204)110(69-85-31-15-13-16-32-85)177-135(205)112(171-122(192)96(145)38-22-24-57-144)71-89-35-27-34-88-33-18-19-36-94(88)89)129(199)166-100(42-29-61-160-142(152)153)127(197)180-114(73-91-76-156-77-163-91)137(207)178-111(70-87-47-51-93(186)52-48-87)133(203)173-108(66-81(7)8)132(202)181-115(74-118(148)189)138(208)175-107(65-80(5)6)131(201)176-109(67-82(9)10)139(209)182-120(83(11)183)140(210)169-101(43-30-62-161-143(154)155)125(195)168-103(54-56-117(147)188)128(198)165-99(41-28-60-159-141(150)151)126(196)170-104(121(149)191)68-86-45-49-92(185)50-46-86/h13,15-16,18-21,27,31-37,39,45-52,75-83,96,98-115,120,162,183,185-186H,14,17,22-26,28-30,38,40-44,53-74,144-145H2,1-12H3,(H2,146,187)(H2,147,188)(H2,148,189)(H2,149,191)(H,156,163)(H,157,190)(H,158,193)(H,164,184)(H,165,198)(H,166,199)(H,167,200)(H,168,195)(H,169,210)(H,170,196)(H,171,192)(H,172,194)(H,173,203)(H,174,206)(H,175,208)(H,176,201)(H,177,205)(H,178,207)(H,179,204)(H,180,197)(H,181,202)(H,182,209)(H4,150,151,159)(H4,152,153,160)(H4,154,155,161)/t83-,96+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112-,113-,114+,115+,120+/s2
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n/an/an/an/a 3.90n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089438
PNG
(CHEMBL3578016)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1/C143H215N39O28/c1-78(2)63-105(172-124(194)98(164-84(12)184)40-23-26-58-157-119(190)44-17-14-25-59-158-123(193)102(53-55-116(146)187)167-130(200)106(64-79(3)4)174-136(206)113(72-90-75-162-97-39-21-20-37-95(90)97)179-134(204)110(69-85-31-15-13-16-32-85)177-135(205)112(171-122(192)96(145)38-22-24-57-144)71-89-35-27-34-88-33-18-19-36-94(88)89)129(199)166-100(42-29-61-160-142(152)153)127(197)180-114(73-91-76-156-77-163-91)137(207)178-111(70-87-47-51-93(186)52-48-87)133(203)173-108(66-81(7)8)132(202)181-115(74-118(148)189)138(208)175-107(65-80(5)6)131(201)176-109(67-82(9)10)139(209)182-120(83(11)183)140(210)169-101(43-30-62-161-143(154)155)125(195)168-103(54-56-117(147)188)128(198)165-99(41-28-60-159-141(150)151)126(196)170-104(121(149)191)68-86-45-49-92(185)50-46-86/h13,15-16,18-21,27,31-37,39,45-52,75-83,96,98-115,120,162,183,185-186H,14,17,22-26,28-30,38,40-44,53-74,144-145H2,1-12H3,(H2,146,187)(H2,147,188)(H2,148,189)(H2,149,191)(H,156,163)(H,157,190)(H,158,193)(H,164,184)(H,165,198)(H,166,199)(H,167,200)(H,168,195)(H,169,210)(H,170,196)(H,171,192)(H,172,194)(H,173,203)(H,174,206)(H,175,208)(H,176,201)(H,177,205)(H,178,207)(H,179,204)(H,180,197)(H,181,202)(H,182,209)(H4,150,151,159)(H4,152,153,160)(H4,154,155,161)/t83-,96+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112-,113-,114+,115+,120+/s2
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n/an/an/an/a 4n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197022
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(N)c(C)c1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C80H123N27O18/c1-39(2)30-56(101-72(120)58(34-45-17-22-49(110)23-18-45)103-73(121)59(35-47-37-91-38-95-47)104-69(117)51(12-9-27-92-78(85)86)96-66(114)46-19-24-50(81)42(7)32-46)71(119)105-60(36-62(83)112)74(122)102-57(31-40(3)4)75(123)106-63(41(5)6)76(124)107-64(43(8)108)77(125)99-53(14-11-29-94-80(89)90)67(115)98-54(25-26-61(82)111)70(118)97-52(13-10-28-93-79(87)88)68(116)100-55(65(84)113)33-44-15-20-48(109)21-16-44/h15-24,32,37-41,43,51-60,63-64,108-110H,9-14,25-31,33-36,81H2,1-8H3,(H2,82,111)(H2,83,112)(H2,84,113)(H,91,95)(H,96,114)(H,97,118)(H,98,115)(H,99,125)(H,100,116)(H,101,120)(H,102,122)(H,103,121)(H,104,117)(H,105,119)(H,106,123)(H,107,124)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t43-,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,63+,64+/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50210327
PNG
((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Show SMILES CSc1ncccc1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C80H123N27O18S/c1-40(2)31-55(70(119)103-57(33-42(5)6)75(124)107-63(43(7)108)76(125)99-52(16-12-30-94-80(88)89)66(115)98-53(25-26-61(81)111)69(118)97-51(15-11-29-93-79(86)87)67(116)100-54(64(83)113)34-44-17-21-47(109)22-18-44)102-74(123)60(37-62(82)112)106-71(120)56(32-41(3)4)101-72(121)58(35-45-19-23-48(110)24-20-45)104-73(122)59(36-46-38-90-39-95-46)105-68(117)50(14-10-28-92-78(84)85)96-65(114)49-13-9-27-91-77(49)126-8/h9,13,17-24,27,38-43,50-60,63,108-110H,10-12,14-16,25-26,28-37H2,1-8H3,(H2,81,111)(H2,82,112)(H2,83,113)(H,90,95)(H,96,114)(H,97,118)(H,98,115)(H,99,125)(H,100,116)(H,101,121)(H,102,123)(H,103,119)(H,104,122)(H,105,117)(H,106,120)(H,107,124)(H4,84,85,92)(H4,86,87,93)(H4,88,89,94)/t43-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,63+/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 by [35S]GTPgammaS cAMP accumulation assay


J Med Chem 50: 2264-8 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50205093
PNG
(CHEMBL428017 | LRHYLNLLTRQRY-NH2)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C81H131N27O19/c1-40(2)30-56(96-45(10)110)71(120)98-52(15-12-28-93-80(87)88)69(118)106-61(36-48-38-91-39-95-48)75(124)105-60(35-47-19-23-50(112)24-20-47)74(123)102-58(32-42(5)6)73(122)107-62(37-64(83)114)76(125)103-57(31-41(3)4)72(121)104-59(33-43(7)8)77(126)108-65(44(9)109)78(127)100-53(16-13-29-94-81(89)90)67(116)99-54(25-26-63(82)113)70(119)97-51(14-11-27-92-79(85)86)68(117)101-55(66(84)115)34-46-17-21-49(111)22-18-46/h17-24,38-44,51-62,65,109,111-112H,11-16,25-37H2,1-10H3,(H2,82,113)(H2,83,114)(H2,84,115)(H,91,95)(H,96,110)(H,97,119)(H,98,120)(H,99,116)(H,100,127)(H,101,117)(H,102,123)(H,103,125)(H,104,121)(H,105,124)(H,106,118)(H,107,122)(H,108,126)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t44-,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,65+/m1/s1
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n/an/an/an/a 6n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor in KAN-TS cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 17: 1916-9 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197021
PNG
((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H120N26O18/c1-40(2)32-55(99-71(118)57(35-45-21-25-49(108)26-22-45)101-72(119)58(36-47-38-89-39-93-47)102-68(115)50(16-11-29-90-77(83)84)94-65(112)46-14-9-8-10-15-46)70(117)103-59(37-61(81)110)73(120)100-56(33-41(3)4)74(121)104-62(42(5)6)75(122)105-63(43(7)106)76(123)97-52(18-13-31-92-79(87)88)66(113)96-53(27-28-60(80)109)69(116)95-51(17-12-30-91-78(85)86)67(114)98-54(64(82)111)34-44-19-23-48(107)24-20-44/h8-10,14-15,19-26,38-43,50-59,62-63,106-108H,11-13,16-18,27-37H2,1-7H3,(H2,80,109)(H2,81,110)(H2,82,111)(H,89,93)(H,94,112)(H,95,116)(H,96,113)(H,97,123)(H,98,114)(H,99,118)(H,100,120)(H,101,119)(H,102,115)(H,103,117)(H,104,121)(H,105,122)(H4,83,84,90)(H4,85,86,91)(H4,87,88,92)/t43-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
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n/an/an/an/a 6n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50205093
PNG
(CHEMBL428017 | LRHYLNLLTRQRY-NH2)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C81H131N27O19/c1-40(2)30-56(96-45(10)110)71(120)98-52(15-12-28-93-80(87)88)69(118)106-61(36-48-38-91-39-95-48)75(124)105-60(35-47-19-23-50(112)24-20-47)74(123)102-58(32-42(5)6)73(122)107-62(37-64(83)114)76(125)103-57(31-41(3)4)72(121)104-59(33-43(7)8)77(126)108-65(44(9)109)78(127)100-53(16-13-29-94-81(89)90)67(116)99-54(25-26-63(82)113)70(119)97-51(14-11-27-92-79(85)86)68(117)101-55(66(84)115)34-46-17-21-49(111)22-18-46/h17-24,38-44,51-62,65,109,111-112H,11-16,25-37H2,1-10H3,(H2,82,113)(H2,83,114)(H2,84,115)(H,91,95)(H,96,110)(H,97,119)(H,98,120)(H,99,116)(H,100,127)(H,101,117)(H,102,123)(H,103,125)(H,104,121)(H,105,124)(H,106,118)(H,107,122)(H,108,126)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t44-,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,65+/m1/s1
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n/an/an/an/a 6n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at NPYY2 receptor (unknown origin)


Bioorg Med Chem Lett 24: 430-41 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50445617
PNG
(CHEMBL3104112)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)c1cccnc1SCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C182H293N43O59S/c1-108(2)93-133(164(252)204-127(22-16-50-199-181(191)192)159(247)218-140(101-119-104-195-107-201-119)169(257)217-139(100-118-31-39-123(233)40-32-118)167(255)212-135(95-110(5)6)166(254)220-142(103-148(185)236)171(259)213-136(96-111(7)8)172(260)223-151(112(9)10)175(263)224-152(114(12)229)176(264)209-128(23-17-51-200-182(193)194)156(244)206-129(41-44-146(183)234)160(248)203-125(20-14-48-197-179(187)188)157(245)210-132(153(186)241)97-115-25-33-120(230)34-26-115)214-173(261)143(105-227)221-154(242)113(11)202-163(251)137(98-116-27-35-121(231)36-28-116)216-168(256)138(99-117-29-37-122(232)38-30-117)215-158(246)126(21-15-49-198-180(189)190)205-170(258)141(102-147(184)235)219-165(253)134(94-109(3)4)211-162(250)130(42-45-149(237)238)207-161(249)131(43-46-150(239)240)208-174(262)145-24-18-52-225(145)178(265)144(106-228)222-155(243)124-19-13-47-196-177(124)285-92-91-284-90-89-283-88-87-282-86-85-281-84-83-280-82-81-279-80-79-278-78-77-277-76-75-276-74-73-275-72-71-274-70-69-273-68-67-272-66-65-271-64-63-270-62-61-269-60-59-268-58-57-267-56-55-266-54-53-226/h13,19,25-40,47,104,107-114,125-145,151-152,226-233H,14-18,20-24,41-46,48-103,105-106H2,1-12H3,(H2,183,234)(H2,184,235)(H2,185,236)(H2,186,241)(H,195,201)(H,202,251)(H,203,248)(H,204,252)(H,205,258)(H,206,244)(H,207,249)(H,208,262)(H,209,264)(H,210,245)(H,211,250)(H,212,255)(H,213,259)(H,214,261)(H,215,246)(H,216,256)(H,217,257)(H,218,247)(H,219,253)(H,220,254)(H,221,242)(H,222,243)(H,223,260)(H,224,263)(H,237,238)(H,239,240)(H4,187,188,197)(H4,189,190,198)(H4,191,192,199)(H4,193,194,200)/t113-,114+,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,151-,152-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 6.5n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Agonist activity at NPYY2 receptor (unknown origin)


Bioorg Med Chem Lett 24: 430-41 (2014)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444591
PNG
(CHEMBL3099726)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)O[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)168(278)212-112(26-17-18-60-178)171(281)228-66-24-32-127(228)166(276)209-109(52-57-134(243)244)145(255)202-92(14)170(280)227-65-23-31-126(227)165(275)197-80-132(240)203-107(51-56-133(241)242)150(260)223-123(78-137(249)250)156(266)200-90(12)143(253)225-125(82-231)172(282)229-67-25-33-128(229)167(277)210-111(54-59-136(247)248)152(262)208-110(53-58-135(245)246)153(263)214-115(69-85(4)5)158(268)222-122(77-131(181)239)163(273)206-104(28-20-62-194-175(186)187)148(258)217-118(73-96-38-46-101(235)47-39-96)161(271)218-117(72-95-36-44-100(234)45-37-95)154(264)199-89(11)142(252)224-124(81-230)164(274)216-114(68-84(2)3)157(267)205-105(29-21-63-195-176(188)189)149(259)220-120(75-98-79-192-83-198-98)162(272)219-119(74-97-40-48-102(236)49-41-97)160(270)215-116(70-86(6)7)159(269)221-121(76-130(180)238)155(265)201-91(13)144(254)226-139(87(8)9)173(283)284-140(93(15)232)169(279)211-106(30-22-64-196-177(190)191)146(256)207-108(50-55-129(179)237)151(261)204-103(27-19-61-193-174(184)185)147(257)213-113(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,275)(H,199,264)(H,200,266)(H,201,265)(H,202,255)(H,203,240)(H,204,261)(H,205,267)(H,206,273)(H,207,256)(H,208,262)(H,209,276)(H,210,277)(H,211,279)(H,212,278)(H,213,257)(H,214,263)(H,215,270)(H,216,274)(H,217,258)(H,218,271)(H,219,272)(H,220,259)(H,221,269)(H,222,268)(H,223,260)(H,224,252)(H,225,253)(H,226,254)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/an/an/a 8.40n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197009
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(N)cc1Cl)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H120ClN27O18/c1-38(2)29-55(101-71(120)57(32-43-16-21-47(110)22-17-43)103-72(121)58(34-45-36-91-37-95-45)104-68(117)50(11-8-26-92-77(85)86)96-65(114)48-23-18-44(81)33-49(48)80)70(119)105-59(35-61(83)112)73(122)102-56(30-39(3)4)74(123)106-62(40(5)6)75(124)107-63(41(7)108)76(125)99-52(13-10-28-94-79(89)90)66(115)98-53(24-25-60(82)111)69(118)97-51(12-9-27-93-78(87)88)67(116)100-54(64(84)113)31-42-14-19-46(109)20-15-42/h14-23,33,36-41,50-59,62-63,108-110H,8-13,24-32,34-35,81H2,1-7H3,(H2,82,111)(H2,83,112)(H2,84,113)(H,91,95)(H,96,114)(H,97,118)(H,98,115)(H,99,125)(H,100,116)(H,101,120)(H,102,122)(H,103,121)(H,104,117)(H,105,119)(H,106,123)(H,107,124)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t41-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197011
PNG
(CHEMBL238533 | PYY(22-36))
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C84H137N29O21/c1-40(2)30-56(107-79(132)62(38-114)111-68(121)44(9)85)73(126)101-52(15-12-28-97-83(91)92)71(124)109-60(35-48-37-95-39-99-48)76(129)108-59(34-47-19-23-50(117)24-20-47)75(128)105-57(31-41(3)4)74(127)110-61(36-64(87)119)77(130)106-58(32-42(5)6)78(131)112-65(43(7)8)80(133)113-66(45(10)115)81(134)103-53(16-13-29-98-84(93)94)69(122)102-54(25-26-63(86)118)72(125)100-51(14-11-27-96-82(89)90)70(123)104-55(67(88)120)33-46-17-21-49(116)22-18-46/h17-24,37,39-45,51-62,65-66,114-117H,11-16,25-36,38,85H2,1-10H3,(H2,86,118)(H2,87,119)(H2,88,120)(H,95,99)(H,100,125)(H,101,126)(H,102,122)(H,103,134)(H,104,123)(H,105,128)(H,106,130)(H,107,132)(H,108,129)(H,109,124)(H,110,127)(H,111,121)(H,112,131)(H,113,133)(H4,89,90,96)(H4,91,92,97)(H4,93,94,98)/t44-,45+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50091668
PNG
(AcPYY(22-36) | CHEMBL269267 | N-alpha-Ac-PYY(22-36...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C86H139N29O22/c1-41(2)31-58(109-81(135)64(39-116)113-70(124)45(9)101-47(11)118)75(129)103-54(16-13-29-98-85(92)93)73(127)111-62(36-50-38-96-40-100-50)78(132)110-61(35-49-20-24-52(120)25-21-49)77(131)107-59(32-42(3)4)76(130)112-63(37-66(88)122)79(133)108-60(33-43(5)6)80(134)114-67(44(7)8)82(136)115-68(46(10)117)83(137)105-55(17-14-30-99-86(94)95)71(125)104-56(26-27-65(87)121)74(128)102-53(15-12-28-97-84(90)91)72(126)106-57(69(89)123)34-48-18-22-51(119)23-19-48/h18-25,38,40-46,53-64,67-68,116-117,119-120H,12-17,26-37,39H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,100)(H,101,118)(H,102,128)(H,103,129)(H,104,125)(H,105,137)(H,106,126)(H,107,131)(H,108,133)(H,109,135)(H,110,132)(H,111,127)(H,112,130)(H,113,124)(H,114,134)(H,115,136)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t45-,46+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 13n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197017
PNG
((2S)-N-[(1S)-4-carbamimidamido-1-{[(1S)-1-carbamoy...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C1Cc2ccccc2N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C81H123N27O18/c1-40(2)31-56(102-72(120)58(34-45-20-24-49(111)25-21-45)104-74(122)60(36-47-38-91-39-95-47)105-69(117)52(16-11-29-93-80(87)88)98-73(121)59-35-46-13-8-9-14-50(46)96-59)71(119)106-61(37-63(83)113)75(123)103-57(32-41(3)4)76(124)107-64(42(5)6)77(125)108-65(43(7)109)78(126)100-53(17-12-30-94-81(89)90)67(115)99-54(26-27-62(82)112)70(118)97-51(15-10-28-92-79(85)86)68(116)101-55(66(84)114)33-44-18-22-48(110)23-19-44/h8-9,13-14,18-25,38-43,51-61,64-65,96,109-111H,10-12,15-17,26-37H2,1-7H3,(H2,82,112)(H2,83,113)(H2,84,114)(H,91,95)(H,97,118)(H,98,121)(H,99,115)(H,100,126)(H,101,116)(H,102,120)(H,103,123)(H,104,122)(H,105,117)(H,106,119)(H,107,124)(H,108,125)(H4,85,86,92)(H4,87,88,93)(H4,89,90,94)/t43-,51+,52+,53+,54+,55+,56+,57+,58+,59?,60+,61+,64+,65+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 19n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197013
PNG
(AcPYY(25-36) | CHEMBL392889)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C74H118N26O18/c1-36(2)28-51(94-66(113)53(31-42-17-21-45(104)22-18-42)96-67(114)54(32-43-34-84-35-88-43)97-61(108)46(89-40(8)102)12-9-25-85-72(78)79)65(112)98-55(33-57(76)106)68(115)95-52(29-37(3)4)69(116)99-58(38(5)6)70(117)100-59(39(7)101)71(118)92-48(14-11-27-87-74(82)83)62(109)91-49(23-24-56(75)105)64(111)90-47(13-10-26-86-73(80)81)63(110)93-50(60(77)107)30-41-15-19-44(103)20-16-41/h15-22,34-39,46-55,58-59,101,103-104H,9-14,23-33H2,1-8H3,(H2,75,105)(H2,76,106)(H2,77,107)(H,84,88)(H,89,102)(H,90,111)(H,91,109)(H,92,118)(H,93,110)(H,94,113)(H,95,115)(H,96,114)(H,97,108)(H,98,112)(H,99,116)(H,100,117)(H4,78,79,85)(H4,80,81,86)(H4,82,83,87)/t39-,46+,47+,48+,49+,50+,51+,52+,53+,54+,55+,58+,59+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 27n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197014
PNG
(AcNPY(25-36) | CHEMBL411793)
Show SMILES CC[C@@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O
Show InChI InChI=1S/C76H119N27O18/c1-6-40(4)61-73(121)97-52(68(116)93-49(14-10-30-89-75(82)83)64(112)96-51(24-26-58(77)107)67(115)94-50(15-11-31-90-76(84)85)65(113)98-53(62(79)110)33-42-16-20-45(105)21-17-42)25-27-60(109)87-28-8-7-12-48(66(114)102-57(36-59(78)108)71(119)99-54(32-39(2)3)72(120)103-61)95-69(117)55(34-43-18-22-46(106)23-19-43)100-70(118)56(35-44-37-86-38-91-44)101-63(111)47(92-41(5)104)13-9-29-88-74(80)81/h16-23,37-40,47-57,61,105-106H,6-15,24-36H2,1-5H3,(H2,77,107)(H2,78,108)(H2,79,110)(H,86,91)(H,87,109)(H,92,104)(H,93,116)(H,94,115)(H,95,117)(H,96,112)(H,97,121)(H,98,113)(H,99,119)(H,100,118)(H,101,111)(H,102,114)(H,103,120)(H4,80,81,88)(H4,82,83,89)(H4,84,85,90)/t40-,47+,48+,49+,50+,51+,52+,53+,54+,55+,56+,57+,61+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
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PubMed
n/an/an/an/a 31n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50205095
PNG
((S)-2-((S)-2-((2S,3R)-2-((S)-2-((S)-2-((S)-2-((S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CS)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C84H136N28O20S/c1-41(2)30-57(108-80(131)64(39-133)99-46(10)114)73(124)101-53(15-12-28-96-83(90)91)71(122)110-62(36-49-38-94-40-98-49)77(128)109-61(35-48-19-23-51(116)24-20-48)76(127)105-59(32-43(5)6)75(126)111-63(37-66(86)118)78(129)106-58(31-42(3)4)74(125)107-60(33-44(7)8)79(130)112-67(45(9)113)81(132)103-54(16-13-29-97-84(92)93)69(120)102-55(25-26-65(85)117)72(123)100-52(14-11-27-95-82(88)89)70(121)104-56(68(87)119)34-47-17-21-50(115)22-18-47/h17-24,38,40-45,52-64,67,113,115-116,133H,11-16,25-37,39H2,1-10H3,(H2,85,117)(H2,86,118)(H2,87,119)(H,94,98)(H,99,114)(H,100,123)(H,101,124)(H,102,120)(H,103,132)(H,104,121)(H,105,127)(H,106,129)(H,107,125)(H,108,131)(H,109,128)(H,110,122)(H,111,126)(H,112,130)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,67+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 33n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor in KAN-TS cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 17: 1916-9 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444589
PNG
(CHEMBL3099723)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)O[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)210-110(26-17-18-60-178)171(281)228-66-24-32-126(228)164(274)207-107(51-57-134(243)244)145(255)202-92(14)170(280)227-65-23-31-125(227)163(273)197-80-132(240)203-106(50-56-133(241)242)149(259)222-122(78-137(249)250)154(264)200-90(12)143(253)224-124(82-231)172(282)229-67-25-33-127(229)165(275)208-109(53-59-136(247)248)150(260)206-108(52-58-135(245)246)151(261)213-114(69-85(4)5)156(266)221-121(77-131(181)239)161(271)205-103(27-19-61-193-174(184)185)147(257)216-117(73-96-38-46-101(235)47-39-96)159(269)217-116(72-95-36-44-100(234)45-37-95)152(262)199-89(11)142(252)223-123(81-230)162(272)215-113(68-84(2)3)155(265)204-104(28-20-62-194-175(186)187)148(258)219-119(75-98-79-192-83-198-98)160(270)218-118(74-97-40-48-102(236)49-41-97)158(268)214-115(70-86(6)7)157(267)220-120(76-130(180)238)153(263)201-91(13)144(254)225-139(87(8)9)168(278)226-140(93(15)232)169(279)211-111(30-22-64-196-177(190)191)173(283)284-128(54-55-129(179)237)166(276)209-105(29-21-63-195-176(188)189)146(256)212-112(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,273)(H,199,262)(H,200,264)(H,201,263)(H,202,255)(H,203,240)(H,204,265)(H,205,271)(H,206,260)(H,207,274)(H,208,275)(H,209,276)(H,210,277)(H,211,279)(H,212,256)(H,213,261)(H,214,268)(H,215,272)(H,216,257)(H,217,269)(H,218,270)(H,219,258)(H,220,267)(H,221,266)(H,222,259)(H,223,252)(H,224,253)(H,225,254)(H,226,278)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
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PC cid
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UniChem
Article
n/an/an/an/a 62n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197016
PNG
((2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C1CCCC(N)C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C79H127N27O18/c1-39(2)30-55(100-71(119)57(33-44-19-23-49(109)24-20-44)102-72(120)58(35-47-37-90-38-94-47)103-68(116)50(14-9-27-91-77(84)85)95-65(113)45-12-8-13-46(80)34-45)70(118)104-59(36-61(82)111)73(121)101-56(31-40(3)4)74(122)105-62(41(5)6)75(123)106-63(42(7)107)76(124)98-52(16-11-29-93-79(88)89)66(114)97-53(25-26-60(81)110)69(117)96-51(15-10-28-92-78(86)87)67(115)99-54(64(83)112)32-43-17-21-48(108)22-18-43/h17-24,37-42,45-46,50-59,62-63,107-109H,8-16,25-36,80H2,1-7H3,(H2,81,110)(H2,82,111)(H2,83,112)(H,90,94)(H,95,113)(H,96,117)(H,97,114)(H,98,124)(H,99,115)(H,100,119)(H,101,121)(H,102,120)(H,103,116)(H,104,118)(H,105,122)(H,106,123)(H4,84,85,91)(H4,86,87,92)(H4,88,89,93)/t42-,45?,46?,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,62+,63+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 82n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197012
PNG
(9H-fluoren-9-ylmethyl N-[(1S)-4-carbamimidamido-1-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C87H126N26O19/c1-44(2)35-63(106-78(125)65(38-49-24-28-52(116)29-25-49)108-79(126)66(39-50-41-97-43-101-50)109-75(122)60(21-14-34-100-86(95)96)111-87(131)132-42-57-55-17-10-8-15-53(55)54-16-9-11-18-56(54)57)77(124)110-67(40-69(89)118)80(127)107-64(36-45(3)4)81(128)112-70(46(5)6)82(129)113-71(47(7)114)83(130)104-59(20-13-33-99-85(93)94)73(120)103-61(30-31-68(88)117)76(123)102-58(19-12-32-98-84(91)92)74(121)105-62(72(90)119)37-48-22-26-51(115)27-23-48/h8-11,15-18,22-29,41,43-47,57-67,70-71,114-116H,12-14,19-21,30-40,42H2,1-7H3,(H2,88,117)(H2,89,118)(H2,90,119)(H,97,101)(H,102,123)(H,103,120)(H,104,130)(H,105,121)(H,106,125)(H,107,127)(H,108,126)(H,109,122)(H,110,124)(H,111,131)(H,112,128)(H,113,129)(H4,91,92,98)(H4,93,94,99)(H4,95,96,100)/t47-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,70+,71+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 106n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50205094
PNG
((S)-2-((S)-2-((2S,3R)-2-((S)-2-((S)-2-((S)-2-((S)-...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(N)=O
Show InChI InChI=1S/C84H136N28O20S/c1-41(2)30-56(99-46(10)114)73(124)101-53(15-12-28-96-83(90)91)71(122)109-62(36-49-38-94-40-98-49)78(129)108-60(34-47-17-21-50(115)22-18-47)76(127)104-58(32-43(5)6)75(126)110-63(37-66(86)118)79(130)105-57(31-42(3)4)74(125)106-59(33-44(7)8)80(131)112-67(45(9)113)81(132)103-54(16-13-29-97-84(92)93)69(120)102-55(25-26-65(85)117)72(123)100-52(14-11-27-95-82(88)89)70(121)107-61(35-48-19-23-51(116)24-20-48)77(128)111-64(39-133)68(87)119/h17-24,38,40-45,52-64,67,113,115-116,133H,11-16,25-37,39H2,1-10H3,(H2,85,117)(H2,86,118)(H2,87,119)(H,94,98)(H,99,114)(H,100,123)(H,101,124)(H,102,120)(H,103,132)(H,104,127)(H,105,130)(H,106,125)(H,107,121)(H,108,129)(H,109,122)(H,110,126)(H,111,128)(H,112,131)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)/t45-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,67+/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 160n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor in KAN-TS cells by [35S]GTPgammaS binding assay


Bioorg Med Chem Lett 17: 1916-9 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50444586
PNG
(CHEMBL3099725)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)O[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C177H272N52O55/c1-16-88(10)138(182)167(277)212-112(26-17-18-60-178)171(281)228-66-24-32-127(228)165(275)209-109(52-57-134(243)244)144(254)201-91(13)170(280)227-65-23-31-126(227)164(274)197-80-132(240)203-107(51-56-133(241)242)149(259)223-123(78-137(249)250)155(265)200-90(12)143(253)225-125(82-231)172(282)229-67-25-33-128(229)166(276)210-111(54-59-136(247)248)151(261)208-110(53-58-135(245)246)152(262)214-115(69-85(4)5)157(267)222-122(77-131(181)239)162(272)206-104(28-20-62-194-175(186)187)147(257)217-118(73-96-38-46-101(235)47-39-96)160(270)218-117(72-95-36-44-100(234)45-37-95)153(263)199-89(11)142(252)224-124(81-230)163(273)216-114(68-84(2)3)156(266)205-105(29-21-63-195-176(188)189)148(258)220-120(75-98-79-192-83-198-98)161(271)219-119(74-97-40-48-102(236)49-41-97)159(269)215-116(70-86(6)7)158(268)221-121(76-130(180)238)154(264)202-92(14)173(283)284-140(87(8)9)169(279)226-139(93(15)232)168(278)211-106(30-22-64-196-177(190)191)145(255)207-108(50-55-129(179)237)150(260)204-103(27-19-61-193-174(184)185)146(256)213-113(141(183)251)71-94-34-42-99(233)43-35-94/h34-49,79,83-93,103-128,138-140,230-236H,16-33,50-78,80-82,178,182H2,1-15H3,(H2,179,237)(H2,180,238)(H2,181,239)(H2,183,251)(H,192,198)(H,197,274)(H,199,263)(H,200,265)(H,201,254)(H,202,264)(H,203,240)(H,204,260)(H,205,266)(H,206,272)(H,207,255)(H,208,261)(H,209,275)(H,210,276)(H,211,278)(H,212,277)(H,213,256)(H,214,262)(H,215,269)(H,216,273)(H,217,257)(H,218,270)(H,219,271)(H,220,258)(H,221,268)(H,222,267)(H,223,259)(H,224,252)(H,225,253)(H,226,279)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,184,185,193)(H4,186,187,194)(H4,188,189,195)(H4,190,191,196)/t88-,89-,90-,91-,92-,93+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,138-,139-,140-/m0/s1
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n/an/an/an/a 228n/an/an/an/a


TBA

Assay Description
Agonist activity at human NPYY2 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs fo...


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197018
PNG
(CHEMBL268200 | PYY(25-36))
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C72H116N26O17/c1-35(2)27-49(93-64(110)51(30-40-16-20-43(101)21-17-40)95-65(111)52(31-41-33-83-34-87-41)92-59(105)44(73)11-8-24-84-70(77)78)63(109)96-53(32-55(75)103)66(112)94-50(28-36(3)4)67(113)97-56(37(5)6)68(114)98-57(38(7)99)69(115)90-46(13-10-26-86-72(81)82)60(106)89-47(22-23-54(74)102)62(108)88-45(12-9-25-85-71(79)80)61(107)91-48(58(76)104)29-39-14-18-42(100)19-15-39/h14-21,33-38,44-53,56-57,99-101H,8-13,22-32,73H2,1-7H3,(H2,74,102)(H2,75,103)(H2,76,104)(H,83,87)(H,88,108)(H,89,106)(H,90,115)(H,91,107)(H,92,105)(H,93,110)(H,94,112)(H,95,111)(H,96,109)(H,97,113)(H,98,114)(H4,77,78,84)(H4,79,80,85)(H4,81,82,86)/t38-,44+,45+,46+,47+,48+,49+,50+,51+,52+,53+,56+,57+/m1/s1
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n/an/an/an/a 240n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50426596
PNG
(CHEMBL2324952)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N(C(=O)CCCCCN)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@H](Cc2ccc(O)cc2)NC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C125H203N37O27/c1-12-72(6)100(117(186)156-96(67-98(131)169)112(181)152-91(61-70(2)3)110(179)153-92(62-71(4)5)113(182)159-101(74(8)163)118(187)150-86(36-30-60-142-123(137)138)105(174)149-89(50-51-97(130)168)109(178)147-85(35-29-59-141-122(135)136)106(175)151-90(102(132)171)63-76-38-44-80(165)45-39-76)158-114(183)93(64-77-40-46-81(166)47-41-77)154-111(180)95(66-79-68-139-69-143-79)155-107(176)84(34-28-58-140-121(133)134)145-103(172)73(7)162(99(170)37-18-17-24-54-126)120(189)125(11)53-23-16-14-13-15-22-52-124(10,160-116(185)94(144-75(9)164)65-78-42-48-82(167)49-43-78)119(188)157-87(32-20-26-56-128)108(177)146-83(31-19-25-55-127)104(173)148-88(115(184)161-125)33-21-27-57-129/h13-14,38-49,68-74,83-96,100-101,163,165-167H,12,15-37,50-67,126-129H2,1-11H3,(H2,130,168)(H2,131,169)(H2,132,171)(H,139,143)(H,144,164)(H,145,172)(H,146,177)(H,147,178)(H,148,173)(H,149,174)(H,150,187)(H,151,175)(H,152,181)(H,153,179)(H,154,180)(H,155,176)(H,156,186)(H,157,188)(H,158,183)(H,159,182)(H,160,185)(H,161,184)(H4,133,134,140)(H4,135,136,141)(H4,137,138,142)/b14-13-/t72-,73-,74+,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,100-,101-,124-,125-/m0/s1
Reactome pathway
KEGG

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n/an/an/an/a 403n/an/an/an/a



University of Utah

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2R expressed inj CHOK1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 mins by luminescenc...


Bioorg Med Chem 21: 303-10 (2012)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50197024
PNG
(AcPYY(26-36) | CHEMBL397527)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C68H106N22O17/c1-33(2)25-47(85-61(102)49(28-39-15-19-42(94)20-16-39)87-62(103)50(80-37(8)92)29-40-31-76-32-79-40)60(101)88-51(30-53(70)96)63(104)86-48(26-34(3)4)64(105)89-54(35(5)6)65(106)90-55(36(7)91)66(107)83-44(12-10-24-78-68(74)75)57(98)82-45(21-22-52(69)95)59(100)81-43(11-9-23-77-67(72)73)58(99)84-46(56(71)97)27-38-13-17-41(93)18-14-38/h13-20,31-36,43-51,54-55,91,93-94H,9-12,21-30H2,1-8H3,(H2,69,95)(H2,70,96)(H2,71,97)(H,76,79)(H,80,92)(H,81,100)(H,82,98)(H,83,107)(H,84,99)(H,85,102)(H,86,104)(H,87,103)(H,88,101)(H,89,105)(H,90,106)(H4,72,73,77)(H4,74,75,78)/t36-,43+,44+,45+,46+,47+,48+,49+,50+,51+,54+,55+/m1/s1
Reactome pathway
KEGG

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n/an/an/an/a 430n/an/an/an/a



Bayer Pharmaceuticals Corporation

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor expressed in human KAN-TS cells by [35S]GTPgammaS incorporation assay


Bioorg Med Chem Lett 17: 538-41 (2007)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50409214
PNG
(CHEMBL2110365 | GR-231118)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)NC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C110H170N34O24/c1-9-59(7)87(111)103(165)133-73-39-41-85(149)127-55-81(99(161)139-79(53-63-27-35-67(147)36-28-63)97(159)131-71(19-13-45-125-109(119)120)93(155)137-77(49-57(3)4)95(157)129-69(17-11-43-123-107(115)116)91(153)135-75(89(113)151)51-61-23-31-65(145)32-24-61)142-102(164)84-22-16-48-144(84)106(168)74(134-104(166)88(112)60(8)10-2)40-42-86(150)128-56-82(141-101(163)83-21-15-47-143(83)105(73)167)100(162)140-80(54-64-29-37-68(148)38-30-64)98(160)132-72(20-14-46-126-110(121)122)94(156)138-78(50-58(5)6)96(158)130-70(18-12-44-124-108(117)118)92(154)136-76(90(114)152)52-62-25-33-66(146)34-26-62/h23-38,57-60,69-84,87-88,145-148H,9-22,39-56,111-112H2,1-8H3,(H2,113,151)(H2,114,152)(H,127,149)(H,128,150)(H,129,157)(H,130,158)(H,131,159)(H,132,160)(H,133,165)(H,134,166)(H,135,153)(H,136,154)(H,137,155)(H,138,156)(H,139,161)(H,140,162)(H,141,163)(H,142,164)(H4,115,116,123)(H4,117,118,124)(H4,119,120,125)(H4,121,122,126)/t59-,60-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,87-,88-/m0/s1
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n/an/an/an/a 983n/an/an/an/a



University of Cincinnati and VA Medical Centers

Curated by ChEMBL


Assay Description
Agonist potency for the inhibition of Forskolin stimulated cAMP synthesis in cells expressing cloned Y2 receptors


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 2


(HUMAN)
BDBM50089431
PNG
(CHEMBL3578009)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(O)=O)C(N)=O
Show InChI InChI=1/C61H83N11O10/c1-37(2)31-48(55(64)76)68-58(79)49(32-38(3)4)69-61(82)52(35-42-36-65-45-24-11-10-23-44(42)45)72-59(80)50(33-39-17-6-5-7-18-39)70-60(81)51(34-41-21-16-20-40-19-8-9-22-43(40)41)71-57(78)47(26-13-15-30-63)67-56(77)46(25-12-14-29-62)66-53(73)27-28-54(74)75/h5-11,16-24,36-38,46-52,65H,12-15,25-35,62-63H2,1-4H3,(H2,64,76)(H,66,73)(H,67,77)(H,68,79)(H,69,82)(H,70,81)(H,71,78)(H,72,80)(H,74,75)/t46-,47-,48-,49-,50-,51-,52+/s2
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KEGG

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n/an/an/an/a>1.00E+3n/an/an/an/a



Universit£t Leipzig

Curated by ChEMBL


Assay Description
Agonist activity at human neuropeptide Y Y2 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate...


J Med Chem 58: 4180-93 (2015)

More data for this
Ligand-Target Pair
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