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Compile Data Set for Download or QSAR

Found 22 hits of ec50 data for polymerid = 49000904   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Parathyroid hormone receptor


(HUMAN)
BDBM50269975
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C77H129N23O19/c1-13-15-20-47(91-69(114)54(35-40(3)4)95-67(112)51(28-31-57(80)103)93-71(116)60(42(7)14-2)98-68(113)52(29-32-58(104)105)97-74(119)77(11,12)100-72(117)59(41(5)6)99-73(118)76(9,10)84)65(110)96-55(37-45-38-85-39-87-45)70(115)92-50(27-30-56(79)102)66(111)90-48(22-17-19-34-86-75(82)83)63(108)88-43(8)62(107)89-49(21-16-18-33-78)64(109)94-53(61(81)106)36-44-23-25-46(101)26-24-44/h23-26,38-43,47-55,59-60,101H,13-22,27-37,78,84H2,1-12H3,(H2,79,102)(H2,80,103)(H2,81,106)(H,85,87)(H,88,108)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,116)(H,94,109)(H,95,112)(H,96,110)(H,97,119)(H,98,113)(H,99,118)(H,100,117)(H,104,105)(H4,82,83,86)/t42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.0600n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.150n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50331021
PNG
((S)-5-((2S,3S)-1-((3S,6S,9S,12S,15S)-6-((1H-imidaz...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](COC(=O)CCCCC(=O)OC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC
Show InChI InChI=1S/C61H103N17O17/c1-12-14-19-37-49(84)72-40(27-35-28-66-31-68-35)52(87)73-41(53(88)69-36(48(62)83)20-17-18-25-67-59(63)64)29-94-44(81)21-15-16-22-45(82)95-30-42(54(89)71-39(26-32(3)4)51(86)70-37)74-55(90)47(34(7)13-2)76-50(85)38(23-24-43(79)80)75-58(93)61(10,11)78-56(91)46(33(5)6)77-57(92)60(8,9)65/h28,31-34,36-42,46-47H,12-27,29-30,65H2,1-11H3,(H2,62,83)(H,66,68)(H,69,88)(H,70,86)(H,71,89)(H,72,84)(H,73,87)(H,74,90)(H,75,93)(H,76,85)(H,77,92)(H,78,91)(H,79,80)(H4,63,64,67)/t34-,36-,37-,38-,39-,40-,41-,42-,46-,47-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.200n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.300n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP production


J Med Chem 53: 4332-53 (2010)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269978
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 0.920n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50318885
PNG
((2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization


J Med Chem 53: 4332-53 (2010)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269977
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 1.10n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/an/an/a 2.20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50331022
PNG
((7S,10S,13S,16S,19S,22S,25S,28S)-13-((1H-imidazol-...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O
Show InChI InChI=1S/C59H103N19O15/c1-12-14-17-35(47(84)74-40(27-33-28-66-29-68-33)52(89)71-36(19-22-41(60)79)48(85)69-34(46(62)83)18-15-16-25-67-57(63)64)70-51(88)39(26-30(3)4)73-49(86)37(20-23-42(61)80)72-53(90)45(32(7)13-2)76-50(87)38(21-24-43(81)82)75-56(93)59(10,11)78-54(91)44(31(5)6)77-55(92)58(8,9)65/h28-32,34-40,44-45H,12-27,65H2,1-11H3,(H2,60,79)(H2,61,80)(H2,62,83)(H,66,68)(H,69,85)(H,70,88)(H,71,89)(H,72,90)(H,73,86)(H,74,84)(H,75,93)(H,76,87)(H,77,92)(H,78,91)(H,81,82)(H4,63,64,67)/t32-,34-,35-,36-,37-,38-,39-,40-,44-,45-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 2.40n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269978
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 7.20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269974
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 13n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269977
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C102H149N25O24/c1-13-15-25-67(118-93(144)73(46-53(3)4)121-91(142)71(38-41-79(105)132)120-96(147)83(55(7)14-2)125-92(143)72(39-42-80(133)134)124-99(150)102(11,12)127-97(148)82(54(5)6)126-98(149)101(9,10)109)88(139)123-75(48-58-51-110-52-113-58)95(146)119-70(37-40-78(104)131)90(141)117-69(28-22-45-112-100(107)108)87(138)114-56(8)85(136)116-68(27-18-20-43-103)89(140)122-74(47-57-29-31-59(128)32-30-57)94(145)115-66(84(106)135)26-19-21-44-111-86(137)63-24-17-16-23-62(63)81-64-35-33-60(129)49-76(64)151-77-50-61(130)34-36-65(77)81/h16-17,23-24,29-36,49-56,66-75,82-83,128-129H,13-15,18-22,25-28,37-48,103,109H2,1-12H3,(H2,104,131)(H2,105,132)(H2,106,135)(H,110,113)(H,111,137)(H,114,138)(H,115,145)(H,116,136)(H,117,141)(H,118,144)(H,119,146)(H,120,147)(H,121,142)(H,122,140)(H,123,139)(H,124,150)(H,125,143)(H,126,149)(H,127,148)(H,133,134)(H4,107,108,112)/t55-,56-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,82-,83-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 20n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269976
PNG
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C76H127N23O19/c1-13-15-19-46(90-68(113)53(34-39(3)4)94-66(111)50(27-30-56(79)102)92-70(115)59(41(7)14-2)97-67(112)51(28-31-57(103)104)96-73(118)76(11,12)99-71(116)58(40(5)6)98-72(117)75(9,10)83)64(109)95-54(36-44-37-84-38-86-44)69(114)91-49(26-29-55(78)101)65(110)89-48(21-18-33-85-74(81)82)62(107)87-42(8)61(106)88-47(20-16-17-32-77)63(108)93-52(60(80)105)35-43-22-24-45(100)25-23-43/h22-25,37-42,46-54,58-59,100H,13-21,26-36,77,83H2,1-12H3,(H2,78,101)(H2,79,102)(H2,80,105)(H,84,86)(H,87,107)(H,88,106)(H,89,110)(H,90,113)(H,91,114)(H,92,115)(H,93,108)(H,94,111)(H,95,109)(H,96,118)(H,97,112)(H,98,117)(H,99,116)(H,103,104)(H4,81,82,85)/t41-,42-,46-,47-,48-,49-,50-,51-,52-,53-,54-,58-,59-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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Article
PubMed
n/an/an/an/a 26n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of intracellular calcium mobilization


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269973
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C86H135N25O20/c1-11-13-21-56(103-81(127)63(37-44(3)4)107-79(125)60(30-33-67(90)114)105-85(131)70(46(7)12-2)111-80(126)61(31-34-68(115)116)101-74(120)49(10)99-84(130)69(45(5)6)110-72(118)47(8)88)76(122)109-65(40-52-42-94-43-97-52)83(129)104-59(29-32-66(89)113)78(124)102-57(24-17-19-36-95-86(92)93)75(121)98-48(9)73(119)100-58(23-16-18-35-87)77(123)108-64(39-51-41-96-55-22-15-14-20-54(51)55)82(128)106-62(71(91)117)38-50-25-27-53(112)28-26-50/h14-15,20,22,25-28,41-49,56-65,69-70,96,112H,11-13,16-19,21,23-24,29-40,87-88H2,1-10H3,(H2,89,113)(H2,90,114)(H2,91,117)(H,94,97)(H,98,121)(H,99,130)(H,100,119)(H,101,120)(H,102,124)(H,103,127)(H,104,129)(H,105,131)(H,106,128)(H,107,125)(H,108,123)(H,109,122)(H,110,118)(H,111,126)(H,115,116)(H4,92,93,95)/t46-,47-,48-,49-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,69-,70-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

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n/an/an/an/a 26n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269971
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C76H124N24O18S/c1-11-40(6)61(100-71(114)52(24-27-59(103)104)91-65(108)43(9)89-74(117)60(39(4)5)99-63(106)41(7)78)75(118)95-51(23-26-58(80)102)69(112)97-55(32-38(2)3)72(115)94-53(28-31-119-10)70(113)98-56(34-45-36-84-37-87-45)73(116)93-50(22-25-57(79)101)68(111)92-48(21-15-17-30-85-76(82)83)66(109)88-42(8)64(107)90-49(20-14-16-29-77)67(110)96-54(62(81)105)33-44-35-86-47-19-13-12-18-46(44)47/h12-13,18-19,35-43,48-56,60-61,86H,11,14-17,20-34,77-78H2,1-10H3,(H2,79,101)(H2,80,102)(H2,81,105)(H,84,87)(H,88,109)(H,89,117)(H,90,107)(H,91,108)(H,92,111)(H,93,116)(H,94,115)(H,95,118)(H,96,110)(H,97,112)(H,98,113)(H,99,106)(H,100,114)(H,103,104)(H4,82,83,85)/t40-,41-,42-,43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-/m0/s1
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n/an/an/an/a 32n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269972
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C102H146N26O23S/c1-11-54(6)85(128-96(145)73(35-38-82(133)134)119-89(138)57(9)116-100(149)84(53(4)5)127-87(136)55(7)104)101(150)123-72(34-37-81(106)132)94(143)124-75(44-52(2)3)97(146)122-74(39-43-152-10)95(144)126-77(46-59-50-110-51-114-59)99(148)121-71(33-36-80(105)131)93(142)120-69(28-18-21-42-112-102(108)109)91(140)115-56(8)88(137)118-70(27-16-19-40-103)92(141)125-76(45-58-49-113-67-25-15-14-22-62(58)67)98(147)117-68(86(107)135)26-17-20-41-111-90(139)64-24-13-12-23-63(64)83-65-31-29-60(129)47-78(65)151-79-48-61(130)30-32-66(79)83/h12-15,22-25,29-32,47-57,68-77,84-85,113,129H,11,16-21,26-28,33-46,103-104H2,1-10H3,(H2,105,131)(H2,106,132)(H2,107,135)(H,110,114)(H,111,139)(H,115,140)(H,116,149)(H,117,147)(H,118,137)(H,119,138)(H,120,142)(H,121,148)(H,122,146)(H,123,150)(H,124,143)(H,125,141)(H,126,144)(H,127,136)(H,128,145)(H,133,134)(H4,108,109,112)/t54-,55-,56-,57-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,84-,85-/m0/s1
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n/an/an/an/a 53n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ...


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269971
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C76H124N24O18S/c1-11-40(6)61(100-71(114)52(24-27-59(103)104)91-65(108)43(9)89-74(117)60(39(4)5)99-63(106)41(7)78)75(118)95-51(23-26-58(80)102)69(112)97-55(32-38(2)3)72(115)94-53(28-31-119-10)70(113)98-56(34-45-36-84-37-87-45)73(116)93-50(22-25-57(79)101)68(111)92-48(21-15-17-30-85-76(82)83)66(109)88-42(8)64(107)90-49(20-14-16-29-77)67(110)96-54(62(81)105)33-44-35-86-47-19-13-12-18-46(44)47/h12-13,18-19,35-43,48-56,60-61,86H,11,14-17,20-34,77-78H2,1-10H3,(H2,79,101)(H2,80,102)(H2,81,105)(H,84,87)(H,88,109)(H,89,117)(H,90,107)(H,91,108)(H,92,111)(H,93,116)(H,94,115)(H,95,118)(H,96,110)(H,97,112)(H,98,113)(H,99,106)(H,100,114)(H,103,104)(H4,82,83,85)/t40-,41-,42-,43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,60-,61-/m0/s1
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n/an/an/an/a 800n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269972
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Met-His-Gln-Har-Ala-Ly...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(N)=O
Show InChI InChI=1S/C102H146N26O23S/c1-11-54(6)85(128-96(145)73(35-38-82(133)134)119-89(138)57(9)116-100(149)84(53(4)5)127-87(136)55(7)104)101(150)123-72(34-37-81(106)132)94(143)124-75(44-52(2)3)97(146)122-74(39-43-152-10)95(144)126-77(46-59-50-110-51-114-59)99(148)121-71(33-36-80(105)131)93(142)120-69(28-18-21-42-112-102(108)109)91(140)115-56(8)88(137)118-70(27-16-19-40-103)92(141)125-76(45-58-49-113-67-25-15-14-22-62(58)67)98(147)117-68(86(107)135)26-17-20-41-111-90(139)64-24-13-12-23-63(64)83-65-31-29-60(129)47-78(65)151-79-48-61(130)30-32-66(79)83/h12-15,22-25,29-32,47-57,68-77,84-85,113,129H,11,16-21,26-28,33-46,103-104H2,1-10H3,(H2,105,131)(H2,106,132)(H2,107,135)(H,110,114)(H,111,139)(H,115,140)(H,116,149)(H,117,147)(H,118,137)(H,119,138)(H,120,142)(H,121,148)(H,122,146)(H,123,150)(H,124,143)(H,125,141)(H,126,144)(H,127,136)(H,128,145)(H,133,134)(H4,108,109,112)/t54-,55-,56-,57-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,84-,85-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50331020
PNG
((S)-5-((2S,3S)-1-((2S,5S,8S,11S,20S)-8-((1H-imidaz...)
Show SMILES CCCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(=O)N[C@@H](CCCCN=C(N)N)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC
Show InChI InChI=1S/C60H104N18O14/c1-12-14-19-37-48(83)74-42(29-35-30-65-31-68-35)53(88)71-39(50(85)69-36(47(61)82)20-15-18-27-67-58(62)63)22-24-43(79)66-26-17-16-21-38(49(84)73-41(28-32(3)4)52(87)70-37)72-54(89)46(34(7)13-2)76-51(86)40(23-25-44(80)81)75-57(92)60(10,11)78-55(90)45(33(5)6)77-56(91)59(8,9)64/h30-34,36-42,45-46H,12-29,64H2,1-11H3,(H2,61,82)(H,65,68)(H,66,79)(H,69,85)(H,70,87)(H,71,88)(H,72,89)(H,73,84)(H,74,83)(H,75,92)(H,76,86)(H,77,91)(H,78,90)(H,80,81)(H4,62,63,67)/t34-,36-,37-,38-,39-,40-,41-,42-,45-,46-/m0/s1
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n/an/an/an/a 1.12E+3n/an/an/an/a



University of Padova

Curated by ChEMBL


Assay Description
Agonist activity at recombinant PTHR1 expressed in HEK293 cells co-transfected with CRE-Luc assessed as increase of adenylyl-cyclase activity after 4...


J Med Chem 53: 8072-9 (2010)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269974
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C75H125N23O19/c1-11-13-18-47(91-71(114)54(33-38(3)4)95-69(112)51(26-29-57(79)101)93-74(117)60(40(7)12-2)98-70(113)52(27-30-58(102)103)89-64(107)43(10)87-73(116)59(39(5)6)97-62(105)41(8)77)67(110)96-55(35-45-36-83-37-85-45)72(115)92-50(25-28-56(78)100)68(111)90-48(20-15-17-32-84-75(81)82)65(108)86-42(9)63(106)88-49(19-14-16-31-76)66(109)94-53(61(80)104)34-44-21-23-46(99)24-22-44/h21-24,36-43,47-55,59-60,99H,11-20,25-35,76-77H2,1-10H3,(H2,78,100)(H2,79,101)(H2,80,104)(H,83,85)(H,86,108)(H,87,116)(H,88,106)(H,89,107)(H,90,111)(H,91,114)(H,92,115)(H,93,117)(H,94,109)(H,95,112)(H,96,110)(H,97,105)(H,98,113)(H,102,103)(H4,81,82,84)/t40-,41-,42-,43-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1
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n/an/an/an/a 1.43E+3n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50269973
PNG
(Ala-Val-Ala-Glu-lle-Gln-Leu-Nle-His-Gln-Har-Ala-Ly...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C86H135N25O20/c1-11-13-21-56(103-81(127)63(37-44(3)4)107-79(125)60(30-33-67(90)114)105-85(131)70(46(7)12-2)111-80(126)61(31-34-68(115)116)101-74(120)49(10)99-84(130)69(45(5)6)110-72(118)47(8)88)76(122)109-65(40-52-42-94-43-97-52)83(129)104-59(29-32-66(89)113)78(124)102-57(24-17-19-36-95-86(92)93)75(121)98-48(9)73(119)100-58(23-16-18-35-87)77(123)108-64(39-51-41-96-55-22-15-14-20-54(51)55)82(128)106-62(71(91)117)38-50-25-27-53(112)28-26-50/h14-15,20,22,25-28,41-49,56-65,69-70,96,112H,11-13,16-19,21,23-24,29-40,87-88H2,1-10H3,(H2,89,113)(H2,90,114)(H2,91,117)(H,94,97)(H,98,121)(H,99,130)(H,100,119)(H,101,120)(H,102,124)(H,103,127)(H,104,129)(H,105,131)(H,106,128)(H,107,125)(H,108,123)(H,109,122)(H,110,118)(H,111,126)(H,115,116)(H4,92,93,95)/t46-,47-,48-,49-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,69-,70-/m0/s1
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n/an/an/an/a 1.46E+3n/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation


Proc Natl Acad Sci U S A 104: 6846-51 (2007)

More data for this
Ligand-Target Pair
Parathyroid hormone receptor


(HUMAN)
BDBM50318886
PNG
(1,3-dibutyl-5-(diaminomethylene)pyrimidine-2,4,6(1...)
Show SMILES CCCCN1C(=O)C(C(N)=N)C(=O)N(CCCC)C1=O
Show InChI InChI=1S/C13H22N4O3/c1-3-5-7-16-11(18)9(10(14)15)12(19)17(13(16)20)8-6-4-2/h9H,3-8H2,1-2H3,(H3,14,15)
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n/an/an/an/a 3.20E+3n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization


J Med Chem 53: 4332-53 (2010)

More data for this
Ligand-Target Pair