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Compile Data Set for Download or QSAR

Found 31 hits of ec50 data for polymerid = 50000092,50006576   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335467
PNG
(5-amino-N-tert-butyl-2-(methylthio)-4-(3-(2-oxo-2-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCC#C)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C23H26N6O2S2/c1-6-10-25-15(30)12-26-14-9-7-8-13(11-14)18-16-17(24)19(20(31)29-23(2,3)4)33-21(16)28-22(27-18)32-5/h1,7-9,11,26H,10,12,24H2,2-5H3,(H,25,30)(H,29,31)
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n/an/an/an/a 1n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335473
PNG
(5-amino-4-(3-(2-((1-(2-(2-(2-azidoethoxy)ethoxy)et...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C29H38N12O4S2/c1-29(2,3)37-26(43)25-23(30)22-24(35-28(46-4)36-27(22)47-25)18-6-5-7-19(14-18)32-16-21(42)33-15-20-17-41(40-38-20)9-11-45-13-12-44-10-8-34-39-31/h5-7,14,17,32H,8-13,15-16,30H2,1-4H3,(H,33,42)(H,37,43)
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335468
PNG
((R)-4-(3-(2-((1-(2-(4-((4-(1-acetyl-6-biphenyl-4-y...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc(cc5)[C@@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C61H64N14O5S2/c1-37(76)75-49-26-23-44(65-55(78)40-19-17-39(18-20-40)38-13-10-9-11-14-38)30-48(49)61(7,36-60(75,5)6)42-21-24-47(25-22-42)80-35-46-34-74(72-70-46)28-27-73-33-45(69-71-73)31-64-50(77)32-63-43-16-12-15-41(29-43)53-51-52(62)54(56(79)68-59(2,3)4)82-57(51)67-58(66-53)81-8/h9-26,29-30,33-34,63H,27-28,31-32,35-36,62H2,1-8H3,(H,64,77)(H,65,78)(H,68,79)/t61-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206401
PNG
(CHEMBL246321 | N-((S)-1-amino-3-(4-hydroxyphenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1cccnc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-12-14-25(15-13-24)37-26(20-28(36-37)23-7-6-18-34-21-23)8-4-5-9-30(39)35-29(31(33)40)19-22-10-16-27(38)17-11-22/h6-7,10-18,20-21,29,38H,4-5,8-9,19H2,1-3H3,(H2,33,40)(H,35,39)/t29-/m0/s1
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n/an/an/an/a 20n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335474
PNG
((S)-4-(3-(2-((1-(2-(4-((4-(1-acetyl-6-biphenyl-4-y...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCn4cc(COc5ccc(cc5)[C@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C61H64N14O5S2/c1-37(76)75-49-26-23-44(65-55(78)40-19-17-39(18-20-40)38-13-10-9-11-14-38)30-48(49)61(7,36-60(75,5)6)42-21-24-47(25-22-42)80-35-46-34-74(72-70-46)28-27-73-33-45(69-71-73)31-64-50(77)32-63-43-16-12-15-41(29-43)53-51-52(62)54(56(79)68-59(2,3)4)82-57(51)67-58(66-53)81-8/h9-26,29-30,33-34,63H,27-28,31-32,35-36,62H2,1-8H3,(H,64,77)(H,65,78)(H,68,79)/t61-/m0/s1
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n/an/an/an/a 24n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335469
PNG
((R)-4-(3-(2-((1-(2-(2-(4-((4-(1-acetyl-6-biphenyl-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc(cc5)[C@@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C63H68N14O6S2/c1-39(78)77-51-26-23-46(67-57(80)42-19-17-41(18-20-42)40-13-10-9-11-14-40)32-50(51)63(7,38-62(77,5)6)44-21-24-49(25-22-44)83-37-48-36-76(74-72-48)28-30-82-29-27-75-35-47(71-73-75)33-66-52(79)34-65-45-16-12-15-43(31-45)55-53-54(64)56(58(81)70-61(2,3)4)85-59(53)69-60(68-55)84-8/h9-26,31-32,35-36,65H,27-30,33-34,37-38,64H2,1-8H3,(H,66,79)(H,67,80)(H,70,81)/t63-/m1/s1
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n/an/an/an/a 27n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335478
PNG
((S)-4-(3-(2-((1-(14-(4-((4-(1-acetyl-6-biphenyl-4-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc(cc5)[C@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C69H80N14O9S2/c1-45(84)83-57-26-23-52(73-63(86)48-19-17-47(18-20-48)46-13-10-9-11-14-46)38-56(57)69(7,44-68(83,5)6)50-21-24-55(25-22-50)92-43-54-42-82(80-78-54)28-30-89-32-34-91-36-35-90-33-31-88-29-27-81-41-53(77-79-81)39-72-58(85)40-71-51-16-12-15-49(37-51)61-59-60(70)62(64(87)76-67(2,3)4)94-65(59)75-66(74-61)93-8/h9-26,37-38,41-42,71H,27-36,39-40,43-44,70H2,1-8H3,(H,72,85)(H,73,86)(H,76,87)/t69-/m0/s1
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n/an/an/an/a 39n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335470
PNG
((R)-4-(3-(2-((1-(2-(2-(2-(4-((4-(1-acetyl-6-biphen...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc(cc5)[C@@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C65H72N14O7S2/c1-41(80)79-53-26-23-48(69-59(82)44-19-17-43(18-20-44)42-13-10-9-11-14-42)34-52(53)65(7,40-64(79,5)6)46-21-24-51(25-22-46)86-39-50-38-78(76-74-50)28-30-85-32-31-84-29-27-77-37-49(73-75-77)35-68-54(81)36-67-47-16-12-15-45(33-47)57-55-56(66)58(60(83)72-63(2,3)4)88-61(55)71-62(70-57)87-8/h9-26,33-34,37-38,67H,27-32,35-36,39-40,66H2,1-8H3,(H,68,81)(H,69,82)(H,72,83)/t65-/m1/s1
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n/an/an/an/a 43n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335472
PNG
((R)-4-(3-(2-((1-(14-(4-((4-(1-acetyl-6-biphenyl-4-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc(cc5)[C@@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C69H80N14O9S2/c1-45(84)83-57-26-23-52(73-63(86)48-19-17-47(18-20-48)46-13-10-9-11-14-46)38-56(57)69(7,44-68(83,5)6)50-21-24-55(25-22-50)92-43-54-42-82(80-78-54)28-30-89-32-34-91-36-35-90-33-31-88-29-27-81-41-53(77-79-81)39-72-58(85)40-71-51-16-12-15-49(37-51)61-59-60(70)62(64(87)76-67(2,3)4)94-65(59)75-66(74-61)93-8/h9-26,37-38,41-42,71H,27-36,39-40,43-44,70H2,1-8H3,(H,72,85)(H,73,86)(H,76,87)/t69-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335477
PNG
((S)-4-(3-(2-((1-(2-(2-(2-(2-(4-((4-(1-acetyl-6-bip...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc(cc5)[C@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C67H76N14O8S2/c1-43(82)81-55-26-23-50(71-61(84)46-19-17-45(18-20-46)44-13-10-9-11-14-44)36-54(55)67(7,42-66(81,5)6)48-21-24-53(25-22-48)89-41-52-40-80(78-76-52)28-30-87-32-34-88-33-31-86-29-27-79-39-51(75-77-79)37-70-56(83)38-69-49-16-12-15-47(35-49)59-57-58(68)60(62(85)74-65(2,3)4)91-63(57)73-64(72-59)90-8/h9-26,35-36,39-40,69H,27-34,37-38,41-42,68H2,1-8H3,(H,70,83)(H,71,84)(H,74,85)/t67-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335471
PNG
((R)-4-(3-(2-((1-(2-(2-(2-(2-(4-((4-(1-acetyl-6-bip...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc(cc5)[C@@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C67H76N14O8S2/c1-43(82)81-55-26-23-50(71-61(84)46-19-17-45(18-20-46)44-13-10-9-11-14-44)36-54(55)67(7,42-66(81,5)6)48-21-24-53(25-22-48)89-41-52-40-80(78-76-52)28-30-87-32-34-88-33-31-86-29-27-79-39-51(75-77-79)37-70-56(83)38-69-49-16-12-15-47(35-49)59-57-58(68)60(62(85)74-65(2,3)4)91-63(57)73-64(72-59)90-8/h9-26,35-36,39-40,69H,27-34,37-38,41-42,68H2,1-8H3,(H,70,83)(H,71,84)(H,74,85)/t67-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335476
PNG
((S)-4-(3-(2-((1-(2-(2-(2-(4-((4-(1-acetyl-6-biphen...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc(cc5)[C@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C65H72N14O7S2/c1-41(80)79-53-26-23-48(69-59(82)44-19-17-43(18-20-44)42-13-10-9-11-14-42)34-52(53)65(7,40-64(79,5)6)46-21-24-51(25-22-46)86-39-50-38-78(76-74-50)28-30-85-32-31-84-29-27-77-37-49(73-75-77)35-68-54(81)36-67-47-16-12-15-45(33-47)57-55-56(66)58(60(83)72-63(2,3)4)88-61(55)71-62(70-57)87-8/h9-26,33-34,37-38,67H,27-32,35-36,39-40,66H2,1-8H3,(H,68,81)(H,69,82)(H,72,83)/t65-/m0/s1
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n/an/an/an/a 75n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206398
PNG
(CHEMBL429108 | N-(4-hydroxyphenethyl)-5-(1-(4-tert...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)NCCc1ccc(O)cc1)-c1cccnc1
Show InChI InChI=1S/C31H36N4O2/c1-31(2,3)25-12-14-26(15-13-25)35-27(21-29(34-35)24-7-6-19-32-22-24)8-4-5-9-30(37)33-20-18-23-10-16-28(36)17-11-23/h6-7,10-17,19,21-22,36H,4-5,8-9,18,20H2,1-3H3,(H,33,37)
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n/an/an/an/a 80n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50335475
PNG
((S)-4-(3-(2-((1-(2-(2-(4-((4-(1-acetyl-6-biphenyl-...)
Show SMILES CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCn4cc(COc5ccc(cc5)[C@]5(C)CC(C)(C)N(C(C)=O)c6ccc(NC(=O)c7ccc(cc7)-c7ccccc7)cc56)nn4)nn3)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C63H68N14O6S2/c1-39(78)77-51-26-23-46(67-57(80)42-19-17-41(18-20-42)40-13-10-9-11-14-40)32-50(51)63(7,38-62(77,5)6)44-21-24-49(25-22-44)83-37-48-36-76(74-72-48)28-30-82-29-27-75-35-47(71-73-75)33-66-52(79)34-65-45-16-12-15-43(31-45)55-53-54(64)56(58(81)70-61(2,3)4)85-59(53)69-60(68-55)84-8/h9-26,31-32,35-36,65H,27-30,33-34,37-38,64H2,1-8H3,(H,66,79)(H,67,80)(H,70,81)/t63-/m0/s1
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n/an/an/an/a 80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene...


ACS Med Chem Lett 2: 85-89 (2011)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206402
PNG
(CHEMBL439392 | N-((S)-1-amino-3-(3-hydroxyphenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1NCCCCCC(=O)N[C@@H](Cc1cccc(O)c1)C(N)=O)-c1ccccn1
Show InChI InChI=1S/C33H40N6O3/c1-33(2,3)24-14-16-25(17-15-24)39-30(22-28(38-39)27-12-6-8-18-35-27)36-19-7-4-5-13-31(41)37-29(32(34)42)21-23-10-9-11-26(40)20-23/h6,8-12,14-18,20,22,29,36,40H,4-5,7,13,19,21H2,1-3H3,(H2,34,42)(H,37,41)/t29-/m0/s1
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n/an/an/an/a 150n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206399
PNG
(CHEMBL247700 | N-((S)-2-amino-1-(4-hydroxyphenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1NCCCCCC(=O)N[C@H](C(N)=O)c1ccc(O)cc1)-c1ccccn1
Show InChI InChI=1S/C32H38N6O3/c1-32(2,3)23-13-15-24(16-14-23)38-28(21-27(37-38)26-9-6-8-19-34-26)35-20-7-4-5-10-29(40)36-30(31(33)41)22-11-17-25(39)18-12-22/h6,8-9,11-19,21,30,35,39H,4-5,7,10,20H2,1-3H3,(H2,33,41)(H,36,40)/t30-/m0/s1
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n/an/an/an/a 170n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206397
PNG
((S)-N-(4-amino-4-oxo-1-phenylbutan-2-yl)-5-(1-(4-t...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@H](CC(N)=O)Cc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C33H39N5O2/c1-33(2,3)26-13-15-28(16-14-26)38-29(23-30(37-38)25-17-19-35-20-18-25)11-7-8-12-32(40)36-27(22-31(34)39)21-24-9-5-4-6-10-24/h4-6,9-10,13-20,23,27H,7-8,11-12,21-22H2,1-3H3,(H2,34,39)(H,36,40)/t27-/m0/s1
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n/an/an/an/a 190n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206395
PNG
((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1ccncc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-10-12-25(13-11-24)37-26(21-28(36-37)23-16-18-34-19-17-23)6-4-5-7-30(39)35-29(31(33)40)20-22-8-14-27(38)15-9-22/h8-19,21,29,38H,4-7,20H2,1-3H3,(H2,33,40)(H,35,39)/t29-/m0/s1
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n/an/an/an/a 250n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189778
PNG
(CHEMBL211405 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H22N4O2S2/c1-19(2,3)23-16(24)15-13(20)12-14(10-7-6-8-11(9-10)25-4)21-18(26-5)22-17(12)27-15/h6-9H,20H2,1-5H3,(H,23,24)
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n/an/an/an/a 300n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206400
PNG
(CHEMBL247945 | N-((S)-1-amino-3-(4-hydroxyphenyl)-...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1-c1cccc(c1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1cc2ccccc2cn1
Show InChI InChI=1S/C38H35N5O3/c1-38(2,3)29-13-15-30(16-14-29)43-35(22-33(42-43)32-21-25-7-4-5-8-28(25)23-40-32)26-9-6-10-27(20-26)37(46)41-34(36(39)45)19-24-11-17-31(44)18-12-24/h4-18,20-23,34,44H,19H2,1-3H3,(H2,39,45)(H,41,46)/t34-/m0/s1
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n/an/an/an/a 500n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189779
PNG
(CHEMBL377399 | N-tert-butyl-5-amino-4-(3-methoxyph...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)N(C)C(C)(C)C)c(N)c12
Show InChI InChI=1S/C20H24N4O2S2/c1-20(2,3)24(4)18(25)16-14(21)13-15(11-8-7-9-12(10-11)26-5)22-19(27-6)23-17(13)28-16/h7-10H,21H2,1-6H3
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n/an/an/an/a 800n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189775
PNG
(CHEMBL377769 | N-tert-butyl-5-amino-4-(2,3-dimetho...)
Show SMILES COc1cccc(c1OC)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C20H24N4O3S2/c1-20(2,3)24-17(25)16-13(21)12-14(22-19(28-6)23-18(12)29-16)10-8-7-9-11(26-4)15(10)27-5/h7-9H,21H2,1-6H3,(H,24,25)
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n/an/an/an/a 800n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189776
PNG
(CHEMBL211871 | tert-butyl 5-amino-4-(3-methoxyphen...)
Show SMILES COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)OC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H21N3O3S2/c1-19(2,3)25-17(23)15-13(20)12-14(10-7-6-8-11(9-10)24-4)21-18(26-5)22-16(12)27-15/h6-9H,20H2,1-5H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189777
PNG
(CHEMBL212815 | N-tert-butyl-5-amino-4-(3-fluorophe...)
Show SMILES CSc1nc(-c2cccc(F)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C18H19FN4OS2/c1-18(2,3)23-15(24)14-12(20)11-13(9-6-5-7-10(19)8-9)21-17(25-4)22-16(11)26-14/h5-8H,20H2,1-4H3,(H,23,24)
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n/an/an/an/a 1.20E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189773
PNG
(CHEMBL211129 | N-tert-butyl-5-amino-4-(2-fluoro-3-...)
Show SMILES COc1cccc(c1F)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12
Show InChI InChI=1S/C19H21FN4O2S2/c1-19(2,3)24-16(25)15-13(21)11-14(22-18(27-5)23-17(11)28-15)9-7-6-8-10(26-4)12(9)20/h6-8H,21H2,1-5H3,(H,24,25)
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n/an/an/an/a 1.50E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50256858
PNG
(CHEMBL474041 | Cyclopentyl-carbamic acid [1,1',3',...)
Show SMILES O=C(NC1CCCC1)Oc1cc(cc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H23NO2/c26-24(25-22-13-7-8-14-22)27-23-16-20(18-9-3-1-4-10-18)15-21(17-23)19-11-5-2-6-12-19/h1-6,9-12,15-17,22H,7-8,13-14H2,(H,25,26)
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n/an/an/an/a 1.60E+3n/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Agonist activity at human luteinizing hormone receptor expressed in CHOK1 cells assessed as c-AMP-mediated luciferase production


J Med Chem 52: 2036-42 (2009)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50189774
PNG
(CHEMBL378091 | N-tert-butyl-5-amino-4-(3-hydroxyph...)
Show SMILES CSc1nc(-c2cccc(O)c2)c2c(N)c(sc2n1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C18H20N4O2S2/c1-18(2,3)22-15(24)14-12(19)11-13(9-6-5-7-10(23)8-9)20-17(25-4)21-16(11)26-14/h5-8,23H,19H2,1-4H3,(H,22,24)
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n/an/an/an/a 1.90E+3n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at LHCGR expressed in HEK293 EM cells measured by intracellular cAMP accumulation


J Med Chem 49: 3888-96 (2006)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206405
PNG
((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(CCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)cc1-c1ccncc1
Show InChI InChI=1S/C32H37N5O3/c1-32(2,3)24-10-12-26(13-11-24)37-29(23-16-18-34-19-17-23)21-25(36-37)6-4-5-7-30(39)35-28(31(33)40)20-22-8-14-27(38)15-9-22/h8-19,21,28,38H,4-7,20H2,1-3H3,(H2,33,40)(H,35,39)/t28-/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206403
PNG
(CHEMBL269261 | N-((S)-1-amino-3-(4-tert-butoxyphen...)
Show SMILES CC(C)(C)Oc1ccc(C[C@H](NC(=O)CCCCNc2cc(nn2-c2ccc(cc2)C(C)(C)C)-c2cccnc2)C(N)=O)cc1
Show InChI InChI=1S/C36H46N6O3/c1-35(2,3)27-14-16-28(17-15-27)42-32(23-30(41-42)26-10-9-20-38-24-26)39-21-8-7-11-33(43)40-31(34(37)44)22-25-12-18-29(19-13-25)45-36(4,5)6/h9-10,12-20,23-24,31,39H,7-8,11,21-22H2,1-6H3,(H2,37,44)(H,40,43)/t31-/m0/s1
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n/an/an/an/a 1.21E+4n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206404
PNG
((S)-N-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-y...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1NCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1ccncc1
Show InChI InChI=1S/C31H36N6O3/c1-31(2,3)23-8-10-24(11-9-23)37-28(20-26(36-37)22-14-17-33-18-15-22)34-16-4-5-29(39)35-27(30(32)40)19-21-6-12-25(38)13-7-21/h6-15,17-18,20,27,34,38H,4-5,16,19H2,1-3H3,(H2,32,40)(H,35,39)/t27-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair
Luteinizing hormone/Choriogonadotropin receptor


(Homo sapiens)
BDBM50206396
PNG
((S)-2-{3-[2-(4-tert-butyl-phenyl)-5-pyridin-3-yl-2...)
Show SMILES CC(C)(C)c1ccc(cc1)-n1nc(cc1CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)-c1cccnc1
Show InChI InChI=1S/C30H33N5O3/c1-30(2,3)22-8-10-23(11-9-22)35-24(18-26(34-35)21-5-4-16-32-19-21)12-15-28(37)33-27(29(31)38)17-20-6-13-25(36)14-7-20/h4-11,13-14,16,18-19,27,36H,12,15,17H2,1-3H3,(H2,31,38)(H,33,37)/t27-/m0/s1
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Merck Serono Geneva Research Center

Curated by ChEMBL


Assay Description
Agonist activity at human LH receptor expressed in CHO cells assessed as production of cAMP after 60 mins by SPA


Bioorg Med Chem Lett 17: 2080-5 (2007)

More data for this
Ligand-Target Pair