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Compile Data Set for Download or QSAR

Found 153 hits of ec50 data for polymerid = 50000109   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258185
PNG
(CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 19n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258224
PNG
(CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 20n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258223
PNG
(CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 21n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258186
PNG
(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 25n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258226
PNG
(CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...)
Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1
Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)
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n/an/an/an/a 38n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258184
PNG
(CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258141
PNG
(CHEMBL492570 | rac-2-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)27-13)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258142
PNG
(2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)
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n/an/an/an/a 44n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258227
PNG
(4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 47n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258139
PNG
(CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...)
Show SMILES Cc1nc(NC(=O)C2c3ccccc3Oc3ccccc23)no1
Show InChI InChI=1S/C17H13N3O3/c1-10-18-17(20-23-10)19-16(21)15-11-6-2-4-8-13(11)22-14-9-5-3-7-12(14)15/h2-9,15H,1H3,(H,19,20,21)
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n/an/an/an/a 52n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258140
PNG
(CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...)
Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1
Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)
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n/an/an/an/a 56n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258224
PNG
(CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 67n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258142
PNG
(2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)
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n/an/an/an/a 90n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258185
PNG
(CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 102n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127965
PNG
(CHEMBL3628112)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 112n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127993
PNG
(CHEMBL3628115)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)
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n/an/an/an/a 112n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127965
PNG
(CHEMBL3628112)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 113n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127993
PNG
(CHEMBL3628115)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccncc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H12ClN3O4/c1-10-5-7-27-16(10)17(24)22-11-2-3-15(14(20)8-11)23-18(25)12-4-6-21-9-13(12)19(23)26/h2-9H,1H3,(H,22,24)
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n/an/an/an/a 113n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258225
PNG
(2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...)
Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3ncco3)c2c1
Show InChI InChI=1S/C17H10F2N2O3/c18-9-1-3-13-11(7-9)15(16(22)21-17-20-5-6-23-17)12-8-10(19)2-4-14(12)24-13/h1-8,15H,(H,20,21,22)
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n/an/an/an/a 124n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258223
PNG
(CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 131n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258225
PNG
(2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxa...)
Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3ncco3)c2c1
Show InChI InChI=1S/C17H10F2N2O3/c18-9-1-3-13-11(7-9)15(16(22)21-17-20-5-6-23-17)12-8-10(19)2-4-14(12)24-13/h1-8,15H,(H,20,21,22)
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n/an/an/an/a 140n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258227
PNG
(4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 161n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258186
PNG
(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 162n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258140
PNG
(CHEMBL521982 | N-(4-(trifluoromethyl)oxazol-2-yl)-...)
Show SMILES FC(F)(F)c1coc(NC(=O)C2c3ccccc3Oc3ccccc23)n1
Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-25-17(22-14)23-16(24)15-10-5-1-3-7-12(10)26-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)
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n/an/an/an/a 202n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258139
PNG
(CHEMBL492378 | N-(5-methyl-1,2,4-oxadiazol-3-yl)-9...)
Show SMILES Cc1nc(NC(=O)C2c3ccccc3Oc3ccccc23)no1
Show InChI InChI=1S/C17H13N3O3/c1-10-18-17(20-23-10)19-16(21)15-11-6-2-4-8-13(11)22-14-9-5-3-7-12(14)15/h2-9,15H,1H3,(H,19,20,21)
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n/an/an/an/a 220n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258184
PNG
(CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 260n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50128021
PNG
(CHEMBL3628116)
Show SMILES Clc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2Cl)cc1Cl
Show InChI InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
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n/an/an/an/a 356n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258226
PNG
(CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...)
Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1
Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)
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n/an/an/an/a 394n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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n/an/an/an/a 700n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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n/an/an/an/a 750n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR1c in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM55081
PNG
(ML182 | VU0400195-3 | cid_46869947)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)C2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O
Show InChI InChI=1S/C21H16ClN3O3/c22-14-10-13(24-19(26)15-3-1-2-8-23-15)6-7-16(14)25-20(27)17-11-4-5-12(9-11)18(17)21(25)28/h1-8,10-12,17-18H,9H2,(H,24,26)/t11-,12+,17-,18?/m1/s1
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n/an/an/an/a 1.45E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 1.59E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 1.60E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells by intracellular Ca2+ mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50293721
PNG
(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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n/an/an/an/a 2.34E+3n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assigned Assay Grant Number: NS053536-01 Screening Center Name & PI: Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters, C. David W...


PubChem Bioassay (2010)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17660
PNG
((2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl...)
Show SMILES N[C@@H](Cn1oc(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR1b in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Universit£ Ren£ Descartes

Curated by ChEMBL


Assay Description
Agonist activity in rat at Metabotropic glutamate receptor 1 expressed in HEK293 cells


Bioorg Med Chem Lett 11: 1569-72 (2001)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50034501
PNG
((S)-Amino-(3-hydroxy-isoxazol-5-yl)-acetic acid | ...)
Show SMILES N[C@H](C(O)=O)c1cc(=O)[nH]o1
Show InChI InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)/t4-/m0/s1
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n/an/an/an/a 6.00E+3n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 7.30E+3n/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Activity at rat mGluR1 by measuring intracellular calcium concentration in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 7.30E+3n/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Activity at rat recombinant mGluR1 expressed in CHO cells assessed as intracellular calcium concentration


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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n/an/an/an/a 9.00E+3n/an/an/an/a



CNS Research

Curated by ChEMBL


Assay Description
Concentration for half maximal activation of metabotropic glutamate mGluR1a in rat


J Med Chem 38: 1417-26 (1995)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50429413
PNG
(CHEMBL2338579)
Show SMILES Cc1cccc(n1)C(=O)N[C@H]1CCC[C@]2(CN=C(O2)c2cccc(Cl)c2)C1
Show InChI InChI=1S/C21H22ClN3O2/c1-14-5-2-9-18(24-14)19(26)25-17-8-4-10-21(12-17)13-23-20(27-21)15-6-3-7-16(22)11-15/h2-3,5-7,9,11,17H,4,8,10,12-13H2,1H3,(H,25,26)/t17-,21+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as Ca2+ mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50429414
PNG
(CHEMBL2338567)
Show SMILES Fc1cccc(c1)C(=O)N[C@@H]1CCC[C@H](C1)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H20ClFN2O2/c21-15-6-1-4-13(10-15)19(25)23-17-8-3-9-18(12-17)24-20(26)14-5-2-7-16(22)11-14/h1-2,4-7,10-11,17-18H,3,8-9,12H2,(H,23,25)(H,24,26)/t17-,18-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as Ca2+ mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50429415
PNG
(CHEMBL2338590)
Show SMILES Clc1cccc(c1)C(=O)N[C@@H]1CCC[C@H](C1)NC(=O)c1ccccn1
Show InChI InChI=1S/C19H20ClN3O2/c20-14-6-3-5-13(11-14)18(24)22-15-7-4-8-16(12-15)23-19(25)17-9-1-2-10-21-17/h1-3,5-6,9-11,15-16H,4,7-8,12H2,(H,22,24)(H,23,25)/t15-,16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as Ca2+ mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Effect on Metabotropic glutamate receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50429416
PNG
(CHEMBL2338587)
Show SMILES O=C(N[C@@H]1CCC[C@H](C1)NC(=O)c1ccccn1)c1cccc(c1)C#N
Show InChI InChI=1S/C20H20N4O2/c21-13-14-5-3-6-15(11-14)19(25)23-16-7-4-8-17(12-16)24-20(26)18-9-1-2-10-22-18/h1-3,5-6,9-11,16-17H,4,7-8,12H2,(H,23,25)(H,24,26)/t16-,17-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as Ca2+ mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50022759
PNG
(CHEMBL3298273)
Show SMILES Fc1cccc(COc2ccc3C(=O)NCCc3n2)c1
Show InChI InChI=1S/C15H13FN2O2/c16-11-3-1-2-10(8-11)9-20-14-5-4-12-13(18-14)6-7-17-15(12)19/h1-5,8H,6-7,9H2,(H,17,19)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu1 receptor expressed in HEK293 cells assessed as glutamate-induced calcium mobilization treated 140...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



The Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1


J Med Chem 45: 4240-5 (2002)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50429412
PNG
(CHEMBL2338582)
Show SMILES Clc1cccc(c1)C1=NC[C@]2(CCC[C@@H](C2)NC(=O)c2ccccn2)O1
Show InChI InChI=1S/C20H20ClN3O2/c21-15-6-3-5-14(11-15)19-23-13-20(26-19)9-4-7-16(12-20)24-18(25)17-8-1-2-10-22-17/h1-3,5-6,8,10-11,16H,4,7,9,12-13H2,(H,24,25)/t16-,20+/m0/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as Ca2+ mobilization by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
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