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Compile Data Set for Download or QSAR

Found 551 hits of ec50 data for polymerid = 50000109,50002822,8650   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143061
PNG
(CHEMBL3759901)
Show SMILES Nc1nc2nn(nc2c(=O)[nH]1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C11H8N6O3/c12-11-13-8-7(9(18)14-11)15-17(16-8)6-3-1-2-5(4-6)10(19)20/h1-4H,(H,19,20)(H3,12,13,14,16,18)
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n/an/an/an/a 5.40n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1nc(N)[nH]c(=O)c1N(Cc1ccc(Cl)c(Cl)c1)N=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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n/an/an/an/a 11n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132795
PNG
(CHEMBL3634447)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1C)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H16N2O4/c1-12-9-10-27-18(12)19(24)22-17-8-7-14(11-13(17)2)23-20(25)15-5-3-4-6-16(15)21(23)26/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 15n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132800
PNG
(CHEMBL3634442)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c2ccccc12
Show InChI InChI=1S/C25H18N2O4/c1-14-6-5-9-18-21(14)25(30)27(24(18)29)20-11-10-19(16-7-3-4-8-17(16)20)26-23(28)22-15(2)12-13-31-22/h3-13H,1-2H3,(H,26,28)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]batrachotoxin from sodium channel in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132789
PNG
(CHEMBL3634415)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(C)c2C1=O
Show InChI InChI=1S/C21H16N2O4/c1-12-4-3-5-16-17(12)21(26)23(20(16)25)15-8-6-14(7-9-15)22-19(24)18-13(2)10-11-27-18/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132712
PNG
(CHEMBL3632642)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C21H15ClN2O5/c1-11-8-9-29-18(11)19(25)23-12-6-7-15(16(10-12)28-2)24-20(26)13-4-3-5-14(22)17(13)21(24)27/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 18n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]hPP from human NPY4 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258185
PNG
(CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 19n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143062
PNG
(CHEMBL3758435)
Show SMILES Cn1c(N)nc(-c2ccccc2)c(Br)c1=O
Show InChI InChI=1S/C11H10BrN3O/c1-15-10(16)8(12)9(14-11(15)13)7-5-3-2-4-6-7/h2-6H,1H3,(H2,13,14)
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n/an/an/an/a 19n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258224
PNG
(CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 20n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132801
PNG
(CHEMBL3634441)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c2ccccc12
Show InChI InChI=1S/C24H16N2O4/c1-14-12-13-30-21(14)22(27)25-19-10-11-20(16-7-3-2-6-15(16)19)26-23(28)17-8-4-5-9-18(17)24(26)29/h2-13H,1H3,(H,25,27)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR1 by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132798
PNG
(CHEMBL3634444)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c2ccccc12
Show InChI InChI=1S/C24H15FN2O4/c1-13-11-12-31-21(13)22(28)26-18-9-10-19(15-6-3-2-5-14(15)18)27-23(29)16-7-4-8-17(25)20(16)24(27)30/h2-12H,1H3,(H,26,28)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132781
PNG
(CHEMBL3634423)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(C)c1
Show InChI InChI=1S/C22H18N2O4/c1-12-5-4-6-16-18(12)22(27)24(21(16)26)17-8-7-15(11-14(17)3)23-20(25)19-13(2)9-10-28-19/h4-11H,1-3H3,(H,23,25)
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n/an/an/an/a 21n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258223
PNG
(CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 21n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143063
PNG
(CHEMBL3758465)
Show SMILES Nc1nc2nn(nc2c(=O)[nH]1)-c1cccc(c1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H13F6N7O2/c21-19(22,23)11-4-9(5-12(7-11)20(24,25)26)8-28-16(34)10-2-1-3-13(6-10)33-31-14-15(32-33)29-18(27)30-17(14)35/h1-7H,8H2,(H,28,34)(H3,27,29,30,32,35)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143166
PNG
(CHEMBL3759038)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143081
PNG
(CHEMBL3759028)
Show SMILES Cc1cn[nH]c1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143166
PNG
(CHEMBL3759038)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132786
PNG
(CHEMBL3634418)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(F)c1
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132799
PNG
(CHEMBL3634443)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c2ccccc12
Show InChI InChI=1S/C24H15ClN2O4/c1-13-11-12-31-21(13)22(28)26-18-9-10-19(15-6-3-2-5-14(15)18)27-23(29)16-7-4-8-17(25)20(16)24(27)30/h2-12H,1H3,(H,26,28)
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n/an/an/an/a 23n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128120
PNG
(CHEMBL3628109)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128117
PNG
(CHEMBL3628114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128117
PNG
(CHEMBL3628114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258186
PNG
(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 25n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128120
PNG
(CHEMBL3628109)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 25n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132785
PNG
(CHEMBL3634419)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(F)c1
Show InChI InChI=1S/C21H15FN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1nc(N)[nH]c(=O)c1N(Cc1ccc(Cl)c(Cl)c1)N=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143060
PNG
(CHEMBL3758305)
Show SMILES CCOC(=O)c1cnc(N)[nH]c1=O
Show InChI InChI=1S/C7H9N3O3/c1-2-13-6(12)4-3-9-7(8)10-5(4)11/h3H,2H2,1H3,(H3,8,9,10,11)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132784
PNG
(CHEMBL3634420)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 28n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132788
PNG
(CHEMBL3634416)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H13ClN2O4/c1-11-9-10-27-17(11)18(24)22-12-5-7-13(8-6-12)23-19(25)14-3-2-4-15(21)16(14)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 29n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132796
PNG
(CHEMBL3634446)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1Cl)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13ClN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 29n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128118
PNG
(CHEMBL3628111)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128118
PNG
(CHEMBL3628111)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132807
PNG
(CHEMBL3634435)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(nc1)N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C19H12ClN3O4/c1-10-7-8-27-16(10)17(24)22-11-5-6-14(21-9-11)23-18(25)12-3-2-4-13(20)15(12)19(23)26/h2-9H,1H3,(H,22,24)
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n/an/an/an/a 35n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR1 by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132783
PNG
(CHEMBL3634421)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(F)c1
Show InChI InChI=1S/C20H12F2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 35n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258226
PNG
(CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...)
Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1
Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)
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n/an/an/an/a 38n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258141
PNG
(CHEMBL492570 | rac-2-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)27-13)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258184
PNG
(CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143076
PNG
(CHEMBL3758587)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143076
PNG
(CHEMBL3758587)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 42n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258142
PNG
(2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)
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n/an/an/an/a 44n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132787
PNG
(CHEMBL3634417)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(F)c2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-9-10-27-17(11)18(24)22-12-5-7-13(8-6-12)23-19(25)14-3-2-4-15(21)16(14)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 44n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132774
PNG
(CHEMBL3634430)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H16N2O5/c1-12-9-10-28-18(12)19(24)22-13-7-8-16(17(11-13)27-2)23-20(25)14-5-3-4-6-15(14)21(23)26/h3-11H,1-2H3,(H,22,24)
PDB

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antibodypedia
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PC sid
UniChem

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Article
PubMed
n/an/an/an/a 46n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Rattus norvegicus)
BDBM50258227
PNG
(4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/an/an/a 47n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
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