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Compile Data Set for Download or QSAR

Found 327 hits of ec50 data for polymerid = 50000262   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens)
BDBM50327452
PNG
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O
Show InChI InChI=1S/C25H25N5O3S/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33)
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n/an/an/an/a 3n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327451
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C24H25N5O3S/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32)
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n/an/an/an/a 6n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219622
PNG
(CHEMBL429295 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(OC(F)(F)F)c2F)ncn1
Show InChI InChI=1S/C24H18F4N6O3S/c25-21-16(2-1-3-18(21)37-24(26,27)28)17-11-38-23(32-17)33-22(36)13-4-6-14(7-5-13)31-19-8-20(30-12-29-19)34-9-15(35)10-34/h1-8,11-12,15,35H,9-10H2,(H,29,30,31)(H,32,33,36)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219622
PNG
(CHEMBL429295 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(OC(F)(F)F)c2F)ncn1
Show InChI InChI=1S/C24H18F4N6O3S/c25-21-16(2-1-3-18(21)37-24(26,27)28)17-11-38-23(32-17)33-22(36)13-4-6-14(7-5-13)31-19-8-20(30-12-29-19)34-9-15(35)10-34/h1-8,11-12,15,35H,9-10H2,(H,29,30,31)(H,32,33,36)
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Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219613
PNG
(CHEMBL248218 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H18F4N6O2S/c25-21-16(2-1-3-17(21)24(26,27)28)18-11-37-23(32-18)33-22(36)13-4-6-14(7-5-13)31-19-8-20(30-12-29-19)34-9-15(35)10-34/h1-8,11-12,15,35H,9-10H2,(H,29,30,31)(H,32,33,36)
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n/an/an/an/a 9n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248023
PNG
(1-(2,6-dichloro-4-(4-(2-fluoro-3-(trifluoromethyl)...)
Show SMILES OC(=O)C1CCN(CC1)c1c(Cl)cc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C23H17Cl2F4N3O3S/c24-15-8-12(9-16(25)19(15)32-6-4-11(5-7-32)21(34)35)20(33)31-22-30-17(10-36-22)13-2-1-3-14(18(13)26)23(27,28)29/h1-3,8-11H,4-7H2,(H,34,35)(H,30,31,33)
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n/an/an/an/a 10n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219644
PNG
(CHEMBL248390 | N-(5-chloro-4-(4-fluoro-3-(trifluor...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(Cl)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H17ClF4N6OS/c1-34(2)18-10-17(29-11-30-18)31-14-6-3-12(4-7-14)21(35)33-22-32-19(20(24)36-22)13-5-8-16(25)15(9-13)23(26,27)28/h3-11H,1-2H3,(H,29,30,31)(H,32,33,35)
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n/an/an/an/a 11n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219670
PNG
(CHEMBL249471 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES OC1CN(C1)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H17F4N7O2S/c24-17-6-3-13(7-16(17)23(25,26)27)20-31-22(37-33-20)32-21(36)12-1-4-14(5-2-12)30-18-8-19(29-11-28-18)34-9-15(35)10-34/h1-8,11,15,35H,9-10H2,(H,28,29,30)(H,31,32,33,36)
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n/an/an/an/a 13n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105970
PNG
(4-{N'-[1-(4-tert-Butyl-phenyl)-3-methyl-5-oxo-1,5-...)
Show SMILES Cc1[nH]n(-c2ccc(cc2)C(C)(C)C)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C24H24N4O5S/c1-14-21(23(30)28(27-14)16-11-9-15(10-12-16)24(2,3)4)25-26-22-18-8-6-5-7-17(18)20(13-19(22)29)34(31,32)33/h5-13,27,29H,1-4H3,(H,31,32,33)
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n/an/an/an/a 20n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50265150
PNG
(2-(7-(4-butylphenyl)-6-fluoro-5,10-dihydroindeno[1...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3Cc4cc(NC(=O)C(O)=O)ccc4-c3[nH]c2c1F
Show InChI InChI=1S/C27H23FN2O3/c1-2-3-4-15-5-7-16(8-6-15)19-11-12-21-22-14-17-13-18(29-26(31)27(32)33)9-10-20(17)24(22)30-25(21)23(19)28/h5-13,30H,2-4,14H2,1H3,(H,29,31)(H,32,33)
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n/an/an/an/a 21n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219654
PNG
(CHEMBL440231 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(CCO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H20F4N6O2S/c1-34(9-10-35)20-11-19(29-13-30-20)31-15-7-5-14(6-8-15)22(36)33-23-32-18(12-37-23)16-3-2-4-17(21(16)25)24(26,27)28/h2-8,11-13,35H,9-10H2,1H3,(H,29,30,31)(H,32,33,36)
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n/an/an/an/a 22n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327455
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C25H28N6O2S/c1-14-6-8-20(12-15(14)2)31-24(33)22(17(4)29-31)16(3)27-28-25(34)30-11-10-18-13-19(23(32)26-5)7-9-21(18)30/h6-9,12-13,29H,10-11H2,1-5H3,(H,26,32)(H,28,34)
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n/an/an/an/a 22n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219633
PNG
(4-(6-(azetidin-1-yl)pyrimidin-4-ylamino)-N-(4-(2-f...)
Show SMILES Fc1c(cccc1C(F)(F)F)-c1csc(NC(=O)c2ccc(Nc3cc(ncn3)N3CCC3)cc2)n1
Show InChI InChI=1S/C24H18F4N6OS/c25-21-16(3-1-4-17(21)24(26,27)28)18-12-36-23(32-18)33-22(35)14-5-7-15(8-6-14)31-19-11-20(30-13-29-19)34-9-2-10-34/h1,3-8,11-13H,2,9-10H2,(H,29,30,31)(H,32,33,35)
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n/an/an/an/a 23n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50265108
PNG
(CHEMBL498581 | N-(7-(4-butylphenyl)-6-fluoro-5,10-...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3Cc4cc(NC(C)=O)ccc4-c3[nH]c2c1F
Show InChI InChI=1S/C27H25FN2O/c1-3-4-5-17-6-8-18(9-7-17)21-12-13-23-24-15-19-14-20(29-16(2)31)10-11-22(19)26(24)30-27(23)25(21)28/h6-14,30H,3-5,15H2,1-2H3,(H,29,31)
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n/an/an/an/a 25n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263454
PNG
(9-(4-butylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C27H25NO3/c1-2-3-4-16-5-7-17(8-6-16)18-9-11-20-21-12-10-19-13-23(27(30)31)25(29)15-22(19)26(21)28-24(20)14-18/h5-9,11,13-15,28-29H,2-4,10,12H2,1H3,(H,30,31)
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n/an/an/an/a 26n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50264952
PNG
(6-fluoro-7-(4-fluoro-3-methylphenyl)-5,10-dihydroi...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O
Show InChI InChI=1S/C23H15F2NO2/c1-11-8-12(3-7-19(11)24)15-5-6-17-18-10-14-9-13(23(27)28)2-4-16(14)21(18)26-22(17)20(15)25/h2-9,26H,10H2,1H3,(H,27,28)
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n/an/an/an/a 26n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327457
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CCNC(=O)c1ccc2N(CCc2c1)C(=S)NN=C(C)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C26H30N6O2S/c1-6-27-24(33)20-8-10-22-19(14-20)11-12-31(22)26(35)29-28-17(4)23-18(5)30-32(25(23)34)21-9-7-15(2)16(3)13-21/h7-10,13-14,30H,6,11-12H2,1-5H3,(H,27,33)(H,29,35)
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n/an/an/an/a 26n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219621
PNG
(4-(pyrimidin-4-ylamino)-N-(7-trifluoromethyl-4,5-d...)
Show SMILES FC(F)(F)c1cccc2-c3nc(NC(=O)c4ccc(Nc5ccncn5)cc4)sc3CCOc12
Show InChI InChI=1S/C23H16F3N5O2S/c24-23(25,26)16-3-1-2-15-19-17(9-11-33-20(15)16)34-22(30-19)31-21(32)13-4-6-14(7-5-13)29-18-8-10-27-12-28-18/h1-8,10,12H,9,11H2,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 27n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248580
PNG
(6-(4-carbamoylpiperidin-1-yl)-5-chloro-N-(4-(2-flu...)
Show SMILES NC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H18ClF4N5O2S/c23-15-8-12(9-29-19(15)32-6-4-11(5-7-32)18(28)33)20(34)31-21-30-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H2,28,33)(H,30,31,34)
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n/an/an/an/a 28n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219659
PNG
((Z)-N-(4-(3,4-difluorophenyl)thiazol-2-yl)-4-((2,4...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H11F2N3O3S2/c21-13-6-5-12(8-14(13)22)15-9-29-19(23-15)24-17(26)11-3-1-10(2-4-11)7-16-18(27)25-20(28)30-16/h1-9H,(H,23,24,26)(H,25,27,28)
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n/an/an/an/a 28n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219614
PNG
(CHEMBL249672 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES CN(C(CO)NO)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C23H20F4N8O3S/c1-35(19(10-36)33-38)18-9-17(28-11-29-18)30-14-5-2-12(3-6-14)21(37)32-22-31-20(34-39-22)13-4-7-16(24)15(8-13)23(25,26)27/h2-9,11,19,33,36,38H,10H2,1H3,(H,28,29,30)(H,31,32,34,37)
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n/an/an/an/a 29n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219619
PNG
(CHEMBL248428 | N-(3-(4-fluoro-3-(trifluoromethyl)p...)
Show SMILES OCCNc1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H17F4N7O2S/c23-16-6-3-13(9-15(16)22(24,25)26)19-31-21(36-33-19)32-20(35)12-1-4-14(5-2-12)30-18-10-17(27-7-8-34)28-11-29-18/h1-6,9-11,34H,7-8H2,(H2,27,28,29,30)(H,31,32,33,35)
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n/an/an/an/a 30n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327456
PNG
(CHEMBL1257847 | N'-(1-(1-(3,4-dimethylphenyl)-3-me...)
Show SMILES CC(=NNC(=S)N1CCc2cc(ccc12)C(=O)N1CCOCC1)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C28H32N6O3S/c1-17-5-7-23(15-18(17)2)34-27(36)25(20(4)31-34)19(3)29-30-28(38)33-10-9-21-16-22(6-8-24(21)33)26(35)32-11-13-37-14-12-32/h5-8,15-16,31H,9-14H2,1-4H3,(H,30,38)
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n/an/an/an/a 31n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50377376
PNG
(CHEMBL408853)
Show SMILES Nc1nc(cs1)-c1cccc(OC(F)(F)F)c1F
Show InChI InChI=1S/C10H6F4N2OS/c11-8-5(6-4-18-9(15)16-6)2-1-3-7(8)17-10(12,13)14/h1-4H,(H2,15,16)
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n/an/an/an/a 32n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219625
PNG
(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 32n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219625
PNG
(CHEMBL247606 | N-(4-(2-fluoro-3-(trifluoromethoxy)...)
Show SMILES Fc1c(OC(F)(F)F)cccc1-c1csc(NC(=O)c2ccc(Nc3ccncn3)cc2)n1
Show InChI InChI=1S/C21H13F4N5O2S/c22-18-14(2-1-3-16(18)32-21(23,24)25)15-10-33-20(29-15)30-19(31)12-4-6-13(7-5-12)28-17-8-9-26-11-27-17/h1-11H,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 32n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248531
PNG
(1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248531
PNG
(1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl)phen...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human TPO receptor expressed in rat BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219679
PNG
(CHEMBL247645 | N-(4-(2,4-difluoro-3-(trifluorometh...)
Show SMILES Fc1ccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H12F5N5OS/c22-14-6-5-13(18(23)17(14)21(24,25)26)15-9-33-20(30-15)31-19(32)11-1-3-12(4-2-11)29-16-7-8-27-10-28-16/h1-10H,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 33n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248581
PNG
(5-chloro-N-(4-(2-fluoro-3-(trifluoromethyl)phenyl)...)
Show SMILES NS(=O)(=O)C1CCN(CC1)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C21H18ClF4N5O3S2/c22-15-8-11(9-28-18(15)31-6-4-12(5-7-31)36(27,33)34)19(32)30-20-29-16(10-35-20)13-2-1-3-14(17(13)23)21(24,25)26/h1-3,8-10,12H,4-7H2,(H2,27,33,34)(H,29,30,32)
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n/an/an/an/a 34n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263334
PNG
(9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H18FNO3/c1-12-8-13(4-7-20(12)25)14-2-5-16-17-6-3-15-9-19(24(28)29)22(27)11-18(15)23(17)26-21(16)10-14/h2,4-5,7-11,26-27H,3,6H2,1H3,(H,28,29)
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n/an/an/an/a 35n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219650
PNG
(CHEMBL247041 | N-(4-(2-fluoro-3-isobutylphenyl)thi...)
Show SMILES CC(C)Cc1cccc(-c2csc(NC(=O)c3ccc(Nc4ccncn4)cc3)n2)c1F
Show InChI InChI=1S/C24H22FN5OS/c1-15(2)12-17-4-3-5-19(22(17)25)20-13-32-24(29-20)30-23(31)16-6-8-18(9-7-16)28-21-10-11-26-14-27-21/h3-11,13-15H,12H2,1-2H3,(H,26,27,28)(H,29,30,31)
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n/an/an/an/a 35n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327454
PNG
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Show SMILES CC(=NNC(=S)N1CCCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O
Show InChI InChI=1S/C26H27N5O3S/c1-15(23-16(2)29-31(24(23)32)21-10-8-17-5-3-6-18(17)14-21)27-28-26(35)30-12-4-7-19-13-20(25(33)34)9-11-22(19)30/h8-11,13-14,29H,3-7,12H2,1-2H3,(H,28,35)(H,33,34)
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n/an/an/an/a 35n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50264951
PNG
(6-fluoro-7-(4-propylphenyl)-5,10-dihydroindeno[1,2...)
Show SMILES CCCc1ccc(cc1)-c1ccc2c3Cc4cc(ccc4-c3[nH]c2c1F)C(O)=O
Show InChI InChI=1S/C25H20FNO2/c1-2-3-14-4-6-15(7-5-14)18-10-11-20-21-13-17-12-16(25(28)29)8-9-19(17)23(21)27-24(20)22(18)26/h4-12,27H,2-3,13H2,1H3,(H,28,29)
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n/an/an/an/a 37n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248106
PNG
(CHEMBL461101 | ELTROMBOPAG)
Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O
Show InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)
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n/an/an/an/a 38n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219643
PNG
(CHEMBL246847 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES COc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H15F4N5O2S/c1-33-18-9-17(27-11-28-18)29-13-7-5-12(6-8-13)20(32)31-21-30-16(10-34-21)14-3-2-4-15(19(14)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 38n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248106
PNG
(CHEMBL461101 | ELTROMBOPAG)
Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O
Show InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)
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n/an/an/an/a 38n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105947
PNG
(3-Hydroxy-4-{N'-[3-methyl-5-oxo-1-(3-trifluorometh...)
Show SMILES Cc1[nH]n(-c2cccc(c2)C(F)(F)F)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C21H15F3N4O5S/c1-11-18(20(30)28(27-11)13-6-4-5-12(9-13)21(22,23)24)25-26-19-15-8-3-2-7-14(15)17(10-16(19)29)34(31,32)33/h2-10,27,29H,1H3,(H,31,32,33)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50105963
PNG
(4-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-...)
Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O
Show InChI InChI=1S/C22H20N4O5S/c1-12-8-9-15(10-13(12)2)26-22(28)20(14(3)25-26)23-24-21-17-7-5-4-6-16(17)19(11-18(21)27)32(29,30)31/h4-11,25,27H,1-3H3,(H,29,30,31)
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n/an/an/an/a 40n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263455
PNG
(2-hydroxy-9-(4-propoxyphenyl)-6,11-dihydro-5H-benz...)
Show SMILES CCCOc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C26H23NO4/c1-2-11-31-18-7-3-15(4-8-18)16-5-9-19-20-10-6-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-5,7-9,12-14,27-28H,2,6,10-11H2,1H3,(H,29,30)
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n/an/an/an/a 41n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327458
PNG
(1-(2-(1-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-...)
Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc(C)c(C)c2)c1=O
Show InChI InChI=1S/C24H25N5O4/c1-13-5-7-19(11-14(13)2)29-22(30)21(16(4)27-29)15(3)25-26-24(33)28-10-9-17-12-18(23(31)32)6-8-20(17)28/h5-8,11-12,27H,9-10H2,1-4H3,(H,26,33)(H,31,32)
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n/an/an/an/a 42n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219715
PNG
(CHEMBL245794 | N-(4-(2-fluoro-3-(trifluoromethyl)p...)
Show SMILES Cc1cc(Nc2ccc(cc2)C(=O)Nc2nc(cs2)-c2cccc(c2F)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H15F4N5OS/c1-12-9-18(28-11-27-12)29-14-7-5-13(6-8-14)20(32)31-21-30-17(10-33-21)15-3-2-4-16(19(15)23)22(24,25)26/h2-11H,1H3,(H,27,28,29)(H,30,31,32)
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n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219698
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(3-(4-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(ns2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C22H17F4N7OS/c1-33(2)18-10-17(27-11-28-18)29-14-6-3-12(4-7-14)20(34)31-21-30-19(32-35-21)13-5-8-16(23)15(9-13)22(24,25)26/h3-11H,1-2H3,(H,27,28,29)(H,30,31,32,34)
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n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248582
PNG
((4R)-1-(3-chloro-5-(4-(2-fluoro-3-(trifluoromethyl...)
Show SMILES C[C@H]1CN(CC1C(O)=O)c1ncc(cc1Cl)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17ClF4N4O3S/c1-10-7-31(8-13(10)20(33)34)18-15(23)5-11(6-28-18)19(32)30-21-29-16(9-35-21)12-3-2-4-14(17(12)24)22(25,26)27/h2-6,9-10,13H,7-8H2,1H3,(H,33,34)(H,29,30,32)/t10-,13?/m0/s1
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n/an/an/an/a 43n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50263457
PNG
(2-hydroxy-9-(3-propoxyphenyl)-6,11-dihydro-5H-benz...)
Show SMILES CCCOc1cccc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C26H23NO4/c1-2-10-31-18-5-3-4-15(11-18)16-6-8-19-20-9-7-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-6,8,11-14,27-28H,2,7,9-10H2,1H3,(H,29,30)
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n/an/an/an/a 43n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50325421
PNG
(4-(2-(1-(5-fluoro-2-oxo-1-p-tolylindolin-3-ylidene...)
Show SMILES CC(=NNC(=S)c1ccc(cc1)C(O)=O)C1C(=O)N(c2ccc(F)cc12)c1ccc(C)cc1
Show InChI InChI=1S/C25H20FN3O3S/c1-14-3-10-19(11-4-14)29-21-12-9-18(26)13-20(21)22(24(29)30)15(2)27-28-23(33)16-5-7-17(8-6-16)25(31)32/h3-13,22H,1-2H3,(H,28,33)(H,31,32)
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n/an/an/an/a 44n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant TPO receptor expressed in mouse BaF3 cells after 24 hrs


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50219675
PNG
(4-(6-(dimethylamino)pyrimidin-4-ylamino)-N-(4-(4-f...)
Show SMILES CN(C)c1cc(Nc2ccc(cc2)C(=O)Nc2nc(c(C)s2)-c2ccc(F)c(c2)C(F)(F)F)ncn1
Show InChI InChI=1S/C24H20F4N6OS/c1-13-21(15-6-9-18(25)17(10-15)24(26,27)28)32-23(36-13)33-22(35)14-4-7-16(8-5-14)31-19-11-20(34(2)3)30-12-29-19/h4-12H,1-3H3,(H,29,30,31)(H,32,33,35)
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n/an/an/an/a 45n/an/an/an/a



Pfizer Global Research & Development

Curated by ChEMBL


Assay Description
Agonist activity at human TPOr expressed in BaF3 cells by reporter assay


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50327459
PNG
(1-(2-(1-(1-(2,3-dihydro-1H-inden-5-yl)-3-methyl-5-...)
Show SMILES CC(=NN=C(O)N1CCc2cc(ccc12)C(O)=O)c1c(C)[nH]n(-c2ccc3CCCc3c2)c1=O
Show InChI InChI=1S/C25H25N5O4/c1-14(26-27-25(34)29-11-10-18-12-19(24(32)33)7-9-21(18)29)22-15(2)28-30(23(22)31)20-8-6-16-4-3-5-17(16)13-20/h6-9,12-13,28H,3-5,10-11H2,1-2H3,(H,27,34)(H,32,33)
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n/an/an/an/a 46n/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of human TPOR expressed in human BaF3 cells


Citation and Details
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens)
BDBM50248024
PNG
(1-(3-bromo-5-(4-(2-fluoro-3-(trifluoromethyl)pheny...)
Show SMILES OC(=O)C1CCN(CC1)c1ncc(cc1Br)C(=O)Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C22H17BrF4N4O3S/c23-15-8-12(9-28-18(15)31-6-4-11(5-7-31)20(33)34)19(32)30-21-29-16(10-35-21)13-2-1-3-14(17(13)24)22(25,26)27/h1-3,8-11H,4-7H2,(H,33,34)(H,29,30,32)
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n/an/an/an/a 50n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor transfected in mouse BAF3 cells assessed as stimulation of beta lactamase activity incubated in dar...


Citation and Details
More data for this
Ligand-Target Pair
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