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Compile Data Set for Download or QSAR

Found 7 hits of ec50 data for polymerid = 50001342   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM20608
PNG
(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Show SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
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Article
PubMed
n/an/an/an/a 15n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM22439
PNG
(GSK 9089 | GSK9089 | N'-[(1E)-[4-(diethylamino)phe...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)c2ccc(O)cc2)cc1
Show InChI InChI=1S/C18H21N3O2/c1-3-21(4-2)16-9-5-14(6-10-16)13-19-20-18(23)15-7-11-17(22)12-8-15/h5-13,22H,3-4H2,1-2H3,(H,20,23)/b19-13+
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Article
PubMed
n/an/an/an/a 130n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM22445
PNG
(Acyl Hydrazone, 10 | N'-[(1E)-1-[4-(diethylamino)p...)
Show SMILES CCN(CC)c1ccc(cc1)C(C)=NNC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C19H23N3O2/c1-4-22(5-2)17-10-6-15(7-11-17)14(3)20-21-19(24)16-8-12-18(23)13-9-16/h6-13,23H,4-5H2,1-3H3,(H,21,24)
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PubMed
n/an/an/an/a 500n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM22443
PNG
(4-amino-N'-[(1E)-[4-(diethylamino)phenyl]methylide...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)c2ccc(N)cc2)cc1
Show InChI InChI=1S/C18H22N4O/c1-3-22(4-2)17-11-5-14(6-12-17)13-20-21-18(23)15-7-9-16(19)10-8-15/h5-13H,3-4,19H2,1-2H3,(H,21,23)/b20-13+
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PubMed
n/an/an/an/a 630n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM20625
PNG
(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Show SMILES CC\C(=C(\CC)c1ccc(O)cc1)c1ccc(O)cc1
Show InChI InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
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PubMed
n/an/an/an/a 630n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM22438
PNG
(4-Hydroxy-benzoic acid (4-isopropyl-benzylidene)-h...)
Show SMILES CC(C)c1ccc(\C=N\NC(=O)c2ccc(O)cc2)cc1
Show InChI InChI=1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+
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Article
PubMed
n/an/an/an/a 1.30E+3n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens)
BDBM22442
PNG
(Acyl Hydrazone, 7 | N'-[(1E)-[4-(diethylamino)phen...)
Show SMILES CCN(CC)c1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H21N3O/c1-3-21(4-2)17-12-10-15(11-13-17)14-19-20-18(22)16-8-6-5-7-9-16/h5-14H,3-4H2,1-2H3,(H,20,22)/b19-14+
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Article
PubMed
n/an/an/an/a 1.60E+3n/an/a7.022



GSK



Assay Description
Recruitment of the RIP140 NR-box peptide to the ERRgamma ligand binding domain was assayed by FRET detection. Proteins were set up in a one to one ra...


J Med Chem 48: 3107-9 (2005)

More data for this
Ligand-Target Pair