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Compile Data Set for Download or QSAR

Found 322 hits of ec50 data for polymerid = 50001822,50005704   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50197695
PNG
(({[({[(2R,3S,4R,5R)-5-(5-fluoro-1,3-benzothiazol-2...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)c1nc2cc(F)ccc2s1
Show InChI InChI=1S/C12H15FNO13P3S/c13-5-1-2-8-6(3-5)14-12(31-8)11-10(16)9(15)7(25-11)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h1-3,7,9-11,15-16H,4H2,(H,20,21)(H,22,23)(H2,17,18,19)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a 3n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195835
PNG
(({[({[(2R,3S,4R,5R)-5-[7-fluoro-6-(methylsulfanyl)...)
Show SMILES CSc1cc2ccn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)c2cc1F
Show InChI InChI=1S/C15H19FNO14P3S/c1-35-11-4-7-2-3-17(14(20)8(7)5-9(11)16)15-13(19)12(18)10(29-15)6-28-33(24,25)31-34(26,27)30-32(21,22)23/h2-5,10,12-13,15,18-19H,6H2,1H3,(H,24,25)(H,26,27)(H2,21,22,23)/t10-,12-,13-,15-/m1/s1
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n/an/an/an/a 3n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195845
PNG
(({[({[(2R,3S,4R,5R)-5-[6-(dimethylamino)-7-fluoro-...)
Show SMILES CN(C)c1cc2ccn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)c2cc1F
Show InChI InChI=1S/C16H22FN2O14P3/c1-18(2)11-5-8-3-4-19(15(22)9(8)6-10(11)17)16-14(21)13(20)12(31-16)7-30-35(26,27)33-36(28,29)32-34(23,24)25/h3-6,12-14,16,20-21H,7H2,1-2H3,(H,26,27)(H,28,29)(H2,23,24,25)/t12-,13-,14-,16-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195825
PNG
(({[({[(2R,3S,4R,5R)-5-(7-fluoro-1-oxo-1,2-dihydroi...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2ccc(F)cc2c1=O
Show InChI InChI=1S/C14H17FNO14P3/c15-8-2-1-7-3-4-16(13(19)9(7)5-8)14-12(18)11(17)10(28-14)6-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-5,10-12,14,17-18H,6H2,(H,23,24)(H,25,26)(H2,20,21,22)/t10-,11-,12-,14-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195825
PNG
(({[({[(2R,3S,4R,5R)-5-(7-fluoro-1-oxo-1,2-dihydroi...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2ccc(F)cc2c1=O
Show InChI InChI=1S/C14H17FNO14P3/c15-8-2-1-7-3-4-16(13(19)9(7)5-8)14-12(18)11(17)10(28-14)6-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-5,10-12,14,17-18H,6H2,(H,23,24)(H,25,26)(H2,20,21,22)/t10-,11-,12-,14-/m1/s1
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n/an/an/an/a 5n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195847
PNG
(({[({[(2R,3S,4R,5R)-5-(7-fluoro-6-methoxy-1-oxo-1,...)
Show SMILES COc1cc2ccn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)c2cc1F
Show InChI InChI=1S/C15H19FNO15P3/c1-28-10-4-7-2-3-17(14(20)8(7)5-9(10)16)15-13(19)12(18)11(30-15)6-29-34(24,25)32-35(26,27)31-33(21,22)23/h2-5,11-13,15,18-19H,6H2,1H3,(H,24,25)(H,26,27)(H2,21,22,23)/t11-,12-,13-,15-/m1/s1
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n/an/an/an/a 6n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50197694
PNG
(({[({[(2R,3S,4R,5R)-5-(6-chloro-4-fluoro-1,3-benzo...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)c1nc2c(F)cc(Cl)cc2s1
Show InChI InChI=1S/C12H14ClFNO13P3S/c13-4-1-5(14)8-7(2-4)32-12(15-8)11-10(17)9(16)6(26-11)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6,9-11,16-17H,3H2,(H,21,22)(H,23,24)(H2,18,19,20)/t6-,9-,10-,11-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50205406
PNG
(((2R,3S,4R,5R)-4-amino-3-hydroxy-5-(4-oxo-2-thioxo...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H16N3O13P3S/c10-6-7(14)4(23-8(6)12-2-1-5(13)11-9(12)29)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,14H,3,10H2,(H,18,19)(H,20,21)(H,11,13,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 8n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2


J Med Chem 54: 4018-33 (2011)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50306712
PNG
(((1R,2R,3S,4R,5S)-4-(2,4-dioxo-3,4-dihydropyrimidi...)
Show SMILES O[C@@H]1[C@H](O)[C@]2(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C[C@@H]2[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C11H17N2O14P3/c14-6-1-2-13(10(17)12-6)7-5-3-11(5,9(16)8(7)15)4-25-29(21,22)27-30(23,24)26-28(18,19)20/h1-2,5,7-9,15-16H,3-4H2,(H,21,22)(H,23,24)(H,12,14,17)(H2,18,19,20)/t5-,7-,8+,9+,11+/m1/s1
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National Institute of Diabetes

Curated by ChEMBL


Assay Description
Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell


J Med Chem 45: 208-18 (2001)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50205406
PNG
(((2R,3S,4R,5R)-4-amino-3-hydroxy-5-(4-oxo-2-thioxo...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H16N3O13P3S/c10-6-7(14)4(23-8(6)12-2-1-5(13)11-9(12)29)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,14H,3,10H2,(H,18,19)(H,20,21)(H,11,13,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C


J Med Chem 50: 1166-76 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50197698
PNG
(({[({[(2R,3S,4R,5R)-5-(6-chloro-1,3-benzothiazol-2...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)c1nc2ccc(Cl)cc2s1
Show InChI InChI=1S/C12H15ClNO13P3S/c13-5-1-2-6-8(3-5)31-12(14-6)11-10(16)9(15)7(25-11)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h1-3,7,9-11,15-16H,4H2,(H,20,21)(H,22,23)(H2,17,18,19)/t7-,9-,10-,11-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50205406
PNG
(((2R,3S,4R,5R)-4-amino-3-hydroxy-5-(4-oxo-2-thioxo...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H16N3O13P3S/c10-6-7(14)4(23-8(6)12-2-1-5(13)11-9(12)29)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,14H,3,10H2,(H,18,19)(H,20,21)(H,11,13,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...


Bioorg Med Chem 16: 6319-32 (2008)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50205406
PNG
(((2R,3S,4R,5R)-4-amino-3-hydroxy-5-(4-oxo-2-thioxo...)
Show SMILES N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H16N3O13P3S/c10-6-7(14)4(23-8(6)12-2-1-5(13)11-9(12)29)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,14H,3,10H2,(H,18,19)(H,20,21)(H,11,13,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay


J Med Chem 53: 1673-85 (2010)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50197696
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(trifluorom...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)c1nc2cc(ccc2s1)C(F)(F)F
Show InChI InChI=1S/C13H15F3NO13P3S/c14-13(15,16)5-1-2-8-6(3-5)17-12(34-8)11-10(19)9(18)7(28-11)4-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-3,7,9-11,18-19H,4H2,(H,23,24)(H,25,26)(H2,20,21,22)/t7-,9-,10-,11-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195828
PNG
(({[({[(2R,3S,4R,5R)-5-(7-chloro-1-oxo-1,2-dihydroi...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C14H17ClNO14P3/c15-8-2-1-7-3-4-16(13(19)9(7)5-8)14-12(18)11(17)10(28-14)6-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-5,10-12,14,17-18H,6H2,(H,23,24)(H,25,26)(H2,20,21,22)/t10-,11-,12-,14-/m1/s1
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UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195842
PNG
(({[({[(2R,3S,4R,5R)-5-(7-cyano-1-oxo-1,2-dihydrois...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2ccc(cc2c1=O)C#N
Show InChI InChI=1S/C15H17N2O14P3/c16-6-8-1-2-9-3-4-17(14(20)10(9)5-8)15-13(19)12(18)11(29-15)7-28-33(24,25)31-34(26,27)30-32(21,22)23/h1-5,11-13,15,18-19H,7H2,(H,24,25)(H,26,27)(H2,21,22,23)/t11-,12-,13-,15-/m1/s1
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n/an/an/an/a 12n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195840
PNG
(({[({[(2R,3S,4R,5R)-5-(6,7-dichloro-1-oxo-1,2-dihy...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2cc(Cl)c(Cl)cc2c1=O
Show InChI InChI=1S/C14H16Cl2NO14P3/c15-8-3-6-1-2-17(13(20)7(6)4-9(8)16)14-12(19)11(18)10(29-14)5-28-33(24,25)31-34(26,27)30-32(21,22)23/h1-4,10-12,14,18-19H,5H2,(H,24,25)(H,26,27)(H2,21,22,23)/t10-,11-,12-,14-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50306712
PNG
(((1R,2R,3S,4R,5S)-4-(2,4-dioxo-3,4-dihydropyrimidi...)
Show SMILES O[C@@H]1[C@H](O)[C@]2(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C[C@@H]2[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C11H17N2O14P3/c14-6-1-2-13(10(17)12-6)7-5-3-11(5,9(16)8(7)15)4-25-29(21,22)27-30(23,24)26-28(18,19)20/h1-2,5,7-9,15-16H,3-4H2,(H,21,22)(H,23,24)(H,12,14,17)(H2,18,19,20)/t5-,7-,8+,9+,11+/m1/s1
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n/an/an/an/a 15.9n/an/an/an/a



Bar-Ilan University

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay


J Med Chem 53: 1673-85 (2010)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50306712
PNG
(((1R,2R,3S,4R,5S)-4-(2,4-dioxo-3,4-dihydropyrimidi...)
Show SMILES O[C@@H]1[C@H](O)[C@]2(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C[C@@H]2[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C11H17N2O14P3/c14-6-1-2-13(10(17)12-6)7-5-3-11(5,9(16)8(7)15)4-25-29(21,22)27-30(23,24)26-28(18,19)20/h1-2,5,7-9,15-16H,3-4H2,(H,21,22)(H,23,24)(H,12,14,17)(H2,18,19,20)/t5-,7-,8+,9+,11+/m1/s1
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n/an/an/an/a 15.9n/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Measure of Agonist Potency at human P2Y purinoceptor 2 (hP2Y2) stably expressed in 131N1 astrocytoma cell


J Med Chem 45: 208-18 (2001)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195822
PNG
(({[({[(2R,3S,4R,5R)-5-(6,7-difluoro-1-oxo-1,2-dihy...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2cc(F)c(F)cc2c1=O
Show InChI InChI=1S/C14H16F2NO14P3/c15-8-3-6-1-2-17(13(20)7(6)4-9(8)16)14-12(19)11(18)10(29-14)5-28-33(24,25)31-34(26,27)30-32(21,22)23/h1-4,10-12,14,18-19H,5H2,(H,24,25)(H,26,27)(H2,21,22,23)/t10-,11-,12-,14-/m1/s1
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n/an/an/an/a 16n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50319144
PNG
(((1S,2S,4S,5S)-4-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Show SMILES O[C@H]1C[C@@H]([C@H]2C[C@]12COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C11H17N2O13P3/c14-8-3-7(13-2-1-9(15)12-10(13)16)6-4-11(6,8)5-24-28(20,21)26-29(22,23)25-27(17,18)19/h1-2,6-8,14H,3-5H2,(H,20,21)(H,22,23)(H,12,15,16)(H2,17,18,19)/t6-,7+,8+,11-/m1/s1
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n/an/an/an/a 16n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...


J Med Chem 53: 4488-501 (2010)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 18n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by ...


J Med Chem 54: 2878-90 (2011)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 20n/an/an/an/a



Ghent University

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as stimulation of PLC-induced [3H]inositol phosphate production afte...


Bioorg Med Chem 20: 2304-15 (2012)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50197697
PNG
(({[({[(2R,3S,4R,5R)-5-(1,3-benzothiazol-2-yl)-3,4-...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)c1nc2ccccc2s1
Show InChI InChI=1S/C12H16NO13P3S/c14-9-7(5-23-28(19,20)26-29(21,22)25-27(16,17)18)24-11(10(9)15)12-13-6-3-1-2-4-8(6)30-12/h1-4,7,9-11,14-15H,5H2,(H,19,20)(H,21,22)(H2,16,17,18)/t7-,9-,10-,11-/m1/s1
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n/an/an/an/a 22n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195830
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(7-methoxy-1-o...)
Show SMILES COc1ccc2ccn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)c2c1
Show InChI InChI=1S/C15H20NO15P3/c1-27-9-3-2-8-4-5-16(14(19)10(8)6-9)15-13(18)12(17)11(29-15)7-28-33(23,24)31-34(25,26)30-32(20,21)22/h2-6,11-13,15,17-18H,7H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)/t11-,12-,13-,15-/m1/s1
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n/an/an/an/a 26n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50341880
PNG
(((2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo-4-thioxo-3,4...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=S)[nH]c1=O
Show InChI InChI=1S/C9H15N2O14P3S/c12-6-4(3-22-27(18,19)25-28(20,21)24-26(15,16)17)23-8(7(6)13)11-2-1-5(29)10-9(11)14/h1-2,4,6-8,12-13H,3H2,(H,18,19)(H,20,21)(H,10,14,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 26n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by ...


J Med Chem 54: 2878-90 (2011)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50319143
PNG
(CHEMBL1083764 | CHEMBL1198849 | N4-Methoxycytidine...)
Show SMILES CONc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C10H18N3O15P3/c1-24-12-6-2-3-13(10(16)11-6)9-8(15)7(14)5(26-9)4-25-30(20,21)28-31(22,23)27-29(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 28n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by sc...


J Med Chem 54: 4018-33 (2011)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50270550
PNG
(CHEMBL503798 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=S)[nH]c1=O)n1ccc(=S)[nH]c1=O
Show InChI InChI=1S/C18H26N4O21P4S2/c23-11-7(39-15(13(11)25)21-3-1-9(48)19-17(21)27)5-37-44(29,30)41-46(33,34)43-47(35,36)42-45(31,32)38-6-8-12(24)14(26)16(40-8)22-4-2-10(49)20-18(22)28/h1-4,7-8,11-16,23-26H,5-6H2,(H,29,30)(H,31,32)(H,33,34)(H,35,36)(H,19,27,48)(H,20,28,49)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...


Bioorg Med Chem 16: 6319-32 (2008)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195834
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-{4-oxo-4H,5H-t...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc2sccc2c1=O
Show InChI InChI=1S/C12H16NO14P3S/c14-9-7(5-24-29(20,21)27-30(22,23)26-28(17,18)19)25-12(10(9)15)13-3-1-8-6(11(13)16)2-4-31-8/h1-4,7,9-10,12,14-15H,5H2,(H,20,21)(H,22,23)(H2,17,18,19)/t7-,9-,10-,12-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



Inspire Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y2 ...


Bioorg Med Chem Lett 11: 157-60 (2001)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195826
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(1-oxo-1,2-dih...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2ccccc2c1=O
Show InChI InChI=1S/C14H18NO14P3/c16-11-10(7-26-31(22,23)29-32(24,25)28-30(19,20)21)27-14(12(11)17)15-6-5-8-3-1-2-4-9(8)13(15)18/h1-6,10-12,14,16-17H,7H2,(H,22,23)(H,24,25)(H2,19,20,21)/t10-,11-,12-,14-/m1/s1
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n/an/an/an/a 31n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50371572
PNG
(CHEMBL406266)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])(=O)OC[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)n1ccc(=O)[nH]c1=O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,30)/p-4/t7-,8+,11-,12+,13-,14+,15-,16+
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n/an/an/an/a 34n/an/an/an/a



Inspire Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at P2Y2 receptor expressed in human 1321 cells by calcium mobilization assay


J Med Chem 51: 1007-25 (2008)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195844
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methyl-1-ox...)
Show SMILES Cc1ccc2c(ccn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c2=O)c1
Show InChI InChI=1S/C15H20NO14P3/c1-8-2-3-10-9(6-8)4-5-16(14(10)19)15-13(18)12(17)11(28-15)7-27-32(23,24)30-33(25,26)29-31(20,21)22/h2-6,11-13,15,17-18H,7H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)/t11-,12-,13-,15-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C


J Med Chem 50: 1166-76 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195833
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-oxo-5,6-dih...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc2ncccc2c1=O
Show InChI InChI=1S/C13H17N2O14P3/c16-10-9(6-26-31(22,23)29-32(24,25)28-30(19,20)21)27-13(11(10)17)15-5-3-8-7(12(15)18)2-1-4-14-8/h1-5,9-11,13,16-17H,6H2,(H,22,23)(H,24,25)(H2,19,20,21)/t9-,10-,11-,13-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by sc...


J Med Chem 54: 4018-33 (2011)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 35n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity as...


Bioorg Med Chem 16: 6319-32 (2008)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50197693
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methoxy-1,3...)
Show SMILES COc1ccc2nc(sc2c1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H18NO14P3S/c1-24-6-2-3-7-9(4-6)32-13(14-7)12-11(16)10(15)8(26-12)5-25-30(20,21)28-31(22,23)27-29(17,18)19/h2-4,8,10-12,15-16H,5H2,1H3,(H,20,21)(H,22,23)(H2,17,18,19)/t8-,10-,11-,12-/m1/s1
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n/an/an/an/a 42n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 558-61 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 43n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


J Med Chem 49: 7076-87 (2006)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50371610
PNG
(CHEMBL1162198)
Show SMILES Nc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]3O[C@@H]([C@@H](O)[C@H]3O)n3ccc(=O)[nH]c3=O)[C@@H](O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C18H27N5O22P4/c19-9-1-3-22(17(29)20-9)15-13(27)11(25)7(41-15)5-39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,34)40-6-8-12(26)14(28)16(42-8)23-4-2-10(24)21-18(23)30/h1-4,7-8,11-16,25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H2,19,20,29)(H,21,24,30)/t7-,8+,11-,12+,13-,14+,15-,16+/m1/s1
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n/an/an/an/a 44n/an/an/an/a



Inspire Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at P2Y2 receptor expressed in human 1321 cells by calcium mobilization assay


J Med Chem 51: 1007-25 (2008)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50012978
PNG
(CHEMBL3261369)
Show SMILES COc1ccc(CCCO\N=c2\ccn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(=O)[nH]2)cc1
Show InChI InChI=1S/C19H28N3O16P3/c1-33-13-6-4-12(5-7-13)3-2-10-34-21-15-8-9-22(19(25)20-15)18-17(24)16(23)14(36-18)11-35-40(29,30)38-41(31,32)37-39(26,27)28/h4-9,14,16-18,23-24H,2-3,10-11H2,1H3,(H,29,30)(H,31,32)(H,20,21,25)(H2,26,27,28)/t14-,16-,17-,18-/m1/s1
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n/an/an/an/a 47n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as stimulation of [3H]inositol phosphate accumulation by liquid scin...


J Med Chem 57: 3874-83 (2014)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 49n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C


J Med Chem 50: 1166-76 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50319143
PNG
(CHEMBL1083764 | CHEMBL1198849 | N4-Methoxycytidine...)
Show SMILES CONc1ccn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1
Show InChI InChI=1S/C10H18N3O15P3/c1-24-12-6-2-3-13(10(16)11-6)9-8(15)7(14)5(26-9)4-25-30(20,21)28-31(22,23)27-29(17,18)19/h2-3,5,7-9,14-15H,4H2,1H3,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1
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n/an/an/an/a 50n/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production by scintillation pr...


J Med Chem 53: 4488-501 (2010)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50199176
PNG
(2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-di...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=S
Show InChI InChI=1S/C9H15N2O14P3S/c12-5-1-2-11(9(29)10-5)8-7(14)6(13)4(23-8)3-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,4,6-8,13-14H,3H2,(H,18,19)(H,20,21)(H,10,12,29)(H2,15,16,17)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 50n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA


J Med Chem 49: 7076-87 (2006)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50371598
PNG
(CHEMBL1162170)
Show SMILES Nc1ncnc2n(cnc12)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@@H]3OC(Cc4ccccc4)O[C@H]23)n2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C28H34N10O19P4/c29-23-17-25(33-9-31-23)37(11-35-17)27-20(40)19(39)14(51-27)7-49-58(41,42)55-60(45,46)57-61(47,48)56-59(43,44)50-8-15-21-22(54-16(53-21)6-13-4-2-1-3-5-13)28(52-15)38-12-36-18-24(30)32-10-34-26(18)38/h1-5,9-12,14-16,19-22,27-28,39-40H,6-8H2,(H,41,42)(H,43,44)(H,45,46)(H,47,48)(H2,29,31,33)(H2,30,32,34)/t14-,15+,16?,19-,20-,21+,22+,27-,28+/m0/s1
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n/an/an/an/a 52n/an/an/an/a



Inspire Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Agonist activity at P2Y2 receptor expressed in human 1321 cells by calcium mobilization assay


J Med Chem 51: 1007-25 (2008)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50195827
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(1-oxo-1,2,5,6...)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc2CCCCc2c1=O
Show InChI InChI=1S/C14H22NO14P3/c16-11-10(7-26-31(22,23)29-32(24,25)28-30(19,20)21)27-14(12(11)17)15-6-5-8-3-1-2-4-9(8)13(15)18/h5-6,10-12,14,16-17H,1-4,7H2,(H,22,23)(H,24,25)(H2,19,20,21)/t10-,11-,12-,14-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



UCB-Group

Curated by ChEMBL


Assay Description
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay


Bioorg Med Chem Lett 17: 562-5 (2007)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 55n/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate production after 30 mins by sc...


J Med Chem 54: 4018-33 (2011)

More data for this
Ligand-Target Pair
Purinergic receptor P2Y2


(Homo sapiens)
BDBM50118213
PNG
(5'-UTP | CHEMBL336296 | H4utp | UTP | uridine 5'-(...)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
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n/an/an/an/a 59n/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Agonist activity at N-terminal HA epitope-tagged wild type 4 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellula...


J Med Chem 52: 2762-75 (2009)

More data for this
Ligand-Target Pair
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