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Compile Data Set for Download or QSAR

Found 1039 hits of ec50 data for polymerid = 50002313,6547   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50268793
PNG
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](CN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)N=C(N)N)C(N)=O
Show InChI InChI=1S/C50H67N15O9/c1-3-4-15-36(58-28(2)66)44(69)62-39-23-42(67)55-18-11-10-17-35(43(51)68)60-45(70)37(20-30-24-56-34-16-9-8-14-33(30)34)63-48(73)41-22-32(59-50(52)53)26-65(41)49(74)40(19-29-12-6-5-7-13-29)64-46(71)38(61-47(39)72)21-31-25-54-27-57-31/h5-9,12-14,16,24-25,27,32,35-41,56H,3-4,10-11,15,17-23,26H2,1-2H3,(H2,51,68)(H,54,57)(H,55,67)(H,58,66)(H,60,70)(H,61,72)(H,62,69)(H,63,73)(H,64,71)(H4,52,53,59)/t32-,35-,36-,37-,38-,39-,40+,41-/m0/s1
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n/an/an/an/a 0n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level


J Med Chem 52: 3627-35 (2009)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50268799
PNG
(Ac-Nle-c[Asp-His-DNal(2')-trans-4-guanidinyl-Pro-T...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](CN2C(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)N=C(N)N)C(N)=O
Show InChI InChI=1S/C54H69N15O9/c1-3-4-14-40(62-30(2)70)48(73)66-43-25-46(71)59-19-10-9-16-39(47(55)72)64-49(74)41(22-34-26-60-38-15-8-7-13-37(34)38)67-52(77)45-24-36(63-54(56)57)28-69(45)53(78)44(21-31-17-18-32-11-5-6-12-33(32)20-31)68-50(75)42(65-51(43)76)23-35-27-58-29-61-35/h5-8,11-13,15,17-18,20,26-27,29,36,39-45,60H,3-4,9-10,14,16,19,21-25,28H2,1-2H3,(H2,55,72)(H,58,61)(H,59,71)(H,62,70)(H,64,74)(H,65,76)(H,66,73)(H,67,77)(H,68,75)(H4,56,57,63)/t36-,39-,40-,41-,42-,43-,44+,45-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level


J Med Chem 52: 3627-35 (2009)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250673
PNG
(US9447148, 9.42 | US9447148, 9.55)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C48H70N14O9/c1-3-4-15-33(56-28(2)63)42(66)59-36-19-20-40(64)53-24-21-37(46(70)61-38(41(50)65)26-30-27-55-32-16-9-8-14-31(30)32)60-43(67)35(18-11-23-54-48(51)52)58-47(71)39(25-29-12-6-5-7-13-29)62-44(68)34(17-10-22-49)57-45(36)69/h5-9,12-14,16,27,33-39,55H,3-4,10-11,15,17-26,49H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,71)(H,59,66)(H,60,67)(H,61,70)(H,62,68)(H4,51,52,54)/t33-,34-,35-,36-,37-,38-,39+/s2
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n/an/an/an/a 0.00200n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250661
PNG
(US9447148, 9.30)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1/C51H68N14O9/c1-3-4-18-36(59-30(2)66)45(69)61-38-20-21-43(67)56-24-22-39(48(72)63-40(44(52)68)26-33-16-10-15-32-14-8-9-17-35(32)33)62-46(70)37(19-11-23-57-51(53)54)60-49(73)41(25-31-12-6-5-7-13-31)64-50(74)42(65-47(38)71)27-34-28-55-29-58-34/h5-10,12-17,28-29,36-42H,3-4,11,18-27H2,1-2H3,(H2,52,68)(H,55,58)(H,56,67)(H,59,66)(H,60,73)(H,61,69)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H4,53,54,57)/t36-,37-,38-,39-,40-,41+,42-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250673
PNG
(US9447148, 9.42 | US9447148, 9.55)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C48H70N14O9/c1-3-4-15-33(56-28(2)63)42(66)59-36-19-20-40(64)53-24-21-37(46(70)61-38(41(50)65)26-30-27-55-32-16-9-8-14-31(30)32)60-43(67)35(18-11-23-54-48(51)52)58-47(71)39(25-29-12-6-5-7-13-29)62-44(68)34(17-10-22-49)57-45(36)69/h5-9,12-14,16,27,33-39,55H,3-4,10-11,15,17-26,49H2,1-2H3,(H2,50,65)(H,53,64)(H,56,63)(H,57,69)(H,58,71)(H,59,66)(H,60,67)(H,61,70)(H,62,68)(H4,51,52,54)/t33-,34-,35-,36-,37-,38-,39+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250668
PNG
(US9447148, 9.37 | US9447148, 9.50)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C49H72N16O9/c1-3-4-15-33(59-28(2)66)42(69)62-36-19-20-40(67)55-24-21-37(46(73)64-38(41(50)68)26-30-27-58-32-16-9-8-14-31(30)32)63-43(70)34(17-10-22-56-48(51)52)61-47(74)39(25-29-12-6-5-7-13-29)65-44(71)35(60-45(36)72)18-11-23-57-49(53)54/h5-9,12-14,16,27,33-39,58H,3-4,10-11,15,17-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,72)(H,61,74)(H,62,69)(H,63,70)(H,64,73)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37-,38-,39+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250668
PNG
(US9447148, 9.37 | US9447148, 9.50)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C49H72N16O9/c1-3-4-15-33(59-28(2)66)42(69)62-36-19-20-40(67)55-24-21-37(46(73)64-38(41(50)68)26-30-27-58-32-16-9-8-14-31(30)32)63-43(70)34(17-10-22-56-48(51)52)61-47(74)39(25-29-12-6-5-7-13-29)65-44(71)35(60-45(36)72)18-11-23-57-49(53)54/h5-9,12-14,16,27,33-39,58H,3-4,10-11,15,17-26H2,1-2H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,72)(H,61,74)(H,62,69)(H,63,70)(H,64,73)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t33-,34-,35-,36-,37-,38-,39+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250649
PNG
(US9447148, 9.18)
Show SMILES CCCCCCC(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C48H66N14O8/c1-2-3-4-8-17-41(64)57-35-18-19-40(63)53-22-20-36(45(68)60-37(42(49)65)24-30-26-55-33-15-10-9-14-32(30)33)59-43(66)34(16-11-21-54-48(50)51)58-46(69)38(23-29-12-6-5-7-13-29)61-47(70)39(62-44(35)67)25-31-27-52-28-56-31/h5-7,9-10,12-15,26-28,34-39,55H,2-4,8,11,16-25H2,1H3,(H2,49,65)(H,52,56)(H,53,63)(H,57,64)(H,58,69)(H,59,66)(H,60,68)(H,61,70)(H,62,67)(H4,50,51,54)/t34-,35-,36-,37-,38+,39-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250642
PNG
(US9447148, 9.10)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1/C51H68N14O9/c1-3-4-15-36(59-30(2)66)45(69)61-38-19-20-43(67)56-23-21-39(48(72)63-40(44(52)68)26-32-17-18-33-13-8-9-14-34(33)24-32)62-46(70)37(16-10-22-57-51(53)54)60-49(73)41(25-31-11-6-5-7-12-31)64-50(74)42(65-47(38)71)27-35-28-55-29-58-35/h5-9,11-14,17-18,24,28-29,36-42H,3-4,10,15-16,19-23,25-27H2,1-2H3,(H2,52,68)(H,55,58)(H,56,67)(H,59,66)(H,60,73)(H,61,69)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H4,53,54,57)/t36-,37-,38-,39-,40-,41+,42-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250651
PNG
(US9447148, 9.20)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)NCC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)NC(=O)C1CCCCC1
Show InChI InChI=1/C48H64N14O8/c49-41(64)37(23-30-25-55-33-15-8-7-14-32(30)33)60-45(68)36-19-21-53-40(63)18-17-35(57-42(65)29-12-5-2-6-13-29)44(67)62-39(24-31-26-52-27-56-31)47(70)61-38(22-28-10-3-1-4-11-28)46(69)58-34(43(66)59-36)16-9-20-54-48(50)51/h1,3-4,7-8,10-11,14-15,25-27,29,34-39,55H,2,5-6,9,12-13,16-24H2,(H2,49,64)(H,52,56)(H,53,63)(H,57,65)(H,58,69)(H,59,66)(H,60,68)(H,61,70)(H,62,67)(H4,50,51,54)/t34-,35-,36-,37-,38+,39-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250653
PNG
(US9447148, 9.22)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)NCC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)NC(=O)CC1CCCCC1
Show InChI InChI=1/C49H66N14O8/c50-43(66)38(24-31-26-56-34-15-8-7-14-33(31)34)61-46(69)37-19-21-54-41(64)18-17-36(58-42(65)23-30-12-5-2-6-13-30)45(68)63-40(25-32-27-53-28-57-32)48(71)62-39(22-29-10-3-1-4-11-29)47(70)59-35(44(67)60-37)16-9-20-55-49(51)52/h1,3-4,7-8,10-11,14-15,26-28,30,35-40,56H,2,5-6,9,12-13,16-25H2,(H2,50,66)(H,53,57)(H,54,64)(H,58,65)(H,59,70)(H,60,67)(H,61,69)(H,62,71)(H,63,68)(H4,51,52,55)/t35-,36-,37-,38-,39+,40-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250652
PNG
(US9447148, 9.21)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)NCC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)NC(=O)CC1CCCC1
Show InChI InChI=1/C48H64N14O8/c49-42(65)37(23-30-25-55-33-14-7-6-13-32(30)33)60-45(68)36-18-20-53-40(63)17-16-35(57-41(64)22-29-11-4-5-12-29)44(67)62-39(24-31-26-52-27-56-31)47(70)61-38(21-28-9-2-1-3-10-28)46(69)58-34(43(66)59-36)15-8-19-54-48(50)51/h1-3,6-7,9-10,13-14,25-27,29,34-39,55H,4-5,8,11-12,15-24H2,(H2,49,65)(H,52,56)(H,53,63)(H,57,64)(H,58,69)(H,59,66)(H,60,68)(H,61,70)(H,62,67)(H4,50,51,54)/t34-,35-,36-,37-,38+,39-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250648
PNG
(US9447148, 9.17)
Show SMILES CCCCCC(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C47H64N14O8/c1-2-3-5-16-40(63)56-34-17-18-39(62)52-21-19-35(44(67)59-36(41(48)64)23-29-25-54-32-14-9-8-13-31(29)32)58-42(65)33(15-10-20-53-47(49)50)57-45(68)37(22-28-11-6-4-7-12-28)60-46(69)38(61-43(34)66)24-30-26-51-27-55-30/h4,6-9,11-14,25-27,33-38,54H,2-3,5,10,15-24H2,1H3,(H2,48,64)(H,51,55)(H,52,62)(H,56,63)(H,57,68)(H,58,65)(H,59,67)(H,60,69)(H,61,66)(H4,49,50,53)/t33-,34-,35-,36-,37+,38-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135768
PNG
(US8846601, 153 | US9458201, 153)
Show SMILES CCCCC(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C46H62N14O8/c1-2-3-15-39(62)55-33-16-17-38(61)51-20-18-34(43(66)58-35(40(47)63)22-28-24-53-31-13-8-7-12-30(28)31)57-41(64)32(14-9-19-52-46(48)49)56-44(67)36(21-27-10-5-4-6-11-27)59-45(68)37(60-42(33)65)23-29-25-50-26-54-29/h4-8,10-13,24-26,32-37,53H,2-3,9,14-23H2,1H3,(H2,47,63)(H,50,54)(H,51,61)(H,55,62)(H,56,67)(H,57,64)(H,58,66)(H,59,68)(H,60,65)(H4,48,49,52)/t32-,33-,34-,35-,36+,37-/s2
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n/an/an/an/a 0.00500n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250643
PNG
(US9447148, 9.11)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O
Show InChI InChI=1/C51H68N14O9/c1-3-4-15-36(59-30(2)66)45(69)61-38-19-20-43(67)56-23-21-39(48(72)63-40(44(52)68)26-32-17-18-33-13-8-9-14-34(33)24-32)62-46(70)37(16-10-22-57-51(53)54)60-49(73)41(25-31-11-6-5-7-12-31)64-50(74)42(65-47(38)71)27-35-28-55-29-58-35/h5-9,11-14,17-18,24,28-29,36-42H,3-4,10,15-16,19-23,25-27H2,1-2H3,(H2,52,68)(H,55,58)(H,56,67)(H,59,66)(H,60,73)(H,61,69)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H4,53,54,57)/t36-,37-,38-,39-,40+,41+,42-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM82411
PNG
(CAS_75921-69-6 | NDP-MSH)
Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1
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n/an/an/an/a 0.00500n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Decrease in frog skin reflectivity (melanotropic activity).


J Med Chem 40: 2740-9 (1997)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50033130
PNG
((3R,6S,9R,12S,15S,23R)-15-((S)-2-Acetylamino-hexan...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H68ClN15O9/c1-3-4-11-36(60-28(2)67)44(70)66-41-24-42(68)56-19-8-7-13-35(43(52)69)61-47(73)39(22-30-25-58-34-12-6-5-10-33(30)34)64-45(71)37(14-9-20-57-50(53)54)62-46(72)38(21-29-15-17-31(51)18-16-29)63-48(74)40(65-49(41)75)23-32-26-55-27-59-32/h5-6,10,12,15-18,25-27,35-41,58H,3-4,7-9,11,13-14,19-24H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36+,37+,38-,39-,40+,41+/m1/s1
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n/an/an/an/a 0.00500n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Evaluated for agonist activity against human Melanocortin 1 receptor using hMC1-R assay


J Med Chem 38: 3454-61 (1995)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50033130
PNG
((3R,6S,9R,12S,15S,23R)-15-((S)-2-Acetylamino-hexan...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H68ClN15O9/c1-3-4-11-36(60-28(2)67)44(70)66-41-24-42(68)56-19-8-7-13-35(43(52)69)61-47(73)39(22-30-25-58-34-12-6-5-10-33(30)34)64-45(71)37(14-9-20-57-50(53)54)62-46(72)38(21-29-15-17-31(51)18-16-29)63-48(74)40(65-49(41)75)23-32-26-55-27-59-32/h5-6,10,12,15-18,25-27,35-41,58H,3-4,7-9,11,13-14,19-24H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36+,37+,38-,39-,40+,41+/m1/s1
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n/an/an/an/a 0.00500n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Evaluated for agonist activity at cloned mammalian human MSH1 receptor


J Med Chem 38: 3454-61 (1995)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250660
PNG
(US9447148, 9.29)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCNC(=O)CCC(=O)NC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C51H70N16O10/c1-3-4-14-35(61-29(2)68)45(72)63-37-19-21-56-42(69)17-18-43(70)59-27-41(50(77)64-38(44(52)71)23-31-25-58-34-15-9-8-13-33(31)34)67-46(73)36(16-10-20-57-51(53)54)62-48(75)39(22-30-11-6-5-7-12-30)65-49(76)40(66-47(37)74)24-32-26-55-28-60-32/h5-9,11-13,15,25-26,28,35-41,58H,3-4,10,14,16-24,27H2,1-2H3,(H2,52,71)(H,55,60)(H,56,69)(H,59,70)(H,61,68)(H,62,75)(H,63,72)(H,64,77)(H,65,76)(H,66,74)(H,67,73)(H4,53,54,57)/t35-,36-,37-,38-,39+,40-,41-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250634
PNG
(US9447148, 9.2 | US9447148, 9.31)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C49H67N15O9/c1-3-4-14-34(58-28(2)65)43(68)60-36-17-18-41(66)54-21-19-37(46(71)62-38(42(50)67)23-30-25-56-33-15-9-8-13-32(30)33)61-44(69)35(16-10-20-55-49(51)52)59-47(72)39(22-29-11-6-5-7-12-29)63-48(73)40(64-45(36)70)24-31-26-53-27-57-31/h5-9,11-13,15,25-27,34-40,56H,3-4,10,14,16-24H2,1-2H3,(H2,50,67)(H,53,57)(H,54,66)(H,58,65)(H,59,72)(H,60,68)(H,61,69)(H,62,71)(H,63,73)(H,64,70)(H4,51,52,55)/t34-,35-,36-,37-,38-,39+,40-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250671
PNG
(US9447148, 9.40 | US9447148, 9.53)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C49H72N14O9/c1-3-4-16-34(57-29(2)64)43(67)60-37-20-21-41(65)54-25-22-38(47(71)62-39(42(51)66)27-31-28-56-33-17-9-8-15-32(31)33)61-44(68)36(19-12-24-55-49(52)53)59-48(72)40(26-30-13-6-5-7-14-30)63-45(69)35(58-46(37)70)18-10-11-23-50/h5-9,13-15,17,28,34-40,56H,3-4,10-12,16,18-27,50H2,1-2H3,(H2,51,66)(H,54,65)(H,57,64)(H,58,70)(H,59,72)(H,60,67)(H,61,68)(H,62,71)(H,63,69)(H4,52,53,55)/t34-,35-,36-,37-,38-,39-,40+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250655
PNG
(US9447148, 9.24)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)NCC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)NC(=O)CCc1ccccc1
Show InChI InChI=1/C50H62N14O8/c51-44(67)39(25-32-27-57-35-15-8-7-14-34(32)35)62-47(70)38-21-23-55-42(65)20-18-37(59-43(66)19-17-30-10-3-1-4-11-30)46(69)64-41(26-33-28-54-29-58-33)49(72)63-40(24-31-12-5-2-6-13-31)48(71)60-36(45(68)61-38)16-9-22-56-50(52)53/h1-8,10-15,27-29,36-41,57H,9,16-26H2,(H2,51,67)(H,54,58)(H,55,65)(H,59,66)(H,60,71)(H,61,68)(H,62,70)(H,63,72)(H,64,69)(H4,52,53,56)/t36-,37-,38-,39-,40+,41-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250671
PNG
(US9447148, 9.40 | US9447148, 9.53)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C49H72N14O9/c1-3-4-16-34(57-29(2)64)43(67)60-37-20-21-41(65)54-25-22-38(47(71)62-39(42(51)66)27-31-28-56-33-17-9-8-15-32(31)33)61-44(68)36(19-12-24-55-49(52)53)59-48(72)40(26-30-13-6-5-7-14-30)63-45(69)35(58-46(37)70)18-10-11-23-50/h5-9,13-15,17,28,34-40,56H,3-4,10-12,16,18-27,50H2,1-2H3,(H2,51,66)(H,54,65)(H,57,64)(H,58,70)(H,59,72)(H,60,67)(H,61,68)(H,62,71)(H,63,69)(H4,52,53,55)/t34-,35-,36-,37-,38-,39-,40+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250659
PNG
(US9447148, 9.28)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CNC(=O)CCC(=O)NC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C50H68N16O10/c1-3-4-14-34(60-28(2)67)44(71)65-40-26-58-42(69)18-17-41(68)57-25-39(48(75)62-36(43(51)70)21-30-23-56-33-15-9-8-13-32(30)33)66-45(72)35(16-10-19-55-50(52)53)61-46(73)37(20-29-11-6-5-7-12-29)63-47(74)38(64-49(40)76)22-31-24-54-27-59-31/h5-9,11-13,15,23-24,27,34-40,56H,3-4,10,14,16-22,25-26H2,1-2H3,(H2,51,70)(H,54,59)(H,57,68)(H,58,69)(H,60,67)(H,61,73)(H,62,75)(H,63,74)(H,64,76)(H,65,71)(H,66,72)(H4,52,53,55)/t34-,35-,36-,37+,38-,39-,40-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250654
PNG
(US9447148, 9.23)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCC(=O)NCC[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)NC(=O)Cc1ccccc1
Show InChI InChI=1/C49H60N14O8/c50-43(66)38(24-31-26-56-34-15-8-7-14-33(31)34)61-46(69)37-19-21-54-41(64)18-17-36(58-42(65)23-30-12-5-2-6-13-30)45(68)63-40(25-32-27-53-28-57-32)48(71)62-39(22-29-10-3-1-4-11-29)47(70)59-35(44(67)60-37)16-9-20-55-49(51)52/h1-8,10-15,26-28,35-40,56H,9,16-25H2,(H2,50,66)(H,53,57)(H,54,64)(H,58,65)(H,59,70)(H,60,67)(H,61,69)(H,62,71)(H,63,68)(H4,51,52,55)/t35-,36-,37-,38-,39+,40-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250633
PNG
(US9447148, 9.1)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C51H71N15O9/c1-3-4-16-36(60-30(2)67)45(70)63-39-20-21-43(68)56-22-11-10-18-37(47(72)64-40(44(52)69)25-32-27-58-35-17-9-8-15-34(32)35)61-46(71)38(19-12-23-57-51(53)54)62-49(74)41(24-31-13-6-5-7-14-31)65-50(75)42(66-48(39)73)26-33-28-55-29-59-33/h5-9,13-15,17,27-29,36-42,58H,3-4,10-12,16,18-26H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,71)(H,62,74)(H,63,70)(H,64,72)(H,65,75)(H,66,73)(H4,53,54,57)/t36-,37-,38-,39-,40-,41+,42-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250672
PNG
(US9447148, 9.41 | US9447148, 9.54)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C47H68N14O9/c1-3-4-14-32(55-27(2)62)41(65)57-34-17-18-39(63)52-23-20-36(45(69)60-37(40(49)64)25-29-26-54-31-15-9-8-13-30(29)31)59-42(66)33(16-10-22-53-47(50)51)56-46(70)38(24-28-11-6-5-7-12-28)61-44(68)35(19-21-48)58-43(34)67/h5-9,11-13,15,26,32-38,54H,3-4,10,14,16-25,48H2,1-2H3,(H2,49,64)(H,52,63)(H,55,62)(H,56,70)(H,57,65)(H,58,67)(H,59,66)(H,60,69)(H,61,68)(H4,50,51,53)/t32-,33-,34-,35-,36-,37-,38+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50121900
PNG
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)
Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1
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n/an/an/an/a 0.00800n/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells


J Med Chem 51: 1026-34 (2008)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250635
PNG
(US9447148, 9.3)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C48H65N15O9/c1-3-4-14-33(57-27(2)64)42(67)59-35-17-18-40(65)55-25-39(47(72)60-36(41(49)66)21-29-23-54-32-15-9-8-13-31(29)32)63-43(68)34(16-10-19-53-48(50)51)58-45(70)37(20-28-11-6-5-7-12-28)61-46(71)38(62-44(35)69)22-30-24-52-26-56-30/h5-9,11-13,15,23-24,26,33-39,54H,3-4,10,14,16-22,25H2,1-2H3,(H2,49,66)(H,52,56)(H,55,65)(H,57,64)(H,58,70)(H,59,67)(H,60,72)(H,61,71)(H,62,69)(H,63,68)(H4,50,51,53)/t33-,34-,35-,36-,37+,38-,39-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250672
PNG
(US9447148, 9.41 | US9447148, 9.54)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C47H68N14O9/c1-3-4-14-32(55-27(2)62)41(65)57-34-17-18-39(63)52-23-20-36(45(69)60-37(40(49)64)25-29-26-54-31-15-9-8-13-30(29)31)59-42(66)33(16-10-22-53-47(50)51)56-46(70)38(24-28-11-6-5-7-12-28)61-44(68)35(19-21-48)58-43(34)67/h5-9,11-13,15,26,32-38,54H,3-4,10,14,16-25,48H2,1-2H3,(H2,49,64)(H,52,63)(H,55,62)(H,56,70)(H,57,65)(H,58,67)(H,59,66)(H,60,69)(H,61,68)(H4,50,51,53)/t32-,33-,34-,35-,36-,37-,38+/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250641
PNG
(US9447148, 9.9)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O
Show InChI InChI=1/C51H68N14O9/c1-3-4-18-36(59-30(2)66)45(69)61-38-20-21-43(67)56-24-22-39(48(72)63-40(44(52)68)26-33-16-10-15-32-14-8-9-17-35(32)33)62-46(70)37(19-11-23-57-51(53)54)60-49(73)41(25-31-12-6-5-7-13-31)64-50(74)42(65-47(38)71)27-34-28-55-29-58-34/h5-10,12-17,28-29,36-42H,3-4,11,18-27H2,1-2H3,(H2,52,68)(H,55,58)(H,56,67)(H,59,66)(H,60,73)(H,61,69)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H4,53,54,57)/t36-,37-,38-,39-,40+,41+,42-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50131251
PNG
((S)-5-Guanidino-2-{(S)-2-[(S)-3-(3H-imidazol-4-yl)...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C42H51N11O5/c43-38(55)34(22-29-24-48-32-17-8-7-16-31(29)32)52-39(56)33(18-10-20-47-42(44)45)51-40(57)35(21-28-13-5-2-6-14-28)53-41(58)36(23-30-25-46-26-49-30)50-37(54)19-9-15-27-11-3-1-4-12-27/h1-8,11-14,16-17,24-26,33-36,48H,9-10,15,18-23H2,(H2,43,55)(H,46,49)(H,50,54)(H,51,57)(H,52,56)(H,53,58)(H4,44,45,47)/t33-,34-,35-,36-/m0/s1
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n/an/an/an/a 0.00900n/an/an/an/a



University of Cincinnati

Curated by ChEMBL


Assay Description
In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC1R)


Bioorg Med Chem Lett 13: 2647-50 (2003)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250658
PNG
(US9447148, 9.27)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCNC(=O)CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C52H72N16O10/c1-3-4-14-36(62-30(2)69)46(73)64-39-20-23-58-44(71)18-17-43(70)57-22-19-38(48(75)66-40(45(53)72)25-32-27-60-35-15-9-8-13-34(32)35)65-47(74)37(16-10-21-59-52(54)55)63-50(77)41(24-31-11-6-5-7-12-31)67-51(78)42(68-49(39)76)26-33-28-56-29-61-33/h5-9,11-13,15,27-29,36-42,60H,3-4,10,14,16-26H2,1-2H3,(H2,53,72)(H,56,61)(H,57,70)(H,58,71)(H,62,69)(H,63,77)(H,64,73)(H,65,74)(H,66,75)(H,67,78)(H,68,76)(H4,54,55,59)/t36-,37-,38-,39-,40-,41+,42-/s2
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Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50033130
PNG
((3R,6S,9R,12S,15S,23R)-15-((S)-2-Acetylamino-hexan...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H68ClN15O9/c1-3-4-11-36(60-28(2)67)44(70)66-41-24-42(68)56-19-8-7-13-35(43(52)69)61-47(73)39(22-30-25-58-34-12-6-5-10-33(30)34)64-45(71)37(14-9-20-57-50(53)54)62-46(72)38(21-29-15-17-31(51)18-16-29)63-48(74)40(65-49(41)75)23-32-26-55-27-59-32/h5-6,10,12,15-18,25-27,35-41,58H,3-4,7-9,11,13-14,19-24H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36+,37+,38-,39-,40+,41+/m1/s1
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n/an/an/an/a 0.00950n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Evaluated for agonist activity against mouse Melanocortin 1 receptor using mMC1R assay


J Med Chem 38: 3454-61 (1995)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50152246
PNG
((S)-5-Guanidino-2-((S)-2-{(S)-2-[(S)-3-(3H-imidazo...)
Show SMILES NC(=N)NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C51H60N12O6/c52-46(65)41(28-36-30-57-39-22-11-10-21-38(36)39)61-47(66)40(23-13-25-56-51(53)54)60-48(67)42(26-34-16-6-2-7-17-34)62-49(68)43(27-35-18-8-3-9-19-35)63-50(69)44(29-37-31-55-32-58-37)59-45(64)24-12-20-33-14-4-1-5-15-33/h1-11,14-19,21-22,30-32,40-44,57H,12-13,20,23-29H2,(H2,52,65)(H,55,58)(H,59,64)(H,60,67)(H,61,66)(H,62,68)(H,63,69)(H4,53,54,56)/t40-,41-,42-,43-,44-/m0/s1
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n/an/an/an/a 0.0100n/an/an/an/a



University of Cincinnati

Curated by ChEMBL


Assay Description
Agonistic activity against against human Melanocortin 1 receptor


Bioorg Med Chem Lett 14: 4839-42 (2004)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50301155
PNG
(CHEMBL569693 | Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2)
Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc[nH]c1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C43H52N10O5/c44-39(55)35(25-31-27-49-33-17-8-7-16-32(31)33)52-40(56)34(18-10-21-48-43(45)46)51-42(58)37(23-29-13-5-2-6-14-29)53-41(57)36(24-30-20-22-47-26-30)50-38(54)19-9-15-28-11-3-1-4-12-28/h1-8,11-14,16-17,20,22,26-27,34-37,47,49H,9-10,15,18-19,21,23-25H2,(H2,44,55)(H,50,54)(H,51,58)(H,52,56)(H,53,57)(H4,45,46,48)/t34-,35+,36-,37+/m0/s1
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n/an/an/an/a 0.0100n/an/an/an/a



University of Cincinnati

Curated by ChEMBL


Assay Description
Agonistic activity against human MC1R


Bioorg Med Chem Lett 19: 5176-81 (2009)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250645
PNG
(US9447148, 9.13)
Show SMILES CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C52H65N15O9/c1-30(68)61-41(23-31-11-4-2-5-12-31)49(74)63-38-18-19-44(69)57-22-20-39(48(73)65-40(45(53)70)25-33-27-59-36-16-9-8-15-35(33)36)64-46(71)37(17-10-21-58-52(54)55)62-50(75)42(24-32-13-6-3-7-14-32)66-51(76)43(67-47(38)72)26-34-28-56-29-60-34/h2-9,11-16,27-29,37-43,59H,10,17-26H2,1H3,(H2,53,70)(H,56,60)(H,57,69)(H,61,68)(H,62,75)(H,63,74)(H,64,71)(H,65,73)(H,66,76)(H,67,72)(H4,54,55,58)/t37-,38-,39-,40-,41-,42+,43-/s2
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n/an/an/an/a 0.0100n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250647
PNG
(US9447148, 9.15)
Show SMILES CCCC(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C45H60N14O8/c1-2-9-38(61)54-32-15-16-37(60)50-19-17-33(42(65)57-34(39(46)62)21-27-23-52-30-13-7-6-12-29(27)30)56-40(63)31(14-8-18-51-45(47)48)55-43(66)35(20-26-10-4-3-5-11-26)58-44(67)36(59-41(32)64)22-28-24-49-25-53-28/h3-7,10-13,23-25,31-36,52H,2,8-9,14-22H2,1H3,(H2,46,62)(H,49,53)(H,50,60)(H,54,61)(H,55,66)(H,56,63)(H,57,65)(H,58,67)(H,59,64)(H4,47,48,51)/t31-,32-,33-,34-,35+,36-/s2
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n/an/an/an/a 0.0120n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250638
PNG
(US9447148, 9.6)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C50H69N15O9/c1-3-4-15-35(59-29(2)66)44(69)62-38-19-20-42(67)55-21-10-17-37(46(71)63-39(43(51)68)24-31-26-57-34-16-9-8-14-33(31)34)60-45(70)36(18-11-22-56-50(52)53)61-48(73)40(23-30-12-6-5-7-13-30)64-49(74)41(65-47(38)72)25-32-27-54-28-58-32/h5-9,12-14,16,26-28,35-41,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,70)(H,61,73)(H,62,69)(H,63,71)(H,64,74)(H,65,72)(H4,52,53,56)/t35-,36-,37-,38-,39-,40+,41-/s2
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n/an/an/an/a 0.0140n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50121900
PNG
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)
Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1
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n/an/an/an/a 0.0140n/an/an/an/a



University of Cincinnati

Curated by ChEMBL


Assay Description
Agonistic activity against mouse MC1R


Bioorg Med Chem Lett 19: 5176-81 (2009)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250644
PNG
(US9447148, 9.12)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H]1CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C52H65N15O9/c1-30(68)61-41(23-31-11-4-2-5-12-31)49(74)63-38-18-19-44(69)57-22-20-39(48(73)65-40(45(53)70)25-33-27-59-36-16-9-8-15-35(33)36)64-46(71)37(17-10-21-58-52(54)55)62-50(75)42(24-32-13-6-3-7-14-32)66-51(76)43(67-47(38)72)26-34-28-56-29-60-34/h2-9,11-16,27-29,37-43,59H,10,17-26H2,1H3,(H2,53,70)(H,56,60)(H,57,69)(H,61,68)(H,62,75)(H,63,74)(H,64,71)(H,65,73)(H,66,76)(H,67,72)(H4,54,55,58)/t37-,38-,39-,40-,41+,42+,43-/s2
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n/an/an/an/a 0.0150n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50033133
PNG
((3R,6S,9R,12S,15S,23R)-15-((S)-2-Acetylamino-hexan...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H68FN15O9/c1-3-4-11-36(60-28(2)67)44(70)66-41-24-42(68)56-19-8-7-13-35(43(52)69)61-47(73)39(22-30-25-58-34-12-6-5-10-33(30)34)64-45(71)37(14-9-20-57-50(53)54)62-46(72)38(21-29-15-17-31(51)18-16-29)63-48(74)40(65-49(41)75)23-32-26-55-27-59-32/h5-6,10,12,15-18,25-27,35-41,58H,3-4,7-9,11,13-14,19-24H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36+,37+,38-,39-,40+,41+/m1/s1
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n/an/an/an/a 0.0160n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Evaluated for agonist activity at cloned mammalian human MSH1 receptor


J Med Chem 38: 3454-61 (1995)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM250674
PNG
(US9447148, 9.43)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CNC(=O)CCC(=O)NCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1/C51H70N16O10/c1-3-4-14-35(61-29(2)68)45(72)67-41-27-59-43(70)18-17-42(69)56-21-19-37(47(74)64-38(44(52)71)23-31-25-58-34-15-9-8-13-33(31)34)63-46(73)36(16-10-20-57-51(53)54)62-48(75)39(22-30-11-6-5-7-12-30)65-49(76)40(66-50(41)77)24-32-26-55-28-60-32/h5-9,11-13,15,25-26,28,35-41,58H,3-4,10,14,16-24,27H2,1-2H3,(H2,52,71)(H,55,60)(H,56,69)(H,59,70)(H,61,68)(H,62,75)(H,63,73)(H,64,74)(H,65,76)(H,66,77)(H,67,72)(H4,53,54,57)/t35-,36-,37-,38-,39+,40-,41-/s2
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n/an/an/an/a 0.0160n/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US9447148 (2016)

More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM50033133
PNG
((3R,6S,9R,12S,15S,23R)-15-((S)-2-Acetylamino-hexan...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H68FN15O9/c1-3-4-11-36(60-28(2)67)44(70)66-41-24-42(68)56-19-8-7-13-35(43(52)69)61-47(73)39(22-30-25-58-34-12-6-5-10-33(30)34)64-45(71)37(14-9-20-57-50(53)54)62-46(72)38(21-29-15-17-31(51)18-16-29)63-48(74)40(65-49(41)75)23-32-26-55-27-59-32/h5-6,10,12,15-18,25-27,35-41,58H,3-4,7-9,11,13-14,19-24H2,1-2H3,(H2,52,69)(H,55,59)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,74)(H,64,71)(H,65,75)(H,66,70)(H4,53,54,57)/t35-,36+,37+,38-,39-,40+,41+/m1/s1
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n/an/an/an/a 0.0160n/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Evaluated for agonist activity against human Melanocortin 1 receptor using hMC1-R assay


J Med Chem 38: 3454-61 (1995)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50100757
PNG
(Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-NH...)
Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C68H95N19O17/c1-3-4-16-47(81-67(104)55(36-89)87-64(101)51(29-40-20-22-43(91)23-21-40)84-66(103)54(35-88)78-38(2)90)60(97)82-49(24-25-57(93)94)62(99)86-53(31-42-33-73-37-77-42)65(102)83-50(28-39-13-6-5-7-14-39)63(100)80-48(19-12-27-74-68(71)72)61(98)85-52(30-41-32-75-45-17-9-8-15-44(41)45)59(96)76-34-56(92)79-46(58(70)95)18-10-11-26-69/h5-9,13-15,17,20-23,32-33,37,46-55,75,88-89,91H,3-4,10-12,16,18-19,24-31,34-36,69H2,1-2H3,(H2,70,95)(H,73,77)(H,76,96)(H,78,90)(H,79,92)(H,80,100)(H,81,104)(H,82,97)(H,83,102)(H,84,103)(H,85,98)(H,86,99)(H,87,101)(H,93,94)(H4,71,72,74)/t46-,47-,48-,49-,50+,51-,52-,53-,54-,55-/m0/s1
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n/an/an/an/a 0.0180n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Functional activity at the mouse melanocortin 1 receptor


J Med Chem 44: 2247-52 (2001)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50121900
PNG
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)
Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1
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n/an/an/an/a 0.0180n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Effective concentration for mouse Melanocortin-1 receptor


J Med Chem 48: 3060-75 (2005)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50017181
PNG
(CHEMBL441738)
Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1
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n/an/an/an/a 0.0180n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay


J Med Chem 54: 1379-90 (2011)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50128358
PNG
(CHEMBL3629347)
Show SMILES CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52?,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/s2
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UniChem
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PubMed
n/an/an/an/a 0.0190n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells by AlphaScreen cAMP assay


Bioorg Med Chem Lett 25: 5306-8 (2015)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50114736
PNG
(CHEMBL386583 | [1-(2-Acetylamino-hexanoyl)-17-(4-a...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N1[C@@H](CC(O)=O)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCN)C1=O
Show InChI InChI=1S/C50H68N14O10/c1-3-4-16-36(58-29(2)65)48(73)64-41(25-42(66)67)47(72)63-40(24-32-27-54-28-57-32)46(71)61-38(22-30-13-6-5-7-14-30)44(69)59-35(19-12-21-55-50(52)53)43(68)62-39(23-31-26-56-34-17-9-8-15-33(31)34)45(70)60-37(49(64)74)18-10-11-20-51/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25,51H2,1-2H3,(H,54,57)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,66,67)(H4,52,53,55)/t35-,36+,37-,38+,39+,40-,41+/m1/s1
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PubMed
n/an/an/an/a 0.0200n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
In vitro activaction of mouse recombinant Melanocortin-1 receptor.


J Med Chem 45: 2801-10 (2002)

More data for this
Ligand-Target Pair
Melanocortin receptor 1


(Mus musculus)
BDBM50184359
PNG
((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Show InChI InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1
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PubMed
n/an/an/an/a 0.0200n/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cells


J Med Chem 45: 5736-44 (2002)

More data for this
Ligand-Target Pair
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