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Compile Data Set for Download or QSAR

Found 6 hits of ec50 data for polymerid = 50005943   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301364
PNG
(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC
Show InChI InChI=1S/C32H24N4O5S/c1-39-27-16-23-25(17-28(27)40-2)33-13-12-26(23)41-22-10-11-30(34-18-22)35-31(37)24-15-20(29-9-6-14-42-29)19-36(32(24)38)21-7-4-3-5-8-21/h3-19H,1-2H3,(H,34,35,37)
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n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301364
PNG
(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC
Show InChI InChI=1S/C32H24N4O5S/c1-39-27-16-23-25(17-28(27)40-2)33-13-12-26(23)41-22-10-11-30(34-18-22)35-31(37)24-15-20(29-9-6-14-42-29)19-36(32(24)38)21-7-4-3-5-8-21/h3-19H,1-2H3,(H,34,35,37)
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n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
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PubMed
n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in calcium level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
PDB
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Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in osteocalcin level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair
Protein-tyrosine kinase 2-beta


(Mus musculus)
BDBM50301364
PNG
(CHEMBL570380 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cc(cn(-c5ccccc5)c4=O)-c4cccs4)nc3)c2cc1OC
Show InChI InChI=1S/C32H24N4O5S/c1-39-27-16-23-25(17-28(27)40-2)33-13-12-26(23)41-22-10-11-30(34-18-22)35-31(37)24-15-20(29-9-6-14-42-29)19-36(32(24)38)21-7-4-3-5-8-21/h3-19H,1-2H3,(H,34,35,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of mouse Pyk2 in MC3TC3 cells assessed as increase in alkaline phosphatase level


Bioorg Med Chem Lett 19: 4924-8 (2009)

More data for this
Ligand-Target Pair