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Compile Data Set for Download or QSAR

Found 60 hits of ec50 data for polymerid = 50006387   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088527
PNG
(CHEMBL3527358)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1/C22H36N2O6/c1-12(2)7-8-15-21(5,30-15)18-17(27-6)14(9-10-22(18)11-28-22)29-20(26)24-16(13(3)4)19(23)25/h7,13-18H,8-11H2,1-6H3,(H2,23,25)(H,24,26)/t14-,15-,16-,17-,18-,21+,22+/s2
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n/an/an/an/a 0.0950n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088526
PNG
(CHEMBL3527591)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)N[C@@H](C(N)=O)C(C)(C)O
Show InChI InChI=1/C22H36N2O7/c1-12(2)7-8-14-21(5,31-14)16-15(28-6)13(9-10-22(16)11-29-22)30-19(26)24-17(18(23)25)20(3,4)27/h7,13-17,27H,8-11H2,1-6H3,(H2,23,25)(H,24,26)/t13-,14-,15-,16-,17+,21+,22+/s2
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n/an/an/an/a 0.300n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088525
PNG
(CHEMBL3526173)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@H]1OC1(C)C)OC(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1/C22H36N2O7/c1-11(2)15(18(23)25)24-19(26)29-12-7-8-22(10-28-22)17(16(12)27-6)21(5)14(31-21)9-13-20(3,4)30-13/h11-17H,7-10H2,1-6H3,(H2,23,25)(H,24,26)/t12-,13-,14-,15-,16-,17-,21+,22+/s2
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n/an/an/an/a 1.30n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088524
PNG
(CHEMBL3527328)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@@H]1OC1(C)C)OC(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1/C22H36N2O7/c1-11(2)15(18(23)25)24-19(26)29-12-7-8-22(10-28-22)17(16(12)27-6)21(5)14(31-21)9-13-20(3,4)30-13/h11-17H,7-10H2,1-6H3,(H2,23,25)(H,24,26)/t12-,13+,14-,15-,16-,17-,21+,22+/s2
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n/an/an/an/a 6.5n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088523
PNG
(CHEMBL3527383)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C\C=C(/C)CO)OC(=O)N[C@H](C(C)C)C(N)=O
Show InChI InChI=1/C22H36N2O7/c1-12(2)16(19(23)26)24-20(27)30-14-8-9-22(11-29-22)18(17(14)28-5)21(4)15(31-21)7-6-13(3)10-25/h6,12,14-18,25H,7-11H2,1-5H3,(H2,23,26)(H,24,27)/b13-6+/t14-,15-,16-,17-,18-,21+,22+/s2
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n/an/an/an/a 7.10n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088522
PNG
(CHEMBL3527218)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@H]1OC1(C)C)OC(=O)N[C@@H](C(N)=O)C(C)(C)O
Show InChI InChI=1/C22H36N2O8/c1-19(2,27)16(17(23)25)24-18(26)30-11-7-8-22(10-29-22)15(14(11)28-6)21(5)13(32-21)9-12-20(3,4)31-12/h11-16,27H,7-10H2,1-6H3,(H2,23,25)(H,24,26)/t11-,12-,13-,14-,15-,16+,21+,22+/s2
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n/an/an/an/a 8.80n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50088521
PNG
(CHEMBL3527219)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1C[C@@H]1OC1(C)C)OC(=O)N[C@@H](C(N)=O)C(C)(C)O
Show InChI InChI=1/C22H36N2O8/c1-19(2,27)16(17(23)25)24-18(26)30-11-7-8-22(10-29-22)15(14(11)28-6)21(5)13(32-21)9-12-20(3,4)31-12/h11-16,27H,7-10H2,1-6H3,(H2,23,25)(H,24,26)/t11-,12+,13-,14-,15-,16+,21+,22+/s2
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n/an/an/an/a 12n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 activity in HUVEC assessed as inhibition of cell proliferation by MTT assay


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167274
PNG
(CHEMBL3797399)
Show SMILES Cc1nc2[nH]cnc2cc1-n1c2cn[nH]c2c2cc(F)ccc12
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n/an/an/an/a 13n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167960
PNG
(CHEMBL3799512)
Show SMILES Cc1nc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@@H](O)C1
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n/an/an/an/a 15n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167279
PNG
(CHEMBL3799090)
Show SMILES Cc1cc(ccc1-n1c2cn[nH]c2c2cc(F)ccc12)C(=O)NCCO
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n/an/an/an/a 20n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167281
PNG
(CHEMBL3799796)
Show SMILES Cc1nc2n(C)cnc2cc1-n1c2cn[nH]c2c2cc(F)ccc12
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n/an/an/an/a 25n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167278
PNG
(CHEMBL3800236)
Show SMILES Nc1ncc(cc1Cl)-n1c2cn[nH]c2c2cc(F)ccc12
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n/an/an/an/a 32n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167925
PNG
(CHEMBL3798047)
Show SMILES COc1cc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)C(=O)NCCO
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n/an/an/an/a 37n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167929
PNG
(CHEMBL3798702)
Show SMILES Cc1nc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@@H](O)C1
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n/an/an/an/a 38n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167927
PNG
(CHEMBL3800090)
Show SMILES Cc1cc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)C(=O)NCCO
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n/an/an/an/a 60n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167959
PNG
(CHEMBL3799242)
Show SMILES Cc1nc(ccc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@H](O)C1
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n/an/an/an/a 65n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167277
PNG
(CHEMBL3797386)
Show SMILES Fc1ccc2n(-c3cccnc3)c3cn[nH]c3c2c1
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n/an/an/an/a 100n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167961
PNG
(CHEMBL3800596)
Show SMILES Cc1nc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)N1CC[C@H](O)C1
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n/an/an/an/a 121n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167926
PNG
(CHEMBL3798871)
Show SMILES OCCNC(=O)c1ccc(c(F)c1)-c1cc(cc2[nH]ncc12)C(F)(F)F
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n/an/an/an/a 234n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167285
PNG
(CHEMBL3797780)
Show SMILES Cc1c(cnc2[nH]cnc12)-n1c2cn[nH]c2c2cc(F)ccc12
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n/an/an/an/a 251n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167928
PNG
(CHEMBL3797699)
Show SMILES Cc1cc(ncc1-c1cc(cc2[nH]ncc12)C(F)(F)F)C(=O)NCCO
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n/an/an/an/a 770n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as accumulation of N-Met-14-3-3gamma after 24 hrs by Western blot method


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435206
PNG
(CHEMBL2392911)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccc(cn1)N1CCCC1
Show InChI InChI=1S/C30H39ClN8O/c1-22-28(31)30(37-29(35-22)25-12-11-24(20-33-25)39-16-5-6-17-39)34-21-26(23-8-3-2-4-9-23)36-27(40)10-7-15-38-18-13-32-14-19-38/h2-4,8-9,11-12,20,26,32H,5-7,10,13-19,21H2,1H3,(H,36,40)(H,34,35,37)/t26-/m0/s1
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n/an/an/an/a 1.10E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435210
PNG
(CHEMBL2392907)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H31Cl2N7O/c1-18-24(28)26(34-25(32-18)21-10-9-20(27)16-30-21)31-17-22(19-6-3-2-4-7-19)33-23(36)8-5-13-35-14-11-29-12-15-35/h2-4,6-7,9-10,16,22,29H,5,8,11-15,17H2,1H3,(H,33,36)(H,31,32,34)/t22-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435211
PNG
(CHEMBL2392906)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccc(F)cn1
Show InChI InChI=1S/C26H31ClFN7O/c1-18-24(27)26(34-25(32-18)21-10-9-20(28)16-30-21)31-17-22(19-6-3-2-4-7-19)33-23(36)8-5-13-35-14-11-29-12-15-35/h2-4,6-7,9-10,16,22,29H,5,8,11-15,17H2,1H3,(H,33,36)(H,31,32,34)/t22-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167276
PNG
(CHEMBL3798844)
Show SMILES Fc1cc2n(-c3cccnc3)c3cn[nH]c3c2cc1F
KEGG

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n/an/an/an/a 1.26E+3n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435207
PNG
(CHEMBL2392910)
Show SMILES CN(C)c1ccc(nc1)-c1nc(C)c(Cl)c(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)n1
Show InChI InChI=1S/C28H37ClN8O/c1-20-26(29)28(35-27(33-20)23-12-11-22(18-31-23)36(2)3)32-19-24(21-8-5-4-6-9-21)34-25(38)10-7-15-37-16-13-30-14-17-37/h4-6,8-9,11-12,18,24,30H,7,10,13-17,19H2,1-3H3,(H,34,38)(H,32,33,35)/t24-/m0/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167280
PNG
(CHEMBL3797259)
Show SMILES OCCNC(=O)c1ccc(cc1)-n1c2cn[nH]c2c2cc(F)ccc12
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n/an/an/an/a 2.00E+3n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50167275
PNG
(CHEMBL3798249)
Show SMILES Clc1ccc2c(c1)n(-c1cccnc1)c1cn[nH]c21
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n/an/an/an/a 1.00E+4n/an/an/an/a



Medicinal Chemistry, Takeda California, United States.

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2 in HUVEC cells assessed as accumulation of N-Met 14-3-3gamma after 24 hrs by western blot analysis


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435205
PNG
(CHEMBL2392912)
Show SMILES COc1ccnc(c1)-c1nc(C)c(Cl)c(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)n1
Show InChI InChI=1S/C27H34ClN7O2/c1-19-25(28)27(34-26(32-19)22-17-21(37-2)10-11-30-22)31-18-23(20-7-4-3-5-8-20)33-24(36)9-6-14-35-15-12-29-13-16-35/h3-5,7-8,10-11,17,23,29H,6,9,12-16,18H2,1-2H3,(H,33,36)(H,31,32,34)/t23-/m0/s1
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n/an/an/an/a 1.40E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435208
PNG
(CHEMBL2392909)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccc(cn1)[N+]([O-])=O
Show InChI InChI=1S/C26H31ClN8O3/c1-18-24(27)26(33-25(31-18)21-10-9-20(16-29-21)35(37)38)30-17-22(19-6-3-2-4-7-19)32-23(36)8-5-13-34-14-11-28-12-15-34/h2-4,6-7,9-10,16,22,28H,5,8,11-15,17H2,1H3,(H,32,36)(H,30,31,33)/t22-/m0/s1
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n/an/an/an/a 1.40E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435190
PNG
(CHEMBL2392926)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccc(cc2)C#N)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H28Cl2N6/c1-20-27(31)29(37-28(36-20)25-15-14-24(30)18-34-25)35-19-26(23-8-3-2-4-9-23)33-16-6-5-7-21-10-12-22(17-32)13-11-21/h2-4,8-15,18,26,33H,5-7,16,19H2,1H3,(H,35,36,37)/t26-/m0/s1
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n/an/an/an/a 1.60E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435203
PNG
(CHEMBL2390976)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)Cc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H23Cl2N5O/c1-17-24(28)26(33-25(31-17)21-13-12-20(27)15-29-21)30-16-22(19-10-6-3-7-11-19)32-23(34)14-18-8-4-2-5-9-18/h2-13,15,22H,14,16H2,1H3,(H,32,34)(H,30,31,33)/t22-/m0/s1
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n/an/an/an/a 2.80E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435193
PNG
(CHEMBL2392923)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H33Cl2N5/c1-22-28(32)30(37-29(36-22)26-18-17-25(31)20-34-26)35-21-27(24-15-9-5-10-16-24)33-19-11-3-2-6-12-23-13-7-4-8-14-23/h4-5,7-10,13-18,20,27,33H,2-3,6,11-12,19,21H2,1H3,(H,35,36,37)/t27-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435216
PNG
(CHEMBL2392901)
Show SMILES COc1cccc(n1)-c1nc(C)c(Cl)c(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)n1
Show InChI InChI=1S/C27H34ClN7O2/c1-19-25(28)27(34-26(31-19)21-10-6-12-24(33-21)37-2)30-18-22(20-8-4-3-5-9-20)32-23(36)11-7-15-35-16-13-29-14-17-35/h3-6,8-10,12,22,29H,7,11,13-18H2,1-2H3,(H,32,36)(H,30,31,34)/t22-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435202
PNG
(CHEMBL2392914)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H25Cl2N5O/c1-18-25(29)27(34-26(32-18)22-14-13-21(28)16-30-22)31-17-23(20-10-6-3-7-11-20)33-24(35)15-12-19-8-4-2-5-9-19/h2-11,13-14,16,23H,12,15,17H2,1H3,(H,33,35)(H,31,32,34)/t23-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435215
PNG
(CHEMBL2392902)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1cccc(Cl)n1
Show InChI InChI=1S/C26H31Cl2N7O/c1-18-24(28)26(34-25(31-18)20-9-5-10-22(27)32-20)30-17-21(19-7-3-2-4-8-19)33-23(36)11-6-14-35-15-12-29-13-16-35/h2-5,7-10,21,29H,6,11-17H2,1H3,(H,33,36)(H,30,31,34)/t21-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435201
PNG
(CHEMBL2392915)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H27Cl2N5O/c1-19-26(30)28(35-27(33-19)23-16-15-22(29)17-31-23)32-18-24(21-12-6-3-7-13-21)34-25(36)14-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-13,15-17,24H,8,11,14,18H2,1H3,(H,34,36)(H,32,33,35)/t24-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435200
PNG
(CHEMBL2392916)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H29Cl2N5O/c1-20-27(31)29(36-28(34-20)24-17-16-23(30)18-32-24)33-19-25(22-13-6-3-7-14-22)35-26(37)15-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-14,16-18,25H,8-9,12,15,19H2,1H3,(H,35,37)(H,33,34,36)/t25-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435199
PNG
(CHEMBL2392917)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C30H31Cl2N5O/c1-21-28(32)30(37-29(35-21)25-18-17-24(31)19-33-25)34-20-26(23-14-8-4-9-15-23)36-27(38)16-10-3-7-13-22-11-5-2-6-12-22/h2,4-6,8-9,11-12,14-15,17-19,26H,3,7,10,13,16,20H2,1H3,(H,36,38)(H,34,35,37)/t26-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435198
PNG
(CHEMBL2392918)
Show SMILES Cc1nc(nc(NC[C@H](NCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C25H23Cl2N5/c1-17-23(27)25(32-24(31-17)21-13-12-20(26)15-29-21)30-16-22(19-10-6-3-7-11-19)28-14-18-8-4-2-5-9-18/h2-13,15,22,28H,14,16H2,1H3,(H,30,31,32)/t22-/m0/s1
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n/an/an/an/a 3.10E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435209
PNG
(CHEMBL2392908)
Show SMILES Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1ccc(Br)cn1
Show InChI InChI=1S/C26H31BrClN7O/c1-18-24(28)26(34-25(32-18)21-10-9-20(27)16-30-21)31-17-22(19-6-3-2-4-7-19)33-23(36)8-5-13-35-14-11-29-12-15-35/h2-4,6-7,9-10,16,22,29H,5,8,11-15,17H2,1H3,(H,33,36)(H,31,32,34)/t22-/m0/s1
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n/an/an/an/a 5.30E+4n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435194
PNG
(CHEMBL2392922)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H31Cl2N5/c1-21-27(31)29(36-28(35-21)25-17-16-24(30)19-33-25)34-20-26(23-14-8-3-9-15-23)32-18-10-4-7-13-22-11-5-2-6-12-22/h2-3,5-6,8-9,11-12,14-17,19,26,32H,4,7,10,13,18,20H2,1H3,(H,34,35,36)/t26-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435197
PNG
(CHEMBL2392919)
Show SMILES Cc1nc(nc(NC[C@H](NCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H25Cl2N5/c1-18-24(28)26(33-25(32-18)22-13-12-21(27)16-30-22)31-17-23(20-10-6-3-7-11-20)29-15-14-19-8-4-2-5-9-19/h2-13,16,23,29H,14-15,17H2,1H3,(H,31,32,33)/t23-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435195
PNG
(CHEMBL2392921)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H29Cl2N5/c1-20-26(30)28(35-27(34-20)24-16-15-23(29)18-32-24)33-19-25(22-13-6-3-7-14-22)31-17-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-16,18,25,31H,8-9,12,17,19H2,1H3,(H,33,34,35)/t25-/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435185
PNG
(CHEMBL2392931)
Show SMILES Cc1nc(nc(NC[C@H](NCCCCn2cccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H28Cl2N6/c1-19-24(28)26(33-25(32-19)22-12-11-21(27)17-30-22)31-18-23(20-9-3-2-4-10-20)29-13-5-6-14-34-15-7-8-16-34/h2-4,7-12,15-17,23,29H,5-6,13-14,18H2,1H3,(H,31,32,33)/t23-/m0/s1
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Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


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More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435181
PNG
(CHEMBL2392935)
Show SMILES Cc1nc(nc(NCC(CCCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C29H30Cl2N4/c1-21-27(31)29(35-28(34-21)26-18-17-25(30)20-32-26)33-19-24(23-14-8-4-9-15-23)16-10-3-7-13-22-11-5-2-6-12-22/h2,4-6,8-9,11-12,14-15,17-18,20,24H,3,7,10,13,16,19H2,1H3,(H,33,34,35)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435182
PNG
(CHEMBL2392934)
Show SMILES Cc1nc(nc(NCC(CCCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C28H28Cl2N4/c1-20-26(30)28(34-27(33-20)25-17-16-24(29)19-31-25)32-18-23(22-13-6-3-7-14-22)15-9-8-12-21-10-4-2-5-11-21/h2-7,10-11,13-14,16-17,19,23H,8-9,12,15,18H2,1H3,(H,32,33,34)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435183
PNG
(CHEMBL2392933)
Show SMILES Cc1nc(nc(NCC(CCCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C27H26Cl2N4/c1-19-25(29)27(33-26(32-19)24-16-15-23(28)18-30-24)31-17-22(21-12-6-3-7-13-21)14-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-13,15-16,18,22H,8,11,14,17H2,1H3,(H,31,32,33)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435184
PNG
(CHEMBL2392932)
Show SMILES Cc1nc(nc(NCC(CCc2ccccc2)c2ccccc2)c1Cl)-c1ccc(Cl)cn1
Show InChI InChI=1S/C26H24Cl2N4/c1-18-24(28)26(32-25(31-18)23-15-14-22(27)17-29-23)30-16-21(20-10-6-3-7-11-20)13-12-19-8-4-2-5-9-19/h2-11,14-15,17,21H,12-13,16H2,1H3,(H,30,31,32)
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n/an/an/an/a>2.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
Microtubule-associated protein 2


(Homo sapiens)
BDBM50435212
PNG
(CHEMBL2392905)
Show SMILES COc1ccc(nc1)-c1nc(C)c(Cl)c(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)n1
Show InChI InChI=1S/C27H34ClN7O2/c1-19-25(28)27(34-26(32-19)22-11-10-21(37-2)17-30-22)31-18-23(20-7-4-3-5-8-20)33-24(36)9-6-14-35-15-12-29-13-16-35/h3-5,7-8,10-11,17,23,29H,6,9,12-16,18H2,1-2H3,(H,33,36)(H,31,32,34)/t23-/m0/s1
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n/an/an/an/a>3.00E+5n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani...


Citation and Details
More data for this
Ligand-Target Pair
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