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Compile Data Set for Download or QSAR

Found 60 hits of ec50 data for polymerid = 50007036,9125   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50090256
PNG
((R)-2-((S)-1,2-dihydroxyethyl)-4,5-dihydroxyfuran-...)
Show SMILES OC[C@H](O)c1oc(O)c(O)c1O
Show InChI InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-11H,1H2/t2-/m0/s1
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n/an/an/an/a 0.5n/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay


Bioorg Med Chem 17: 2497-500 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415140
PNG
(CHEMBL569933)
Show SMILES CCCc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-2-5-11-6-3-4-7-12(11)10-16-13-14-8-9-15-13/h3-4,6-7H,2,5,8-10H2,1H3,(H,14,15)
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n/an/an/an/a 62n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 62n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells


J Med Chem 51: 4289-99 (2008)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 62n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation


J Med Chem 50: 3964-8 (2007)

Checked by Author
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50019646
PNG
(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Show SMILES CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
Show InChI InChI=1S/C11H12Cl2N2O/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13/h2-4,7H,5-6H2,1H3,(H,14,15)
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n/an/an/an/a 126n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419890
PNG
(CHEMBL1956191)
Show SMILES CC(Oc1ccccc1Cl)C1=NCCN1
Show InChI InChI=1S/C11H13ClN2O/c1-8(11-13-6-7-14-11)15-10-5-3-2-4-9(10)12/h2-5,8H,6-7H2,1H3,(H,13,14)
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n/an/an/an/a 162n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419873
PNG
(CHEMBL1956203)
Show SMILES CC(Oc1c(cccc1-c1ccccc1)-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C23H22N2O/c1-17(23-24-15-16-25-23)26-22-20(18-9-4-2-5-10-18)13-8-14-21(22)19-11-6-3-7-12-19/h2-14,17H,15-16H2,1H3,(H,24,25)
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n/an/an/an/a 200n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50412258
PNG
(CHEMBL451229)
Show SMILES CC(Oc1ccccc1C1CCCCC1)C1=NCCN1
Show InChI InChI=1S/C17H24N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h5-6,9-10,13-14H,2-4,7-8,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 200n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells


J Med Chem 51: 4289-99 (2008)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419875
PNG
(CHEMBL1956193)
Show SMILES CC(Oc1ccccc1C(F)(F)F)C1=NCCN1
Show InChI InChI=1S/C12H13F3N2O/c1-8(11-16-6-7-17-11)18-10-5-3-2-4-9(10)12(13,14)15/h2-5,8H,6-7H2,1H3,(H,16,17)
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n/an/an/an/a 240n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419876
PNG
(CHEMBL266613)
Show SMILES CC(C)c1ccccc1OC(C)C1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-10(2)12-6-4-5-7-13(12)17-11(3)14-15-8-9-16-14/h4-7,10-11H,8-9H2,1-3H3,(H,15,16)
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n/an/an/an/a 251n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419888
PNG
(CHEMBL1956202)
Show SMILES CC(Oc1ccccc1C(C)=O)C1=NCCN1
Show InChI InChI=1S/C13H16N2O2/c1-9(16)11-5-3-4-6-12(11)17-10(2)13-14-7-8-15-13/h3-6,10H,7-8H2,1-2H3,(H,14,15)
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Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419883
PNG
(CHEMBL1956201)
Show SMILES CC(Oc1ccccc1C=O)C1=NCCN1
Show InChI InChI=1S/C12H14N2O2/c1-9(12-13-6-7-14-12)16-11-5-3-2-4-10(11)8-15/h2-5,8-9H,6-7H2,1H3,(H,13,14)
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n/an/an/an/a 316n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419874
PNG
(CHEMBL1956192)
Show SMILES CC(Oc1ccccc1Br)C1=NCCN1
Show InChI InChI=1S/C11H13BrN2O/c1-8(11-13-6-7-14-11)15-10-5-3-2-4-9(10)12/h2-5,8H,6-7H2,1H3,(H,13,14)
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n/an/an/an/a 316n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50412244
PNG
(CHEMBL495096)
Show SMILES CC(Oc1ccccc1C1CCCC1)C1=NCCN1
Show InChI InChI=1S/C16H22N2O/c1-12(16-17-10-11-18-16)19-15-9-5-4-8-14(15)13-6-2-3-7-13/h4-5,8-9,12-13H,2-3,6-7,10-11H2,1H3,(H,17,18)
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n/an/an/an/a 501n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells


J Med Chem 51: 4289-99 (2008)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419885
PNG
(CHEMBL157206)
Show SMILES CC(Oc1c(CC=C)cccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C17H22N2O/c1-4-7-14-9-6-10-15(8-5-2)16(14)20-13(3)17-18-11-12-19-17/h4-6,9-10,13H,1-2,7-8,11-12H2,3H3,(H,18,19)
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Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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n/an/an/an/a 646n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells


J Med Chem 51: 4289-99 (2008)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50412250
PNG
(CHEMBL128168)
Show SMILES CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)
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Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation


J Med Chem 50: 3964-8 (2007)

Checked by Author
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417354
PNG
(CHEMBL396013)
Show SMILES C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)/t13-/m0/s1
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n/an/an/an/a 692n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation


J Med Chem 50: 3964-8 (2007)

Checked by Author
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417354
PNG
(CHEMBL396013)
Show SMILES C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O/c1-13(17-18-11-12-19-17)20-16-10-6-5-9-15(16)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,18,19)/t13-/m0/s1
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Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417343
PNG
(CHEMBL1276140)
Show SMILES C[C@H](Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)/t11-/m0/s1
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Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417349
PNG
(CHEMBL1276248)
Show SMILES C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1
Show InChI InChI=1S/C15H16N2OS/c1-11(15-16-7-8-17-15)18-14-5-3-2-4-13(14)12-6-9-19-10-12/h2-6,9-11H,7-8H2,1H3,(H,16,17)/t11-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417343
PNG
(CHEMBL1276140)
Show SMILES C[C@H](Oc1ccccc1CC=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)17-11(2)14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)/t11-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human alpha2B adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50002905
PNG
(CHEMBL373535)
Show SMILES CC(Oc1ccccc1-c1cccnc1)C1=NCCN1
Show InChI InChI=1S/C16H17N3O/c1-12(16-18-9-10-19-16)20-15-7-3-2-6-14(15)13-5-4-8-17-11-13/h2-8,11-12H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation


J Med Chem 50: 3964-8 (2007)

Checked by Author
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419884
PNG
(CHEMBL157955)
Show SMILES CCc1cccc(CC)c1OC(C)C1=NCCN1
Show InChI InChI=1S/C15H22N2O/c1-4-12-7-6-8-13(5-2)14(12)18-11(3)15-16-9-10-17-15/h6-8,11H,4-5,9-10H2,1-3H3,(H,16,17)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50016897
PNG
(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Show SMILES Clc1cccc(Cl)c1N=C1NCCN1
Show InChI InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
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n/an/an/an/a 1.18E+3n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419889
PNG
(CHEMBL155866)
Show SMILES CC(Oc1c(C)cccc1C)C1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-9-5-4-6-10(2)12(9)16-11(3)13-14-7-8-15-13/h4-6,11H,7-8H2,1-3H3,(H,14,15)
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n/an/an/an/a 1.48E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419877
PNG
(CHEMBL1956194)
Show SMILES CC(Oc1ccccc1C(C)=C)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-10(2)12-6-4-5-7-13(12)17-11(3)14-15-8-9-16-14/h4-7,11H,1,8-9H2,2-3H3,(H,15,16)
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n/an/an/an/a 1.59E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50420342
PNG
(CHEMBL2089156)
Show SMILES C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)/t11-/m0/s1
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n/an/an/an/a 1.59E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human alpha2B adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419887
PNG
(CHEMBL14208)
Show SMILES CC(C)Oc1ccccc1OC(C)C1=NCCN1
Show InChI InChI=1S/C14H20N2O2/c1-10(2)17-12-6-4-5-7-13(12)18-11(3)14-15-8-9-16-14/h4-7,10-11H,8-9H2,1-3H3,(H,15,16)
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n/an/an/an/a 1.74E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415141
PNG
(CHEMBL576819)
Show SMILES Cc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-3-5-10(9)8-14-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)
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n/an/an/an/a 2.51E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50180251
PNG
(1-((S)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL3713...)
Show SMILES C[C@H](N)Cn1ncc2ccc(O)cc12
Show InChI InChI=1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,14H,6,11H2,1H3/t7-/m0/s1
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n/an/an/an/a 3.05E+3n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assay


J Med Chem 49: 318-28 (2006)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419879
PNG
(CHEMBL1956196)
Show SMILES CCOc1ccccc1OC(C)C1=NCCN1
Show InChI InChI=1S/C13H18N2O2/c1-3-16-11-6-4-5-7-12(11)17-10(2)13-14-8-9-15-13/h4-7,10H,3,8-9H2,1-2H3,(H,14,15)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419891
PNG
(CHEMBL1956198)
Show SMILES CC(Oc1ccccc1OC=C)C1=NCCN1
Show InChI InChI=1S/C13H16N2O2/c1-3-16-11-6-4-5-7-12(11)17-10(2)13-14-8-9-15-13/h3-7,10H,1,8-9H2,2H3,(H,14,15)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417346
PNG
(CHEMBL1276220)
Show SMILES C[C@H](Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-10(14-15-8-9-16-14)17-13-5-3-2-4-12(13)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)/t10-/m0/s1
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n/an/an/an/a 3.16E+3n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417344
PNG
(CHEMBL1276218)
Show SMILES CC(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C14H18N2O/c1-10(14-15-8-9-16-14)17-13-5-3-2-4-12(13)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419878
PNG
(CHEMBL1956195)
Show SMILES CC(Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)
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n/an/an/an/a 3.31E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419878
PNG
(CHEMBL1956195)
Show SMILES CC(Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)
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n/an/an/an/a 3.31E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human alpha2B adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50420341
PNG
(CHEMBL2089155)
Show SMILES C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1
Show InChI InChI=1S/C15H20N2O/c1-11(15-16-8-9-17-15)18-14-5-3-2-4-13(14)10-12-6-7-12/h2-5,11-12H,6-10H2,1H3,(H,16,17)/t11-/m1/s1
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n/an/an/an/a 3.98E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human alpha2B adrenoreceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor m...


Citation and Details
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50412249
PNG
(CHEMBL493675)
Show SMILES CC(Oc1ccccc1CN=O)C1=NCCN1
Show InChI InChI=1S/C12H15N3O2/c1-9(12-13-6-7-14-12)17-11-5-3-2-4-10(11)8-15-16/h2-5,9H,6-8H2,1H3,(H,13,14)
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n/an/an/an/a 3.98E+3n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant adrenergic alpha2B receptor expressed in CHO cells


J Med Chem 51: 4289-99 (2008)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50250521
PNG
((-)-dibromophakellin | CHEMBL447696 | dibromophake...)
Show SMILES NC1=N[C@H]2n3c(Br)c(Br)cc3C(=O)N3CCC[C@]23N1
Show InChI InChI=1S/C11H11Br2N5O/c12-5-4-6-8(19)17-3-1-2-11(17)9(15-10(14)16-11)18(6)7(5)13/h4,9H,1-3H2,(H3,14,15,16)/t9-,11+/m0/s1
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n/an/an/an/a 4.20E+3n/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha2B receptor expressed in HEK293 cells coexpressing Gqi5 protein by FLIPR assay


Bioorg Med Chem 17: 2497-500 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50180256
PNG
(1-((R)-2-aminopropyl)-1H-indazol-6-ol | CHEMBL4373...)
Show SMILES C[C@@H](N)Cn1ncc2ccc(O)cc12
Show InChI InChI=1S/C10H13N3O/c1-7(11)6-13-10-4-9(14)3-2-8(10)5-12-13/h2-5,7,14H,6,11H2,1H3/t7-/m1/s1
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n/an/an/an/a 4.71E+3n/an/an/an/a



Alcon Research, Ltd.

Curated by ChEMBL


Assay Description
Activity at adrenergic alpha-2B receptor expressed in opposum kidney OK cell by adenylyl cyclase assay


J Med Chem 49: 318-28 (2006)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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n/an/an/an/a 5.01E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 5.25E+3n/an/an/an/a



Università degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonistic potency at human adrenergic alpha-2B receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation


J Med Chem 50: 3964-8 (2007)

Checked by Author
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50417350
PNG
(CHEMBL374584)
Show SMILES CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
Show InChI InChI=1S/C17H18N2O2/c1-12(17-18-9-10-19-17)21-16-8-3-2-7-15(16)13-5-4-6-14(20)11-13/h2-8,11-12,20H,9-10H2,1H3,(H,18,19)
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n/an/an/an/a 5.25E+3n/an/an/an/a



Universita` di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry


J Med Chem 53: 7825-35 (2010)

More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50419886
PNG
(CHEMBL156336)
Show SMILES CCc1ccccc1OC(C)C1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-3-11-6-4-5-7-12(11)16-10(2)13-14-8-9-15-13/h4-7,10H,3,8-9H2,1-2H3,(H,14,15)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Universit£ degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human adrenoceptor aplha 2B expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometri...


Bioorg Med Chem 20: 2082-90 (2012)

More data for this
Ligand-Target Pair
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