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Compile Data Set for Download or QSAR

Found 41 hits of ec50 data for polymerid = 50007039   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140891
PNG
(CHEMBL3753487)
Show SMILES OC(CN1CCNS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C17H19N3O3S/c21-13(11-19-10-9-18-24(19,22)23)12-20-16-7-3-1-5-14(16)15-6-2-4-8-17(15)20/h1-8,13,18,21H,9-12H2
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n/an/an/an/a 42n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140890
PNG
(CHEMBL3754594)
Show SMILES OC(CN1CCOCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H20N2O4S/c21-14(11-19-9-10-24-13-25(19,22)23)12-20-17-7-3-1-5-15(17)16-6-2-4-8-18(16)20/h1-8,14,21H,9-13H2
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n/an/an/an/a 73n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140922
PNG
(CHEMBL3752819)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCC1
Show InChI InChI=1/C20H24N2O3S/c1-26(24,25)22(15-7-6-8-15)14-16(23)13-21-19-11-4-2-9-17(19)18-10-3-5-12-20(18)21/h2-5,9-12,15-16,23H,6-8,13-14H2,1H3
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n/an/an/an/a 129n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140892
PNG
(CHEMBL3752737)
Show SMILES CN1CCN(CC(O)Cn2c3ccccc3c3ccccc23)S1(=O)=O
Show InChI InChI=1/C18H21N3O3S/c1-19-10-11-20(25(19,23)24)12-14(22)13-21-17-8-4-2-6-15(17)16-7-3-5-9-18(16)21/h2-9,14,22H,10-13H2,1H3
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n/an/an/an/a 132n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140888
PNG
(CHEMBL3753839)
Show SMILES OC(CN1CCCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H20N2O3S/c21-14(12-19-10-5-11-24(19,22)23)13-20-17-8-3-1-6-15(17)16-7-2-4-9-18(16)20/h1-4,6-9,14,21H,5,10-13H2
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n/an/an/an/a 144n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140889
PNG
(CHEMBL3752502)
Show SMILES OC(CN1CCCCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C19H22N2O3S/c22-15(13-20-11-5-6-12-25(20,23)24)14-21-18-9-3-1-7-16(18)17-8-2-4-10-19(17)21/h1-4,7-10,15,22H,5-6,11-14H2
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n/an/an/an/a 173n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140920
PNG
(CHEMBL3752323)
Show SMILES CC(C)CN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C20H26N2O3S/c1-15(2)12-21(26(3,24)25)13-16(23)14-22-19-10-6-4-8-17(19)18-9-5-7-11-20(18)22/h4-11,15-16,23H,12-14H2,1-3H3
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n/an/an/an/a 178n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140887
PNG
(CHEMBL3753709)
Show SMILES OC(CN1CCS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C17H18N2O3S/c20-13(11-18-9-10-23(18,21)22)12-19-16-7-3-1-5-14(16)15-6-2-4-8-17(15)19/h1-8,13,20H,9-12H2
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n/an/an/an/a 190n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140703
PNG
(CHEMBL3754134)
Show SMILES CCS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1/C22H24N2O4S/c1-2-29(26,27)23(16-18-8-7-13-28-18)14-17(25)15-24-21-11-5-3-9-19(21)20-10-4-6-12-22(20)24/h3-13,17,25H,2,14-16H2,1H3
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n/an/an/an/a 197n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140765
PNG
(CHEMBL1446115)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccccc1
Show InChI InChI=1/C22H22N2O3S/c1-28(26,27)24(17-9-3-2-4-10-17)16-18(25)15-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h2-14,18,25H,15-16H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140693
PNG
(CHEMBL3753394)
Show SMILES COCCS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1/C23H26N2O5S/c1-29-13-14-31(27,28)24(17-19-7-6-12-30-19)15-18(26)16-25-22-10-4-2-8-20(22)21-9-3-5-11-23(21)25/h2-12,18,26H,13-17H2,1H3
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n/an/an/an/a 288n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140736
PNG
(CHEMBL3754710)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCCC1
Show InChI InChI=1/C21H26N2O3S/c1-27(25,26)23(16-8-2-3-9-16)15-17(24)14-22-20-12-6-4-10-18(20)19-11-5-7-13-21(19)22/h4-7,10-13,16-17,24H,2-3,8-9,14-15H2,1H3
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n/an/an/an/a 308n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140698
PNG
(CHEMBL3753223)
Show SMILES CC(C)CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1/C24H28N2O4S/c1-18(2)17-31(28,29)25(16-20-8-7-13-30-20)14-19(27)15-26-23-11-5-3-9-21(23)22-10-4-6-12-24(22)26/h3-13,18-19,27H,14-17H2,1-2H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140697
PNG
(CHEMBL3754783)
Show SMILES CCCCS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1/C24H28N2O4S/c1-2-3-15-31(28,29)25(18-20-9-8-14-30-20)16-19(27)17-26-23-12-6-4-10-21(23)22-11-5-7-13-24(22)26/h4-14,19,27H,2-3,15-18H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140893
PNG
(CHEMBL3753932)
Show SMILES OC(CN1CCCNS1(=O)=O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H21N3O3S/c22-14(12-20-11-5-10-19-25(20,23)24)13-21-17-8-3-1-6-15(17)16-7-2-4-9-18(16)21/h1-4,6-9,14,19,22H,5,10-13H2
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140884
PNG
(CHEMBL3752425)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1cccc(F)c1
Show InChI InChI=1/C22H21FN2O3S/c1-29(27,28)25(17-8-6-7-16(23)13-17)15-18(26)14-24-21-11-4-2-9-19(21)20-10-3-5-12-22(20)24/h2-13,18,26H,14-15H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140918
PNG
(CHEMBL3752371)
Show SMILES CCCN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C19H24N2O3S/c1-3-12-20(25(2,23)24)13-15(22)14-21-18-10-6-4-8-16(18)17-9-5-7-11-19(17)21/h4-11,15,22H,3,12-14H2,1-2H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140896
PNG
(CHEMBL3752727)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)Cc1ccccc1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C27H26N2O4S/c30-22(18-29-26-14-6-4-12-24(26)25-13-5-7-15-27(25)29)17-28(19-23-11-8-16-33-23)34(31,32)20-21-9-2-1-3-10-21/h1-16,22,30H,17-20H2
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140701
PNG
(CHEMBL3753497)
Show SMILES CC(C)S(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1/C23H26N2O4S/c1-17(2)30(27,28)24(16-19-8-7-13-29-19)14-18(26)15-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-13,17-18,26H,14-16H2,1-2H3
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n/an/an/an/a 438n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140921
PNG
(CHEMBL3753693)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CC1
Show InChI InChI=1/C19H22N2O3S/c1-25(23,24)21(14-10-11-14)13-15(22)12-20-18-8-4-2-6-16(18)17-7-3-5-9-19(17)20/h2-9,14-15,22H,10-13H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140904
PNG
(CHEMBL3752018)
Show SMILES CS(=O)(=O)NCC(O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C16H18N2O3S/c1-22(20,21)17-10-12(19)11-18-15-8-4-2-6-13(15)14-7-3-5-9-16(14)18/h2-9,12,17,19H,10-11H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140915
PNG
(CHEMBL3754372)
Show SMILES CCN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C18H22N2O3S/c1-3-19(24(2,22)23)12-14(21)13-20-17-10-6-4-8-15(17)16-9-5-7-11-18(16)20/h4-11,14,21H,3,12-13H2,1-2H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140919
PNG
(CHEMBL3753078)
Show SMILES CC(C)N(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C19H24N2O3S/c1-14(2)21(25(3,23)24)13-15(22)12-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,14-15,22H,12-13H2,1-3H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140702
PNG
(CHEMBL3753702)
Show SMILES CCCS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1/C23H26N2O4S/c1-2-14-30(27,28)24(17-19-8-7-13-29-19)15-18(26)16-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-13,18,26H,2,14-17H2,1H3
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n/an/an/an/a 516n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140749
PNG
(CHEMBL3752740)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCCCC1
Show InChI InChI=1/C22H28N2O3S/c1-28(26,27)24(17-9-3-2-4-10-17)16-18(25)15-23-21-13-7-5-11-19(21)20-12-6-8-14-22(20)23/h5-8,11-14,17-18,25H,2-4,9-10,15-16H2,1H3
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n/an/an/an/a 532n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140696
PNG
(CHEMBL3752613)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)C1CC1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C23H24N2O4S/c26-17(14-24(16-18-6-5-13-29-18)30(27,28)19-11-12-19)15-25-22-9-3-1-7-20(22)21-8-2-4-10-23(21)25/h1-10,13,17,19,26H,11-12,14-16H2
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140759
PNG
(CHEMBL3752021)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCC(F)(F)CC1
Show InChI InChI=1/C22H26F2N2O3S/c1-30(28,29)26(16-10-12-22(23,24)13-11-16)15-17(27)14-25-20-8-4-2-6-18(20)19-7-3-5-9-21(19)25/h2-9,16-17,27H,10-15H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140894
PNG
(CHEMBL3754467)
Show SMILES CN1CCCN(CC(O)Cn2c3ccccc3c3ccccc23)S1(=O)=O
Show InChI InChI=1/C19H23N3O3S/c1-20-11-6-12-21(26(20,24)25)13-15(23)14-22-18-9-4-2-7-16(18)17-8-3-5-10-19(17)22/h2-5,7-10,15,23H,6,11-14H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140907
PNG
(CHEMBL1487843)
Show SMILES CN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C17H20N2O3S/c1-18(23(2,21)22)11-13(20)12-19-16-9-5-3-7-14(16)15-8-4-6-10-17(15)19/h3-10,13,20H,11-12H2,1-2H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140886
PNG
(CHEMBL3753460)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccccc1
Show InChI InChI=1/C23H24N2O3S/c1-29(27,28)24(15-18-9-3-2-4-10-18)16-19(26)17-25-22-13-7-5-11-20(22)21-12-6-8-14-23(21)25/h2-14,19,26H,15-17H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140756
PNG
(CHEMBL3753763)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CCOCC1
Show InChI InChI=1/C21H26N2O4S/c1-28(25,26)23(16-10-12-27-13-11-16)15-17(24)14-22-20-8-4-2-6-18(20)19-7-3-5-9-21(19)22/h2-9,16-17,24H,10-15H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM56256
PNG
(MLS000110334 | N-(3-carbazol-9-yl-2-hydroxy-propyl...)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
Show InChI InChI=1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140885
PNG
(CHEMBL3752453)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1/C22H21FN2O3S/c1-29(27,28)25(17-12-10-16(23)11-13-17)15-18(26)14-24-21-8-4-2-6-19(21)20-7-3-5-9-22(20)24/h2-13,18,26H,14-15H2,1H3
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Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140692
PNG
(CHEMBL3754517)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)C1CCCCC1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C26H30N2O4S/c29-20(18-28-25-14-6-4-12-23(25)24-13-5-7-15-26(24)28)17-27(19-21-9-8-16-32-21)33(30,31)22-10-2-1-3-11-22/h4-9,12-16,20,22,29H,1-3,10-11,17-19H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140764
PNG
(CHEMBL3754396)
Show SMILES COCCN(CC(O)Cn1c2ccccc2c2ccccc12)S(C)(=O)=O
Show InChI InChI=1/C19H24N2O4S/c1-25-12-11-20(26(2,23)24)13-15(22)14-21-18-9-5-3-7-16(18)17-8-4-6-10-19(17)21/h3-10,15,22H,11-14H2,1-2H3
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n/an/an/an/a 1.02E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140895
PNG
(CHEMBL3753417)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)c1ccccc1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C26H24N2O4S/c29-20(18-28-25-14-6-4-12-23(25)24-13-5-7-15-26(24)28)17-27(19-21-9-8-16-32-21)33(30,31)22-10-2-1-3-11-22/h1-16,20,29H,17-19H2
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n/an/an/an/a 1.09E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140700
PNG
(CHEMBL3754797)
Show SMILES OC(CN(Cc1ccco1)S(=O)(=O)C1CCOC1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C24H26N2O5S/c27-18(15-26-23-9-3-1-7-21(23)22-8-2-4-10-24(22)26)14-25(16-19-6-5-12-31-19)32(28,29)20-11-13-30-17-20/h1-10,12,18,20,27H,11,13-17H2
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n/an/an/an/a 1.18E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140758
PNG
(CHEMBL3752125)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1CC(F)(F)C1
Show InChI InChI=1/C20H22F2N2O3S/c1-28(26,27)24(14-10-20(21,22)11-14)13-15(25)12-23-18-8-4-2-6-16(18)17-7-3-5-9-19(17)23/h2-9,14-15,25H,10-13H2,1H3
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n/an/an/an/a 1.27E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140769
PNG
(CHEMBL3754502)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccccc1F
Show InChI InChI=1/C22H21FN2O3S/c1-29(27,28)25(22-13-7-4-10-19(22)23)15-16(26)14-24-20-11-5-2-8-17(20)18-9-3-6-12-21(18)24/h2-13,16,26H,14-15H2,1H3
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n/an/an/an/a 2.55E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140753
PNG
(CHEMBL3752876)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)C1COC1
Show InChI InChI=1/C19H22N2O4S/c1-26(23,24)21(14-12-25-13-14)11-15(22)10-20-18-8-4-2-6-16(18)17-7-3-5-9-19(17)20/h2-9,14-15,22H,10-13H2,1H3
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n/an/an/an/a 3.53E+3n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens)
BDBM50140732
PNG
(CHEMBL3753313)
Show SMILES CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)c1ccccn1
Show InChI InChI=1/C21H21N3O3S/c1-28(26,27)24(21-12-6-7-13-22-21)15-16(25)14-23-19-10-4-2-8-17(19)18-9-3-5-11-20(18)23/h2-13,16,25H,14-15H2,1H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Reset Therapeutics

Curated by ChEMBL


Assay Description
Reduction of amplitude effect of PER2 in human U2OS cells harboring Per2-dLuc luciferase reporter gene assessed as effects on circadian rhythms


Bioorg Med Chem Lett 26: 757-60 (2016)

More data for this
Ligand-Target Pair