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Compile Data Set for Download or QSAR

Found 130 hits of ec50 data for polymerid = 50007042,50007043   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144380
PNG
(CHEMBL3759074)
Show SMILES Cc1cc(F)c2CCc3cc(sc3-c2c1F)C(O)=O
Show InChI InChI=1S/C14H10F2O2S/c1-6-4-9(15)8-3-2-7-5-10(14(17)18)19-13(7)11(8)12(6)16/h4-5H,2-3H2,1H3,(H,17,18)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144548
PNG
(CHEMBL3760048)
Show SMILES OC(=O)c1cc2CSc3c(F)cc(F)cc3-c2s1
Show InChI InChI=1S/C12H6F2O2S2/c13-6-2-7-10-5(1-9(18-10)12(15)16)4-17-11(7)8(14)3-6/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144565
PNG
(CHEMBL3758963)
Show SMILES CC1(C)Cc2cc(sc2-c2ccccc12)C(N)=O
Show InChI InChI=1S/C15H15NOS/c1-15(2)8-9-7-12(14(16)17)18-13(9)10-5-3-4-6-11(10)15/h3-7H,8H2,1-2H3,(H2,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144563
PNG
(CHEMBL3758280)
Show SMILES CC1Cc2cc(sc2-c2ccccc12)C(N)=O
Show InChI InChI=1/C14H13NOS/c1-8-6-9-7-12(14(15)16)17-13(9)11-5-3-2-4-10(8)11/h2-5,7-8H,6H2,1H3,(H2,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144566
PNG
(CHEMBL3759297)
Show SMILES NC(=O)c1cc2CCCc3ccccc3-c2s1
Show InChI InChI=1S/C14H13NOS/c15-14(16)12-8-10-6-3-5-9-4-1-2-7-11(9)13(10)17-12/h1-2,4,7-8H,3,5-6H2,(H2,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144380
PNG
(CHEMBL3759074)
Show SMILES Cc1cc(F)c2CCc3cc(sc3-c2c1F)C(O)=O
Show InChI InChI=1S/C14H10F2O2S/c1-6-4-9(15)8-3-2-7-5-10(14(17)18)19-13(7)11(8)12(6)16/h4-5H,2-3H2,1H3,(H,17,18)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144571
PNG
(CHEMBL3758275)
Show SMILES NC(=O)c1cc2CCOc3ccccc3-c2s1
Show InChI InChI=1S/C13H11NO2S/c14-13(15)11-7-8-5-6-16-10-4-2-1-3-9(10)12(8)17-11/h1-4,7H,5-6H2,(H2,14,15)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144549
PNG
(CHEMBL3758291)
Show SMILES OC(=O)c1cc2CSc3c(F)c(F)c(F)cc3-c2s1
Show InChI InChI=1S/C12H5F3O2S2/c13-6-2-5-10-4(1-7(19-10)12(16)17)3-18-11(5)9(15)8(6)14/h1-2H,3H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144560
PNG
(CHEMBL3759069)
Show SMILES NC(=O)c1cc2CCc3ccccc3-c2s1
Show InChI InChI=1S/C13H11NOS/c14-13(15)11-7-9-6-5-8-3-1-2-4-10(8)12(9)16-11/h1-4,7H,5-6H2,(H2,14,15)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144377
PNG
(CHEMBL3759274)
Show SMILES Cc1cc(F)c2CCc3cc(sc3-c2c1)C(O)=O
Show InChI InChI=1S/C14H11FO2S/c1-7-4-10-9(11(15)5-7)3-2-8-6-12(14(16)17)18-13(8)10/h4-6H,2-3H2,1H3,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50154398
PNG
(CHEMBL3774864)
Show SMILES OC(=O)CSc1ncnc2c(C3CC3)c(sc12)C(F)(F)F
Show InChI InChI=1S/C12H9F3N2O2S2/c13-12(14,15)10-7(5-1-2-5)8-9(21-10)11(17-4-16-8)20-3-6(18)19/h4-5H,1-3H2,(H,18,19)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assay


Bioorg Med Chem Lett 26: 1525-8 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144574
PNG
(CHEMBL3758560)
Show SMILES OC(=O)c1cc2CCc3c(Cl)c(Cl)ccc3-c2s1
Show InChI InChI=1S/C13H8Cl2O2S/c14-9-4-3-8-7(11(9)15)2-1-6-5-10(13(16)17)18-12(6)8/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144560
PNG
(CHEMBL3759069)
Show SMILES NC(=O)c1cc2CCc3ccccc3-c2s1
Show InChI InChI=1S/C13H11NOS/c14-13(15)11-7-9-6-5-8-3-1-2-4-10(8)12(9)16-11/h1-4,7H,5-6H2,(H2,14,15)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144578
PNG
(CHEMBL3760062)
Show SMILES OC(=O)c1cc2CCc3c(Cl)cc(F)cc3-c2s1
Show InChI InChI=1S/C13H8ClFO2S/c14-10-5-7(15)4-9-8(10)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144562
PNG
(CHEMBL3759323)
Show SMILES CC1Cc2ccccc2-c2sc(cc12)C(N)=O
Show InChI InChI=1/C14H13NOS/c1-8-6-9-4-2-3-5-10(9)13-11(8)7-12(17-13)14(15)16/h2-5,7-8H,6H2,1H3,(H2,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144571
PNG
(CHEMBL3758275)
Show SMILES NC(=O)c1cc2CCOc3ccccc3-c2s1
Show InChI InChI=1S/C13H11NO2S/c14-13(15)11-7-8-5-6-16-10-4-2-1-3-9(10)12(8)17-11/h1-4,7H,5-6H2,(H2,14,15)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144565
PNG
(CHEMBL3758963)
Show SMILES CC1(C)Cc2cc(sc2-c2ccccc12)C(N)=O
Show InChI InChI=1S/C15H15NOS/c1-15(2)8-9-7-12(14(16)17)18-13(9)10-5-3-4-6-11(10)15/h3-7H,8H2,1-2H3,(H2,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144538
PNG
(CHEMBL3758326)
Show InChI InChI=1S/C12H6ClFO3S/c13-6-2-7-10(8(14)3-6)17-4-5-1-9(12(15)16)18-11(5)7/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144563
PNG
(CHEMBL3758280)
Show SMILES CC1Cc2cc(sc2-c2ccccc12)C(N)=O
Show InChI InChI=1/C14H13NOS/c1-8-6-9-7-12(14(15)16)17-13(9)11-5-3-2-4-10(8)11/h2-5,7-8H,6H2,1H3,(H2,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144583
PNG
(CHEMBL3758279)
Show SMILES Cc1ccc2-c3sc(cc3CCc2c1C#N)C(O)=O
Show InChI InChI=1S/C15H11NO2S/c1-8-2-4-11-10(12(8)7-16)5-3-9-6-13(15(17)18)19-14(9)11/h2,4,6H,3,5H2,1H3,(H,17,18)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144375
PNG
(CHEMBL3759908)
Show SMILES OC(=O)c1cc2CCc3c(F)c(F)ccc3-c2s1
Show InChI InChI=1S/C13H8F2O2S/c14-9-4-3-8-7(11(9)15)2-1-6-5-10(13(16)17)18-12(6)8/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144534
PNG
(CHEMBL3759117)
Show SMILES Cc1cc(F)c2OCc3cc(sc3-c2c1)C(O)=O
Show InChI InChI=1S/C13H9FO3S/c1-6-2-8-11(9(14)3-6)17-5-7-4-10(13(15)16)18-12(7)8/h2-4H,5H2,1H3,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144374
PNG
(CHEMBL3759576)
Show SMILES Cc1cc(Cl)c2CCc3cc(sc3-c2c1)C(O)=O
Show InChI InChI=1S/C14H11ClO2S/c1-7-4-10-9(11(15)5-7)3-2-8-6-12(14(16)17)18-13(8)10/h4-6H,2-3H2,1H3,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144566
PNG
(CHEMBL3759297)
Show SMILES NC(=O)c1cc2CCCc3ccccc3-c2s1
Show InChI InChI=1S/C14H13NOS/c15-14(16)12-8-10-6-3-5-9-4-1-2-7-11(9)13(10)17-12/h1-2,4,7-8H,3,5-6H2,(H2,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144576
PNG
(CHEMBL3760106)
Show SMILES OC(=O)c1cc2CCc3c(Cl)cc(Cl)cc3-c2s1
Show InChI InChI=1S/C13H8Cl2O2S/c14-7-4-9-8(10(15)5-7)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144549
PNG
(CHEMBL3758291)
Show SMILES OC(=O)c1cc2CSc3c(F)c(F)c(F)cc3-c2s1
Show InChI InChI=1S/C12H5F3O2S2/c13-6-2-5-10-4(1-7(19-10)12(16)17)3-18-11(5)9(15)8(6)14/h1-2H,3H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144548
PNG
(CHEMBL3760048)
Show SMILES OC(=O)c1cc2CSc3c(F)cc(F)cc3-c2s1
Show InChI InChI=1S/C12H6F2O2S2/c13-6-2-7-10-5(1-9(18-10)12(15)16)4-17-11(7)8(14)3-6/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50154397
PNG
(CHEMBL3774760)
Show SMILES OC(=O)CSc1ncnc2c(C3CC3)c(Cl)sc12
Show InChI InChI=1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assay


Bioorg Med Chem Lett 26: 1525-8 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144585
PNG
(CHEMBL3759044)
Show SMILES OC(=O)c1cc2CCc3c(ccc(F)c3C#N)-c2s1
Show InChI InChI=1S/C14H8FNO2S/c15-11-4-3-9-8(10(11)6-16)2-1-7-5-12(14(17)18)19-13(7)9/h3-5H,1-2H2,(H,17,18)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144574
PNG
(CHEMBL3758560)
Show SMILES OC(=O)c1cc2CCc3c(Cl)c(Cl)ccc3-c2s1
Show InChI InChI=1S/C13H8Cl2O2S/c14-9-4-3-8-7(11(9)15)2-1-6-5-10(13(16)17)18-12(6)8/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144372
PNG
(CHEMBL3758668)
Show SMILES COc1ccc2-c3sc(cc3CCc2c1Cl)C(O)=O
Show InChI InChI=1S/C14H11ClO3S/c1-18-10-5-4-9-8(12(10)15)3-2-7-6-11(14(16)17)19-13(7)9/h4-6H,2-3H2,1H3,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144377
PNG
(CHEMBL3759274)
Show SMILES Cc1cc(F)c2CCc3cc(sc3-c2c1)C(O)=O
Show InChI InChI=1S/C14H11FO2S/c1-7-4-10-9(11(15)5-7)3-2-8-6-12(14(16)17)18-13(8)10/h4-6H,2-3H2,1H3,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144578
PNG
(CHEMBL3760062)
Show SMILES OC(=O)c1cc2CCc3c(Cl)cc(F)cc3-c2s1
Show InChI InChI=1S/C13H8ClFO2S/c14-10-5-7(15)4-9-8(10)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144539
PNG
(CHEMBL3759027)
Show SMILES OC(=O)c1cc2COc3c(Cl)cc(F)cc3-c2s1
Show InChI InChI=1S/C12H6ClFO3S/c13-8-3-6(14)2-7-10(8)17-4-5-1-9(12(15)16)18-11(5)7/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144543
PNG
(CHEMBL3758454)
Show SMILES OC(=O)c1cc2CS(=O)(=O)c3ccccc3-c2s1
Show InChI InChI=1S/C12H8O4S2/c13-12(14)9-5-7-6-18(15,16)10-4-2-1-3-8(10)11(7)17-9/h1-5H,6H2,(H,13,14)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144372
PNG
(CHEMBL3758668)
Show SMILES COc1ccc2-c3sc(cc3CCc2c1Cl)C(O)=O
Show InChI InChI=1S/C14H11ClO3S/c1-18-10-5-4-9-8(12(10)15)3-2-7-6-11(14(16)17)19-13(7)9/h4-6H,2-3H2,1H3,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144533
PNG
(CHEMBL3759406)
Show SMILES OC(=O)c1cc2COc3c(cc(F)cc3-c2s1)C#N
Show InChI InChI=1S/C13H6FNO3S/c14-8-1-6(4-15)11-9(3-8)12-7(5-18-11)2-10(19-12)13(16)17/h1-3H,5H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144576
PNG
(CHEMBL3760106)
Show SMILES OC(=O)c1cc2CCc3c(Cl)cc(Cl)cc3-c2s1
Show InChI InChI=1S/C13H8Cl2O2S/c14-7-4-9-8(10(15)5-7)2-1-6-3-11(13(16)17)18-12(6)9/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144539
PNG
(CHEMBL3759027)
Show SMILES OC(=O)c1cc2COc3c(Cl)cc(F)cc3-c2s1
Show InChI InChI=1S/C12H6ClFO3S/c13-8-3-6(14)2-7-10(8)17-4-5-1-9(12(15)16)18-11(5)7/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144534
PNG
(CHEMBL3759117)
Show SMILES Cc1cc(F)c2OCc3cc(sc3-c2c1)C(O)=O
Show InChI InChI=1S/C13H9FO3S/c1-6-2-8-11(9(14)3-6)17-5-7-4-10(13(15)16)18-12(7)8/h2-4H,5H2,1H3,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144573
PNG
(CHEMBL3759035)
Show SMILES COc1ccc2-c3sc(cc3CCc2c1C#N)C(O)=O
Show InChI InChI=1S/C15H11NO3S/c1-19-12-5-4-10-9(11(12)7-16)3-2-8-6-13(15(17)18)20-14(8)10/h4-6H,2-3H2,1H3,(H,17,18)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144374
PNG
(CHEMBL3759576)
Show SMILES Cc1cc(Cl)c2CCc3cc(sc3-c2c1)C(O)=O
Show InChI InChI=1S/C14H11ClO2S/c1-7-4-10-9(11(15)5-7)3-2-8-6-12(14(16)17)18-13(8)10/h4-6H,2-3H2,1H3,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144540
PNG
(CHEMBL3759995)
Show SMILES OC(=O)c1cc2COc3cc(F)c(F)c(F)c3-c2s1
Show InChI InChI=1S/C12H5F3O3S/c13-5-2-6-8(10(15)9(5)14)11-4(3-18-6)1-7(19-11)12(16)17/h1-2H,3H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144502
PNG
(CHEMBL3758201)
Show SMILES OC(=O)c1cc2COc3c(Cl)c(Cl)ccc3-c2s1
Show InChI InChI=1S/C12H6Cl2O3S/c13-7-2-1-6-10(9(7)14)17-4-5-3-8(12(15)16)18-11(5)6/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144547
PNG
(CHEMBL3758520)
Show SMILES OC(=O)c1cc2CSc3c(F)ccc(F)c3-c2s1
Show InChI InChI=1S/C12H6F2O2S2/c13-6-1-2-7(14)11-9(6)10-5(4-17-11)3-8(18-10)12(15)16/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144562
PNG
(CHEMBL3759323)
Show SMILES CC1Cc2ccccc2-c2sc(cc12)C(N)=O
Show InChI InChI=1/C14H13NOS/c1-8-6-9-4-2-3-5-10(9)13-11(8)7-12(17-13)14(15)16/h2-5,7-8H,6H2,1H3,(H2,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144501
PNG
(CHEMBL3758861)
Show SMILES OC(=O)c1cc2COc3c(Cl)cc(Cl)cc3-c2s1
Show InChI InChI=1S/C12H6Cl2O3S/c13-6-2-7-10(8(14)3-6)17-4-5-1-9(12(15)16)18-11(5)7/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Homo sapiens)
BDBM50144502
PNG
(CHEMBL3758201)
Show SMILES OC(=O)c1cc2COc3c(Cl)c(Cl)ccc3-c2s1
Show InChI InChI=1S/C12H6Cl2O3S/c13-7-2-1-6-10(9(7)14)17-4-5-3-8(12(15)16)18-11(5)6/h1-3H,4H2,(H,15,16)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of human notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50154398
PNG
(CHEMBL3774864)
Show SMILES OC(=O)CSc1ncnc2c(C3CC3)c(sc12)C(F)(F)F
Show InChI InChI=1S/C12H9F3N2O2S2/c13-12(14,15)10-7(5-1-2-5)8-9(21-10)11(17-4-16-8)20-3-6(18)19/h4-5H,1-3H2,(H,18,19)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells after 30 mins by TCF/LEF cell sensor assay


Bioorg Med Chem Lett 26: 1525-8 (2016)

More data for this
Ligand-Target Pair
Palmitoleoyl-protein carboxylesterase NOTUM


(Mus musculus)
BDBM50144581
PNG
(CHEMBL3759700)
Show SMILES OC(=O)c1cc2CCc3c(Cl)c(F)ccc3-c2s1
Show InChI InChI=1S/C13H8ClFO2S/c14-11-7-2-1-6-5-10(13(16)17)18-12(6)8(7)3-4-9(11)15/h3-5H,1-2H2,(H,16,17)
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Lexicon Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of mouse notum pectinacetylesterase expressed in 293F cells by TCF/LEF CellSensor assay


Bioorg Med Chem Lett 26: 1184-7 (2016)

More data for this
Ligand-Target Pair
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