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Compile Data Set for Download or QSAR

Found 48 hits of ec50 data for polymerid = 5583   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM182732
PNG
(US9145408, 405)
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(C([O-])=O)c1=O
Show InChI InChI=1/C27H35N3O3/c1-16-9-17-11-18(10-16)13-21(12-17)29-19-5-4-6-20(29)15-22(14-19)30-24-8-3-2-7-23(24)28-25(26(30)31)27(32)33/h2-3,7-8,16-22H,4-6,9-15H2,1H3,(H,32,33)/p-1/t16-,17-,18+,19-,20+,21+,22+
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n/an/an/an/a 0.550n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220366
PNG
(US9290488, B34a)
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC(CC(O)=O)C2)c1=O
Show InChI InChI=1/C31H42N4O3/c1-19-9-20-11-21(10-19)13-25(12-20)34-23-5-4-6-24(34)16-26(15-23)35-28-8-3-2-7-27(28)32-30(31(35)38)33-17-22(18-33)14-29(36)37/h2-3,7-8,19-26H,4-6,9-18H2,1H3,(H,36,37)/t19-,20-,21+,23-,24+,25+,26+
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n/an/an/an/a 1.24n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220363
PNG
(US9290488, B20a(i))
Show SMILES CC12C[C@@H]3C[C@H]1C[C@H]2C[C@@H](C3)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@@H]2C(O)=O)c1=O
Show InChI InChI=1/C31H40N4O3/c1-31-17-18-11-19(31)13-20(31)14-23(12-18)34-21-5-4-6-22(34)16-24(15-21)35-26-8-3-2-7-25(26)32-28(29(35)36)33-10-9-27(33)30(37)38/h2-3,7-8,18-24,27H,4-6,9-17H2,1H3,(H,37,38)/t18-,19+,20+,21-,22+,23-,24+,27-,31?/s2
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n/an/an/an/a 2.62n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM97710
PNG
(US8476271, 16 | US9145408, 362)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O
Show InChI InChI=1S/C26H33N3O3/c30-25-24(26(31)32)27-22-9-1-2-10-23(22)29(25)21-14-18-7-4-8-19(15-21)28(18)20-12-16-5-3-6-17(11-16)13-20/h1-2,9-10,16-21H,3-8,11-15H2,(H,31,32)/t16?,17?,18-,19+,20?,21+
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n/an/an/an/a 4.03n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220379
PNG
(US9290488, L29b)
Show SMILES OC(=O)CC1CN(C1)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C31H42N4O3/c36-29(37)15-22-18-33(19-22)30-31(38)35(28-11-4-3-10-27(28)32-30)26-16-23-8-5-9-24(17-26)34(23)25-13-20-6-1-2-7-21(12-20)14-25/h3-4,10-11,20-26H,1-2,5-9,12-19H2,(H,36,37)/t20-,21+,23-,24+,25-,26+
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n/an/an/an/a 4.20n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220383
PNG
(US9290488, ZA04)
Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C30H41N5O3/c31-24-17-33(27(24)30(37)38)28-29(36)35(26-11-4-3-10-25(26)32-28)23-15-20-8-5-9-21(16-23)34(20)22-13-18-6-1-2-7-19(12-18)14-22/h3-4,10-11,18-24,27H,1-2,5-9,12-17,31H2,(H,37,38)/t18-,19+,20-,21+,22-,23+,24-,27+/s2
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n/an/an/an/a 5.84n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220361
PNG
(US9290488, B11a(ii))
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@H]2C(O)=O)c1=O
Show InChI InChI=1/C30H40N4O3/c1-18-11-19-13-20(12-18)15-23(14-19)33-21-5-4-6-22(33)17-24(16-21)34-26-8-3-2-7-25(26)31-28(29(34)35)32-10-9-27(32)30(36)37/h2-3,7-8,18-24,27H,4-6,9-17H2,1H3,(H,36,37)/t18-,19-,20+,21-,22+,23+,24+,27-/s2
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n/an/an/an/a 6.54n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220376
PNG
(US9290488, K29b)
Show SMILES OC(=O)CC1CN(C1)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C30H40N4O3/c35-28(36)14-21-17-32(18-21)29-30(37)34(27-8-4-3-7-26(27)31-29)25-15-22-9-10-23(16-25)33(22)24-12-19-5-1-2-6-20(11-19)13-24/h3-4,7-8,19-25H,1-2,5-6,9-18H2,(H,35,36)/t19-,20+,22-,23+,24-,25+
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n/an/an/an/a 7.24n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220365
PNG
(US9290488, B21a)
Show SMILES CC12C[C@@H]3C[C@H]1C[C@H]2C[C@@H](C3)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC(C2)C(O)=O)c1=O
Show InChI InChI=1/C31H40N4O3/c1-31-15-18-9-20(31)11-21(31)12-24(10-18)34-22-5-4-6-23(34)14-25(13-22)35-27-8-3-2-7-26(27)32-28(29(35)36)33-16-19(17-33)30(37)38/h2-3,7-8,18-25H,4-6,9-17H2,1H3,(H,37,38)/t18-,20+,21+,22-,23+,24-,25+,31?/s2
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n/an/an/an/a 7.80n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220362
PNG
(US9290488, B12a)
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC(C2)C(O)=O)c1=O
Show InChI InChI=1/C30H40N4O3/c1-18-9-19-11-20(10-18)13-24(12-19)33-22-5-4-6-23(33)15-25(14-22)34-27-8-3-2-7-26(27)31-28(29(34)35)32-16-21(17-32)30(36)37/h2-3,7-8,18-25H,4-6,9-17H2,1H3,(H,36,37)/t18-,19-,20+,22-,23+,24+,25+
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n/an/an/an/a 8.14n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220378
PNG
(US9290488, L2b(ii))
Show SMILES OC(=O)[C@@H]1CCN1c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C30H40N4O3/c35-29-28(32-13-12-27(32)30(36)37)31-25-10-3-4-11-26(25)34(29)24-17-21-8-5-9-22(18-24)33(21)23-15-19-6-1-2-7-20(14-19)16-23/h3-4,10-11,19-24,27H,1-2,5-9,12-18H2,(H,36,37)/t19-,20+,21-,22+,23-,24+,27-/s2
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n/an/an/an/a 12n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220375
PNG
(US9290488, K2b(ii))
Show SMILES OC(=O)[C@@H]1CCN1c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C29H38N4O3/c34-28-27(31-12-11-26(31)29(35)36)30-24-7-3-4-8-25(24)33(28)23-16-20-9-10-21(17-23)32(20)22-14-18-5-1-2-6-19(13-18)15-22/h3-4,7-8,18-23,26H,1-2,5-6,9-17H2,(H,35,36)/t18-,19+,20-,21+,22-,23+,26-/s2
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n/an/an/an/a 14.3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220377
PNG
(US9290488, L2b(i))
Show SMILES OC(=O)[C@H]1CCN1c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C30H40N4O3/c35-29-28(32-13-12-27(32)30(36)37)31-25-10-3-4-11-26(25)34(29)24-17-21-8-5-9-22(18-24)33(21)23-15-19-6-1-2-7-20(14-19)16-23/h3-4,10-11,19-24,27H,1-2,5-9,12-18H2,(H,36,37)/t19-,20+,21-,22+,23-,24+,27-/s2
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n/an/an/an/a 14.6n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220360
PNG
(US9290488, B11a(i))
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@@H]2C(O)=O)c1=O
Show InChI InChI=1/C30H40N4O3/c1-18-11-19-13-20(12-18)15-23(14-19)33-21-5-4-6-22(33)17-24(16-21)34-26-8-3-2-7-25(26)31-28(29(34)35)32-10-9-27(32)30(36)37/h2-3,7-8,18-24,27H,4-6,9-17H2,1H3,(H,36,37)/t18-,19-,20+,21-,22+,23+,24+,27-/s2
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n/an/an/an/a 16.2n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220373
PNG
(US9290488, E54a)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@H](CCN1[C@H]3CCC[C@@H]1C[C@@H](C3)n1c3ccccc3nc(N3CC(C3)C(O)=O)c1=O)CC2
Show InChI InChI=1/C31H42N4O3/c1-31(2)21-11-10-19(25(31)14-21)12-13-34-22-6-5-7-23(34)16-24(15-22)35-27-9-4-3-8-26(27)32-28(29(35)36)33-17-20(18-33)30(37)38/h3-4,8-9,19-25H,5-7,10-18H2,1-2H3,(H,37,38)/t19-,21-,22-,23+,24+,25-/s2
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n/an/an/an/a 21.7n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220386
PNG
(US9290488, ZA07)
Show SMILES CO[C@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C31H42N4O4/c1-39-27-18-33(28(27)31(37)38)29-30(36)35(26-12-5-4-11-25(26)32-29)24-16-21-9-6-10-22(17-24)34(21)23-14-19-7-2-3-8-20(13-19)15-23/h4-5,11-12,19-24,27-28H,2-3,6-10,13-18H2,1H3,(H,37,38)/t19-,20+,21-,22+,23-,24+,27-,28-/s2
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n/an/an/an/a 22.9n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220381
PNG
(US9290488, ZA02)
Show SMILES CC(=O)N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C32H43N5O4/c1-19(38)33-27-18-35(29(27)32(40)41)30-31(39)37(28-12-5-4-11-26(28)34-30)25-16-22-9-6-10-23(17-25)36(22)24-14-20-7-2-3-8-21(13-20)15-24/h4-5,11-12,20-25,27,29H,2-3,6-10,13-18H2,1H3,(H,33,38)(H,40,41)/t20-,21+,22-,23+,24-,25+,27-,29+/s2
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n/an/an/an/a 24.2n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220384
PNG
(US9290488, ZA05)
Show SMILES CN(C)[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C32H45N5O3/c1-34(2)28-19-35(29(28)32(39)40)30-31(38)37(27-13-6-5-12-26(27)33-30)25-17-22-10-7-11-23(18-25)36(22)24-15-20-8-3-4-9-21(14-20)16-24/h5-6,12-13,20-25,28-29H,3-4,7-11,14-19H2,1-2H3,(H,39,40)/t20-,21+,22-,23+,24-,25+,28-,29+/s2
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n/an/an/an/a 24.5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220387
PNG
(US9290488, ZA08)
Show SMILES CO[C@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)c1=O
Show InChI InChI=1/C30H40N4O4/c1-38-26-17-32(27(26)30(36)37)28-29(35)34(25-11-3-2-10-24(25)31-28)23-15-20-8-5-9-21(16-23)33(20)22-13-18-6-4-7-19(12-18)14-22/h2-3,10-11,18-23,26-27H,4-9,12-17H2,1H3,(H,36,37)/t18-,19+,20-,21+,22+,23+,26-,27-/s2
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n/an/an/an/a 29.3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220374
PNG
(US9290488, H3a)
Show SMILES OC(=O)C1CN(C1)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CCCCCCCCC2)c1=O
Show InChI InChI=1/C30H42N4O3/c35-29-28(32-19-21(20-32)30(36)37)31-26-15-8-9-16-27(26)34(29)25-17-23-13-10-14-24(18-25)33(23)22-11-6-4-2-1-3-5-7-12-22/h8-9,15-16,21-25H,1-7,10-14,17-20H2,(H,36,37)/t23-,24+,25+
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n/an/an/an/a 40.1n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220357
PNG
(US9290488, A11a(ii))
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@H]2C(O)=O)c1=O
Show InChI InChI=1/C29H38N4O3/c1-17-10-18-12-19(11-17)14-22(13-18)32-20-6-7-21(32)16-23(15-20)33-25-5-3-2-4-24(25)30-27(28(33)34)31-9-8-26(31)29(35)36/h2-5,17-23,26H,6-16H2,1H3,(H,35,36)/t17-,18-,19+,20-,21+,22+,23+,26-/s2
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n/an/an/an/a 42.5n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220364
PNG
(US9290488, B20a(ii))
Show SMILES CC12C[C@@H]3C[C@H]1C[C@H]2C[C@@H](C3)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@H]2C(O)=O)c1=O
Show InChI InChI=1/C31H40N4O3/c1-31-17-18-11-19(31)13-20(31)14-23(12-18)34-21-5-4-6-22(34)16-24(15-21)35-26-8-3-2-7-25(26)32-28(29(35)36)33-10-9-27(33)30(37)38/h2-3,7-8,18-24,27H,4-6,9-17H2,1H3,(H,37,38)/t18-,19+,20+,21-,22+,23-,24+,27+,31?/s2
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n/an/an/an/a 51.1n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM97711
PNG
(US8476271, 17 | US8846929, 360 | US8846929, 361 | ...)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O
Show InChI InChI=1S/C25H31N3O3/c29-24-23(25(30)31)26-21-6-1-2-7-22(21)28(24)20-13-17-8-9-18(14-20)27(17)19-11-15-4-3-5-16(10-15)12-19/h1-2,6-7,15-20H,3-5,8-14H2,(H,30,31)/t15?,16?,17-,18+,19?,20+
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n/an/an/an/a 57.2n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220359
PNG
(US9290488, B2a(ii))
Show SMILES OC(=O)[C@@H]1CCN1c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)c1=O
Show InChI InChI=1/C29H38N4O3/c34-28-27(31-12-11-26(31)29(35)36)30-24-9-1-2-10-25(24)33(28)23-16-20-7-4-8-21(17-23)32(20)22-14-18-5-3-6-19(13-18)15-22/h1-2,9-10,18-23,26H,3-8,11-17H2,(H,35,36)/t18-,19+,20-,21+,22+,23+,26-/s2
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n/an/an/an/a 61.3n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM97712
PNG
(US8476271, 18 | US8846929, 358 | US9145408, 358)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCCCCC2)c1=O
Show InChI InChI=1S/C27H37N3O3/c31-26-25(27(32)33)28-23-13-9-10-14-24(23)30(26)22-17-20-15-16-21(18-22)29(20)19-11-7-5-3-1-2-4-6-8-12-19/h9-10,13-14,19-22H,1-8,11-12,15-18H2,(H,32,33)/t20-,21+,22+
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n/an/an/an/a 62.6n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220371
PNG
(US9290488, E53a(i))
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@H](CCN1[C@H]3CCC[C@@H]1C[C@@H](C3)n1c3ccccc3nc(N3CC[C@@H]3C(O)=O)c1=O)CC2
Show InChI InChI=1/C31H42N4O3/c1-31(2)20-11-10-19(24(31)16-20)12-14-33-21-6-5-7-22(33)18-23(17-21)35-26-9-4-3-8-25(26)32-28(29(35)36)34-15-13-27(34)30(37)38/h3-4,8-9,19-24,27H,5-7,10-18H2,1-2H3,(H,37,38)/t19-,20-,21-,22+,23+,24-,27+/s2
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n/an/an/an/a 65.7n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220372
PNG
(US9290488, E53a(ii))
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@H](CCN1[C@H]3CCC[C@@H]1C[C@@H](C3)n1c3ccccc3nc(N3CC[C@H]3C(O)=O)c1=O)CC2
Show InChI InChI=1/C31H42N4O3/c1-31(2)20-11-10-19(24(31)16-20)12-14-33-21-6-5-7-22(33)18-23(17-21)35-26-9-4-3-8-25(26)32-28(29(35)36)34-15-13-27(34)30(37)38/h3-4,8-9,19-24,27H,5-7,10-18H2,1-2H3,(H,37,38)/t19-,20-,21-,22+,23+,24-,27-/s2
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n/an/an/an/a 130n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220356
PNG
(US9290488, A11a(i))
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@@H]2C(O)=O)c1=O
Show InChI InChI=1/C29H38N4O3/c1-17-10-18-12-19(11-17)14-22(13-18)32-20-6-7-21(32)16-23(15-20)33-25-5-3-2-4-24(25)30-27(28(33)34)31-9-8-26(31)29(35)36/h2-5,17-23,26H,6-16H2,1H3,(H,35,36)/t17-,18-,19+,20-,21+,22+,23+,26-/s2
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n/an/an/an/a 139n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220368
PNG
(US9290488, C20a(ii))
Show SMILES CC12C[C@@H]3C[C@H]1C[C@H]2C[C@@H](C3)N1[C@H]2COC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(N2CC[C@H]2C(O)=O)c1=O
Show InChI InChI=1/C30H38N4O4/c1-30-14-17-8-18(30)10-19(30)11-20(9-17)33-22-12-21(13-23(33)16-38-15-22)34-25-5-3-2-4-24(25)31-27(28(34)35)32-7-6-26(32)29(36)37/h2-5,17-23,26H,6-16H2,1H3,(H,36,37)/t17-,18+,19+,20-,21-,22-,23+,26+,30?/s2
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n/an/an/an/a 146n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199350
PNG
(US9221831, 15)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(F)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
Show InChI InChI=1/C31H36FNO3/c1-34-31-12-11-29(16-23(31)19-35-18-21-5-3-2-4-6-21)25-15-22-9-10-24(32)27-26(22)30(29,28(31)36-27)13-14-33(25)17-20-7-8-20/h2-6,9-10,20,23,25,28H,7-8,11-19H2,1H3/t23-,25-,28-,29-,30+,31-/s2
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n/an/an/an/a 261n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220358
PNG
(US9290488, B2a(i))
Show SMILES OC(=O)[C@H]1CCN1c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)c1=O
Show InChI InChI=1/C29H38N4O3/c34-28-27(31-12-11-26(31)29(35)36)30-24-9-1-2-10-25(24)33(28)23-16-20-7-4-8-21(17-23)32(20)22-14-18-5-3-6-19(13-18)15-22/h1-2,9-10,18-23,26H,3-8,11-17H2,(H,35,36)/t18-,19+,20-,21+,22+,23+,26-/s2
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n/an/an/an/a 319n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM182734
PNG
(US9145408, 369)
Show SMILES N[C@]12CCC[C@H](C[C@@H](C1)n1c3ccccc3nc(C(O)=O)c1=O)N2C1CC2CCCC(C2)C1
Show InChI InChI=1/C26H34N4O3/c27-26-10-4-7-18(30(26)19-12-16-5-3-6-17(11-16)13-19)14-20(15-26)29-22-9-2-1-8-21(22)28-23(24(29)31)25(32)33/h1-2,8-9,16-20H,3-7,10-15,27H2,(H,32,33)/t16?,17?,18-,19?,20+,26+/s2
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n/an/an/an/a 545n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM97715
PNG
(US8476271, 96 | US8846929, 356 | US9145408, 356)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCCCCCC2)c1=O
Show InChI InChI=1S/C28H39N3O3/c32-27-26(28(33)34)29-24-14-10-11-15-25(24)31(27)23-18-21-16-17-22(19-23)30(21)20-12-8-6-4-2-1-3-5-7-9-13-20/h10-11,14-15,20-23H,1-9,12-13,16-19H2,(H,33,34)/t21-,22+,23+
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n/an/an/an/a 686n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199363
PNG
(US9221831, 28)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1CNCc1ccccc1)OC
Show InChI InChI=1/C32H40N2O3/c1-35-25-11-10-23-16-26-30-12-13-32(36-2,24(17-30)19-33-18-21-6-4-3-5-7-21)29-31(30,27(23)28(25)37-29)14-15-34(26)20-22-8-9-22/h3-7,10-11,22,24,26,29,33H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/s2
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n/an/an/an/a 1.22E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM4203
PNG
(US8530494, 6 | US9221831, 10)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1COCc1ccccc1)OC
Show InChI InChI=1S/C32H39NO4/c1-34-25-11-10-23-16-26-30-12-13-32(35-2,24(17-30)20-36-19-22-6-4-3-5-7-22)29-31(30,27(23)28(25)37-29)14-15-33(26)18-21-8-9-21/h3-7,10-11,21,24,26,29H,8-9,12-20H2,1-2H3/t24-,26-,29-,30-,31+,32-/m1/s1
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n/an/an/an/a 1.64E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM182733
PNG
(US9145408, 360)
Show SMILES OC(=O)c1nc2ccccc2n(C2CC3CCC(C2)N3C2CC3CCCC(C3)C2)c1=O
Show InChI InChI=1/C25H31N3O3/c29-24-23(25(30)31)26-21-6-1-2-7-22(21)28(24)20-13-17-8-9-18(14-20)27(17)19-11-15-4-3-5-16(10-15)12-19/h1-2,6-7,15-20H,3-5,8-14H2,(H,30,31)
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n/an/an/an/a 1.67E+3n/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor [35S]GTPγS Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like (ORL-1) (...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199357
PNG
(US9221831, 22)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1)c45
Show InChI InChI=1/C27H31NO4/c1-30-27-10-9-25(14-19(27)16-31-15-17-5-3-2-4-6-17)21-13-18-7-8-20(29)23-22(18)26(25,11-12-28-21)24(27)32-23/h2-8,19,21,24,28-29H,9-16H2,1H3/t19-,21-,24-,25-,26+,27-/s2
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n/an/an/an/a 2.44E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199340
PNG
(US9221831, 4)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(F)c5O[C@@H]2[C@]3(CCN1C)c45
Show InChI InChI=1/C28H32FNO3/c1-30-13-12-27-23-19-8-9-21(29)24(23)33-25(27)28(31-2)11-10-26(27,22(30)14-19)15-20(28)17-32-16-18-6-4-3-5-7-18/h3-9,20,22,25H,10-17H2,1-2H3/t20-,22-,25-,26-,27+,28-/s2
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n/an/an/an/a 2.92E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199352
PNG
(US9221831, 17)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(NC(C)=O)c5O[C@@H]2[C@]3(CCN1C)c45
Show InChI InChI=1/C30H36N2O4/c1-19(33)31-23-10-9-21-15-24-28-11-12-30(34-3,22(16-28)18-35-17-20-7-5-4-6-8-20)27-29(28,13-14-32(24)2)25(21)26(23)36-27/h4-10,22,24,27H,11-18H2,1-3H3,(H,31,33)/t22-,24-,27-,28-,29+,30-/s2
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n/an/an/an/a 3.52E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199337
PNG
(US9221831, 1)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1C)[C@H]1Cc4ccc(OCCO)c5O[C@@H]2[C@]3(CCN1C)c45
Show InChI InChI=1/C31H39NO5/c1-20-6-4-5-7-22(20)18-35-19-23-17-29-10-11-31(23,34-3)28-30(29)12-13-32(2)25(29)16-21-8-9-24(36-15-14-33)27(37-28)26(21)30/h4-9,23,25,28,33H,10-19H2,1-3H3/t23-,25-,28-,29-,30+,31-/s2
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n/an/an/an/a 4.10E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199339
PNG
(US9221831, 3)
Show SMILES CO[C@]12CC[C@@]3(C[C@@H]1COCc1ccccc1)[C@H]1Cc4ccc(C=C)c5O[C@@H]2[C@]3(CCN1C)c45
Show InChI InChI=1/C30H35NO3/c1-4-21-10-11-22-16-24-28-12-13-30(32-3,23(17-28)19-33-18-20-8-6-5-7-9-20)27-29(28,14-15-31(24)2)25(22)26(21)34-27/h4-11,23-24,27H,1,12-19H2,2-3H3/t23-,24-,27-,28-,29+,30-/s2
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n/an/an/an/a 6.55E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM199353
PNG
(US9221831, 18)
Show SMILES COc1ccc2C[C@H]3NCC[C@@]45[C@@H](Oc1c24)[C@]1(CC[C@@]35C[C@@H]1COCc1ccccc1)OC
Show InChI InChI=1/C28H33NO4/c1-30-21-9-8-19-14-22-26-10-11-28(31-2,20(15-26)17-32-16-18-6-4-3-5-7-18)25-27(26,12-13-29-22)23(19)24(21)33-25/h3-9,20,22,25,29H,10-17H2,1-2H3/t20-,22-,25-,26-,27+,28-/s2
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n/an/an/an/a 7.89E+3n/an/an/an/a



Purdue Pharma, L.P.

US Patent


Assay Description
Functional [35S]GTPgammaS binding assays were conducted as follows. ORL-1 membrane solution was prepared by sequentially adding final concentrations ...


US Patent US9221831 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220389
PNG
(US9290488, ZA10)
Show SMILES CN(C)[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)c1=O
Show InChI InChI=1/C31H43N5O3/c1-33(2)27-18-34(28(27)31(38)39)29-30(37)36(26-12-4-3-11-25(26)32-29)24-16-21-9-6-10-22(17-24)35(21)23-14-19-7-5-8-20(13-19)15-23/h3-4,11-12,19-24,27-28H,5-10,13-18H2,1-2H3,(H,38,39)/t19-,20+,21-,22+,23+,24+,27-,28+/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220388
PNG
(US9290488, ZA09)
Show SMILES N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)c1=O
Show InChI InChI=1/C29H39N5O3/c30-23-16-32(26(23)29(36)37)27-28(35)34(25-10-2-1-9-24(25)31-27)22-14-19-7-4-8-20(15-22)33(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-23,26H,3-8,11-16,30H2,(H,36,37)/t17-,18+,19-,20+,21+,22+,23-,26+/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220390
PNG
(US9290488, ZA11)
Show SMILES CC(=O)N[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@@H]2C[C@H]3CCC[C@H](C3)C2)c1=O
Show InChI InChI=1/C31H41N5O4/c1-18(37)32-26-17-34(28(26)31(39)40)29-30(38)36(27-11-3-2-10-25(27)33-29)24-15-21-8-5-9-22(16-24)35(21)23-13-19-6-4-7-20(12-19)14-23/h2-3,10-11,19-24,26,28H,4-9,12-17H2,1H3,(H,32,37)(H,39,40)/t19-,20+,21-,22+,23+,24+,26-,28+/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220385
PNG
(US9290488, ZA06)
Show SMILES CN[C@@H]1CN([C@@H]1C(O)=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O
Show InChI InChI=1/C31H43N5O3/c1-32-26-18-34(28(26)31(38)39)29-30(37)36(27-12-5-4-11-25(27)33-29)24-16-21-9-6-10-22(17-24)35(21)23-14-19-7-2-3-8-20(13-19)15-23/h4-5,11-12,19-24,26,28,32H,2-3,6-10,13-18H2,1H3,(H,38,39)/t19-,20+,21-,22+,23-,24+,26-,28+/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220382
PNG
(US9290488, ZA03)
Show SMILES CN(C)C1(CN(C1)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O)C(O)=O
Show InChI InChI=1/C32H45N5O3/c1-34(2)32(31(39)40)19-35(20-32)29-30(38)37(28-13-6-5-12-27(28)33-29)26-17-23-10-7-11-24(18-26)36(23)25-15-21-8-3-4-9-22(14-21)16-25/h5-6,12-13,21-26H,3-4,7-11,14-20H2,1-2H3,(H,39,40)/t21-,22+,23-,24+,25-,26+
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n/an/an/an/a>2.00E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM220380
PNG
(US9290488, ZA01)
Show SMILES NC1(CN(C1)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c1=O)C(O)=O
Show InChI InChI=1/C30H41N5O3/c31-30(29(37)38)17-33(18-30)27-28(36)35(26-11-4-3-10-25(26)32-27)24-15-21-8-5-9-22(16-24)34(21)23-13-19-6-1-2-7-20(12-19)14-23/h3-4,10-11,19-24H,1-2,5-9,12-18,31H2,(H,37,38)/t19-,20+,21-,22+,23-,24+
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n/an/an/an/a>2.00E+4n/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
ORL-1 membrane solution was prepared by sequentially adding final concentrations of 0.066 μg/μL ORL-1 membrane protein, 10 μg/mL saponin, 3 ...


US Patent US9290488 (2016)

More data for this
Ligand-Target Pair