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Compile Data Set for Download or QSAR

Found 54 hits of ec50 data for polymerid = 6539   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50012295
PNG
(CHEMBL217378 | ISHKDMQLGR | Ile-Ser-His-Lys-Asp-Me...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C49H85N17O15S/c1-6-26(4)39(52)47(79)66-35(23-67)46(78)64-33(19-27-21-55-24-58-27)44(76)60-28(10-7-8-15-50)41(73)65-34(20-38(70)71)45(77)62-30(14-17-82-5)43(75)61-29(12-13-36(51)68)42(74)63-32(18-25(2)3)40(72)57-22-37(69)59-31(48(80)81)11-9-16-56-49(53)54/h21,24-26,28-35,39,67H,6-20,22-23,50,52H2,1-5H3,(H2,51,68)(H,55,58)(H,57,72)(H,59,69)(H,60,76)(H,61,75)(H,62,77)(H,63,74)(H,64,78)(H,65,73)(H,66,79)(H,70,71)(H,80,81)(H4,53,54,56)/t26-,28-,29-,30-,31-,32-,33-,34-,35-,39-/m0/s1
KEGG

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n/an/an/an/a 1.30n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50012295
PNG
(CHEMBL217378 | ISHKDMQLGR | Ile-Ser-His-Lys-Asp-Me...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C49H85N17O15S/c1-6-26(4)39(52)47(79)66-35(23-67)46(78)64-33(19-27-21-55-24-58-27)44(76)60-28(10-7-8-15-50)41(73)65-34(20-38(70)71)45(77)62-30(14-17-82-5)43(75)61-29(12-13-36(51)68)42(74)63-32(18-25(2)3)40(72)57-22-37(69)59-31(48(80)81)11-9-16-56-49(53)54/h21,24-26,28-35,39,67H,6-20,22-23,50,52H2,1-5H3,(H2,51,68)(H,55,58)(H,57,72)(H,59,69)(H,60,76)(H,61,75)(H,62,77)(H,63,74)(H,64,78)(H,65,73)(H,66,79)(H,70,71)(H,80,81)(H4,53,54,56)/t26-,28-,29-,30-,31-,32-,33-,34-,35-,39-/m0/s1
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n/an/an/an/a 12n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50413240
PNG
(CHEMBL471412)
Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1
Show InChI InChI=1S/C28H29FN2O4/c1-34-21-16-17-24(25(18-21)35-2)31(28(33)19-10-4-3-5-11-19)26(22-14-8-9-15-23(22)29)27(32)30-20-12-6-7-13-20/h3-5,8-11,14-18,20,26H,6-7,12-13H2,1-2H3,(H,30,32)
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PubMed
n/an/an/an/a 123n/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant C5a receptor expressed in HEK cells assessed as inhibition of C5a-induced [35S]GTPgammaS binding


Bioorg Med Chem Lett 19: 1143-7 (2009)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033567
PNG
(CHEMBL408796 | Tyr-Ser-Phe-Lys-Gly-Leu-Leu-Leu-Gly...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C55H88N14O13/c1-31(2)23-40(49(76)62-28-45(72)63-39(54(81)82)16-12-22-60-55(58)59)66-51(78)42(25-33(5)6)67-50(77)41(24-32(3)4)64-46(73)29-61-48(75)38(15-10-11-21-56)65-52(79)43(27-34-13-8-7-9-14-34)68-53(80)44(30-70)69-47(74)37(57)26-35-17-19-36(71)20-18-35/h7-9,13-14,17-20,31-33,37-44,70-71H,10-12,15-16,21-30,56-57H2,1-6H3,(H,61,75)(H,62,76)(H,63,72)(H,64,73)(H,65,79)(H,66,78)(H,67,77)(H,68,80)(H,69,74)(H,81,82)(H4,58,59,60)/t37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
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n/an/an/an/a 300n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50008381
PNG
(CHEMBL441393 | H-Ile-Ser-Phe-Lys-AspMet-GIn-Leu-Gl...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C52H87N15O15S/c1-6-29(4)42(55)50(80)67-38(27-68)49(79)65-36(24-30-13-8-7-9-14-30)47(77)61-31(15-10-11-20-53)44(74)66-37(25-41(71)72)48(78)63-33(19-22-83-5)46(76)62-32(17-18-39(54)69)45(75)64-35(23-28(2)3)43(73)59-26-40(70)60-34(51(81)82)16-12-21-58-52(56)57/h7-9,13-14,28-29,31-38,42,68H,6,10-12,15-27,53,55H2,1-5H3,(H2,54,69)(H,59,73)(H,60,70)(H,61,77)(H,62,76)(H,63,78)(H,64,75)(H,65,79)(H,66,74)(H,67,80)(H,71,72)(H,81,82)(H4,56,57,58)/t29-,31-,32-,33-,34-,35-,36-,37-,38-,42-/m0/s1
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n/an/an/an/a 900n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033570
PNG
(CHEMBL265884 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-D-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C56H87N15O16S/c1-30(2)25-40(51(82)63-31(3)46(77)67-39(55(86)87)14-10-23-62-56(60)61)68-49(80)37(19-20-44(59)74)65-50(81)38(21-24-88-4)66-53(84)42(28-45(75)76)70-48(79)36(13-8-9-22-57)64-52(83)41(27-32-11-6-5-7-12-32)69-54(85)43(29-72)71-47(78)35(58)26-33-15-17-34(73)18-16-33/h5-7,11-12,15-18,30-31,35-43,72-73H,8-10,13-14,19-29,57-58H2,1-4H3,(H2,59,74)(H,63,82)(H,64,83)(H,65,81)(H,66,84)(H,67,77)(H,68,80)(H,69,85)(H,70,79)(H,71,78)(H,75,76)(H,86,87)(H4,60,61,62)/t31-,35+,36+,37+,38+,39+,40+,41+,42+,43+/m1/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033577
PNG
(CHEMBL269480 | Tyr-Ser-Phe-Lys-Gly-Met-Pro-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C53H82N14O13S/c1-31(2)25-39(47(74)60-29-44(71)62-38(52(79)80)14-9-22-58-53(56)57)65-50(77)42-15-10-23-67(42)51(78)37(20-24-81-3)61-43(70)28-59-46(73)36(13-7-8-21-54)63-48(75)40(27-32-11-5-4-6-12-32)64-49(76)41(30-68)66-45(72)35(55)26-33-16-18-34(69)19-17-33/h4-6,11-12,16-19,31,35-42,68-69H,7-10,13-15,20-30,54-55H2,1-3H3,(H,59,73)(H,60,74)(H,61,70)(H,62,71)(H,63,75)(H,64,76)(H,65,77)(H,66,72)(H,79,80)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033563
PNG
(CHEMBL429535 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-D-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C56H86N14O15S/c1-31(2)26-40(49(78)62-32(3)46(75)65-39(55(84)85)15-10-23-61-56(59)60)68-53(82)44-16-11-24-70(44)54(83)38(21-25-86-4)64-51(80)42(29-45(73)74)67-48(77)37(14-8-9-22-57)63-50(79)41(28-33-12-6-5-7-13-33)66-52(81)43(30-71)69-47(76)36(58)27-34-17-19-35(72)20-18-34/h5-7,12-13,17-20,31-32,36-44,71-72H,8-11,14-16,21-30,57-58H2,1-4H3,(H,62,78)(H,63,79)(H,64,80)(H,65,75)(H,66,81)(H,67,77)(H,68,82)(H,69,76)(H,73,74)(H,84,85)(H4,59,60,61)/t32-,36+,37+,38+,39+,40+,41+,42+,43+,44+/m1/s1
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n/an/an/an/a 2.10E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033573
PNG
(CHEMBL268322 | Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-Ala...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H82N14O15/c1-29(2)24-38(47(76)60-30(3)44(73)63-37(53(82)83)15-10-22-59-54(57)58)66-51(80)42-16-11-23-68(42)52(81)31(4)61-48(77)40(27-43(71)72)65-46(75)36(14-8-9-21-55)62-49(78)39(26-32-12-6-5-7-13-32)64-50(79)41(28-69)67-45(74)35(56)25-33-17-19-34(70)20-18-33/h5-7,12-13,17-20,29-31,35-42,69-70H,8-11,14-16,21-28,55-56H2,1-4H3,(H,60,76)(H,61,77)(H,62,78)(H,63,73)(H,64,79)(H,65,75)(H,66,80)(H,67,74)(H,71,72)(H,82,83)(H4,57,58,59)/t30-,31+,35+,36+,37+,38+,39+,40+,41+,42+/m1/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033558
PNG
(CHEMBL414361 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Pro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C58H88N14O15S/c1-33(2)28-43(56(85)72-26-11-16-45(72)53(82)66-40(57(86)87)15-9-24-63-58(61)62)69-54(83)46-17-10-25-71(46)55(84)39(22-27-88-3)65-51(80)42(31-47(75)76)68-49(78)38(14-7-8-23-59)64-50(79)41(30-34-12-5-4-6-13-34)67-52(81)44(32-73)70-48(77)37(60)29-35-18-20-36(74)21-19-35/h4-6,12-13,18-21,33,37-46,73-74H,7-11,14-17,22-32,59-60H2,1-3H3,(H,64,79)(H,65,80)(H,66,82)(H,67,81)(H,68,78)(H,69,83)(H,70,77)(H,75,76)(H,86,87)(H4,61,62,63)/t37-,38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033561
PNG
(CHEMBL438728 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Phe...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C62H90N14O15S/c1-36(2)30-45(54(83)71-47(33-38-16-8-5-9-17-38)56(85)70-44(61(90)91)19-12-27-67-62(65)66)74-59(88)50-20-13-28-76(50)60(89)43(25-29-92-3)69-57(86)48(34-51(79)80)73-53(82)42(18-10-11-26-63)68-55(84)46(32-37-14-6-4-7-15-37)72-58(87)49(35-77)75-52(81)41(64)31-39-21-23-40(78)24-22-39/h4-9,14-17,21-24,36,41-50,77-78H,10-13,18-20,25-35,63-64H2,1-3H3,(H,68,84)(H,69,86)(H,70,85)(H,71,83)(H,72,87)(H,73,82)(H,74,88)(H,75,81)(H,79,80)(H,90,91)(H4,65,66,67)/t41-,42-,43-,44-,45-,46-,47+,48-,49-,50-/m0/s1
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n/an/an/an/a 4.00E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033559
PNG
(CHEMBL435318 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C55H84N14O15S/c1-31(2)25-39(47(76)61-29-44(72)62-38(54(83)84)14-9-22-60-55(58)59)67-52(81)43-15-10-23-69(43)53(82)37(20-24-85-3)64-50(79)41(28-45(73)74)66-48(77)36(13-7-8-21-56)63-49(78)40(27-32-11-5-4-6-12-32)65-51(80)42(30-70)68-46(75)35(57)26-33-16-18-34(71)19-17-33/h4-6,11-12,16-19,31,35-43,70-71H,7-10,13-15,20-30,56-57H2,1-3H3,(H,61,76)(H,62,72)(H,63,78)(H,64,79)(H,65,80)(H,66,77)(H,67,81)(H,68,75)(H,73,74)(H,83,84)(H4,58,59,60)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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n/an/an/an/a 5.00E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033560
PNG
(CHEMBL412249 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Ala-D-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C53H80N14O15S/c1-29(43(72)59-30(2)44(73)63-37(52(81)82)14-9-22-58-53(56)57)60-50(79)41-15-10-23-67(41)51(80)36(20-24-83-3)62-48(77)39(27-42(70)71)65-46(75)35(13-7-8-21-54)61-47(76)38(26-31-11-5-4-6-12-31)64-49(78)40(28-68)66-45(74)34(55)25-32-16-18-33(69)19-17-32/h4-6,11-12,16-19,29-30,34-41,68-69H,7-10,13-15,20-28,54-55H2,1-3H3,(H,59,72)(H,60,79)(H,61,76)(H,62,77)(H,63,73)(H,64,78)(H,65,75)(H,66,74)(H,70,71)(H,81,82)(H4,56,57,58)/t29-,30+,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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n/an/an/an/a 5.60E+3n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033566
PNG
(CHEMBL427936 | Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-Gly...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C53H80N14O15/c1-29(2)23-37(45(74)59-27-42(70)61-36(52(81)82)14-9-21-58-53(56)57)65-50(79)41-15-10-22-67(41)51(80)30(3)60-47(76)39(26-43(71)72)64-46(75)35(13-7-8-20-54)62-48(77)38(25-31-11-5-4-6-12-31)63-49(78)40(28-68)66-44(73)34(55)24-32-16-18-33(69)19-17-32/h4-6,11-12,16-19,29-30,34-41,68-69H,7-10,13-15,20-28,54-55H2,1-3H3,(H,59,74)(H,60,76)(H,61,70)(H,62,77)(H,63,78)(H,64,75)(H,65,79)(H,66,73)(H,71,72)(H,81,82)(H4,56,57,58)/t30-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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n/an/an/an/a 1.58E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033565
PNG
(CHEMBL262653 | Tyr-Ser-Phe-Lys-Asp-Cys-Pro-Leu-Gly...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C53H80N14O15S/c1-29(2)22-36(45(74)59-26-42(70)60-35(52(81)82)13-8-20-58-53(56)57)64-50(79)41-14-9-21-67(41)51(80)40(28-83)66-48(77)38(25-43(71)72)63-46(75)34(12-6-7-19-54)61-47(76)37(24-30-10-4-3-5-11-30)62-49(78)39(27-68)65-44(73)33(55)23-31-15-17-32(69)18-16-31/h3-5,10-11,15-18,29,33-41,68-69,83H,6-9,12-14,19-28,54-55H2,1-2H3,(H,59,74)(H,60,70)(H,61,76)(H,62,78)(H,63,75)(H,64,79)(H,65,73)(H,66,77)(H,71,72)(H,81,82)(H4,56,57,58)/t33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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n/an/an/an/a 1.95E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033575
PNG
(CHEMBL412680 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Pro-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H81N15O16S/c1-86-24-20-35(47(78)65-36(18-19-42(57)72)52(83)69-23-8-13-41(69)51(82)61-28-43(73)62-37(53(84)85)12-7-22-60-54(58)59)64-49(80)39(27-44(74)75)67-46(77)34(11-5-6-21-55)63-48(79)38(26-30-9-3-2-4-10-30)66-50(81)40(29-70)68-45(76)33(56)25-31-14-16-32(71)17-15-31/h2-4,9-10,14-17,33-41,70-71H,5-8,11-13,18-29,55-56H2,1H3,(H2,57,72)(H,61,82)(H,62,73)(H,63,79)(H,64,80)(H,65,78)(H,66,81)(H,67,77)(H,68,76)(H,74,75)(H,84,85)(H4,58,59,60)/t33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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n/an/an/an/a 2.20E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033567
PNG
(CHEMBL408796 | Tyr-Ser-Phe-Lys-Gly-Leu-Leu-Leu-Gly...)
Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C55H88N14O13/c1-31(2)23-40(49(76)62-28-45(72)63-39(54(81)82)16-12-22-60-55(58)59)66-51(78)42(25-33(5)6)67-50(77)41(24-32(3)4)64-46(73)29-61-48(75)38(15-10-11-21-56)65-52(79)43(27-34-13-8-7-9-14-34)68-53(80)44(30-70)69-47(74)37(57)26-35-17-19-36(71)20-18-35/h7-9,13-14,17-20,31-33,37-44,70-71H,10-12,15-16,21-30,56-57H2,1-6H3,(H,61,75)(H,62,76)(H,63,72)(H,64,73)(H,65,79)(H,66,78)(H,67,77)(H,68,80)(H,69,74)(H,81,82)(H4,58,59,60)/t37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
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n/an/an/an/a 2.77E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033570
PNG
(CHEMBL265884 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-D-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C56H87N15O16S/c1-30(2)25-40(51(82)63-31(3)46(77)67-39(55(86)87)14-10-23-62-56(60)61)68-49(80)37(19-20-44(59)74)65-50(81)38(21-24-88-4)66-53(84)42(28-45(75)76)70-48(79)36(13-8-9-22-57)64-52(83)41(27-32-11-6-5-7-12-32)69-54(85)43(29-72)71-47(78)35(58)26-33-15-17-34(73)18-16-33/h5-7,11-12,15-18,30-31,35-43,72-73H,8-10,13-14,19-29,57-58H2,1-4H3,(H2,59,74)(H,63,82)(H,64,83)(H,65,81)(H,66,84)(H,67,77)(H,68,80)(H,69,85)(H,70,79)(H,71,78)(H,75,76)(H,86,87)(H4,60,61,62)/t31-,35+,36+,37+,38+,39+,40+,41+,42+,43+/m1/s1
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n/an/an/an/a 3.20E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033562
PNG
(CHEMBL406011 | Tyr-Ser-Phe-LyS-Asp-Met-Glu-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C55H85N15O16S/c1-30(2)24-39(47(78)62-28-44(74)63-38(54(85)86)13-9-22-61-55(59)60)67-49(80)36(18-19-43(58)73)65-50(81)37(20-23-87-3)66-52(83)41(27-45(75)76)69-48(79)35(12-7-8-21-56)64-51(82)40(26-31-10-5-4-6-11-31)68-53(84)42(29-71)70-46(77)34(57)25-32-14-16-33(72)17-15-32/h4-6,10-11,14-17,30,34-42,71-72H,7-9,12-13,18-29,56-57H2,1-3H3,(H2,58,73)(H,62,78)(H,63,74)(H,64,82)(H,65,81)(H,66,83)(H,67,80)(H,68,84)(H,69,79)(H,70,77)(H,75,76)(H,85,86)(H4,59,60,61)/t34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 3.70E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033575
PNG
(CHEMBL412680 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Pro-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H81N15O16S/c1-86-24-20-35(47(78)65-36(18-19-42(57)72)52(83)69-23-8-13-41(69)51(82)61-28-43(73)62-37(53(84)85)12-7-22-60-54(58)59)64-49(80)39(27-44(74)75)67-46(77)34(11-5-6-21-55)63-48(79)38(26-30-9-3-2-4-10-30)66-50(81)40(29-70)68-45(76)33(56)25-31-14-16-32(71)17-15-31/h2-4,9-10,14-17,33-41,70-71H,5-8,11-13,18-29,55-56H2,1H3,(H2,57,72)(H,61,82)(H,62,73)(H,63,79)(H,64,80)(H,65,78)(H,66,81)(H,67,77)(H,68,76)(H,74,75)(H,84,85)(H4,58,59,60)/t33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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n/an/an/an/a 4.20E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033558
PNG
(CHEMBL414361 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Pro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C58H88N14O15S/c1-33(2)28-43(56(85)72-26-11-16-45(72)53(82)66-40(57(86)87)15-9-24-63-58(61)62)69-54(83)46-17-10-25-71(46)55(84)39(22-27-88-3)65-51(80)42(31-47(75)76)68-49(78)38(14-7-8-23-59)64-50(79)41(30-34-12-5-4-6-13-34)67-52(81)44(32-73)70-48(77)37(60)29-35-18-20-36(74)21-19-35/h4-6,12-13,18-21,33,37-46,73-74H,7-11,14-17,22-32,59-60H2,1-3H3,(H,64,79)(H,65,80)(H,66,82)(H,67,81)(H,68,78)(H,69,83)(H,70,77)(H,75,76)(H,86,87)(H4,61,62,63)/t37-,38-,39-,40-,41-,42-,43-,44-,45+,46-/m0/s1
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n/an/an/an/a 4.65E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033568
PNG
(CHEMBL386427 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-Ala...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C56H87N15O16S/c1-30(2)25-40(51(82)63-31(3)46(77)67-39(55(86)87)14-10-23-62-56(60)61)68-49(80)37(19-20-44(59)74)65-50(81)38(21-24-88-4)66-53(84)42(28-45(75)76)70-48(79)36(13-8-9-22-57)64-52(83)41(27-32-11-6-5-7-12-32)69-54(85)43(29-72)71-47(78)35(58)26-33-15-17-34(73)18-16-33/h5-7,11-12,15-18,30-31,35-43,72-73H,8-10,13-14,19-29,57-58H2,1-4H3,(H2,59,74)(H,63,82)(H,64,83)(H,65,81)(H,66,84)(H,67,77)(H,68,80)(H,69,85)(H,70,79)(H,71,78)(H,75,76)(H,86,87)(H4,60,61,62)/t31-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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n/an/an/an/a 4.80E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033577
PNG
(CHEMBL269480 | Tyr-Ser-Phe-Lys-Gly-Met-Pro-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C53H82N14O13S/c1-31(2)25-39(47(74)60-29-44(71)62-38(52(79)80)14-9-22-58-53(56)57)65-50(77)42-15-10-23-67(42)51(78)37(20-24-81-3)61-43(70)28-59-46(73)36(13-7-8-21-54)63-48(75)40(27-32-11-5-4-6-12-32)64-49(76)41(30-68)66-45(72)35(55)26-33-16-18-34(69)19-17-33/h4-6,11-12,16-19,31,35-42,68-69H,7-10,13-15,20-30,54-55H2,1-3H3,(H,59,73)(H,60,74)(H,61,70)(H,62,71)(H,63,75)(H,64,76)(H,65,77)(H,66,72)(H,79,80)(H4,56,57,58)/t35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 4.96E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033562
PNG
(CHEMBL406011 | Tyr-Ser-Phe-LyS-Asp-Met-Glu-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C55H85N15O16S/c1-30(2)24-39(47(78)62-28-44(74)63-38(54(85)86)13-9-22-61-55(59)60)67-49(80)36(18-19-43(58)73)65-50(81)37(20-23-87-3)66-52(83)41(27-45(75)76)69-48(79)35(12-7-8-21-56)64-51(82)40(26-31-10-5-4-6-11-31)68-53(84)42(29-71)70-46(77)34(57)25-32-14-16-33(72)17-15-32/h4-6,10-11,14-17,30,34-42,71-72H,7-9,12-13,18-29,56-57H2,1-3H3,(H2,58,73)(H,62,78)(H,63,74)(H,64,82)(H,65,81)(H,66,83)(H,67,80)(H,68,84)(H,69,79)(H,70,77)(H,75,76)(H,85,86)(H4,59,60,61)/t34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 5.00E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033576
PNG
(CHEMBL405966 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Pro-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H80N14O15S/c1-84-25-20-36(51(80)68-24-9-15-42(68)52(81)67-23-8-14-41(67)50(79)60-29-43(71)61-37(53(82)83)13-7-22-59-54(57)58)63-48(77)39(28-44(72)73)65-46(75)35(12-5-6-21-55)62-47(76)38(27-31-10-3-2-4-11-31)64-49(78)40(30-69)66-45(74)34(56)26-32-16-18-33(70)19-17-32/h2-4,10-11,16-19,34-42,69-70H,5-9,12-15,20-30,55-56H2,1H3,(H,60,79)(H,61,71)(H,62,76)(H,63,77)(H,64,78)(H,65,75)(H,66,74)(H,72,73)(H,82,83)(H4,57,58,59)/t34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 5.00E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033563
PNG
(CHEMBL429535 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-D-A...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C56H86N14O15S/c1-31(2)26-40(49(78)62-32(3)46(75)65-39(55(84)85)15-10-23-61-56(59)60)68-53(82)44-16-11-24-70(44)54(83)38(21-25-86-4)64-51(80)42(29-45(73)74)67-48(77)37(14-8-9-22-57)63-50(79)41(28-33-12-6-5-7-13-33)66-52(81)43(30-71)69-47(76)36(58)27-34-17-19-35(72)20-18-34/h5-7,12-13,17-20,31-32,36-44,71-72H,8-11,14-16,21-30,57-58H2,1-4H3,(H,62,78)(H,63,79)(H,64,80)(H,65,75)(H,66,81)(H,67,77)(H,68,82)(H,69,76)(H,73,74)(H,84,85)(H4,59,60,61)/t32-,36+,37+,38+,39+,40+,41+,42+,43+,44+/m1/s1
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n/an/an/an/a 5.77E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305736
PNG
(CHEMBL593033 | N,N'-(1,2-phenylene)bis(N-methylben...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O4S2/c1-21(27(23,24)17-11-5-3-6-12-17)19-15-9-10-16-20(19)22(2)28(25,26)18-13-7-4-8-14-18/h3-16H,1-2H3
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n/an/an/an/a>6.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305735
PNG
(CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-...)
Show SMILES CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2O4S2/c1-17-9-13-19(14-10-17)29(25,26)23(3)21-7-5-6-8-22(21)24(4)30(27,28)20-15-11-18(2)12-16-20/h5-16H,1-4H3
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n/an/an/an/a>6.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305739
PNG
(5,12-ditosyl-5,6,11,12-tetrahydrodibenzo[b,f][1,4]...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2CN(c2ccccc12)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C28H26N2O4S2/c1-21-11-15-25(16-12-21)35(31,32)29-19-23-7-3-4-8-24(23)20-30(28-10-6-5-9-27(28)29)36(33,34)26-17-13-22(2)14-18-26/h3-18H,19-20H2,1-2H3
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n/an/an/an/a>6.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305737
PNG
(CHEMBL604277 | N,N'-(1,2-phenylene)bis(N-allyl-4-m...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N(CC=C)c1ccccc1N(CC=C)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C26H28N2O4S2/c1-5-19-27(33(29,30)23-15-11-21(3)12-16-23)25-9-7-8-10-26(25)28(20-6-2)34(31,32)24-17-13-22(4)14-18-24/h5-18H,1-2,19-20H2,3-4H3
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n/an/an/an/a>6.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305738
PNG
(1,4-ditosyl-1,2,3,4-tetrahydroquinoxaline | CHEMBL...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(c2ccccc12)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H22N2O4S2/c1-17-7-11-19(12-8-17)29(25,26)23-15-16-24(22-6-4-3-5-21(22)23)30(27,28)20-13-9-18(2)10-14-20/h3-14H,15-16H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305740
PNG
(CHEMBL603858 | N-(2-(indoline-1-carbonyl)phenyl)-N...)
Show SMILES CN(c1ccccc1C(=O)N1CCc2ccccc12)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H22N2O3S/c1-17-11-13-19(14-12-17)29(27,28)24(2)22-10-6-4-8-20(22)23(26)25-16-15-18-7-3-5-9-21(18)25/h3-14H,15-16H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305731
PNG
(CHEMBL604583 | N,4-dimethyl-N-(2-(thiophene-3-carb...)
Show SMILES CN(c1ccccc1C(=O)c1ccsc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H17NO3S2/c1-14-7-9-16(10-8-14)25(22,23)20(2)18-6-4-3-5-17(18)19(21)15-11-12-24-13-15/h3-13H,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305732
PNG
(CHEMBL595824 | N-(2-benzoyl-4-chlorophenyl)-N,4-di...)
Show SMILES CN(c1ccc(Cl)cc1C(=O)c1ccccc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C21H18ClNO3S/c1-15-8-11-18(12-9-15)27(25,26)23(2)20-13-10-17(22)14-19(20)21(24)16-6-4-3-5-7-16/h3-14H,1-2H3
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n/an/an/an/a>6.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305733
PNG
(CHEMBL596055 | N-(2-benzoyl-4-bromophenyl)-N,4-dim...)
Show SMILES CN(c1ccc(Br)cc1C(=O)c1ccccc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C21H18BrNO3S/c1-15-8-11-18(12-9-15)27(25,26)23(2)20-13-10-17(22)14-19(20)21(24)16-6-4-3-5-7-16/h3-14H,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50305734
PNG
(CHEMBL611350 | N-(2-acetylphenyl)-N,4-dimethylbenz...)
Show SMILES CN(c1ccccc1C(C)=O)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C16H17NO3S/c1-12-8-10-14(11-9-12)21(19,20)17(3)16-7-5-4-6-15(16)13(2)18/h4-11H,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity at human C5a receptor expressed in CHO cells co-expressed with Galpha16 assessed as effect on anaphylatoxin C5a-induced intracellula...


Bioorg Med Chem Lett 20: 662-4 (2010)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50008381
PNG
(CHEMBL441393 | H-Ile-Ser-Phe-Lys-AspMet-GIn-Leu-Gl...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C52H87N15O15S/c1-6-29(4)42(55)50(80)67-38(27-68)49(79)65-36(24-30-13-8-7-9-14-30)47(77)61-31(15-10-11-20-53)44(74)66-37(25-41(71)72)48(78)63-33(19-22-83-5)46(76)62-32(17-18-39(54)69)45(75)64-35(23-28(2)3)43(73)59-26-40(70)60-34(51(81)82)16-12-21-58-52(56)57/h7-9,13-14,28-29,31-38,42,68H,6,10-12,15-27,53,55H2,1-5H3,(H2,54,69)(H,59,73)(H,60,70)(H,61,77)(H,62,76)(H,63,78)(H,64,75)(H,65,79)(H,66,74)(H,67,80)(H,71,72)(H,81,82)(H4,56,57,58)/t29-,31-,32-,33-,34-,35-,36-,37-,38-,42-/m0/s1
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n/an/an/an/a 6.77E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033564
PNG
(CHEMBL374912 | Tyr-Ser-Phe-Lys-Gly-Met-Leu-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H86N14O13S/c1-31(2)24-40(48(75)61-29-45(72)63-39(53(80)81)15-11-22-59-54(57)58)65-50(77)41(25-32(3)4)66-49(76)38(20-23-82-5)62-44(71)28-60-47(74)37(14-9-10-21-55)64-51(78)42(27-33-12-7-6-8-13-33)67-52(79)43(30-69)68-46(73)36(56)26-34-16-18-35(70)19-17-34/h6-8,12-13,16-19,31-32,36-43,69-70H,9-11,14-15,20-30,55-56H2,1-5H3,(H,60,74)(H,61,75)(H,62,71)(H,63,72)(H,64,78)(H,65,77)(H,66,76)(H,67,79)(H,68,73)(H,80,81)(H4,57,58,59)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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n/an/an/an/a 7.00E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033559
PNG
(CHEMBL435318 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C55H84N14O15S/c1-31(2)25-39(47(76)61-29-44(72)62-38(54(83)84)14-9-22-60-55(58)59)67-52(81)43-15-10-23-69(43)53(82)37(20-24-85-3)64-50(79)41(28-45(73)74)66-48(77)36(13-7-8-21-56)63-49(78)40(27-32-11-5-4-6-12-32)65-51(80)42(30-70)68-46(75)35(57)26-33-16-18-34(71)19-17-33/h4-6,11-12,16-19,31,35-43,70-71H,7-10,13-15,20-30,56-57H2,1-3H3,(H,61,76)(H,62,72)(H,63,78)(H,64,79)(H,65,80)(H,66,77)(H,67,81)(H,68,75)(H,73,74)(H,83,84)(H4,58,59,60)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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n/an/an/an/a 8.00E+4n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033561
PNG
(CHEMBL438728 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Leu-Phe...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C62H90N14O15S/c1-36(2)30-45(54(83)71-47(33-38-16-8-5-9-17-38)56(85)70-44(61(90)91)19-12-27-67-62(65)66)74-59(88)50-20-13-28-76(50)60(89)43(25-29-92-3)69-57(86)48(34-51(79)80)73-53(82)42(18-10-11-26-63)68-55(84)46(32-37-14-6-4-7-15-37)72-58(87)49(35-77)75-52(81)41(64)31-39-21-23-40(78)24-22-39/h4-9,14-17,21-24,36,41-50,77-78H,10-13,18-20,25-35,63-64H2,1-3H3,(H,68,84)(H,69,86)(H,70,85)(H,71,83)(H,72,87)(H,73,82)(H,74,88)(H,75,81)(H,79,80)(H,90,91)(H4,65,66,67)/t41-,42-,43-,44-,45-,46-,47+,48-,49-,50-/m0/s1
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n/an/an/an/a 1.14E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033573
PNG
(CHEMBL268322 | Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-Ala...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H82N14O15/c1-29(2)24-38(47(76)60-30(3)44(73)63-37(53(82)83)15-10-22-59-54(57)58)66-51(80)42-16-11-23-68(42)52(81)31(4)61-48(77)40(27-43(71)72)65-46(75)36(14-8-9-21-55)62-49(78)39(26-32-12-6-5-7-13-32)64-50(79)41(28-69)67-45(74)35(56)25-33-17-19-34(70)20-18-33/h5-7,12-13,17-20,29-31,35-42,69-70H,8-11,14-16,21-28,55-56H2,1-4H3,(H,60,76)(H,61,77)(H,62,78)(H,63,73)(H,64,79)(H,65,75)(H,66,80)(H,67,74)(H,71,72)(H,82,83)(H4,57,58,59)/t30-,31+,35+,36+,37+,38+,39+,40+,41+,42+/m1/s1
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n/an/an/an/a 1.14E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033566
PNG
(CHEMBL427936 | Tyr-Ser-Phe-Lys-Asp-Ala-Pro-Leu-Gly...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C53H80N14O15/c1-29(2)23-37(45(74)59-27-42(70)61-36(52(81)82)14-9-21-58-53(56)57)65-50(79)41-15-10-22-67(41)51(80)30(3)60-47(76)39(26-43(71)72)64-46(75)35(13-7-8-20-54)62-48(77)38(25-31-11-5-4-6-12-31)63-49(78)40(28-68)66-44(73)34(55)24-32-16-18-33(69)19-17-32/h4-6,11-12,16-19,29-30,34-41,68-69H,7-10,13-15,20-28,54-55H2,1-3H3,(H,59,74)(H,60,76)(H,61,70)(H,62,77)(H,63,78)(H,64,75)(H,65,79)(H,66,73)(H,71,72)(H,81,82)(H4,56,57,58)/t30-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
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n/an/an/an/a 2.07E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033571
PNG
(CHEMBL413642 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Ala-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C52H78N14O15S/c1-29(43(72)58-27-41(69)60-36(51(80)81)13-8-21-57-52(55)56)59-49(78)40-14-9-22-66(40)50(79)35(19-23-82-2)62-47(76)38(26-42(70)71)64-45(74)34(12-6-7-20-53)61-46(75)37(25-30-10-4-3-5-11-30)63-48(77)39(28-67)65-44(73)33(54)24-31-15-17-32(68)18-16-31/h3-5,10-11,15-18,29,33-40,67-68H,6-9,12-14,19-28,53-54H2,1-2H3,(H,58,72)(H,59,78)(H,60,69)(H,61,75)(H,62,76)(H,63,77)(H,64,74)(H,65,73)(H,70,71)(H,80,81)(H4,55,56,57)/t29-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
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n/an/an/an/a 2.15E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033572
PNG
(CHEMBL386860 | Tyr-Ser-Phe-Lys-Asp-Cys-Pro-Leu-Cys...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H82N14O15S2/c1-29(2)22-36(46(75)66-40(27-84)50(79)61-35(53(82)83)13-8-20-59-54(57)58)64-51(80)42-14-9-21-68(42)52(81)41(28-85)67-48(77)38(25-43(71)72)63-45(74)34(12-6-7-19-55)60-47(76)37(24-30-10-4-3-5-11-30)62-49(78)39(26-69)65-44(73)33(56)23-31-15-17-32(70)18-16-31/h3-5,10-11,15-18,29,33-42,69-70,84-85H,6-9,12-14,19-28,55-56H2,1-2H3,(H,60,76)(H,61,79)(H,62,78)(H,63,74)(H,64,80)(H,65,73)(H,66,75)(H,67,77)(H,71,72)(H,82,83)(H4,57,58,59)/t33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 2.24E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033569
PNG
(CHEMBL407045 | Tyr-Ser-Phe-Lys-Asp-cyclo[Cys-Pro-L...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C54H80N14O15S2/c1-29(2)22-36-46(75)66-40(50(79)61-35(53(82)83)13-8-20-59-54(57)58)27-84-85-28-41(52(81)68-21-9-14-42(68)51(80)64-36)67-48(77)38(25-43(71)72)63-45(74)34(12-6-7-19-55)60-47(76)37(24-30-10-4-3-5-11-30)62-49(78)39(26-69)65-44(73)33(56)23-31-15-17-32(70)18-16-31/h3-5,10-11,15-18,29,33-42,69-70H,6-9,12-14,19-28,55-56H2,1-2H3,(H,60,76)(H,61,79)(H,62,78)(H,63,74)(H,64,80)(H,65,73)(H,66,75)(H,67,77)(H,71,72)(H,82,83)(H4,57,58,59)/t33-,34-,35-,36-,37-,38-,39-,40-,41+,42+/m0/s1
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n/an/an/an/a 5.00E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033574
PNG
(CHEMBL261966 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-Pro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C58H89N15O16S/c1-32(2)27-43(56(87)73-25-10-15-45(73)55(86)68-40(57(88)89)14-9-24-64-58(62)63)71-50(81)38(20-21-46(61)76)66-51(82)39(22-26-90-3)67-53(84)42(30-47(77)78)70-49(80)37(13-7-8-23-59)65-52(83)41(29-33-11-5-4-6-12-33)69-54(85)44(31-74)72-48(79)36(60)28-34-16-18-35(75)19-17-34/h4-6,11-12,16-19,32,36-45,74-75H,7-10,13-15,20-31,59-60H2,1-3H3,(H2,61,76)(H,65,83)(H,66,82)(H,67,84)(H,68,86)(H,69,85)(H,70,80)(H,71,81)(H,72,79)(H,77,78)(H,88,89)(H4,62,63,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1
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n/an/an/an/a 5.00E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Abilitiy to induce shape change (polarization) in human polymorphonuclear leukocytes (PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033571
PNG
(CHEMBL413642 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Ala-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C52H78N14O15S/c1-29(43(72)58-27-41(69)60-36(51(80)81)13-8-21-57-52(55)56)59-49(78)40-14-9-22-66(40)50(79)35(19-23-82-2)62-47(76)38(26-42(70)71)64-45(74)34(12-6-7-20-53)61-46(75)37(25-30-10-4-3-5-11-30)63-48(77)39(28-67)65-44(73)33(54)24-31-15-17-32(68)18-16-31/h3-5,10-11,15-18,29,33-40,67-68H,6-9,12-14,19-28,53-54H2,1-2H3,(H,58,72)(H,59,78)(H,60,69)(H,61,75)(H,62,76)(H,63,77)(H,64,74)(H,65,73)(H,70,71)(H,80,81)(H4,55,56,57)/t29-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
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n/an/an/an/a 6.80E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033576
PNG
(CHEMBL405966 | Tyr-Ser-Phe-Lys-Asp-Met-Pro-Pro-Gly...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C54H80N14O15S/c1-84-25-20-36(51(80)68-24-9-15-42(68)52(81)67-23-8-14-41(67)50(79)60-29-43(71)61-37(53(82)83)13-7-22-59-54(57)58)63-48(77)39(28-44(72)73)65-46(75)35(12-5-6-21-55)62-47(76)38(27-31-10-3-2-4-11-31)64-49(78)40(30-69)66-45(74)34(56)26-32-16-18-33(70)19-17-32/h2-4,10-11,16-19,34-42,69-70H,5-9,12-15,20-30,55-56H2,1H3,(H,60,79)(H,61,71)(H,62,76)(H,63,77)(H,64,78)(H,65,75)(H,66,74)(H,72,73)(H,82,83)(H4,57,58,59)/t34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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n/an/an/an/a 7.00E+5n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033569
PNG
(CHEMBL407045 | Tyr-Ser-Phe-Lys-Asp-cyclo[Cys-Pro-L...)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C54H80N14O15S2/c1-29(2)22-36-46(75)66-40(50(79)61-35(53(82)83)13-8-20-59-54(57)58)27-84-85-28-41(52(81)68-21-9-14-42(68)51(80)64-36)67-48(77)38(25-43(71)72)63-45(74)34(12-6-7-19-55)60-47(76)37(24-30-10-4-3-5-11-30)62-49(78)39(26-69)65-44(73)33(56)23-31-15-17-32(70)18-16-31/h3-5,10-11,15-18,29,33-42,69-70H,6-9,12-14,19-28,55-56H2,1-2H3,(H,60,76)(H,61,79)(H,62,78)(H,63,74)(H,64,80)(H,65,73)(H,66,75)(H,67,77)(H,71,72)(H,82,83)(H4,57,58,59)/t33-,34-,35-,36-,37-,38-,39-,40-,41+,42+/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM50033574
PNG
(CHEMBL261966 | Tyr-Ser-Phe-Lys-Asp-Met-Gln-Leu-Pro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C58H89N15O16S/c1-32(2)27-43(56(87)73-25-10-15-45(73)55(86)68-40(57(88)89)14-9-24-64-58(62)63)71-50(81)38(20-21-46(61)76)66-51(82)39(22-26-90-3)67-53(84)42(30-47(77)78)70-49(80)37(13-7-8-23-59)65-52(83)41(29-33-11-5-4-6-12-33)69-54(85)44(31-74)72-48(79)36(60)28-34-16-18-35(75)19-17-34/h4-6,11-12,16-19,32,36-45,74-75H,7-10,13-15,20-31,59-60H2,1-3H3,(H2,61,76)(H,65,83)(H,66,82)(H,67,84)(H,68,86)(H,69,85)(H,70,80)(H,71,81)(H,72,79)(H,77,78)(H,88,89)(H4,62,63,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Release of beta-glucuronidase from human polymorphonuclear leukocytes(PMN)


J Med Chem 38: 3669-75 (1995)

More data for this
Ligand-Target Pair
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