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Compile Data Set for Download or QSAR

Found 53 hits of ec50 data for polymerid = 6745   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES COCCOc1ccc(cc1)N1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
KEGG

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n/an/an/an/a 0.800n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138051
PNG
(CHEMBL3753221)
Show SMILES CCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138050
PNG
(CHEMBL3752406)
Show SMILES CC(C)(CCCCF)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 4.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138046
PNG
(CHEMBL3752435)
Show SMILES CC(C)(C)CCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 6.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138044
PNG
(CHEMBL3754197)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCC2CCCCC2)CCC1
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n/an/an/an/a 7.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138102
PNG
(CHEMBL3752377)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 8.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138052
PNG
(CHEMBL3751951)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCCCF)CCC1
KEGG

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n/an/an/an/a 10n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138045
PNG
(CHEMBL3753268)
Show SMILES CC#CCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 18n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138053
PNG
(CHEMBL3753788)
Show SMILES COCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 25n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50248168
PNG
(3-(4-(2,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)...)
Show SMILES Cn1cc(\C=C\C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc12
Show InChI InChI=1S/C24H16Cl2F2N2O4S/c1-30-13-14(5-10-23(31)29-35(32,33)16-7-8-18(27)19(28)12-16)24-20(30)3-2-4-22(24)34-21-9-6-15(25)11-17(21)26/h2-13H,1H3,(H,29,31)/b10-5+
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n/an/an/an/a 26.1n/an/an/an/a



deCODE Chemistry

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3-2 receptor expressed in CHOK1 cells


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138055
PNG
(CHEMBL3753622)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCc2ccccc2)CCC1
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n/an/an/an/a 27n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM62356
PNG
(US9422273, 12b)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
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n/an/an/an/a 47n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138047
PNG
(CHEMBL3753853)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 50n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238326
PNG
(US9394273, 15)
Show SMILES OC(Cc1ccc2ccsc2c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
KEGG

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n/an/an/an/a 67n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240744
PNG
(US9422273, 12a)
Show SMILES Fc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
KEGG

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n/an/an/an/a 82n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240745
PNG
(US9422273, 12c)
Show SMILES COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
KEGG

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n/an/an/an/a 100n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240747
PNG
(US9422273, 12e)
Show SMILES CCCCCCCCNC(=O)c1coc(n1)[C@@H]1CCCN1Cc1cc(F)ccc1CCC(=O)NS(=O)(=O)C(F)(F)F
KEGG

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n/an/an/an/a 110n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240746
PNG
(US9422273, 12d)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1cc2OCOc2cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
KEGG

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n/an/an/an/a 150n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
KEGG

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n/an/an/an/a 177n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
KEGG

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n/an/an/an/a 180n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)-c1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 260n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138101
PNG
(CHEMBL3754586)
Show SMILES CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a 310n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES COCCOc1cccc(c1)N1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 360n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238330
PNG
(US9394273, 19 | US9394273, 20)
Show SMILES OC(Cc1ccc(F)cc1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
KEGG

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n/an/an/an/a 952n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES CC(C)(C)CNC1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
KEGG

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n/an/an/an/a 1.40E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238334
PNG
(US9394273, 23 | US9394273, 24)
Show SMILES OC(Cc1ccc(F)c(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
KEGG

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n/an/an/an/a 1.51E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50090136
PNG
((Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(R)-3-hy...)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H38O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-20,23-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,18+,19-,20-/m1/s1
KEGG

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PubMed
n/an/an/an/a 2.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone=130%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50035622
PNG
((5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone=50%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138054
PNG
(CHEMBL3753898)
Show SMILES CCOCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
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n/an/an/an/a 2.61E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50360629
PNG
(CHEMBL1933725)
Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H22N2O4S2/c23-16(12-14-4-2-1-3-5-14)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h1-6,8,13,15-16,23H,7,9-12H2,(H,25,26)/b8-6+/t15-,16+/m0/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238316
PNG
(US9394273, 5 | US9394273, 6)
Show SMILES OC(Cc1cccc(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
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n/an/an/an/a 3.72E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238332
PNG
(US9394273, 21 | US9394273, 22)
Show SMILES OC(Cc1ccccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
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n/an/an/an/a 4.67E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50085910
PNG
((Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenox...)
Show SMILES O[C@@H](COc1cccc(Cl)c1)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
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n/an/an/an/a 5.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3(% of control ligand, sulprostone=75%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES CC(C)OC(=O)N1CCN(CC1)c1cccc(c1)-c1cc2nc(nn2c(N)n1)-c1ccco1
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a 5.80E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238338
PNG
(US9394273, 27 | US9394273, 28)
Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
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n/an/an/an/a 5.99E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES Nc1nc(cc2nc(nn12)-c1ccco1)-c1cccc(c1)N1CCC(=O)CC1
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a 7.60E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238336
PNG
(US9394273, 25 | US9394273, 26)
Show SMILES OC(Cc1cccc(F)c1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
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n/an/an/an/a 9.95E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccccc1)c1nc(cs1)C(O)=O
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL




ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156472
PNG
(CHEMBL3793167)
Show SMILES Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156473
PNG
(CHEMBL3793724)
Show SMILES CO[C@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1)c1nc(cs1)C(O)=O
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156474
PNG
(CHEMBL3793515)
Show SMILES Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156528
PNG
(CHEMBL3794185)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2csc(c2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156529
PNG
(CHEMBL3794226)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2ccc(o2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156530
PNG
(CHEMBL3793009)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(co2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156539
PNG
(CHEMBL3793892)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156491
PNG
(CHEMBL3792668)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2coc(c2)C(O)=O)ccc1Cl
KEGG

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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Citation and Details
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50085911
PNG
(7-{(1R,2R,3R,5S)-2-[(R)-4-(3-Chloro-phenoxy)-3-hyd...)
Show SMILES O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O)COc1cccc(Cl)c1
Show InChI InChI=1S/C22H33ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h5-7,12,16,18-21,24-26H,1-4,8-11,13-14H2,(H,27,28)/t16-,18-,19-,20+,21-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<50%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50090137
PNG
(7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-4,...)
Show SMILES CCCCC(C)(C)[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C22H42O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h16-20,23-25H,4-15H2,1-3H3,(H,26,27)/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<20%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50090133
PNG
((Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-(S)-3-hy...)
Show SMILES O[C@@H](CCc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C24H31F3O5/c25-24(26,27)17-7-5-6-16(14-17)10-11-18(28)12-13-20-19(21(29)15-22(20)30)8-3-1-2-4-9-23(31)32/h1,3,5-7,12-14,18-22,28-30H,2,4,8-11,15H2,(H,31,32)/b3-1-,13-12+/t18-,19+,20+,21-,22+/m0/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<50%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
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