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Compile Data Set for Download or QSAR

Found 53 hits of ec50 data for polymerid = 6745   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169552
PNG
(CHEMBL3804978)
Show SMILES O[C@@H](COc1ccccc1)\C=C\[C@H]1[C@H](O)C[C@@H]2O[C@H](CC[C@H]12)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C28H29N7O3/c1-36-16-17-37-23-9-7-21(8-10-23)33-11-13-34(14-12-33)22-5-2-4-20(18-22)24-19-26-31-27(25-6-3-15-38-25)32-35(26)28(29)30-24/h2-10,15,18-19H,11-14,16-17H2,1H3,(H2,29,30)
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n/an/an/an/a 0.800n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM35847
PNG
((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
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n/an/an/an/a 2.5n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138051
PNG
(CHEMBL3753221)
Show SMILES CCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C20H28N2O5S2/c1-2-3-7-20(8-4-9-20)16(23)6-5-14-12-27-19(26)22(14)10-11-28-18-21-15(13-29-18)17(24)25/h5-6,13-14,16,23H,2-4,7-12H2,1H3,(H,24,25)/b6-5+/t14-,16+/s2
KEGG

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n/an/an/an/a 3.90n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138050
PNG
(CHEMBL3752406)
Show SMILES CC(C)(CCCCF)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C19H27FN2O5S2/c1-19(2,7-3-4-8-20)15(23)6-5-13-11-27-18(26)22(13)9-10-28-17-21-14(12-29-17)16(24)25/h5-6,12-13,15,23H,3-4,7-11H2,1-2H3,(H,24,25)/b6-5+/t13-,15+/s2
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n/an/an/an/a 4.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138046
PNG
(CHEMBL3752435)
Show SMILES CC(C)(C)CCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C22H32N2O5S2/c1-21(2,3)9-10-22(7-4-8-22)17(25)6-5-15-13-29-20(28)24(15)11-12-30-19-23-16(14-31-19)18(26)27/h5-6,14-15,17,25H,4,7-13H2,1-3H3,(H,26,27)/b6-5+/t15-,17+/s2
KEGG

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n/an/an/an/a 6.70n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138044
PNG
(CHEMBL3754197)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCC2CCCCC2)CCC1
Show InChI InChI=1/C24H34N2O5S2/c27-20(24(10-4-11-24)12-9-17-5-2-1-3-6-17)8-7-18-15-31-23(30)26(18)13-14-32-22-25-19(16-33-22)21(28)29/h7-8,16-18,20,27H,1-6,9-15H2,(H,28,29)/b8-7+/t18-,20+/s2
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n/an/an/an/a 7.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138102
PNG
(CHEMBL3752377)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C20H30N2O4S2/c1-4-5-10-20(2,3)16(23)8-6-14-7-9-17(24)22(14)11-12-27-19-21-15(13-28-19)18(25)26/h6,8,13-14,16,23H,4-5,7,9-12H2,1-3H3,(H,25,26)/b8-6+/t14-,16+/s2
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n/an/an/an/a 8.40n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138052
PNG
(CHEMBL3751951)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCCCF)CCC1
Show InChI InChI=1/C20H27FN2O5S2/c21-9-2-1-6-20(7-3-8-20)16(24)5-4-14-12-28-19(27)23(14)10-11-29-18-22-15(13-30-18)17(25)26/h4-5,13-14,16,24H,1-3,6-12H2,(H,25,26)/b5-4+/t14-,16+/s2
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n/an/an/an/a 10n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138045
PNG
(CHEMBL3753268)
Show SMILES CC#CCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C20H24N2O5S2/c1-2-3-7-20(8-4-9-20)16(23)6-5-14-12-27-19(26)22(14)10-11-28-18-21-15(13-29-18)17(24)25/h5-6,13-14,16,23H,4,7-12H2,1H3,(H,24,25)/b6-5+/t14-,16+/s2
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n/an/an/an/a 18n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138053
PNG
(CHEMBL3753788)
Show SMILES COCCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C20H28N2O6S2/c1-27-10-3-8-20(6-2-7-20)16(23)5-4-14-12-28-19(26)22(14)9-11-29-18-21-15(13-30-18)17(24)25/h4-5,13-14,16,23H,2-3,6-12H2,1H3,(H,24,25)/b5-4+/t14-,16+/s2
KEGG

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n/an/an/an/a 25n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50248168
PNG
(3-(4-(2,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)...)
Show SMILES Cn1cc(\C=C\C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc12
Show InChI InChI=1S/C24H16Cl2F2N2O4S/c1-30-13-14(5-10-23(31)29-35(32,33)16-7-8-18(27)19(28)12-16)24-20(30)3-2-4-22(24)34-21-9-6-15(25)11-17(21)26/h2-13H,1H3,(H,29,31)/b10-5+
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Article
PubMed
n/an/an/an/a 26.1n/an/an/an/a



deCODE Chemistry

Curated by ChEMBL


Assay Description
Antagonist activity at human EP3-2 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 19: 1528-31 (2009)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138055
PNG
(CHEMBL3753622)
Show SMILES O[C@H](\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O)C1(CCc2ccccc2)CCC1
Show InChI InChI=1/C24H28N2O5S2/c27-20(24(10-4-11-24)12-9-17-5-2-1-3-6-17)8-7-18-15-31-23(30)26(18)13-14-32-22-25-19(16-33-22)21(28)29/h1-3,5-8,16,18,20,27H,4,9-15H2,(H,28,29)/b8-7+/t18-,20+/s2
KEGG

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n/an/an/an/a 27n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM62356
PNG
(US9422273, 12b)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1/C29H38ClF3N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/s2
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n/an/an/an/a 47n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138047
PNG
(CHEMBL3753853)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C19H28N2O5S2/c1-4-5-8-19(2,3)15(22)7-6-13-11-26-18(25)21(13)9-10-27-17-20-14(12-28-17)16(23)24/h6-7,12-13,15,22H,4-5,8-11H2,1-3H3,(H,23,24)/b7-6+/t13-,15+/s2
KEGG

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n/an/an/an/a 50n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238326
PNG
(US9394273, 15)
Show SMILES OC(Cc1ccc2ccsc2c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C26H26O4S/c27-22(15-18-3-5-20-13-14-31-25(20)16-18)10-8-19-9-12-24(28)23(19)11-4-17-1-6-21(7-2-17)26(29)30/h1-3,5-8,10,13-14,16,19,22-23,27H,4,9,11-12,15H2,(H,29,30)/b10-8+/t19-,22?,23+/s2
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n/an/an/an/a 67n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240744
PNG
(US9422273, 12a)
Show SMILES Fc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
Show InChI InChI=1/C29H38F4N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/s2
KEGG

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n/an/an/an/a 82n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240745
PNG
(US9422273, 12c)
Show SMILES COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
Show InChI InChI=1/C30H41F3N4O6S/c1-42-24-14-12-22(13-15-27(38)36-44(40,41)30(31,32)33)23(18-24)19-37-17-7-11-26(37)29-35-25(20-43-29)28(39)34-16-6-5-10-21-8-3-2-4-9-21/h12,14,18,20-21,26H,2-11,13,15-17,19H2,1H3,(H,34,39)(H,36,38)/t26-/s2
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n/an/an/an/a 100n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240747
PNG
(US9422273, 12e)
Show SMILES CCCCCCCCNC(=O)c1coc(n1)[C@@H]1CCCN1Cc1cc(F)ccc1CCC(=O)NS(=O)(=O)C(F)(F)F
Show InChI InChI=1/C27H36F4N4O5S/c1-2-3-4-5-6-7-14-32-25(37)22-18-40-26(33-22)23-9-8-15-35(23)17-20-16-21(28)12-10-19(20)11-13-24(36)34-41(38,39)27(29,30)31/h10,12,16,18,23H,2-9,11,13-15,17H2,1H3,(H,32,37)(H,34,36)/t23-/s2
KEGG

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n/an/an/an/a 110n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM240746
PNG
(US9422273, 12d)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1cc2OCOc2cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1/C30H39F3N4O7S/c31-30(32,33)45(40,41)36-27(38)12-11-21-15-25-26(44-19-43-25)16-22(21)17-37-14-6-10-24(37)29-35-23(18-42-29)28(39)34-13-5-4-9-20-7-2-1-3-8-20/h15-16,18,20,24H,1-14,17,19H2,(H,34,39)(H,36,38)/t24-/s2
KEGG

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n/an/an/an/a 150n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...


US Patent US9422273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H25BrO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/s2
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n/an/an/an/a 177n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H25BrO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/s2
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n/an/an/an/a 180n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169548
PNG
(CHEMBL3805176)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\CCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C19H19N7O/c20-19-22-15(12-17-23-18(24-26(17)19)16-5-2-10-27-16)13-3-1-4-14(11-13)25-8-6-21-7-9-25/h1-5,10-12,21H,6-9H2,(H2,20,22)
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n/an/an/an/a 260n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138101
PNG
(CHEMBL3754586)
Show SMILES CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C20H30N2O4S2/c1-3-4-5-14(2)12-16(23)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h6,8,13-16,23H,3-5,7,9-12H2,1-2H3,(H,25,26)/b8-6+/t14-,15-,16+/s2
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n/an/an/an/a 310n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169549
PNG
(CHEMBL3805169)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\CCCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C28H29N7O3/c1-36-15-16-37-23-8-3-7-22(18-23)34-12-10-33(11-13-34)21-6-2-5-20(17-21)24-19-26-31-27(25-9-4-14-38-25)32-35(26)28(29)30-24/h2-9,14,17-19H,10-13,15-16H2,1H3,(H2,29,30)
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n/an/an/an/a 360n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238330
PNG
(US9394273, 19 | US9394273, 20)
Show SMILES OC(Cc1ccc(F)cc1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H25FO4/c25-20-10-3-17(4-11-20)15-21(26)12-8-18-9-14-23(27)22(18)13-5-16-1-6-19(7-2-16)24(28)29/h1-4,6-8,10-12,18,21-22,26H,5,9,13-15H2,(H,28,29)/b12-8+/t18-,21?,22+/s2
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n/an/an/an/a 952n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169550
PNG
(CHEMBL3806130)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1CCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C25H31N7O/c1-25(2,3)16-27-18-9-11-31(12-10-18)19-7-4-6-17(14-19)20-15-22-29-23(21-8-5-13-33-21)30-32(22)24(26)28-20/h4-8,13-15,18,27H,9-12,16H2,1-3H3,(H2,26,28)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238334
PNG
(US9394273, 23 | US9394273, 24)
Show SMILES OC(Cc1ccc(F)c(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H24F2O4/c25-21-11-4-16(14-22(21)26)13-19(27)9-7-17-8-12-23(28)20(17)10-3-15-1-5-18(6-2-15)24(29)30/h1-2,4-7,9,11,14,17,19-20,27H,3,8,10,12-13H2,(H,29,30)/b9-7+/t17-,19?,20+/s2
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n/an/an/an/a 1.51E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50090136
PNG
((Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((E)-(R)-3-hy...)
Show SMILES CCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H38O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-20,23-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6-,13-12+/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone=130%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50035622
PNG
((5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,...)
Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone=50%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50138054
PNG
(CHEMBL3753898)
Show SMILES CCOCCC1(CCC1)[C@H](O)\C=C\[C@H]1COC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1/C20H28N2O6S2/c1-2-27-10-8-20(6-3-7-20)16(23)5-4-14-12-28-19(26)22(14)9-11-29-18-21-15(13-30-18)17(24)25/h4-5,13-14,16,23H,2-3,6-12H2,1H3,(H,24,25)/b5-4+/t14-,16+/s2
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n/an/an/an/a 2.61E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor


Bioorg Med Chem Lett 26: 1016-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50360629
PNG
(CHEMBL1933725)
Show SMILES O[C@@H](Cc1ccccc1)\C=C\[C@H]1CCC(=O)N1CCSc1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H22N2O4S2/c23-16(12-14-4-2-1-3-5-14)8-6-15-7-9-18(24)22(15)10-11-27-20-21-17(13-28-20)19(25)26/h1-6,8,13,15-16,23H,7,9-12H2,(H,25,26)/b8-6+/t15-,16+/m0/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238316
PNG
(US9394273, 5 | US9394273, 6)
Show SMILES OC(Cc1cccc(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H25FO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/s2
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n/an/an/an/a 3.72E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238332
PNG
(US9394273, 21 | US9394273, 22)
Show SMILES OC(Cc1ccccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H25FO4/c25-22-4-2-1-3-19(22)15-20(26)12-10-17-11-14-23(27)21(17)13-7-16-5-8-18(9-6-16)24(28)29/h1-6,8-10,12,17,20-21,26H,7,11,13-15H2,(H,28,29)/b12-10+/t17-,20?,21+/s2
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n/an/an/an/a 4.67E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50085910
PNG
((Z)-7-{(1R,2R,3R,5S)-2-[(E)-(R)-4-(3-Chloro-phenox...)
Show SMILES O[C@@H](COc1cccc(Cl)c1)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
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n/an/an/an/a 5.00E+3n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3(% of control ligand, sulprostone=75%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169547
PNG
(CHEMBL3805044)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1CCCOc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C23H25N7O3/c1-15(2)33-23(31)29-10-8-28(9-11-29)17-6-3-5-16(13-17)18-14-20-26-21(19-7-4-12-32-19)27-30(20)22(24)25-18/h3-7,12-15H,8-11H2,1-2H3,(H2,24,25)
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n/an/an/an/a 5.80E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238338
PNG
(US9394273, 27 | US9394273, 28)
Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/s2
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n/an/an/an/a 5.99E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50169546
PNG
(CHEMBL3805693)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1\C=C\COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
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n/an/an/an/a 7.60E+3n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM238336
PNG
(US9394273, 25 | US9394273, 26)
Show SMILES OC(Cc1cccc(F)c1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1/C24H24F2O4/c25-21-3-1-2-18(23(21)26)14-19(27)11-9-16-10-13-22(28)20(16)12-6-15-4-7-17(8-5-15)24(29)30/h1-5,7-9,11,16,19-20,27H,6,10,12-14H2,(H,29,30)/b11-9+/t16-,19?,20+/s2
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n/an/an/an/a 9.95E+3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Calciium Signal Studies of the Flipr. Cells were seeded at a density of 5×104 cells per well in BiocoatiŽ Poly-D-lysine-coated black-wall, clear-bott...


US Patent US9394273 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156544
PNG
(CHEMBL3793209)
Show SMILES O[C@@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccccc1)c1nc(cs1)C(O)=O
Show InChI InChI=1/C19H21NO5S/c21-15-8-17-12(13(15)9-24-11-4-2-1-3-5-11)6-7-16(25-17)18-20-14(10-26-18)19(22)23/h1-5,10,12-13,15-17,21H,6-9H2,(H,22,23)/t12-,13-,15-,16-,17+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as increase in intracellular calcium level by fluorescence based analysis


ACS Med Chem Lett 7: 306-11 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156472
PNG
(CHEMBL3793167)
Show SMILES Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1/C20H21ClFNO4S/c1-10-6-11(2-4-14(10)21)26-8-13-12-3-5-17(27-18(12)7-15(13)22)19-23-16(9-28-19)20(24)25/h2,4,6,9,12-13,15,17-18H,3,5,7-8H2,1H3,(H,24,25)/t12-,13-,15+,17-,18+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156473
PNG
(CHEMBL3793724)
Show SMILES CO[C@H]1C[C@@H]2O[C@H](CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1)c1nc(cs1)C(O)=O
Show InChI InChI=1/C21H24ClNO5S/c1-11-7-12(3-5-15(11)22)27-9-14-13-4-6-17(28-19(13)8-18(14)26-2)20-23-16(10-29-20)21(24)25/h3,5,7,10,13-14,17-19H,4,6,8-9H2,1-2H3,(H,24,25)/t13-,14-,17-,18+,19+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156474
PNG
(CHEMBL3793515)
Show SMILES Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1/C20H22ClNO5S/c1-10-6-11(2-4-14(10)21)26-8-13-12-3-5-17(27-18(12)7-16(13)23)19-22-15(9-28-19)20(24)25/h2,4,6,9,12-13,16-18,23H,3,5,7-8H2,1H3,(H,24,25)/t12-,13-,16+,17-,18+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156528
PNG
(CHEMBL3794185)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2csc(c2)C(O)=O)ccc1Cl
Show InChI InChI=1/C21H23ClO5S/c1-11-6-13(2-4-16(11)22)26-9-15-14-3-5-18(27-19(14)8-17(15)23)12-7-20(21(24)25)28-10-12/h2,4,6-7,10,14-15,17-19,23H,3,5,8-9H2,1H3,(H,24,25)/t14-,15-,17-,18-,19+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156529
PNG
(CHEMBL3794226)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2ccc(o2)C(O)=O)ccc1Cl
Show InChI InChI=1/C21H23ClO6/c1-11-8-12(2-4-15(11)22)26-10-14-13-3-5-17(28-20(13)9-16(14)23)18-6-7-19(27-18)21(24)25/h2,4,6-8,13-14,16-17,20,23H,3,5,9-10H2,1H3,(H,24,25)/t13-,14-,16-,17-,20+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156530
PNG
(CHEMBL3793009)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(co2)C(O)=O)ccc1Cl
Show InChI InChI=1/C20H22ClNO6/c1-10-6-11(2-4-14(10)21)26-8-13-12-3-5-17(28-18(12)7-16(13)23)19-22-15(9-27-19)20(24)25/h2,4,6,9,12-13,16-18,23H,3,5,7-8H2,1H3,(H,24,25)/t12-,13-,16-,17-,18+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156539
PNG
(CHEMBL3793892)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2nc(cs2)C(O)=O)ccc1Cl
Show InChI InChI=1/C20H22ClNO5S/c1-10-6-11(2-4-14(10)21)26-8-13-12-3-5-17(27-18(12)7-16(13)23)19-22-15(9-28-19)20(24)25/h2,4,6,9,12-13,16-18,23H,3,5,7-8H2,1H3,(H,24,25)/t12-,13-,16-,17-,18+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50156491
PNG
(CHEMBL3792668)
Show SMILES Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@H](CC[C@H]23)c2coc(c2)C(O)=O)ccc1Cl
Show InChI InChI=1/C21H23ClO6/c1-11-6-13(2-4-16(11)22)26-10-15-14-3-5-18(28-19(14)8-17(15)23)12-7-20(21(24)25)27-9-12/h2,4,6-7,9,14-15,17-19,23H,3,5,8,10H2,1H3,(H,24,25)/t14-,15-,17-,18-,19+/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Ono Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human EP3 receptor expressed in CHO cells assessed as intracellular Ca2+ level by fluorescence analysis


Bioorg Med Chem Lett 26: 2446-9 (2016)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50085911
PNG
(7-{(1R,2R,3R,5S)-2-[(R)-4-(3-Chloro-phenoxy)-3-hyd...)
Show SMILES O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O)COc1cccc(Cl)c1
Show InChI InChI=1S/C22H33ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h5-7,12,16,18-21,24-26H,1-4,8-11,13-14H2,(H,27,28)/t16-,18-,19-,20+,21-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<50%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50090137
PNG
(7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-((R)-3-hydroxy-4,...)
Show SMILES CCCCC(C)(C)[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O
Show InChI InChI=1S/C22H42O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h16-20,23-25H,4-15H2,1-3H3,(H,26,27)/t16-,17-,18+,19-,20-/m1/s1
KEGG

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n/an/an/an/a>2.00E+4n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<20%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50090133
PNG
((Z)-7-{(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E)-(S)-3-hy...)
Show SMILES O[C@@H](CCc1cccc(c1)C(F)(F)F)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C24H31F3O5/c25-24(26,27)17-7-5-6-16(14-17)10-11-18(28)12-13-20-19(21(29)15-22(20)30)8-3-1-2-4-9-23(31)32/h1,3,5-7,12-14,18-22,28-30H,2,4,8-11,15H2,(H,31,32)/b3-1-,13-12+/t18-,19+,20+,21-,22+/m0/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Procter & Gamble Pharmaceuticals

Curated by ChEMBL


Assay Description
Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3 (% of control ligand, sulprostone<50%)


Bioorg Med Chem Lett 10: 1519-22 (2000)

More data for this
Ligand-Target Pair
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