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Compile Data Set for Download or QSAR

Found 37 hits of ec50 data for polymerid = 692   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21095
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3,5-d...)
Show SMILES Cc1cc(C)cc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)c1
Show InChI InChI=1S/C22H20N4O2/c1-13-10-14(2)12-17(11-13)25-22(27)24-16-8-6-15(7-9-16)18-4-3-5-19-20(18)21(23)26-28-19/h3-12H,1-2H3,(H2,23,26)(H2,24,25,27)
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n/an/a 8n/a 3n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21088
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-bro...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12
Show InChI InChI=1S/C20H15BrN4O2/c21-13-3-1-4-15(11-13)24-20(26)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)
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n/an/a 10n/a 5n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21084
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-met...)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)c1
Show InChI InChI=1S/C21H18N4O2/c1-13-4-2-5-16(12-13)24-21(26)23-15-10-8-14(9-11-15)17-6-3-7-18-19(17)20(22)25-27-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)
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n/an/a 7n/a 5n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21085
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-met...)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)c1
Show InChI InChI=1S/C21H18N4O3/c1-27-16-5-2-4-15(12-16)24-21(26)23-14-10-8-13(9-11-14)17-6-3-7-18-19(17)20(22)25-28-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)
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n/an/a 17n/a 11n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21106
PNG
(3-[4-(3-amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12
Show InChI InChI=1S/C21H17BrN4O3/c1-28-17-10-9-16(18-19(17)29-26-20(18)23)12-5-7-14(8-6-12)24-21(27)25-15-4-2-3-13(22)11-15/h2-11H,1H3,(H2,23,26)(H2,24,25,27)
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n/an/a 8n/a 15n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21086
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-nit...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(c4)[N+]([O-])=O)cc3)c12
Show InChI InChI=1S/C20H15N5O4/c21-19-18-16(5-2-6-17(18)29-24-19)12-7-9-13(10-8-12)22-20(26)23-14-3-1-4-15(11-14)25(27)28/h1-11H,(H2,21,24)(H2,22,23,26)
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n/an/a 19n/a 17n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21105
PNG
(3-[4-(3-amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)c2c(N)noc12
Show InChI InChI=1S/C21H17ClN4O3/c1-28-17-10-9-16(18-19(17)29-26-20(18)23)12-5-7-14(8-6-12)24-21(27)25-15-4-2-3-13(22)11-15/h2-11H,1H3,(H2,23,26)(H2,24,25,27)
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n/an/a 41n/a 18n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21099
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-chl...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(F)c(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H14ClFN4O2/c21-15-10-13(8-9-16(15)22)25-20(27)24-12-6-4-11(5-7-12)14-2-1-3-17-18(14)19(23)26-28-17/h1-10H,(H2,23,26)(H2,24,25,27)
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n/an/a 59n/a 19n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21103
PNG
(3-[4-(3-amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)c2c(N)noc12
Show InChI InChI=1S/C22H19FN4O3/c1-12-3-9-16(23)17(11-12)26-22(28)25-14-6-4-13(5-7-14)15-8-10-18(29-2)20-19(15)21(24)27-30-20/h3-11H,1-2H3,(H2,24,27)(H2,25,26,28)
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n/an/a 21n/a 20n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21087
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-flu...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Show InChI InChI=1S/C20H15FN4O2/c21-13-3-1-4-15(11-13)24-20(26)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)
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n/an/a 44n/a 21n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of KDR by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21111
PNG
(3-(4-{3-amino-7-[2-(morpholin-4-yl)ethoxy]-1,2-ben...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccc(OCCN3CCOCC3)c3onc(N)c23)c1
Show InChI InChI=1S/C27H28FN5O4/c1-17-2-8-21(28)22(16-17)31-27(34)30-19-5-3-18(4-6-19)20-7-9-23(25-24(20)26(29)32-37-25)36-15-12-33-10-13-35-14-11-33/h2-9,16H,10-15H2,1H3,(H2,29,32)(H2,30,31,34)
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n/an/a 45n/a 22n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21093
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-flu...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12
Show InChI InChI=1S/C20H15FN4O2/c21-13-6-10-15(11-7-13)24-20(26)23-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)
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n/an/a 134n/a 23n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21080
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-phenyl...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12
Show InChI InChI=1S/C20H16N4O2/c21-19-18-16(7-4-8-17(18)26-24-19)13-9-11-15(12-10-13)23-20(25)22-14-5-2-1-3-6-14/h1-12H,(H2,21,24)(H2,22,23,25)
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n/an/a 23n/a 25n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21089
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-chl...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12
Show InChI InChI=1S/C20H15ClN4O2/c21-13-3-1-4-15(11-13)24-20(26)23-14-9-7-12(8-10-14)16-5-2-6-17-18(16)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)
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n/an/a 8n/a 28n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21104
PNG
(3-[4-(3-amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl...)
Show SMILES COc1ccc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)noc12
Show InChI InChI=1S/C22H17F3N4O3/c1-31-17-10-9-16(18-19(17)32-29-20(18)26)12-5-7-14(8-6-12)27-21(30)28-15-4-2-3-13(11-15)22(23,24)25/h2-11H,1H3,(H2,26,29)(H2,27,28,30)
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n/an/a 11n/a 31n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21102
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-chl...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1Cl
Show InChI InChI=1S/C21H17ClN4O2/c1-12-5-8-15(11-17(12)22)25-21(27)24-14-9-6-13(7-10-14)16-3-2-4-18-19(16)20(23)26-28-18/h2-11H,1H3,(H2,23,26)(H2,24,25,27)
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n/an/a 8n/a 32n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/an/a 36n/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR in VEGF-stimulated HUVEC assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21101
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-chl...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1Cl
Show InChI InChI=1S/C21H17ClN4O3/c1-28-17-10-9-14(11-16(17)22)25-21(27)24-13-7-5-12(6-8-13)15-3-2-4-18-19(15)20(23)26-29-18/h2-11H,1H3,(H2,23,26)(H2,24,25,27)
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Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21107
PNG
(3-[4-(3-amino-7-methyl-1,2-benzoxazol-4-yl)phenyl]...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccc(C)c3onc(N)c23)c1
Show InChI InChI=1S/C22H19FN4O2/c1-12-3-10-17(23)18(11-12)26-22(28)25-15-7-5-14(6-8-15)16-9-4-13(2)20-19(16)21(24)27-29-20/h3-11H,1-2H3,(H2,24,27)(H2,25,26,28)
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n/an/a 71n/a 39n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21097
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3-flu...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1F
Show InChI InChI=1S/C21H17FN4O2/c1-12-5-8-15(11-17(12)22)25-21(27)24-14-9-6-13(7-10-14)16-3-2-4-18-19(16)20(23)26-28-18/h2-11H,1H3,(H2,23,26)(H2,24,25,27)
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n/an/a 15n/a 40n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21090
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-met...)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1
Show InChI InChI=1S/C21H18N4O2/c1-13-5-9-15(10-6-13)23-21(26)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)25-27-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)
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n/an/a 16n/a 44n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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n/an/an/an/a 46n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant VEGFR2


J Med Chem 52: 278-92 (2009)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21096
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-[2-flu...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H14F4N4O2/c22-15-9-6-12(21(23,24)25)10-16(15)28-20(30)27-13-7-4-11(5-8-13)14-2-1-3-17-18(14)19(26)29-31-17/h1-10H,(H2,26,29)(H2,27,28,30)
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n/an/a 104n/a 80n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21100
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(3,5-d...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c12
Show InChI InChI=1S/C20H14F2N4O2/c21-12-8-13(22)10-15(9-12)25-20(27)24-14-6-4-11(5-7-14)16-2-1-3-17-18(16)19(23)26-28-17/h1-10H,(H2,23,26)(H2,24,25,27)
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n/an/a 67n/a 81n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21098
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-[4-flu...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(F)c(c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H14F4N4O2/c22-16-9-8-13(10-15(16)21(23,24)25)28-20(30)27-12-6-4-11(5-7-12)14-2-1-3-17-18(14)19(26)29-31-17/h1-10H,(H2,26,29)(H2,27,28,30)
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n/an/a 23n/a 94n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21092
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(4-met...)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2cccc3onc(N)c23)cc1
Show InChI InChI=1S/C21H18N4O3/c1-27-16-11-9-15(10-12-16)24-21(26)23-14-7-5-13(6-8-14)17-3-2-4-18-19(17)20(22)25-28-18/h2-12H,1H3,(H2,22,25)(H2,23,24,26)
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n/an/a 22n/a 106n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21094
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-[4-(tr...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(OC(F)(F)F)cc4)cc3)c12
Show InChI InChI=1S/C21H15F3N4O3/c22-21(23,24)30-15-10-8-14(9-11-15)27-20(29)26-13-6-4-12(5-7-13)16-2-1-3-17-18(16)19(25)28-31-17/h1-11H,(H2,25,28)(H2,26,27,29)
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n/an/a 42n/a 123n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21091
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-[4-(tr...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccc(cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H15F3N4O2/c22-21(23,24)13-6-10-15(11-7-13)27-20(29)26-14-8-4-12(5-9-14)16-2-1-3-17-18(16)19(25)28-30-17/h1-11H,(H2,25,28)(H2,26,27,29)
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n/an/a 32n/a 173n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21109
PNG
(3-{4-[3-amino-7-(trifluoromethoxy)-1,2-benzoxazol-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2ccc(OC(F)(F)F)c3onc(N)c23)c1
Show InChI InChI=1S/C22H16F4N4O3/c1-11-2-8-15(23)16(10-11)29-21(31)28-13-5-3-12(4-6-13)14-7-9-17(32-22(24,25)26)19-18(14)20(27)30-33-19/h2-10H,1H3,(H2,27,30)(H2,28,29,31)
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n/an/a 158n/a 179n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM6190
PNG
(3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...)
Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)
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n/an/an/an/a 250n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21081
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-(2-flu...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12
Show InChI InChI=1S/C20H15FN4O2/c21-15-5-1-2-6-16(15)24-20(26)23-13-10-8-12(9-11-13)14-4-3-7-17-18(14)19(22)25-27-17/h1-11H,(H2,22,25)(H2,23,24,26)
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n/an/a 318n/a 497n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/an/an/a 500n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of KDR by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21082
PNG
(3-[4-(3-amino-1,2-benzoxazol-4-yl)phenyl]-1-[2-(tr...)
Show SMILES Nc1noc2cccc(-c3ccc(NC(=O)Nc4ccccc4OC(F)(F)F)cc3)c12
Show InChI InChI=1S/C21H15F3N4O3/c22-21(23,24)30-16-6-2-1-5-15(16)27-20(29)26-13-10-8-12(9-11-13)14-4-3-7-17-18(14)19(25)28-31-17/h1-11H,(H2,25,28)(H2,26,27,29)
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n/an/a 806n/a 1.00E+3n/an/a7.522



Abbott Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 51: 1231-41 (2008)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of KDR by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR in VEGF-stimulated HUVEC assessed as phosphorylation after 1 hr incubation


J Med Chem 57: 3856-73 (2014)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50242737
PNG
((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1
Show InChI InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of Flk1 by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)

More data for this
Ligand-Target Pair