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Compile Data Set for Download or QSAR

Found 1089 hits of ec50 data for polymerid = 7877,8283   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190443
PNG
(US9180192, 38)
Show SMILES Cc1cc(cnc1Cl)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C15H12ClN5O3S/c1-10-6-12(8-18-14(10)16)25(23,24)21-9-11(7-19-21)20-15(22)13-4-2-3-5-17-13/h2-9H,1H3,(H,20,22)
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n/an/an/an/a 2.05E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190436
PNG
(US9180192, 31)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2OCOc2c1)c1ccccn1
Show InChI InChI=1S/C16H12N4O5S/c21-16(13-3-1-2-6-17-13)19-11-8-18-20(9-11)26(22,23)12-4-5-14-15(7-12)25-10-24-14/h1-9H,10H2,(H,19,21)
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n/an/an/an/a 2.16E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190442
PNG
(US9180192, 37)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1cnc2ccccc2c1)c1ccccn1
Show InChI InChI=1S/C18H13N5O3S/c24-18(17-7-3-4-8-19-17)22-14-10-21-23(12-14)27(25,26)15-9-13-5-1-2-6-16(13)20-11-15/h1-12H,(H,22,24)
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n/an/an/an/a 2.23E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190439
PNG
(US9180192, 34)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2OCCCOc2c1)c1ccccn1
Show InChI InChI=1S/C18H16N4O5S/c23-18(15-4-1-2-7-19-15)21-13-11-20-22(12-13)28(24,25)14-5-6-16-17(10-14)27-9-3-8-26-16/h1-2,4-7,10-12H,3,8-9H2,(H,21,23)
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n/an/an/an/a 2.40E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190441
PNG
(US9180192, 36)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2occc2c1)c1ccccn1
Show InChI InChI=1S/C17H12N4O4S/c22-17(15-3-1-2-7-18-15)20-13-10-19-21(11-13)26(23,24)14-4-5-16-12(9-14)6-8-25-16/h1-11H,(H,20,22)
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n/an/an/an/a 2.50E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190444
PNG
(US9180192, 39)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc2OCCOc2c1)c1ccccn1
Show InChI InChI=1S/C17H14N4O5S/c22-17(14-3-1-2-6-18-14)20-12-10-19-21(11-12)27(23,24)13-4-5-15-16(9-13)26-8-7-25-15/h1-6,9-11H,7-8H2,(H,20,22)
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n/an/an/an/a 3.35E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190447
PNG
(US9180192, 42)
Show SMILES Clc1cccc(n1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H10ClN5O3S/c15-12-5-3-6-13(19-12)24(22,23)20-9-10(8-17-20)18-14(21)11-4-1-2-7-16-11/h1-9H,(H,18,21)
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n/an/an/an/a 4.48E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190448
PNG
(US9180192, 43)
Show SMILES COc1ccc(cn1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C15H13N5O4S/c1-24-14-6-5-12(9-17-14)25(22,23)20-10-11(8-18-20)19-15(21)13-4-2-3-7-16-13/h2-10H,1H3,(H,19,21)
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n/an/an/an/a 6.40E-7n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190451
PNG
(US9180192, 46)
Show SMILES Clc1ccc(cn1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H10ClN5O3S/c15-13-5-4-11(8-17-13)24(22,23)20-9-10(7-18-20)19-14(21)12-3-1-2-6-16-12/h1-9H,(H,19,21)
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n/an/an/an/a 0.00000101n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190438
PNG
(US9180192, 33)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccsc1)c1ccccn1
Show InChI InChI=1S/C13H10N4O3S2/c18-13(12-3-1-2-5-14-12)16-10-7-15-17(8-10)22(19,20)11-4-6-21-9-11/h1-9H,(H,16,18)
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n/an/an/an/a 0.00000106n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190450
PNG
(US9180192, 45)
Show SMILES Cc1ccc(o1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H12N4O4S/c1-10-5-6-13(22-10)23(20,21)18-9-11(8-16-18)17-14(19)12-4-2-3-7-15-12/h2-9H,1H3,(H,17,19)
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n/an/an/an/a 0.00000128n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190440
PNG
(US9180192, 35)
Show SMILES CC1(C)CCc2ccc(cc2O1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C20H20N4O4S/c1-20(2)9-8-14-6-7-16(11-18(14)28-20)29(26,27)24-13-15(12-22-24)23-19(25)17-5-3-4-10-21-17/h3-7,10-13H,8-9H2,1-2H3,(H,23,25)
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n/an/an/an/a 0.00000150n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190437
PNG
(US9180192, 32)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)c1ccccn1
Show InChI InChI=1S/C19H19N5O4S/c25-19(18-3-1-2-8-20-18)22-15-13-21-24(14-15)29(26,27)17-6-4-16(5-7-17)23-9-11-28-12-10-23/h1-8,13-14H,9-12H2,(H,22,25)
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n/an/an/an/a 0.00000182n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190445
PNG
(US9180192, 40)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccoc1)c1ccccn1
Show InChI InChI=1S/C13H10N4O4S/c18-13(12-3-1-2-5-14-12)16-10-7-15-17(8-10)22(19,20)11-4-6-21-9-11/h1-9H,(H,16,18)
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n/an/an/an/a 0.00000231n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190446
PNG
(US9180192, 41)
Show SMILES O=C(Nc1cnn(c1)S(=O)(=O)c1ccco1)c1ccccn1
Show InChI InChI=1S/C13H10N4O4S/c18-13(11-4-1-2-6-14-11)16-10-8-15-17(9-10)22(19,20)12-5-3-7-21-12/h1-9H,(H,16,18)
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n/an/an/an/a 0.00000245n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190452
PNG
(US9180192, 47)
Show SMILES Cc1nc(C)c(s1)S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H13N5O3S2/c1-9-14(23-10(2)17-9)24(21,22)19-8-11(7-16-19)18-13(20)12-5-3-4-6-15-12/h3-8H,1-2H3,(H,18,20)
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n/an/an/an/a 0.00000642n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM190449
PNG
(US9180192, 44)
Show SMILES Clc1ncccc1S(=O)(=O)n1cc(NC(=O)c2ccccn2)cn1
Show InChI InChI=1S/C14H10ClN5O3S/c15-13-12(5-3-7-17-13)24(22,23)20-9-10(8-18-20)19-14(21)11-4-1-2-6-16-11/h1-9H,(H,19,21)
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n/an/an/an/a 0.00000737n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...


US Patent US9180192 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166956
PNG
(CHEMBL3798517)
Show SMILES CCc1cnc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)nc1
Show InChI InChI=1S/C18H16ClN5O2/c1-2-11-9-22-18(23-10-11)26-15-6-5-12(8-13(15)19)24-17(25)16-14(20)4-3-7-21-16/h3-10H,2,20H2,1H3,(H,24,25)
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n/an/an/an/a 0.0650n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166968
PNG
(CHEMBL3798234)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H13ClN4O3/c21-14-10-11(24-18(26)17-15(22)6-3-9-23-17)7-8-16(14)25-19(27)12-4-1-2-5-13(12)20(25)28/h1-10H,22H2,(H,24,26)
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n/an/an/an/a 0.0950n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166972
PNG
(CHEMBL3798197)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H15ClN4O2/c21-15-10-13(24-19(26)18-16(22)6-3-9-23-18)7-8-17(15)25-11-12-4-1-2-5-14(12)20(25)27/h1-10H,11,22H2,(H,24,26)
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n/an/an/an/a 0.236n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166971
PNG
(CHEMBL3797445)
Show SMILES COc1ccc2CN(C(=O)c2c1)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1S/C21H17ClN4O3/c1-29-14-6-4-12-11-26(21(28)15(12)10-14)18-7-5-13(9-16(18)22)25-20(27)19-17(23)3-2-8-24-19/h2-10H,11,23H2,1H3,(H,25,27)
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n/an/an/an/a 0.319n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166975
PNG
(CHEMBL3799261)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1S/C21H15ClN4O3/c1-11-4-2-5-13-17(11)21(29)26(20(13)28)16-8-7-12(10-14(16)22)25-19(27)18-15(23)6-3-9-24-18/h2-10H,23H2,1H3,(H,25,27)
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n/an/an/an/a 0.689n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166961
PNG
(CHEMBL3797923)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(Cc3ccccc3)CC2=O)c(Cl)c1
Show InChI InChI=1/C23H21ClN4O2/c24-18-13-17(27-23(30)22-19(25)7-4-10-26-22)8-9-20(18)28-14-16(12-21(28)29)11-15-5-2-1-3-6-15/h1-10,13,16H,11-12,14,25H2,(H,27,30)
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n/an/an/an/a 0.758n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166974
PNG
(CHEMBL3797463)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCc3ccccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN4O2/c22-16-12-14(25-20(27)19-17(23)6-3-10-24-19)7-8-18(16)26-11-9-13-4-1-2-5-15(13)21(26)28/h1-8,10,12H,9,11,23H2,(H,25,27)
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n/an/an/an/a 0.921n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166958
PNG
(CHEMBL3798366)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CC2=O)CCCCC3)c(Cl)c1
Show InChI InChI=1S/C21H23ClN4O2/c22-15-11-14(25-20(28)19-16(23)5-4-10-24-19)6-7-17(15)26-13-21(12-18(26)27)8-2-1-3-9-21/h4-7,10-11H,1-3,8-9,12-13,23H2,(H,25,28)
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n/an/an/an/a 1.30n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166969
PNG
(CHEMBL3797390)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ncccc3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H14ClN5O2/c20-13-9-11(24-18(26)17-14(21)4-2-8-23-17)5-6-16(13)25-10-15-12(19(25)27)3-1-7-22-15/h1-9H,10,21H2,(H,24,26)
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n/an/an/an/a 1.30n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166955
PNG
(CHEMBL3798239)
Show SMILES Cc1ncc(Oc2ccc(NC(=O)c3ncccc3N)cc2Cl)cn1
Show InChI InChI=1S/C17H14ClN5O2/c1-10-21-8-12(9-22-10)25-15-5-4-11(7-13(15)18)23-17(24)16-14(19)3-2-6-20-16/h2-9H,19H2,1H3,(H,23,24)
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n/an/an/an/a 1.40n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166960
PNG
(CHEMBL3799708)
Show SMILES CC(C)CC1CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1/C20H23ClN4O2/c1-12(2)8-13-9-18(26)25(11-13)17-6-5-14(10-15(17)21)24-20(27)19-16(22)4-3-7-23-19/h3-7,10,12-13H,8-9,11,22H2,1-2H3,(H,24,27)
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n/an/an/an/a 1.60n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166963
PNG
(CHEMBL3797777)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2c(F)cccc2Cl)c(Cl)c1
Show InChI InChI=1/C22H17Cl2FN4O2/c23-14-3-1-4-16(25)20(14)12-9-19(30)29(11-12)18-7-6-13(10-15(18)24)28-22(31)21-17(26)5-2-8-27-21/h1-8,10,12H,9,11,26H2,(H,28,31)
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n/an/an/an/a 1.90n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166967
PNG
(CHEMBL3798945)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccccc3CC2=O)c(Cl)c1
Show InChI InChI=1S/C21H17ClN4O2/c22-16-11-15(25-21(28)20-17(23)6-3-9-24-20)7-8-18(16)26-12-14-5-2-1-4-13(14)10-19(26)27/h1-9,11H,10,12,23H2,(H,25,28)
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n/an/an/an/a 2.20n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166962
PNG
(CHEMBL3799281)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC(CC2=O)c2cccnc2)c(Cl)c1
Show InChI InChI=1/C21H18ClN5O2/c22-16-10-15(26-21(29)20-17(23)4-2-8-25-20)5-6-18(16)27-12-14(9-19(27)28)13-3-1-7-24-11-13/h1-8,10-11,14H,9,12,23H2,(H,26,29)
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n/an/an/an/a 2.5n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166964
PNG
(CHEMBL3799999)
Show SMILES CC1(CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl)C1CC1
Show InChI InChI=1/C20H21ClN4O2/c1-20(12-4-5-12)10-17(26)25(11-20)16-7-6-13(9-14(16)21)24-19(27)18-15(22)3-2-8-23-18/h2-3,6-9,12H,4-5,10-11,22H2,1H3,(H,24,27)
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n/an/an/an/a 2.80n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50116515
PNG
(CHEMBL3609729)
Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
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n/an/an/an/a 4n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor


Bioorg Med Chem Lett 25: 3956-60 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166973
PNG
(CHEMBL3798583)
Show SMILES CC1N(C(=O)c2ccccc12)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1/C21H17ClN4O2/c1-12-14-5-2-3-6-15(14)21(28)26(12)18-9-8-13(11-16(18)22)25-20(27)19-17(23)7-4-10-24-19/h2-12H,23H2,1H3,(H,25,27)
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n/an/an/an/a 4n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353291
PNG
(CHEMBL1830711)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1
Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)
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n/an/an/an/a 7n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353291
PNG
(CHEMBL1830711)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ncccn3)sc2C1
Show InChI InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)
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n/an/an/an/a 9n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor


Bioorg Med Chem Lett 25: 3956-60 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353290
PNG
(CHEMBL1830707)
Show SMILES C1Cc2[nH]ncc2-c2nc(Nc3ccccn3)sc2C1
Show InChI InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)
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n/an/an/an/a 9n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50116515
PNG
(CHEMBL3609729)
Show SMILES Cc1sc(Nc2nccc(C)n2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
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n/an/an/an/a 9n/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu4 receptor


Bioorg Med Chem Lett 25: 3956-60 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166959
PNG
(CHEMBL3799197)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CC3(CCCC3)CC2=O)c(Cl)c1
Show InChI InChI=1S/C20H21ClN4O2/c21-14-10-13(24-19(27)18-15(22)4-3-9-23-18)5-6-16(14)25-12-20(11-17(25)26)7-1-2-8-20/h3-6,9-10H,1-2,7-8,11-12,22H2,(H,24,27)
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n/an/an/an/a>10n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166966
PNG
(CHEMBL3799524)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2CCCC2=O)c(Cl)c1
Show InChI InChI=1S/C16H15ClN4O2/c17-11-9-10(5-6-13(11)21-8-2-4-14(21)22)20-16(23)15-12(18)3-1-7-19-15/h1,3,5-7,9H,2,4,8,18H2,(H,20,23)
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n/an/an/an/a>10n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166965
PNG
(CHEMBL3800516)
Show SMILES CC1(C)CN(C(=O)C1)c1ccc(NC(=O)c2ncccc2N)cc1Cl
Show InChI InChI=1S/C18H19ClN4O2/c1-18(2)9-15(24)23(10-18)14-6-5-11(8-12(14)19)22-17(25)16-13(20)4-3-7-21-16/h3-8H,9-10,20H2,1-2H3,(H,22,25)
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n/an/an/an/a>10n/an/an/an/a



Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166970
PNG
(CHEMBL3800490)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2Cc3ccc(Cl)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N4O2/c21-12-4-3-11-10-26(20(28)14(11)8-12)17-6-5-13(9-15(17)22)25-19(27)18-16(23)2-1-7-24-18/h1-9H,10,23H2,(H,25,27)
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Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50166957
PNG
(CHEMBL3799087)
Show SMILES Nc1cccnc1C(=O)Nc1ccc(N2C3CCC(C3)C2=O)c(Cl)c1
Show InChI InChI=1/C18H17ClN4O2/c19-13-9-11(22-17(24)16-14(20)2-1-7-21-16)4-6-15(13)23-12-5-3-10(8-12)18(23)25/h1-2,4,6-7,9-10,12H,3,5,8,20H2,(H,22,24)
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Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay


Bioorg Med Chem Lett 26: 2915-2919 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50353332
PNG
(CHEMBL1830694)
Show SMILES Cc1sc(Nc2ccccn2)nc1-c1cn[nH]c1
Show InChI InChI=1S/C12H11N5S/c1-8-11(9-6-14-15-7-9)17-12(18-8)16-10-4-2-3-5-13-10/h2-7H,1H3,(H,14,15)(H,13,16,17)
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n/an/an/an/a 13n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50325108
PNG
(CHEMBL1223381 | N-(3-chloro-4-(N-(2-chlorophenyl)s...)
Show SMILES Clc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O3S/c19-13-5-1-2-6-15(13)23-27(25,26)17-9-8-12(11-14(17)20)22-18(24)16-7-3-4-10-21-16/h1-11,23H,(H,22,24)
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n/an/an/an/a 19.8n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells assessed as potentiation of glutamate-induced calcium mobilization


Bioorg Med Chem Lett 20: 5175-8 (2010)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50325108
PNG
(CHEMBL1223381 | N-(3-chloro-4-(N-(2-chlorophenyl)s...)
Show SMILES Clc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O3S/c19-13-5-1-2-6-15(13)23-27(25,26)17-9-8-12(11-14(17)20)22-18(24)16-7-3-4-10-21-16/h1-11,23H,(H,22,24)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor


Bioorg Med Chem Lett 26: 2984-7 (2016)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50325108
PNG
(CHEMBL1223381 | N-(3-chloro-4-(N-(2-chlorophenyl)s...)
Show SMILES Clc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O3S/c19-13-5-1-2-6-15(13)23-27(25,26)17-9-8-12(11-14(17)20)22-18(24)16-7-3-4-10-21-16/h1-11,23H,(H,22,24)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at human mGlu4 receptor


Bioorg Med Chem Lett 25: 3956-60 (2015)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50325108
PNG
(CHEMBL1223381 | N-(3-chloro-4-(N-(2-chlorophenyl)s...)
Show SMILES Clc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O3S/c19-13-5-1-2-6-15(13)23-27(25,26)17-9-8-12(11-14(17)20)22-18(24)16-7-3-4-10-21-16/h1-11,23H,(H,22,24)
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Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50325123
PNG
(CHEMBL1223083 | N-(4-(N-(2-chlorophenyl)sulfamoyl)...)
Show SMILES Clc1ccccc1NS(=O)(=O)c1ccc(NC(=O)c2ccccn2)cc1
Show InChI InChI=1S/C18H14ClN3O3S/c19-15-5-1-2-6-16(15)22-26(24,25)14-10-8-13(9-11-14)21-18(23)17-7-3-4-12-20-17/h1-12,22H,(H,21,23)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells assessed as potentiation of glutamate-induced calcium mobilization


Bioorg Med Chem Lett 20: 5175-8 (2010)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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Univ. Rouen

Curated by ChEMBL


Assay Description
Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay


Bioorg Med Chem Lett 25: 2523-6 (2015)

More data for this
Ligand-Target Pair
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