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Compile Data Set for Download or QSAR

Found 398 hits of ec50 data for polymerid = 8650   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143061
PNG
(CHEMBL3759901)
Show SMILES Nc1nc2nn(nc2c(=O)[nH]1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C11H8N6O3/c12-11-13-8-7(9(18)14-11)15-17(16-8)6-3-1-2-5(4-6)10(19)20/h1-4H,(H,19,20)(H3,12,13,14,16,18)
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n/an/an/an/a 5.40n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1nc(N)[nH]c(=O)c1N(Cc1ccc(Cl)c(Cl)c1)N=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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n/an/an/an/a 11n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132795
PNG
(CHEMBL3634447)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1C)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H16N2O4/c1-12-9-10-27-18(12)19(24)22-17-8-7-14(11-13(17)2)23-20(25)15-5-3-4-6-16(15)21(23)26/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 15n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132789
PNG
(CHEMBL3634415)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(C)c2C1=O
Show InChI InChI=1S/C21H16N2O4/c1-12-4-3-5-16-17(12)21(26)23(20(16)25)15-8-6-14(7-9-15)22-19(24)18-13(2)10-11-27-18/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132800
PNG
(CHEMBL3634442)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c2ccccc12
Show InChI InChI=1S/C25H18N2O4/c1-14-6-5-9-18-21(14)25(30)27(24(18)29)20-11-10-19(16-7-3-4-8-17(16)20)26-23(28)22-15(2)12-13-31-22/h3-13H,1-2H3,(H,26,28)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]batrachotoxin from sodium channel in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132712
PNG
(CHEMBL3632642)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C21H15ClN2O5/c1-11-8-9-29-18(11)19(25)23-12-6-7-15(16(10-12)28-2)24-20(26)13-4-3-5-14(22)17(13)21(24)27/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 18n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]hPP from human NPY4 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143062
PNG
(CHEMBL3758435)
Show SMILES Cn1c(N)nc(-c2ccccc2)c(Br)c1=O
Show InChI InChI=1S/C11H10BrN3O/c1-15-10(16)8(12)9(14-11(15)13)7-5-3-2-4-6-7/h2-6H,1H3,(H2,13,14)
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n/an/an/an/a 19n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132801
PNG
(CHEMBL3634441)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c2ccccc12
Show InChI InChI=1S/C24H16N2O4/c1-14-12-13-30-21(14)22(27)25-19-10-11-20(16-7-3-2-6-15(16)19)26-23(28)17-8-4-5-9-18(17)24(26)29/h2-13H,1H3,(H,25,27)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR1 by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132798
PNG
(CHEMBL3634444)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c2ccccc12
Show InChI InChI=1S/C24H15FN2O4/c1-13-11-12-31-21(13)22(28)26-18-9-10-19(15-6-3-2-5-14(15)18)27-23(29)16-7-4-8-17(25)20(16)24(27)30/h2-12H,1H3,(H,26,28)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132781
PNG
(CHEMBL3634423)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(C)c1
Show InChI InChI=1S/C22H18N2O4/c1-12-5-4-6-16-18(12)22(27)24(21(16)26)17-8-7-15(11-14(17)3)23-20(25)19-13(2)9-10-28-19/h4-11H,1-3H3,(H,23,25)
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n/an/an/an/a 21n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132786
PNG
(CHEMBL3634418)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(F)c1
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143081
PNG
(CHEMBL3759028)
Show SMILES Cc1cn[nH]c1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143063
PNG
(CHEMBL3758465)
Show SMILES Nc1nc2nn(nc2c(=O)[nH]1)-c1cccc(c1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C20H13F6N7O2/c21-19(22,23)11-4-9(5-12(7-11)20(24,25)26)8-28-16(34)10-2-1-3-13(6-10)33-31-14-15(32-33)29-18(27)30-17(14)35/h1-7H,8H2,(H,28,34)(H3,27,29,30,32,35)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143166
PNG
(CHEMBL3759038)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143166
PNG
(CHEMBL3759038)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132799
PNG
(CHEMBL3634443)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c2ccccc12
Show InChI InChI=1S/C24H15ClN2O4/c1-13-11-12-31-21(13)22(28)26-18-9-10-19(15-6-3-2-5-14(15)18)27-23(29)16-7-4-8-17(25)20(16)24(27)30/h2-12H,1H3,(H,26,28)
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n/an/an/an/a 23n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128117
PNG
(CHEMBL3628114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128120
PNG
(CHEMBL3628109)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128117
PNG
(CHEMBL3628114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128120
PNG
(CHEMBL3628109)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 25n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143060
PNG
(CHEMBL3758305)
Show SMILES CCOC(=O)c1cnc(N)[nH]c1=O
Show InChI InChI=1S/C7H9N3O3/c1-2-13-6(12)4-3-9-7(8)10-5(4)11/h3H,2H2,1H3,(H3,8,9,10,11)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1nc(N)[nH]c(=O)c1N(Cc1ccc(Cl)c(Cl)c1)N=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132785
PNG
(CHEMBL3634419)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(F)c1
Show InChI InChI=1S/C21H15FN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132784
PNG
(CHEMBL3634420)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 28n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132796
PNG
(CHEMBL3634446)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1Cl)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13ClN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 29n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132788
PNG
(CHEMBL3634416)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H13ClN2O4/c1-11-9-10-27-17(11)18(24)22-12-5-7-13(8-6-12)23-19(25)14-3-2-4-15(21)16(14)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 29n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128118
PNG
(CHEMBL3628111)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128118
PNG
(CHEMBL3628111)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132783
PNG
(CHEMBL3634421)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(F)c1
Show InChI InChI=1S/C20H12F2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 35n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132807
PNG
(CHEMBL3634435)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(nc1)N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C19H12ClN3O4/c1-10-7-8-27-16(10)17(24)22-11-5-6-14(21-9-11)23-18(25)12-3-2-4-13(20)15(12)19(23)26/h2-9H,1H3,(H,22,24)
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n/an/an/an/a 35n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR1 by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143076
PNG
(CHEMBL3758587)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143076
PNG
(CHEMBL3758587)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
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n/an/an/an/a 42n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132787
PNG
(CHEMBL3634417)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(F)c2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-9-10-27-17(11)18(24)22-12-5-7-13(8-6-12)23-19(25)14-3-2-4-15(21)16(14)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 44n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132774
PNG
(CHEMBL3634430)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H16N2O5/c1-12-9-10-28-18(12)19(24)22-13-7-8-16(17(11-13)27-2)23-20(25)14-5-3-4-6-15(14)21(23)26/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 46n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132790
PNG
(CHEMBL3634414)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H14N2O4/c1-12-10-11-26-17(12)18(23)21-13-6-8-14(9-7-13)22-19(24)15-4-2-3-5-16(15)20(22)25/h2-11H,1H3,(H,21,23)
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n/an/an/an/a 48n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132773
PNG
(CHEMBL3634431)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(C)c2C1=O
Show InChI InChI=1S/C22H18N2O5/c1-12-5-4-6-15-18(12)22(27)24(21(15)26)16-8-7-14(11-17(16)28-3)23-20(25)19-13(2)9-10-29-19/h4-11H,1-3H3,(H,23,25)
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n/an/an/an/a 49n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132779
PNG
(CHEMBL3634425)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(C)c1
Show InChI InChI=1S/C21H15FN2O4/c1-11-8-9-28-18(11)19(25)23-13-6-7-16(12(2)10-13)24-20(26)14-4-3-5-15(22)17(14)21(24)27/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 49n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50132780
PNG
(CHEMBL3634424)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(C)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-8-9-28-18(11)19(25)23-13-6-7-16(12(2)10-13)24-20(26)14-4-3-5-15(22)17(14)21(24)27/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 49n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143164
PNG
(CHEMBL3758216)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1
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n/an/an/an/a 50n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143164
PNG
(CHEMBL3758216)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1
PDB

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n/an/an/an/a 51n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143086
PNG
(CHEMBL3759289)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1
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n/an/an/an/a 54n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128119
PNG
(CHEMBL3628110)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-3-5-14-15(9-11)21(27)24(20(14)26)17-6-4-13(10-16(17)22)23-19(25)18-12(2)7-8-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 54n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143086
PNG
(CHEMBL3759289)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(Cl)cc3C2=O)c(Cl)c1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50128119
PNG
(CHEMBL3628110)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-3-5-14-15(9-11)21(27)24(20(14)26)17-6-4-13(10-16(17)22)23-19(25)18-12(2)7-8-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 55n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


Citation and Details
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1 (mGluR1)


(Homo sapiens (Human))
BDBM50143171
PNG
(CHEMBL3758683)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(Cl)c1
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
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