Compile Data Set for Download or QSAR
maximum 50k data
Found 58 of ic50 data for polymerid = 50001912,50005670
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075067(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50:  1.60nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075069(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50: <2nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075055(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50:  6nMAssay Description:Compound tested for the inhibition of human isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093005((4aR,6S,7R,7aS)-7-[2-((S)-2-Amino-4-methyl-pentano...)
Affinity DataIC50:  16nMAssay Description:Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458119(Leusa)
Affinity DataIC50:  22nMAssay Description:Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assayMore data for this Ligand-Target Pair
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286775(CHEMBL4174152)
Affinity DataIC50:  33nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50550346(CHEMBL4558130)
Affinity DataIC50:  70nMAssay Description:Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286766(CHEMBL4163450)
Affinity DataIC50:  160nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286768(CHEMBL4171458)
Affinity DataIC50:  220nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50550345(CHEMBL4104169)
Affinity DataIC50:  337nMAssay Description:Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286767(CHEMBL4172643)
Affinity DataIC50:  490nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075067(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50:  600nMAssay Description:Compound tested for the inhibition of human Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075069(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50:  730nMAssay Description:Compound tested for the inhibition of human Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286765(CHEMBL4159778)
Affinity DataIC50:  850nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075068(((2S,3S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286772(CHEMBL4160841)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075055(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)
Affinity DataIC50:  1.15E+3nMAssay Description:Compound tested for the inhibition of human Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286774(CHEMBL4163140)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50111476(1-[5-(4''-Chloro-biphenyl-4-yloxy)-pentyl]-3-pyrid...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibitory activity against Echovirus 9 using plaque reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093003((4aR,6S,7R,7aS)-7-[2-((2S,3S)-2-Amino-3-methyl-pen...)
Affinity DataIC50:  1.55E+3nMAssay Description:Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286771(CHEMBL4167692)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370987(TAVABOROLE)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093001((4aR,6S,7R,7aS)-7-[2-((S)-2-Amino-3-methyl-butyryl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286770(CHEMBL4171058)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286769(CHEMBL4161986)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of human LeuRS assessed as reduction in ATP consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286773(CHEMBL4174897)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of human cytoplasmic LeuRS assessed as reduction in protein synthesis measured after 10 mins in presence of [3H]Leu by scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075064(((S)-2-Amino-3-methyl-butyryl)-sulfamic acid (2R,3...)
Affinity DataIC50:  1.40E+4nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145676(CHEMBL3764310)
Affinity DataIC50:  1.87E+4nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075068(((2S,3S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid...)
Affinity DataIC50: >2.00E+4nMAssay Description:Compound tested for the inhibition of human isoleucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171203(1-[(S)-5-(4'-Chloro-biphenyl-4-yloxy)-3-methyl-pen...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against Echovirus 9 using plaque reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50171204(1-[(R)-5-(4'-Chloro-biphenyl-4-yloxy)-3-methyl-pen...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against Echovirus 9 using plaque reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268308(CHEMBL4061292)
Affinity DataIC50:  2.64E+4nMAssay Description:Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pret...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145675(CHEMBL3764493)
Affinity DataIC50:  2.76E+4nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241754(CHEMBL4077894)
Affinity DataIC50:  3.88E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50268307(CHEMBL4074495)
Affinity DataIC50:  4.49E+4nMAssay Description:Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pret...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145677(CHEMBL3765025)
Affinity DataIC50:  4.58E+4nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241756(CHEMBL4075879)
Affinity DataIC50:  6.69E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370990(CHEMBL214011)
Affinity DataIC50:  9.60E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241780(CHEMBL4105269)
Affinity DataIC50:  9.66E+4nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370991(CHEMBL388368)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075060(((S)-2-Amino-3-phenyl-propionyl)-sulfamic acid (2R...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075057(CHEMBL126919 | [(S)-2-Amino-3-(3H-imidazol-4-yl)-p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075066(((S)-2-Amino-propionyl)-sulfamic acid (2R,3S,4R,5R...)
Affinity DataIC50: >1.00E+5nMAssay Description:Compound tested for the inhibition of E. coli Leucyl-tRNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370988(CHEMBL225804)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370989(CHEMBL226398)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM26128((4-fluorophenyl)boranediol | CHEMBL344890 | Phenyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Saccharomyces cerevisiae S288c)
Anacor Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370992(CHEMBL226509)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145678(CHEMBL3763921)
Affinity DataIC50:  1.16E+5nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145674(CHEMBL2436531)
Affinity DataIC50:  1.16E+5nMAssay Description:Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeucine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
Cubist Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241782(CHEMBL4081207)
Affinity DataIC50:  1.18E+5nMAssay Description:Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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