BindingDB PrimarySearch_ki

Found 195 of ic50 data for polymerid = 50006362

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 60nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details US Patent PDB

3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599021(CHEMBL5195767)

IC50: 70nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM624871(US20230322715, Compound TR-FTO-35)

IC50: 70nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50606681(CHEMBL5219846)

IC50: 80nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details PubMed PDB

3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50596052(CHEMBL5196484)

IC50: 87nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)

IC50: 110nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)

IC50: 110nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)

IC50: 160nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)

IC50: 160nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50594333(CHEMBL5174419)

IC50: 200nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599023(CHEMBL5194680)

IC50: 270nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM624873(US20230322715, Compound TR-FTO-38)

IC50: 270nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50606682(CHEMBL5220094)

IC50: 330nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599011(CHEMBL5204291 | US20230322715, Compound TR-FTO-09)

IC50: 350nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599019(CHEMBL5207797 | US20230322715, Compound TR-FTO-30)

IC50: 350nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599011(CHEMBL5204291 | US20230322715, Compound TR-FTO-09)

IC50: 350nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599019(CHEMBL5207797 | US20230322715, Compound TR-FTO-30)

IC50: 350nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 400nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid PDB

Details PubMed PDB

3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM589238(US11555009, Compound 26)

IC50: 400nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50606686(CHEMBL5219336)

IC50: 430nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)

IC50: 440nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599029(CHEMBL5203668)

IC50: 440nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM589236(US11555009, Compound 17)

IC50: 500nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50596051(CHEMBL5183243)

IC50: 570nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50594336(CHEMBL5176527)

IC50: 600nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599018(CHEMBL5186890 | US20230322715, Compound TR-FTO-27)

IC50: 670nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599018(CHEMBL5186890 | US20230322715, Compound TR-FTO-27)

IC50: 670nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM477000(US11555009, Compound 1)

IC50: 700nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50594337(CHEMBL5176730)

IC50: 700nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50606684(CHEMBL5220148)

IC50: 800nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599022(CHEMBL5181285 | US20230322715, Compound TR-FTO-37)

IC50: 810nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599022(CHEMBL5181285 | US20230322715, Compound TR-FTO-37)

IC50: 810nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)

IC50: 830nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)

IC50: 830nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599015(CHEMBL5177222 | US20230322715, Compound TR-FTO-14)

IC50: 870nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599015(CHEMBL5177222 | US20230322715, Compound TR-FTO-14)

IC50: 870nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50594341(CHEMBL5173835)

IC50: 900nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)

IC50: 900nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50606685(CHEMBL5219099)

IC50: 900nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)

IC50: 900nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50594335(CHEMBL4436398)

IC50: 900nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50594340(CHEMBL5171501)

IC50: 900nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50596053(CHEMBL5173876)

IC50: 930nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details PubMed PDB

3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM624870(US20230322715, Compound TR-FTO-31)

IC50: 950nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599020(CHEMBL5191997)

IC50: 950nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599014(CHEMBL5208073 | US20230322715, Compound TR-FTO-13)

IC50: 1.00E+3nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599028(CHEMBL5174078)

IC50: 1.00E+3nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM50599014(CHEMBL5208073 | US20230322715, Compound TR-FTO-13)

IC50: 1.00E+3nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM589248(US11555009, Compound 39)

IC50: <1.00E+3nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent

PNG

BDBM589247(US11555009, Compound 38)

IC50: <1.00E+3nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Displayed 1 to 50 (of 195 total ) | Next | Last >>

Filter my 195 hits

Targets 1▿
- Alpha-ketoglutarate-dependent dioxygenase FTO 195
Publications 9▿
- US Patent US20230322715 (2023) 61
- J Med Chem 56: 3680-8 (2013) 33
- J Med Chem 65: 10920-10937 (2022) 30
- J Med Chem 64: 16609-16625 (2021) 27
- J Med Chem 65: 10638-10654 (2022) 19
- US Patent US11555009 (2023) 19
- J Med Chem 64: 15810-15824 (2021) 3
- Eur J Med Chem 238: (2022) 2
- J Med Chem 58: 7341-8 (2015) 1
Institutions 8▿
- The Regents Of The University Of California 61
- University Of Oxford 60
- University Of California San Diego 30
- Chinese Academy Of Sciences 19
- Shanghai Institute Of Material Medica, Chinese Academy Of Sciences 19
- Kyoto Prefectural University Of Medicine 3
- Nankai University 2
- Zhengzhou University 1
Affinity: 60 to 1.0E+6 nM▿
- IC50 195
- Affinity ≤ nM
Xtal structures: 12
Docked structures: 0
Catalog Cmpds: 31