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Found 1191 Enz. Inhib. hit(s) with Target = 'Caspase-1'
LigandPNGBDBM50462076(CHEMBL1091826)
Affinity DataEC50:  16nMAssay Description:Activation of caspase cascade in human T47D cells using N-(Ac-DEVD)-N'-ethoxycarbonyl-R110 fluorogenic substrate incubated for 48 hrs by fluorescent ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273338((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273337((S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273992((S)-1-(2-Propynyl)-5-(2-(2,4-difluorophenoxymethyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273991((S)-1-(4-Fluorobenzyl)-5-(2-(pyrimidin-4-yloxymeth...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273990((S)-1-(4-Fluorobenzyl)-5-(2-(tetrahydro-2H-pyran-4...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273989((S)-1-(4-Fluorobenzyl)-5-(2-(3,5-difluorophenoxyme...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273929((S)-1-(4-Fluorobenzyl)-5-(2-(2,4-difluorophenoxyme...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273928((S)-1-(4-Fluorobenzyl)-5-(2-(3-fluorophenoxymethyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273927((S)-1-(4-Fluorobenzyl)-5-(2-(4-fluorophenoxymethyl...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273926(1-(4-Fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isati...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10331((S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolid...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50200305((S)-1-(4-iodobenzyl)-5-(2-phenoxymethyl-pyrrolidin...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50273339((S)-1-(4-Fluorobenzyl)-5-(2-((1-(2-fluoroethyl)-1H...)
Affinity DataEC50: >5.00E+3nMAssay Description:Inhibition of human recombinant caspase 1 assessed as accumulation of 7-amino-4-methylcoumarin substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289410(CHEMBL26544 | Peptidic phenyl ketoether analogue)
Affinity DataKi:  0.150nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289397(3-[(1-{3-Methyl-2-[(naphthalene-2-carbonyl)-amino]...)
Affinity DataKi:  0.150nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289398(CHEMBL553107 | Peptidic phenyl ketoether analogue)
Affinity DataKi:  0.200nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50068972((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of human recombinant IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50068972((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  0.370nMAssay Description:The binding affinity against IL-1 beta converting enzymeChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324937((R)-2-((S)-2-isopropyl-4-(2-(naphthalen-1-yl)ethyl...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50199769((S)-3-((1S,9S)-9-(isoquinoline-1-carboxamido)-6,10...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50068954((S)-5-Butylamino-3-(2-{3-[(naphthalene-2-carbonyl)...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of human recombinant IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM10355((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydr...)
Affinity DataKi:  0.760nMAssay Description:The compound was tested for inhibition of IL-1 beta converting enzyme in whole human blood.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50602641(VRT 043198 | Vrt 043198)
Affinity DataKi:  0.800nMAssay Description:Inhibition of caspase 1 (unknown origin)More data for this Ligand-Target Pair
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50068949((S)-5-Hexylamino-3-(2-{3-[(naphthalene-2-carbonyl)...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of human recombinant IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324953((R)-2-((S)-4-(2-(1,2-dimethyl-1H-indol-3-yl)ethyla...)
Affinity DataKi:  0.900nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324938((R)-2-((S)-4-(2-(3-chlorophenylamino)ethylamino)-2...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50325241(CHEMBL1223114)
Affinity DataKi:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50058526((S)-3-{[(1S,9S)-9-(4-Carboxymethoxy-benzoylamino)-...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50058530((S)-3-{[(1S,9S)-9-(2-Fluoro-benzoylamino)-6,10-dio...)
Affinity DataKi:  1nMAssay Description:Reversible Inhibition constants of the compound against IL-1 beta converting enzyme (ICE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50325237((5S,8S,11S)-11-(2-(3,3-diphenylpropanoyloxy)acetyl...)
Affinity DataKi:  1nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289405(CHEMBL2371932 | Peptidic phenyl ketoether analogue)
Affinity DataKi:  1.10nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50068950((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324960((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(2,5,6-trimethyl...)
Affinity DataKi:  1.26nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324952((R)-2-((S)-2-isopropyl-4-(2-(2-methyl-1H-indol-3-y...)
Affinity DataKi:  1.29nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50084633((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.30nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50084633((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.30nMAssay Description:The binding affinity against IL-1 beta converting enzymeChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324946((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(quinolin-4-yl)e...)
Affinity DataKi:  1.31nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289402((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.40nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289412((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.5nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289393((S)-3-(2-{3-[(Naphthalene-1-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.80nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50091577((S)-3-(2-{3-[(Naphthalene-1-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  1.80nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50068945((S)-5-(Hexyl-methyl-amino)-3-(2-{3-[(naphthalene-2...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50324948((R)-2-((S)-2-isopropyl-4-oxo-4-(2-(quinolin-5-yl)e...)
Affinity DataKi:  1.81nMAssay Description:Inhibition of human ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50325238((5S,8S,11S)-11-(2-(2-benzyl-3-phenylpropanoyloxy)a...)
Affinity DataKi:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50325240(CHEMBL1223113)
Affinity DataKi:  2nMAssay Description:Inhibition of ICEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289407((S)-3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  2nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetCaspase-1(Homo sapiens (Human))
Imperial College

Curated by ChEMBL
LigandPNGBDBM50289388((S)-3-(2-{3-[(Naphthalene-1-carbonyl)-amino]-2-oxo...)
Affinity DataKi:  2.20nMAssay Description:Reversible inhibition of recombinant human IL-1 beta converting enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
Displayed 1 to 50 (of 1191 total ) | Next | Last >>
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