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Found 766 Enz. Inhib. hit(s) with Target = 'Glycine'
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459971(CHEMBL4227144)
Affinity DataEC50:  0.000160nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM198936(US9676786, example 5)
Affinity DataEC50:  0.000160nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM199088(US9676786, example 6)
Affinity DataEC50:  0.00120nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM199088(US9676786, example 6)
Affinity DataEC50:  0.00120nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM198933(US9676786, example 2)
Affinity DataEC50:  0.0600nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459968(CHEMBL4228372)
Affinity DataEC50:  0.0600nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM198934(US9676786, example 3)
Affinity DataEC50:  0.430nMAssay Description:Human embryonic kidney (HEK) 293 cells (ATCC CRL 1573) and/or Xenopus laevis oocytes were used for expressing the human a1-3 glycine receptor subunit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459970(CHEMBL4227297)
Affinity DataEC50:  0.430nMAssay Description:Positive allosteric modulation of GlyRalpha1 (unknown origin) assessed as potentiation of glycine-induced responseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459964(CHEMBL4227298)
Affinity DataEC50:  13nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  16nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  32nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response a...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in ch...More data for this Ligand-Target Pair
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229715(CHEMBL4070615)
Affinity DataEC50:  66nMAssay Description:Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  171nMAssay Description:Positive allosteric modulation of human glycine alpha1beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  171nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Mus musculus)
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  268nMAssay Description:Positive allosteric modulation of mouse GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50464255(CHEMBL4083687)
Affinity DataEC50:  300nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataEC50:  320nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50416875(AMG-073 | AMG073 HCL | CINACALCET | CINACALCET HYD...)
Affinity DataEC50:  320nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  327nMAssay Description:Positive allosteric modulation of human glycine alpha1 receptor expressed in HEK293T cells assessed as glycine-induced increase incurrent response af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  327nMAssay Description:Positive allosteric modulation of human GlyRalpha1 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  330nMAssay Description:Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current respon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  330nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50340481(Avodart | CHEMBL1200969 | DUTASTERIDE | GG-745 | G...)
Affinity DataEC50:  330nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464255(CHEMBL4083687)
Affinity DataEC50:  370nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50012899((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
Affinity DataEC50:  380nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50030475(7-Dehydrocholesterol | CHEBI:28940 | Cholecalcifer...)
Affinity DataEC50:  400nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  450nMAssay Description:Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  454nMAssay Description:Positive allosteric modulation of human GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  454nMAssay Description:Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as glycine-induced increase in current response a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-3(Mus musculus)
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50229711(CHEMBL4074873)
Affinity DataEC50:  490nMAssay Description:Positive allosteric modulation of mouse GlyRalpha3 expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50316015(8-hydroxyircinialactam B | CHEMBL1093847)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464360(CHEMBL4282578)
Affinity DataEC50:  500nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459893(Gelsemine)
Affinity DataEC50:  590nMAssay Description:Positive allosteric modulation of recombinant human glycine receptor alpha1 expressed in HEK293 cells assessed as increase in glycine-induced current...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50464234(CHEMBL4284872)
Affinity DataEC50:  600nMAssay Description:Positive allosteric modulation of human GlyRalpha1beta assessed as increase in glycine-induced chloride ion flux by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50459965(CHEMBL4227048)
Affinity DataEC50:  661nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464234(CHEMBL4284872)
Affinity DataEC50:  700nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464264(CHEMBL4295252)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464361(CHEMBL4290867)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM26948(8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-tr...)
Affinity DataEC50:  1.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50316020((12E,20Z,18S)-8-hydroxyvariabilin | 5-((2S)-13-(fu...)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human recombinant alpha 1 GlyR expressed in HEK293 cells assessed as potentiation of glycine current by whole cell patch clamp as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464258(CHEMBL4285964)
Affinity DataEC50:  1.21E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50048280(6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic ac...)
Affinity DataEC50:  1.30E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM60994((10R,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tet...)
Affinity DataEC50:  1.30E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataEC50:  1.70E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataEC50:  1.80E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464328(CHEMBL4278706)
Affinity DataEC50:  2.10E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464257(CHEMBL4290271)
Affinity DataEC50:  2.30E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycine receptor subunit beta(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50464263(CHEMBL4277386)
Affinity DataEC50:  2.30E+3nMAssay Description:Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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