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Found 2147 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 4'
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataEC50:  115nMAssay Description:Inhibition of recombinant human HDAC4 expressed in baculovirus expression system using KI-104 as substrate incubated for 3 hrs by by fluorescence-bas...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50123974(CHEMBL149534 | N-Hydroxy-3-(4-p-tolylsulfamoyl-phe...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50123967(3-[4-(Biphenyl-4-ylsulfamoyl)-phenyl]-N-hydroxy-ac...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50123958(3-[4-(3,4-Dimethoxy-phenylsulfamoyl)-phenyl]-N-hyd...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50123975(3-[4-(biphenyl-4-sulfonylamino)-phenyl]-N-hydroxy-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105689((E)-3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phen...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105682(4-Benzenesulfonylamino-N-hydroxy-benzamide | CHEMB...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105684(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-propio...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105691((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-ac...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105678((E)-N-Hydroxy-3-[4-(4-methoxy-benzenesulfonylamino...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105677((E)-N-Hydroxy-3-[4-(toluene-4-sulfonylamino)-pheny...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105690(2-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-acetam...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105694(4-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-butyra...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105685((E)-3-[4-(Benzenesulfonyl-methyl-amino)-phenyl]-N-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105695((E)-3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105680(3-(4-Benzenesulfonylamino-phenyl)-N-hydroxy-2-meth...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50123973(3-{4-[3-(3,4-Dimethoxy-phenyl)-ureido]-phenyl}-N-h...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105676(2-(4-Benzenesulfonylamino-benzyl)-N-hydroxy-3-meth...)
Affinity DataEC50: >2.50E+4nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347330(MO-OH-PHE | US9790158, 1)
Affinity DataKi:  0.0800nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347451(MO-OH-NAP | US9790158, 2)
Affinity DataKi:  0.540nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataKi:  0.600nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347456(US9790158, 7)
Affinity DataKi:  1.70nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353233(CHEMBL1830536)
Affinity DataKi:  2.40nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347452(MO-OH-SM | US9790158, 3)
Affinity DataKi:  2.74nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM79632(2-hydroxy-6-isopropyl-cyclohepta-2,4,6-trien-1-one...)
Affinity DataKi:  3.32nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353234(CHEMBL1830537)
Affinity DataKi:  3.60nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353232(CHEMBL1830424)
Affinity DataKi:  5.30nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50319209(6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydro...)
Affinity DataKi:  6nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353230(CHEMBL1830420)
Affinity DataKi:  6.20nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353231(CHEMBL1830422)
Affinity DataKi:  6.60nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347461(US9790158, 12)
Affinity DataKi:  6.64nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  6.70nMAssay Description:Inhibition of human recombinant HDAC4 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353229(CHEMBL1830397)
Affinity DataKi:  7.90nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  8.5nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50248522(CHEMBL489332 | N-hydroxy-3-(2-phenethyl-1-(2-(pipe...)
Affinity DataKi:  8.70nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50248476(CHEMBL491316 | N-hydroxy-3-(2-phenethyl-1-(2-(pyrr...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of recombinant HDAC4 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50248570(3-(1-(3-(dimethylamino)-2,2-dimethylpropyl)-2-phen...)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353228(CHEMBL1830396)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Affinity DataKi:  15nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50105330(CHEMBL1851943)
Affinity DataKi:  16nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  16nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50353227(CHEMBL3215861)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50319235(6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide | ...)
Affinity DataKi:  20nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  20nMAssay Description:Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM347454(MO-OH-TM | US9790158, 5)
Affinity DataKi:  59nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM348883(US9790158, 6)
Affinity DataKi:  72.8nMAssay Description:Key enzyme kinetic parameters for one class I HDAC (HDAC8) and one class Ha HDAC (HDAC4) were determined using commercially available human recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
S£O Paulo State University (Unesp)

Curated by ChEMBL
LigandPNGBDBM50517218(CHEMBL4525406)
Affinity DataKi:  75nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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