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Found 15 Enz. Inhib. hit(s) with Target = 'Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2'
LigandPNGBDBM50526578(CHEMBL4468490)
Affinity DataEC50:  15nMAssay Description:Activation of recombinant mouse HCN2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude at -30 mV holding potential by patc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50326989(3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(meth...)
Affinity DataEC50:  2.30E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326992(CHEMBL471737 | ivabradine)
Affinity DataEC50:  4.52E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326988(3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...)
Affinity DataEC50:  5.45E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326991(3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Affinity DataEC50:  1.72E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326990(3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)pr...)
Affinity DataEC50:  1.83E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50535442(CHEMBL4453882)
Affinity DataEC50:  1.94E+4nMAssay Description:Inhibition of mouse HCN2 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by pat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50326993(3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...)
Affinity DataEC50:  2.46E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326987(3-((Z)-4-(((S)-2-(3,4-dimethoxyphenyl)propyl)(meth...)
Affinity DataEC50:  2.55E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326986(3,3'-((2Z,2'Z)-4,4'-((S)-2-(3,4-dimethoxyphenyl)pr...)
Affinity DataEC50:  5.01E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326985(3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...)
Affinity DataEC50:  1.47E+5nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50419083(CHEMBL1823882)
Affinity DataIC50:  5.01E+3nMAssay Description:Inhibition of human HCN2 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human HCN2 expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50258216(CHEMBL4105630)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of HCN2 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50597430(DALZANEMDOR | Dalzanemdor)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of HCN2 (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails PubMed