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Found 4847 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 5 subunit alpha'
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50546897(CHEMBL4753470)
Affinity DataEC50:  1.90nMAssay Description:Inhibition of NaV1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582057(CHEMBL5077579)
Affinity DataEC50:  28nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582056(CHEMBL5091623)
Affinity DataEC50:  108nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582058(CHEMBL5093878)
Affinity DataEC50:  133nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582054(CHEMBL5091679)
Affinity DataEC50:  138nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582055(CHEMBL5083412)
Affinity DataEC50:  149nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582060(CHEMBL5084333)
Affinity DataEC50:  156nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50582059(CHEMBL5082582)
Affinity DataEC50:  215nMAssay Description:Modulator activity at human Nav1.5 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  5.80E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataEC50: >3.30E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataKi:  370nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM50568135(CHEMBL4849813)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]BNZA from Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM60414(US9051311, 4)
Affinity DataIC50: >1.00E+4nMAssay Description:293 cells stably transfected with human Navl .7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145227(US8952169, 6 | US9771376, Example 6)
Affinity DataIC50:  1.90E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145229(US8952169, 8 | US9771376, Example 8)
Affinity DataIC50:  1.07E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145247(US8952169, 26 | US9771376, Example 26)
Affinity DataIC50:  772nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145264(US8952169, 43)
Affinity DataIC50:  2.58E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145268(US8952169, 47)
Affinity DataIC50:  60.6nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145270(US8952169, 49)
Affinity DataIC50:  101nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145278(US8952169, 57 | US9771376, Example 57)
Affinity DataIC50:  653nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145281(US8952169, 60 | US9771376, Example 60)
Affinity DataIC50:  159nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145282(US8952169, 61)
Affinity DataIC50:  1.95E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  51.5nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145307(US8952169, 86 | US9771376, Example 86)
Affinity DataIC50:  700nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145313(US8952169, 92)
Affinity DataIC50:  3.76E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145356(US8952169, 135 | US9771376, Example 135)
Affinity DataIC50:  7.82E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145366(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Affinity DataIC50:  743nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145367(US8952169, 146 | US9771376, Example 146)
Affinity DataIC50:  427nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145368(US8952169, 147 | US9771376, Example 147)
Affinity DataIC50:  110nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145369(US8952169, 148 | US9771376, Example 148)
Affinity DataIC50:  26nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145371(US8952169, 150 | US9771376, Example 150)
Affinity DataIC50:  422nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145374(US8952169, 153)
Affinity DataIC50:  714nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145376(US8952169, 155)
Affinity DataIC50:  14nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145380(US8952169, 159 | US8952169, 444)
Affinity DataIC50:  326nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145387(US8952169, 166 | US9771376, Example 166)
Affinity DataIC50:  5.23E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145389(US8952169, 168 | US9771376, Example 168)
Affinity DataIC50:  22nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145390(US8952169, 169 | US9771376, Example 169)
Affinity DataIC50:  144nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM47139(US8952169, 175 | US8952169, 295)
Affinity DataIC50:  670nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM47141(US8952169, 185 | US8952169, 297)
Affinity DataIC50:  40nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145407(US8952169, 186)
Affinity DataIC50:  140nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145412(US8952169, 191)
Affinity DataIC50:  130nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145419(US8952169, 198)
Affinity DataIC50:  3.50E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145438(US8952169, 217)
Affinity DataIC50:  630nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145440(US8952169, 219)
Affinity DataIC50:  950nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145442(US8952169, 221)
Affinity DataIC50:  350nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145454(US8952169, 233)
Affinity DataIC50:  430nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145470(US8952169, 249)
Affinity DataIC50:  90nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145481(US8952169, 262)
Affinity DataIC50:  130nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145485(US8952169, 269)
Affinity DataIC50:  160nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Tohoku University

Curated by ChEMBL
LigandPNGBDBM145487(US8952169, 280)
Affinity DataIC50:  7.50E+3nMT: 2°CAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...More data for this Ligand-Target Pair
In DepthDetails US Patent
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