Compile Data Set for Download or QSAR
maximum 50k data
Found 2248 Enz. Inhib. hit(s) with Target = 'Son of sevenless homolog 1'
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280580(CHEMBL4172582)
Affinity DataEC50:  800nMAssay Description:In vitro evaluation for arachidonic acid induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280741(CHEMBL4164690)
Affinity DataEC50:  800nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280551(CHEMBL4168133)
Affinity DataEC50:  800nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459464(CHEMBL4217465)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464212(CHEMBL4239886)
Affinity DataEC50:  1.10E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459426(CHEMBL4212509)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50542995(CHEMBL4636993)
Affinity DataEC50:  1.32E+3nMAssay Description:Agonist activity at His6-tagged-human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli BL21-CodonPlus-RIPL cells assessed a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280564(CHEMBL4160484)
Affinity DataEC50:  1.40E+3nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280665(CHEMBL4167713)
Affinity DataEC50:  1.60E+3nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464211(CHEMBL4243567)
Affinity DataEC50:  1.80E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459455(CHEMBL4203601)
Affinity DataEC50:  1.90E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464226(CHEMBL4248160)
Affinity DataEC50:  2.00E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459437(CHEMBL4210860)
Affinity DataEC50:  2.20E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459436(CHEMBL4208653)
Affinity DataEC50:  2.40E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464208(CHEMBL4241069)
Affinity DataEC50:  2.50E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464209(CHEMBL4247794)
Affinity DataEC50:  2.50E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464219(CHEMBL4238147)
Affinity DataEC50:  2.70E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280735(CHEMBL4170697)
Affinity DataEC50:  2.90E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464210(CHEMBL4243577)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459461(CHEMBL4204326)
Affinity DataEC50:  3.00E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280541(CHEMBL4175584)
Affinity DataEC50:  3.10E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataEC50:  3.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50542998(CHEMBL4638738)
Affinity DataEC50:  3.31E+3nMAssay Description:Agonist activity at His6-tagged-human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli BL21-CodonPlus-RIPL cells assessed a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459460(CHEMBL4215997)
Affinity DataEC50:  3.70E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459459(CHEMBL4209928)
Affinity DataEC50:  4.10E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464213(CHEMBL4239768)
Affinity DataEC50:  4.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50542996(CHEMBL4648789)
Affinity DataEC50:  4.32E+3nMAssay Description:Agonist activity at His6-tagged-human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli BL21-CodonPlus-RIPL cells assessed a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459462(CHEMBL4208139)
Affinity DataEC50:  4.40E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280526(CHEMBL4162765)
Affinity DataEC50:  4.40E+3nMAssay Description:In vitro inhibition of arachidonic acid induced platelet aggregation in human platelet-rich plasmaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280736(CHEMBL4164266)
Affinity DataEC50:  4.50E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50543001(CHEMBL4649512)
Affinity DataEC50:  4.76E+3nMAssay Description:Agonist activity at His6-tagged-human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli BL21-CodonPlus-RIPL cells assessed a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459420(CHEMBL4203773)
Affinity DataEC50:  5.40E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459445(CHEMBL4215811)
Affinity DataEC50:  5.60E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280666(CHEMBL4162049)
Affinity DataEC50:  5.90E+3nMAssay Description:Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the intercept effect(Kii)More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459456(CHEMBL4207963)
Affinity DataEC50:  5.90E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459449(CHEMBL4213025)
Affinity DataEC50:  5.90E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459446(CHEMBL4214844)
Affinity DataEC50:  5.90E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459430(CHEMBL4214821)
Affinity DataEC50:  6.00E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280527(CHEMBL4172730)
Affinity DataEC50:  6.10E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464228(CHEMBL4237333)
Affinity DataEC50:  6.20E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464224(CHEMBL4245081)
Affinity DataEC50:  6.40E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464227(CHEMBL4243999)
Affinity DataEC50:  6.60E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459454(CHEMBL4215515)
Affinity DataEC50:  6.60E+3nMAssay Description:Activation of human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280581(CHEMBL4172148)
Affinity DataEC50:  6.70E+3nMAssay Description:In vitro evaluation for arachidonic acid induced platelet aggregation of human platelet-rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464197(CHEMBL4237885)
Affinity DataEC50:  7.10E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459430(CHEMBL4214821)
Affinity DataEC50:  7.30E+3nMAssay Description:Activation of SOS1 in human NCI-H727 cells expressing KRAS G12V mutant assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459439(CHEMBL4215257)
Affinity DataEC50:  7.30E+3nMAssay Description:Activation of SOS1 in human NCI-H727 cells expressing KRAS G12V mutant assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50464193(CHEMBL4250348)
Affinity DataEC50:  7.70E+3nMAssay Description:Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50280667(CHEMBL4175280)
Affinity DataEC50:  7.80E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSon of sevenless homolog 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50459433(CHEMBL4208983)
Affinity DataEC50:  7.80E+3nMAssay Description:Activation of SOS1 in human HeLa cells expressing wild type KRAS assessed as induction of ERK1/2 T202/Y204 phosphorylation incubated for 30 mins by I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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