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Found 121 Enz. Inhib. hit(s) with Target = 'Spike glycoprotein'
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM429291(med.21724, Compound 27)
Affinity DataEC50:  760nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(MERS-CoV)
University Of Bonn

LigandPNGBDBM429291(med.21724, Compound 27)
Affinity DataEC50:  1.27E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM428938(med.21724, Compound 5)
Affinity DataEC50:  3.89E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein [668-1255](SARS-CoV)
University Of Bonn

LigandPNGBDBM428875(med.21724, Compound 2)
Affinity DataEC50:  4.40E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50580315(CHEMBL5088335)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of SARS-CoV-2 spike glycoprotein expressed in HEK293T cells transfected with pAAV-CAG-HnCovS-RFP assessed as inhibition of membrane fusion...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataEC50:  1.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50580316(CHEMBL5094996)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of SARS-CoV-2 spike glycoprotein expressed in HEK293T cells transfected with pAAV-CAG-HnCovS-RFP assessed as inhibition of membrane fusion...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein [668-1255](SARS-CoV)
University Of Bonn

LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataEC50:  1.06E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataEC50:  8.34E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50590308(CHEMBL5201689)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of biotinylated heparin binding to His-tagged wild type SARS-COV-2 spike protein assessed inhibition constant incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSpike glycoprotein(MERS-CoV)
University Of Bonn

LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  9.51E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50001888((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Affinity DataIC50:  1.30E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(MERS-CoV)
University Of Bonn

LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
Affinity DataIC50:  5.86E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50017696((2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiaz...)
Affinity DataIC50:  2.14E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(MERS-CoV)
University Of Bonn

LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataIC50:  1.18E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataIC50:  1.18E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50559137(CHEMBL4785828)
Affinity DataIC50:  100nMAssay Description:Inhibition of spike protein in SARS-CoV infected in human HeLa cells haboring wild type ACE2 assessed as reduction in virus infectivity preincubated ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50568789(Hypocrellin A | Rel-Hypocrellin A)
Affinity DataIC50:  38nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50568790(CHEMBL4869623)
Affinity DataIC50:  120nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50568791(CHEMBL4861894)
Affinity DataIC50:  170nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataIC50:  160nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50568789(Hypocrellin A | Rel-Hypocrellin A)
Affinity DataKd:  38nMAssay Description:Binding affinity to SARS-CoV-2 spike glycoprotein S RBD at 25 degreeC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50568790(CHEMBL4869623)
Affinity DataKd:  23nMAssay Description:Binding affinity to SARS-CoV-2 spike glycoprotein S RBD at 25 degreeC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540811(Oleanic acid | US11266632, Compound 1)
Affinity DataIC50:  4.76E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540812(Maslinic acid | US11266632, Compound 2)
Affinity DataIC50:  9.99E+4nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540813(Propargyl- (3beta)-3- hydroxyolean- 12-en-28-oate ...)
Affinity DataIC50:  4.20E+4nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540814(Propargyl- (2alpha,3beta)-2,3- dihydroxyolean- 12-...)
Affinity DataIC50:  2.36E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540815(Propargyl-(2alpha)-2- (propargyloxy)- (3beta)-3-hy...)
Affinity DataIC50:  8.52E+4nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540817(Propargyl-(3alpha)-3- (propargyloxy)- (2beta)-2-hy...)
Affinity DataIC50:  1.35E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540818(Propargyl- (2alpha,3beta)-2,3- bis(propargyloxy)- ...)
Affinity DataIC50:  1.08E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540819((1-(3- mcthylphenyl)-1H- 1,2,3-triazol- 5-yl)methy...)
Affinity DataIC50:  1.74E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540820((1-(3- methylphenyl)-1H- 1,2,3-triazol- 5-yl)methy...)
Affinity DataIC50:  1.32E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540821((1-(3- methylphenyl)-1H- 1,2,3-triazol- 4-yl)methy...)
Affinity DataIC50:  7.53E+4nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540822((1-Phenyl-1H- 1,2,3-triazol-4- yl)methyl- (2alpha,...)
Affinity DataIC50:  1.35E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540823((1-(4- Chlorophenyl)-1H- 1,2,3-triazol- 4-yl)methy...)
Affinity DataIC50:  1.16E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540824((1-(4- Methoxyphenyl)- 1H-1,2,3- triazol-4-yl)meth...)
Affinity DataIC50:  1.59E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540826((1-(4- Methoxyphenyl)- 1H-1,2,3- triazol-4-yl)meth...)
Affinity DataIC50:  1.37E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540827((3-(4- methoxyphenyl) isoxazol-5- yl) methyl-(3bet...)
Affinity DataIC50:  5.23E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540828((3-(4- methoxyphenyl) isoxazol-5- yl) methyl-(2alp...)
Affinity DataIC50:  2.19E+5nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(2019-nCoV)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM540829((3-(4-chlorophenyl) isoxazol-5-yl) methyl-(2alpha,...)
Affinity DataIC50:  4.12E+3nMAssay Description:The IC50 values for the tested compounds were determined as previously described [2, 3], with minor modifications. Briefly, in 96-well tissue culture...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567439(CHEMBL4849021)
Affinity DataIC50:  1.81E+4nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567440(CHEMBL4847112)
Affinity DataIC50:  5.54E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567441(CHEMBL4855702)
Affinity DataIC50:  8.33E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567442(CHEMBL4865677)
Affinity DataIC50:  9.97E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567443(CHEMBL4852791)
Affinity DataIC50:  6.27E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567444(CHEMBL4873011)
Affinity DataIC50:  4.37E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567445(CHEMBL4876819)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567446(CHEMBL4869223)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567447(CHEMBL4852531)
Affinity DataIC50:  5.89E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpike glycoprotein(SARS-CoV)
University Of Bonn

LigandPNGBDBM50567448(CHEMBL4875210)
Affinity DataIC50:  7.76E+3nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected human 293T/ACE2 cells assessed as inhibition of viral infection measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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