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Found 14 Enz. Inhib. hit(s) with Target = 'NEDD8-activating enzyme E1 regulatory subunit'
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50594972(CHEMBL5177755)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427034(CHEMBL2322194)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of NAE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427035(CHEMBL2017005)
Affinity DataIC50:  10nMAssay Description:Inhibition of NAE (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50285607(MLN-4924 | MLN-4924003 | Pevonedistat)
Affinity DataIC50:  180nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50574026(CHEMBL4282603)
Affinity DataIC50:  260nMAssay Description:Inhibition of NAE1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427031(CHEMBL2322197)
Affinity DataIC50:  800nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed NEDD8-Ubcl2 intermediate formation by densitometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of NAE (unknown origin) assessed as decrease in NEDD8-Ubcl2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50562350(CHEMBL4788522)
Affinity DataIC50:  5.51E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50562351(CHEMBL4746177)
Affinity DataIC50:  6.67E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50562352(CHEMBL4744561)
Affinity DataIC50:  9.94E+3nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50318907(2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of NAE (unknown origin)-mediated neddylation assessed as suppression of cullin1-Nedd8 adduct formation preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50427032(6,6''-Biapigenin | CHEMBL2322196)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of NAE (unknown origin)-catalyzed transthiolation of NEDD8 from NAE to Ubc12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of Protein kinase C delta expressed in Sf-9 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNEDD8-activating enzyme E1 regulatory subunit(Homo sapiens (Human))
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50537681(CHEMBL4640167)
Affinity DataEC50:  3.56E+3nMAssay Description:Inhibition of NAE-mediated neddylation in human MGC-803 cells assessed as effect on NEDD8-UBC12 coupling product formationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed